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The map label for this gene is tmk [H]

Identifier: 54026585

GI number: 54026585

Start: 4800373

End: 4801020

Strand: Reverse

Name: tmk [H]

Synonym: nfa46120

Alternate gene names: 54026585

Gene position: 4801020-4800373 (Counterclockwise)

Preceding gene: 54026586

Following gene: 54026584

Centisome position: 79.73

GC content: 73.46

Gene sequence:

>648_bases
ATGGGCCTGCTCATCGCGTTGGAGGGACTCGACGGCGCCGGGAAGCGCACGCTGACCGACGCCGTCGTCGCCGCGCTGGG
CGCGCGGGGAGTGCGGGCGGCGACGCTCGGCTTCCCGCGCTACGGCCGATCGGTGCACGCCGACCTGGCCGCGGAGGCGC
TGCACGGCGCACACGGTGATCTGGCGTCCTCGGTGTACGCGATGGCGCTGCTGTTCGCGCTGGACCGCGCCGAGGCCCGC
GACGAGCTGTCGAAGGCGTTGGCCGACAACGACATCGTCATCCTCGACCGCTACGTCGCCTCCAACGCCGCCTACAACGC
CGCCCGGCTGCACCAGTCGGCCACAGGCGAGATCGTCGGCTGGACAGCGGATCTGGAGTTCGGCCGGTTCGGCCTGCCCG
AGCCGGATGTGCAGCTGCTGCTGGACGTGGACACCGAGGTCGCGGCCGAACGCGCGCGCAGGCGCACCGAACTCGACGCC
GACCGGCCGCTGGACGCCTACGAGCGCGACGGCGGGCTACAGCGGCGCACCCTCGCGGTGTACCGTGAGCTGGCCGAACG
CAACTGGCACGGGCCGTGGTGGCGGTATCGCTCCGGTGACGAGCCCGCGGCCCTGGCCGGGCGGCTCGCCGAGCTGATCG
GCCGCTAG

Upstream 100 bases:

>100_bases
AGGCGCTCGGTGGCACCCTGACCAAGCTCACCAAGGACCAGGCCGAGTACATCGGTGTGGACGTGGAGGGCCCGTACAAG
CCGGAGCACTACCGCTACTG

Downstream 100 bases:

>100_bases
GGTTGGATCCGCAGCGGGTTCGCCGCGGTGTTTGGCGTGGCGGCCCGATCCTCGCCTGGGAGATGACAACATAGTAACTA
TGAAGCCGAAGATTCTGGTC

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MGLLIALEGLDGAGKRTLTDAVVAALGARGVRAATLGFPRYGRSVHADLAAEALHGAHGDLASSVYAMALLFALDRAEAR
DELSKALADNDIVILDRYVASNAAYNAARLHQSATGEIVGWTADLEFGRFGLPEPDVQLLLDVDTEVAAERARRRTELDA
DRPLDAYERDGGLQRRTLAVYRELAERNWHGPWWRYRSGDEPAALAGRLAELIGR

Sequences:

>Translated_215_residues
MGLLIALEGLDGAGKRTLTDAVVAALGARGVRAATLGFPRYGRSVHADLAAEALHGAHGDLASSVYAMALLFALDRAEAR
DELSKALADNDIVILDRYVASNAAYNAARLHQSATGEIVGWTADLEFGRFGLPEPDVQLLLDVDTEVAAERARRRTELDA
DRPLDAYERDGGLQRRTLAVYRELAERNWHGPWWRYRSGDEPAALAGRLAELIGR
>Mature_214_residues
GLLIALEGLDGAGKRTLTDAVVAALGARGVRAATLGFPRYGRSVHADLAAEALHGAHGDLASSVYAMALLFALDRAEARD
ELSKALADNDIVILDRYVASNAAYNAARLHQSATGEIVGWTADLEFGRFGLPEPDVQLLLDVDTEVAAERARRRTELDAD
RPLDAYERDGGLQRRTLAVYRELAERNWHGPWWRYRSGDEPAALAGRLAELIGR

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23360; Mature: 23229

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLIALEGLDGAGKRTLTDAVVAALGARGVRAATLGFPRYGRSVHADLAAEALHGAHGD
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCH
LASSVYAMALLFALDRAEARDELSKALADNDIVILDRYVASNAAYNAARLHQSATGEIVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHCCCCCEEE
WTADLEFGRFGLPEPDVQLLLDVDTEVAAERARRRTELDADRPLDAYERDGGLQRRTLAV
EEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHH
YRELAERNWHGPWWRYRSGDEPAALAGRLAELIGR
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLLIALEGLDGAGKRTLTDAVVAALGARGVRAATLGFPRYGRSVHADLAAEALHGAHGD
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCH
LASSVYAMALLFALDRAEARDELSKALADNDIVILDRYVASNAAYNAARLHQSATGEIVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHCCCCCEEE
WTADLEFGRFGLPEPDVQLLLDVDTEVAAERARRRTELDADRPLDAYERDGGLQRRTLAV
EEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHH
YRELAERNWHGPWWRYRSGDEPAALAGRLAELIGR
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]