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The map label for this gene is ahcY

Identifier: 54026586

GI number: 54026586

Start: 4801020

End: 4802504

Strand: Reverse

Name: ahcY

Synonym: nfa46130

Alternate gene names: 54026586

Gene position: 4802504-4801020 (Counterclockwise)

Preceding gene: 54026587

Following gene: 54026585

Centisome position: 79.76

GC content: 66.67

Gene sequence:

>1485_bases
ATGACGACCTCAGAACTTCCCGCTCGCACGTCCCCGACCCCCGATGTCCGCAACGGCATCGACTACAAGGTGGCGGATCT
GACGCTGGCCGAGTTCGGCCGCAAGGAGATCCGGCTGGCCGAGCACGAGATGCCCGGCCTGATGGCGCTGCGCCGCGAAT
ACGCCGACGTGCAGCCGCTGAAGGGCGCCCGCATCTCCGGCTCGCTGCACATGACCGTGCAGACCGCGGTGCTCATCGAG
ACCCTCACCGCGCTCGGCGCGCAGGTGCGCTGGGCCTCCTGCAACATCTTCTCCACCCAGGACCACGCCGCGGCCGCGGT
CGTCGTCGGCCCGCACGGCACCGTCGAGGAGCCGAAGGGCGTGTCGGTGTTCGCGTGGAAGGGCGAGACCCTCGAGGAGT
ACTGGTGGGCGGCCGAGCAGATGCTCACCTGGCCGGGCGAGCCCGCCAACATGATCCTCGACGACGGTGGCGACGCCACC
ATGCTGGTGCTGCGCGGCGCCCAGTTCGAGAAGGCCGGTGTGGTGCCGCCGGAGGACGCCGACCACTCCGCCGAGTACAA
GGTCTTCCTGAACCTGCTGCGCGAGCGCTTCGAGACCGACCGCGGCAAGTGGACCGCCATCGCCGAGAGCGTGCGCGGCG
TCACCGAGGAGACCACCACCGGCGTGCTGCGGCTCTACCAGTTCGCGGCGGCCGGCGAGTTGGTGTTCCCGGCGATCAAC
GTCAACGACTCGGTCACCAAGAGCAAGTTCGACAACAAGTACGGCACCCGCCACTCCCTCATCGACGGCATCAACCGCGG
CACCGATGTGCTCATCGGCGGCAAGAAGGTGCTCATCTGTGGTTACGGCGACGTGGGCAAGGGCTGCGCGGAATCGCTTG
CCGGACAGGGCGCCCGGGTGCAGGTCACCGAGATCGACCCGATCAACGCGCTGCAGGCGCTGATGGACGGCTACGACGTG
GTCACCGTCGAGCAGGCCATCGGCGAAGCCGACATCGTGATCACCGCGACCGGCAACAAGGACATCATCACCCTCGACCA
CATGAAGGCGATGAAGGACCAGGCCATCCTGGGCAACATCGGCCACTTCGACAACGAGATCGACATGGCCGCGCTGGAGC
GTTCCGGCGCAACGAGACTCACCATCAAGCCGCAGGTCGACCTGTGGACCTTCGGTGAGAGCGGCAAGTCGATCATCGTG
CTCTCCGAGGGCCGCCTGCTCAACCTGGGCAACGCCACCGGGCACCCCTCGTTCGTGATGTCCAACAGCTTCTCCAACCA
GGTGATCGCCCAGATCGAGCTGTGGACCAAGCCGGAGGAGTACGACAACGAGGTCTACCGGCTGCCCAAGCACCTGGACG
AGAAGGTCGCCCGCATCCACGTCGAGGCGCTCGGTGGCACCCTGACCAAGCTCACCAAGGACCAGGCCGAGTACATCGGT
GTGGACGTGGAGGGCCCGTACAAGCCGGAGCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
AACGGCCTGCCCGCCTGAGCGGGCGGGTGGCTCCCGCATGTCCACCGGCGCCGCCGAGGCGACTAGCCTTGCTTGCGAAC
AGCCGAACCAGGAGAGGCAT

Downstream 100 bases:

>100_bases
TGGGCCTGCTCATCGCGTTGGAGGGACTCGACGGCGCCGGGAAGCGCACGCTGACCGACGCCGTCGTCGCCGCGCTGGGC
GCGCGGGGAGTGCGGGCGGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTTSELPARTSPTPDVRNGIDYKVADLTLAEFGRKEIRLAEHEMPGLMALRREYADVQPLKGARISGSLHMTVQTAVLIE
TLTALGAQVRWASCNIFSTQDHAAAAVVVGPHGTVEEPKGVSVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDAT
MLVLRGAQFEKAGVVPPEDADHSAEYKVFLNLLRERFETDRGKWTAIAESVRGVTEETTTGVLRLYQFAAAGELVFPAIN
VNDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGYDV
VTVEQAIGEADIVITATGNKDIITLDHMKAMKDQAILGNIGHFDNEIDMAALERSGATRLTIKPQVDLWTFGESGKSIIV
LSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKPEEYDNEVYRLPKHLDEKVARIHVEALGGTLTKLTKDQAEYIG
VDVEGPYKPEHYRY

Sequences:

>Translated_494_residues
MTTSELPARTSPTPDVRNGIDYKVADLTLAEFGRKEIRLAEHEMPGLMALRREYADVQPLKGARISGSLHMTVQTAVLIE
TLTALGAQVRWASCNIFSTQDHAAAAVVVGPHGTVEEPKGVSVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDAT
MLVLRGAQFEKAGVVPPEDADHSAEYKVFLNLLRERFETDRGKWTAIAESVRGVTEETTTGVLRLYQFAAAGELVFPAIN
VNDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGYDV
VTVEQAIGEADIVITATGNKDIITLDHMKAMKDQAILGNIGHFDNEIDMAALERSGATRLTIKPQVDLWTFGESGKSIIV
LSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKPEEYDNEVYRLPKHLDEKVARIHVEALGGTLTKLTKDQAEYIG
VDVEGPYKPEHYRY
>Mature_493_residues
TTSELPARTSPTPDVRNGIDYKVADLTLAEFGRKEIRLAEHEMPGLMALRREYADVQPLKGARISGSLHMTVQTAVLIET
LTALGAQVRWASCNIFSTQDHAAAAVVVGPHGTVEEPKGVSVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATM
LVLRGAQFEKAGVVPPEDADHSAEYKVFLNLLRERFETDRGKWTAIAESVRGVTEETTTGVLRLYQFAAAGELVFPAINV
NDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGYDVV
TVEQAIGEADIVITATGNKDIITLDHMKAMKDQAILGNIGHFDNEIDMAALERSGATRLTIKPQVDLWTFGESGKSIIVL
SEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKPEEYDNEVYRLPKHLDEKVARIHVEALGGTLTKLTKDQAEYIGV
DVEGPYKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=475, Percent_Identity=54.9473684210526, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI239937451, Length=451, Percent_Identity=54.9889135254989, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI24308043, Length=493, Percent_Identity=44.6247464503043, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI298286489, Length=493, Percent_Identity=44.6247464503043, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI195539337, Length=493, Percent_Identity=44.6247464503043, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI195539349, Length=493, Percent_Identity=44.6247464503043, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI21361647, Length=493, Percent_Identity=44.6247464503043, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17506425, Length=477, Percent_Identity=57.0230607966457, Blast_Score=521, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320882, Length=490, Percent_Identity=53.469387755102, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24642172, Length=474, Percent_Identity=57.5949367088608, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=492, Percent_Identity=44.1056910569106, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553387, Length=476, Percent_Identity=45.3781512605042, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45553385, Length=475, Percent_Identity=45.2631578947368, Blast_Score=406, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_NOCFA (Q5YQS7)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_120828.1
- ProteinModelPortal:   Q5YQS7
- SMR:   Q5YQS7
- GeneID:   3109296
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa46130
- NMPDR:   fig|247156.1.peg.4438
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BioCyc:   NFAR247156:NFA46130-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 54045; Mature: 53914

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 72-72 BINDING 155-155 BINDING 217-217 BINDING 247-247 BINDING 251-251 BINDING 252-252 BINDING 304-304 BINDING 339-339 BINDING 408-408

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSELPARTSPTPDVRNGIDYKVADLTLAEFGRKEIRLAEHEMPGLMALRREYADVQPL
CCCCCCCCCCCCCCHHHCCCCEEEEEEEHHHCCCHHEEEHHHCCCHHHHHHHHHCCCCCC
KGARISGSLHMTVQTAVLIETLTALGAQVRWASCNIFSTQDHAAAAVVVGPHGTVEEPKG
CCCEECCEEEEEEHHHHHHHHHHHHCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCC
VSVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVLRGAQFEKAGVVPPEDA
CEEEEECCCCHHHHHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCC
DHSAEYKVFLNLLRERFETDRGKWTAIAESVRGVTEETTTGVLRLYQFAAAGELVFPAIN
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
VNDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARV
CCCCHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHCCCCCEE
QVTEIDPINALQALMDGYDVVTVEQAIGEADIVITATGNKDIITLDHMKAMKDQAILGNI
EEEECCHHHHHHHHHCCCCEEEEHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCCCC
GHFDNEIDMAALERSGATRLTIKPQVDLWTFGESGKSIIVLSEGRLLNLGNATGHPSFVM
CCCCCCHHHHHHHCCCCEEEEEECCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEEE
SNSFSNQVIAQIELWTKPEEYDNEVYRLPKHLDEKVARIHVEALGGTLTKLTKDQAEYIG
ECCCCCCEEEEEEEECCCCHHCHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHCCHHEEE
VDVEGPYKPEHYRY
EECCCCCCCCCCCC
>Mature Secondary Structure 
TTSELPARTSPTPDVRNGIDYKVADLTLAEFGRKEIRLAEHEMPGLMALRREYADVQPL
CCCCCCCCCCCCCHHHCCCCEEEEEEEHHHCCCHHEEEHHHCCCHHHHHHHHHCCCCCC
KGARISGSLHMTVQTAVLIETLTALGAQVRWASCNIFSTQDHAAAAVVVGPHGTVEEPKG
CCCEECCEEEEEEHHHHHHHHHHHHCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCC
VSVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVLRGAQFEKAGVVPPEDA
CEEEEECCCCHHHHHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCC
DHSAEYKVFLNLLRERFETDRGKWTAIAESVRGVTEETTTGVLRLYQFAAAGELVFPAIN
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
VNDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARV
CCCCHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHCCCCCEE
QVTEIDPINALQALMDGYDVVTVEQAIGEADIVITATGNKDIITLDHMKAMKDQAILGNI
EEEECCHHHHHHHHHCCCCEEEEHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCCCC
GHFDNEIDMAALERSGATRLTIKPQVDLWTFGESGKSIIVLSEGRLLNLGNATGHPSFVM
CCCCCCHHHHHHHCCCCEEEEEECCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEEE
SNSFSNQVIAQIELWTKPEEYDNEVYRLPKHLDEKVARIHVEALGGTLTKLTKDQAEYIG
ECCCCCCEEEEEEEECCCCHHCHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHCCHHEEE
VDVEGPYKPEHYRY
EECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA