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The map label for this gene is trpF

Identifier: 54297222

GI number: 54297222

Start: 1404602

End: 1405225

Strand: Direct

Name: trpF

Synonym: lpp1267

Alternate gene names: 54297222

Gene position: 1404602-1405225 (Clockwise)

Preceding gene: 54297221

Following gene: 54297223

Centisome position: 40.09

GC content: 37.34

Gene sequence:

>624_bases
TTGAATCCATCTCGTATAAGAATCAAAATGTGTGGAATGACACGTTCAGAAGATATTCAATACGCCATTGATTTAGGGGT
GGACGCGATTGGCTTAATATTTTATCCCAAAAGTGCGCGTAATGTCTCACTGGAAAAAGCCAGAATAATAGTCAATAATA
TACCTCCATTTGTTGATATTGTTGCAGTTTTGGTAAACCCAGAACAATCTTTTGTTCAACTGATTATTAATGAAATTCCT
GTGCAGTTATTGCAATTTCATGGTGAGGAATCTTCAGAGTTTTGCAGACAATTTAATAAGCCGTTTATCAAAGCGATTCA
TCCTAAGACAGCAATCCAAATCCAAAGTGCTGTTGATGAGTTTTTTGATGCGAGCGCTATATTGTTGGATACGCCATCAG
ACAAGGAACGAGGAGGAACAGGATTAACTTTTGACTGGAATATAATTCCTGAAAATTTATCCAAGCCTTACATATTGGCA
GGTGGTTTGAATGAATCTAACATTTTAGAGGCAATTACCATGTGTCATCCTTATGCAGTGGATGTGTGCAGTGGTATAGA
AGCTTCACCCGGAGTAAAAGATCATTTGAAAATGAGCCGATTTATAAAGGCAATATGGGGATAG

Upstream 100 bases:

>100_bases
TGCACCGTCATATGGCCTATATTTGGTCCAGGTGACTTATCCCAAAGAATTTGGATTGTTGCAAAATAATCCAGGCCCTT
TGTTTCTTTGGGAGAAATAA

Downstream 100 bases:

>100_bases
TATGATTAAAAAAGAGCTTCCAGATGAGTTTGGCCATTTTGGCCCATATGGCGGTATGTTTGTAGCCGATACATTAGTTC
ATGCTTTAAAACAATTAGAG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSARNVSLEKARIIVNNIPPFVDIVAVLVNPEQSFVQLIINEIP
VQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDEFFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILA
GGLNESNILEAITMCHPYAVDVCSGIEASPGVKDHLKMSRFIKAIWG

Sequences:

>Translated_207_residues
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSARNVSLEKARIIVNNIPPFVDIVAVLVNPEQSFVQLIINEIP
VQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDEFFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILA
GGLNESNILEAITMCHPYAVDVCSGIEASPGVKDHLKMSRFIKAIWG
>Mature_207_residues
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSARNVSLEKARIIVNNIPPFVDIVAVLVNPEQSFVQLIINEIP
VQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDEFFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILA
GGLNESNILEAITMCHPYAVDVCSGIEASPGVKDHLKMSRFIKAIWG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=189, Percent_Identity=30.1587301587302, Blast_Score=74, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320210, Length=216, Percent_Identity=31.0185185185185, Blast_Score=85, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_LEGPA (Q5X5Q3)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123591.1
- HSSP:   Q56320
- ProteinModelPortal:   Q5X5Q3
- SMR:   Q5X5Q3
- STRING:   Q5X5Q3
- GeneID:   3118952
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1267
- LegioList:   lpp1267
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- BioCyc:   LPNE297246:LPP1267-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23018; Mature: 23018

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSARNVSLEKARIIVNNIPPFVDI
CCCCEEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHEEEECCCCCHHHH
VAVLVNPEQSFVQLIINEIPVQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDE
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHH
FFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILAGGLNESNILEAITMCHPYAV
HHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCHHH
DVCSGIEASPGVKDHLKMSRFIKAIWG
HHHCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSARNVSLEKARIIVNNIPPFVDI
CCCCEEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHEEEECCCCCHHHH
VAVLVNPEQSFVQLIINEIPVQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDE
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHH
FFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILAGGLNESNILEAITMCHPYAV
HHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCHHH
DVCSGIEASPGVKDHLKMSRFIKAIWG
HHHCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA