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The map label for this gene is yngE [H]

Identifier: 54027304

GI number: 54027304

Start: 5633190

End: 5634788

Strand: Reverse

Name: yngE [H]

Synonym: nfa53300

Alternate gene names: 54027304

Gene position: 5634788-5633190 (Counterclockwise)

Preceding gene: 54027305

Following gene: 54027303

Centisome position: 93.58

GC content: 68.11

Gene sequence:

>1599_bases
ATGACGATCCTGCGCAGCACCCTCGACAGCGCGGCACCGGAATACACCGCCGCCGCCGAGGCGATGACCACCAAACTCAC
CGAGATCGAAGCCGAATTCGCCAAGGCGGTCGCCGGTGGCGGGCCCGAGAAGCTGGCCAGGCATCGCAAGCGCGGCAAGC
TCACCGCCCGCGAACGCATCGAGCTGCTCATCGACGAGGACTCGCCGTTCCTGGAGCTGTGCCCGCTGGCCGCCTGGGGC
AGCGAATTCCACGTCGGTGCCAGCGTGATCGCCGGGATCGGCATCGTGGAGGGCGTGGAGTGCATGATCGTCGCGCCCGA
CCCGACGGTGCGCGGGGGCACCTCCAACCCGTGGACGTTGCGCAAGAACCTGCGCATGAACGACATCGCCATGGAGAACC
GGCTGCCGGTGATCGGCCTGGTCGAATCCGGCGGCGCGGACCTGCCCACCCAGAAGGAGGTCTTCGTCCCCGGCGGGCGG
ATGTTCCGCGACCTCACCAAGCTCTCCGCGATGGGCATTCCCACCATCGCGCTGGTGTTCGGCAATTCCACCGCGGGCGG
TGCCTACATCCCCGGCATGTCCGACTACACGGTGATGATCAAGGAGCGCTCCAAGGTGTTCCTCGGCGGCCCGCCGCTGG
TGAAGATGGCCACCGGGGAGGAATCCGACGACGAATCCCTCGGCGGCGCCGAGATGCATGCCCGCACCTCGGGTCTGGCC
GACTACCTCGCCGCCGACGAGCAGGACGCCATCCGGATCGGCCGCTCCATCGTCAAACGGCTGAACTGGCGCAAGCAGGG
CCCGGCGCCGCGCGGTCCGGTGCTCGAGCCGCGCTACGACCCCGAGGAATTGCTCGGCATCGTGCCCGCCGACCTGAAGA
TCCCGTTCGACCCGCGCGAGGTGATCGCGCGCGTGGTCGACGACTCCGACTTCGACGAGTTCAAGCCGCTCTACGGCAGC
AGCCTGGTCACCGGCTGGGCGCAACTGCACGGCTACCCGGTCGGCATCCTCGCCAACGCGCGCGGCGTGCTGTTCTCCGA
GGAGGCACAGAAGGCCGCGCAGTTCATCCAGCTCGCCAACCAGTCCGACACGCCACTGCTGTTCCTGCACAACACCACCG
GCTACATGGTCGGCAAGGAGTTCGAGCAGAAGGGCATCATCAAGCACGGCGCGATGATGATCAACGCGGTGTCGAACTCG
AAGGTGCCGCACATCTCGCTGCTGATGGGCGCCTCCTACGGCGCGGGCCACTACGGCATGTGCGGCCGCGCCTACGATCC
GCGCTTCGTCTTCGCCTGGCCCAGCGCGAAATCCGCGGTCATGGGTGGTGCGCAGCTGGCCGGTGTGATCTCGATCGTCG
GTCGGGCCGCCGCCGAGGCGCGCGGCAAGCCGTTCGACGAGGAGGCCGACGCGGGGATGCGCGCGATGATCGAGGCGCAG
ATCGAGGCCGAGTCGCTGCCGATGTTCATGTCCGGCAGGCTCTACGACGACGGCGTGATCGATCCCCGCGATACCCGCAC
GGTGTTGGGCATGGCGCTCTCGGCCATCCACAACGCCCCGATCAAGGGCGCCGAGGGCTTCGGCGTCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
AGGTGGAGCGCCAGTACCGCGACATCCGCATCCTCGGTATCGGCGGCGGCACCACCGAGATCCTGACCGGCCTGGCGGCC
AAGCGATTGGGGTACCAGTC

Downstream 100 bases:

>100_bases
GGCACGCGATGACGATTTCCACTGTGCTGGTCGCGAATCGAGGCGAGATCGCCCGGCGCGTGTTCGCCACCTGCCGCCGG
ATGGGACTGGGCACCGTCGC

Product: putative acetyl/propionyl-CoA carboxylase subunit beta

Products: ADP; H+; Malonyl-CoA; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTILRSTLDSAAPEYTAAAEAMTTKLTEIEAEFAKAVAGGGPEKLARHRKRGKLTARERIELLIDEDSPFLELCPLAAWG
SEFHVGASVIAGIGIVEGVECMIVAPDPTVRGGTSNPWTLRKNLRMNDIAMENRLPVIGLVESGGADLPTQKEVFVPGGR
MFRDLTKLSAMGIPTIALVFGNSTAGGAYIPGMSDYTVMIKERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLA
DYLAADEQDAIRIGRSIVKRLNWRKQGPAPRGPVLEPRYDPEELLGIVPADLKIPFDPREVIARVVDDSDFDEFKPLYGS
SLVTGWAQLHGYPVGILANARGVLFSEEAQKAAQFIQLANQSDTPLLFLHNTTGYMVGKEFEQKGIIKHGAMMINAVSNS
KVPHISLLMGASYGAGHYGMCGRAYDPRFVFAWPSAKSAVMGGAQLAGVISIVGRAAAEARGKPFDEEADAGMRAMIEAQ
IEAESLPMFMSGRLYDDGVIDPRDTRTVLGMALSAIHNAPIKGAEGFGVFRM

Sequences:

>Translated_532_residues
MTILRSTLDSAAPEYTAAAEAMTTKLTEIEAEFAKAVAGGGPEKLARHRKRGKLTARERIELLIDEDSPFLELCPLAAWG
SEFHVGASVIAGIGIVEGVECMIVAPDPTVRGGTSNPWTLRKNLRMNDIAMENRLPVIGLVESGGADLPTQKEVFVPGGR
MFRDLTKLSAMGIPTIALVFGNSTAGGAYIPGMSDYTVMIKERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLA
DYLAADEQDAIRIGRSIVKRLNWRKQGPAPRGPVLEPRYDPEELLGIVPADLKIPFDPREVIARVVDDSDFDEFKPLYGS
SLVTGWAQLHGYPVGILANARGVLFSEEAQKAAQFIQLANQSDTPLLFLHNTTGYMVGKEFEQKGIIKHGAMMINAVSNS
KVPHISLLMGASYGAGHYGMCGRAYDPRFVFAWPSAKSAVMGGAQLAGVISIVGRAAAEARGKPFDEEADAGMRAMIEAQ
IEAESLPMFMSGRLYDDGVIDPRDTRTVLGMALSAIHNAPIKGAEGFGVFRM
>Mature_531_residues
TILRSTLDSAAPEYTAAAEAMTTKLTEIEAEFAKAVAGGGPEKLARHRKRGKLTARERIELLIDEDSPFLELCPLAAWGS
EFHVGASVIAGIGIVEGVECMIVAPDPTVRGGTSNPWTLRKNLRMNDIAMENRLPVIGLVESGGADLPTQKEVFVPGGRM
FRDLTKLSAMGIPTIALVFGNSTAGGAYIPGMSDYTVMIKERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLAD
YLAADEQDAIRIGRSIVKRLNWRKQGPAPRGPVLEPRYDPEELLGIVPADLKIPFDPREVIARVVDDSDFDEFKPLYGSS
LVTGWAQLHGYPVGILANARGVLFSEEAQKAAQFIQLANQSDTPLLFLHNTTGYMVGKEFEQKGIIKHGAMMINAVSNSK
VPHISLLMGASYGAGHYGMCGRAYDPRFVFAWPSAKSAVMGGAQLAGVISIVGRAAAEARGKPFDEEADAGMRAMIEAQI
EAESLPMFMSGRLYDDGVIDPRDTRTVLGMALSAIHNAPIKGAEGFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=530, Percent_Identity=48.1132075471698, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI119943100, Length=538, Percent_Identity=31.0408921933086, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI295821216, Length=558, Percent_Identity=30.1075268817204, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=44.6969696969697, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17552936, Length=535, Percent_Identity=46.5420560747664, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI25147362, Length=530, Percent_Identity=30.188679245283, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI25147359, Length=525, Percent_Identity=30.2857142857143, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24586065, Length=555, Percent_Identity=47.3873873873874, Blast_Score=506, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.2 [C]

Molecular weight: Translated: 57125; Mature: 56994

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILRSTLDSAAPEYTAAAEAMTTKLTEIEAEFAKAVAGGGPEKLARHRKRGKLTARERI
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCEE
ELLIDEDSPFLELCPLAAWGSEFHVGASVIAGIGIVEGVECMIVAPDPTVRGGTSNPWTL
EEEECCCCCHHHHCCCHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEE
RKNLRMNDIAMENRLPVIGLVESGGADLPTQKEVFVPGGRMFRDLTKLSAMGIPTIALVF
ECCCCCCHHHHHCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEE
GNSTAGGAYIPGMSDYTVMIKERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLA
CCCCCCCEECCCCCCEEEEEEECCEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
DYLAADEQDAIRIGRSIVKRLNWRKQGPAPRGPVLEPRYDPEELLGIVPADLKIPFDPRE
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCCCHHH
VIARVVDDSDFDEFKPLYGSSLVTGWAQLHGYPVGILANARGVLFSEEAQKAAQFIQLAN
HHHHHHCCCCHHHHCHHCCCHHHHHHHHHCCCCEEEEECCCCCEECHHHHHHHHHHHHCC
QSDTPLLFLHNTTGYMVGKEFEQKGIIKHGAMMINAVSNSKVPHISLLMGASYGAGHYGM
CCCCCEEEEECCCCCEECCHHHHCCCHHHCCEEEEECCCCCCCEEEEEEECCCCCCCCCC
CGRAYDPRFVFAWPSAKSAVMGGAQLAGVISIVGRAAAEARGKPFDEEADAGMRAMIEAQ
CCCCCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHH
IEAESLPMFMSGRLYDDGVIDPRDTRTVLGMALSAIHNAPIKGAEGFGVFRM
HHHHCCCEEECCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECC
>Mature Secondary Structure 
TILRSTLDSAAPEYTAAAEAMTTKLTEIEAEFAKAVAGGGPEKLARHRKRGKLTARERI
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCEE
ELLIDEDSPFLELCPLAAWGSEFHVGASVIAGIGIVEGVECMIVAPDPTVRGGTSNPWTL
EEEECCCCCHHHHCCCHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEE
RKNLRMNDIAMENRLPVIGLVESGGADLPTQKEVFVPGGRMFRDLTKLSAMGIPTIALVF
ECCCCCCHHHHHCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEE
GNSTAGGAYIPGMSDYTVMIKERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLA
CCCCCCCEECCCCCCEEEEEEECCEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
DYLAADEQDAIRIGRSIVKRLNWRKQGPAPRGPVLEPRYDPEELLGIVPADLKIPFDPRE
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCCCHHH
VIARVVDDSDFDEFKPLYGSSLVTGWAQLHGYPVGILANARGVLFSEEAQKAAQFIQLAN
HHHHHHCCCCHHHHCHHCCCHHHHHHHHHCCCCEEEEECCCCCEECHHHHHHHHHHHHCC
QSDTPLLFLHNTTGYMVGKEFEQKGIIKHGAMMINAVSNSKVPHISLLMGASYGAGHYGM
CCCCCEEEEECCCCCEECCHHHHCCCHHHCCEEEEECCCCCCCEEEEEEECCCCCCCCCC
CGRAYDPRFVFAWPSAKSAVMGGAQLAGVISIVGRAAAEARGKPFDEEADAGMRAMIEAQ
CCCCCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHH
IEAESLPMFMSGRLYDDGVIDPRDTRTVLGMALSAIHNAPIKGAEGFGVFRM
HHHHCCCEEECCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; ATP; Bicarbonate [C]

Specific reaction: Acetyl-CoA + ATP + Bicarbonate <==> ADP + H+ + Malonyl-CoA + Phosphate [C]

General reaction: Carboxylation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]