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The map label for this gene is rnc

Identifier: 54026155

GI number: 54026155

Start: 4332866

End: 4333588

Strand: Reverse

Name: rnc

Synonym: nfa41840

Alternate gene names: 54026155

Gene position: 4333588-4332866 (Counterclockwise)

Preceding gene: 54026156

Following gene: 54026154

Centisome position: 71.97

GC content: 69.71

Gene sequence:

>723_bases
GTGACGGCCAGCAAGGACGACGCGGGCGCGTCCGATGATCACGCGAGCCTGCTCGAGGCCCTCGGTGTCGACGTACGACC
GGATCTGCTGCGCTTGGCGCTGACGCACCGGTCGTACGCCTACGAGAACGGCGGCCTGCCCACCAACGAACGCCTGGAAT
TCCTGGGCGACTCGGTGCTGGGCCTGAGCATCACCGAGCGGCTCTACCACGAACACCCGGACAAGTCCGAGGGCGAGTTG
GCGAAGCTGCGCGCGAGCGTGGTGAACATGCACGCGCTCGCCGAGGTGGCGCGTGGTCTGGGCGAAGGCGGTCTCGGCGC
GCACCTGCTGCTCGGTAAGGGCGAGGAGCTCACCGGCGGCCGGGACAAGCCGAGCATTCTCGCCGACGGCATGGAATCGC
TGCTCGGCGCCGTGCATCTGCAGCACGGCATCGACGTGGCCCGTGGCGTGGTGCTGCGGCTGTTCGCCGACCTGCTCGAG
CGCGGCCCCCGCATGGGCGCCGGACTCGACTGGAAGACCAGCCTGCAGGAACTCACCGCCGAACGCGGCCTCGGGGTGCC
TTCCTACGAGATCTCCTCGACCGGACCCGATCACGACAAGGAGTTCACCGCGACCACGGTGATCGGCGGCCGCGCCTACG
GGCAAGGGGTCGGGCGCTCGAAGAAGGAAGCCGAGCAGAAGGCCGCGGGCGCCGCCTACCAGGCGCTGACCGCCGAATCC
TGA

Upstream 100 bases:

>100_bases
CAGAAGACTCTGCCGCACATCGCGTGCCCCTCCTGCGGCACCTACAAGGGCCGCCAGGTCACCGCCGCCGTCTGACCGGT
TCGACCCCCTGACATCGAAC

Downstream 100 bases:

>100_bases
CGTGCCCGAACTTCCCGAGGTCGAGGTCGTCCGGCGTGGGCTGGCCGAGCATGTCGCCGGCCGTGTCGTCGGCGCCGTCA
CCATCACCCACCCGCGTTCG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTASKDDAGASDDHASLLEALGVDVRPDLLRLALTHRSYAYENGGLPTNERLEFLGDSVLGLSITERLYHEHPDKSEGEL
AKLRASVVNMHALAEVARGLGEGGLGAHLLLGKGEELTGGRDKPSILADGMESLLGAVHLQHGIDVARGVVLRLFADLLE
RGPRMGAGLDWKTSLQELTAERGLGVPSYEISSTGPDHDKEFTATTVIGGRAYGQGVGRSKKEAEQKAAGAAYQALTAES

Sequences:

>Translated_240_residues
MTASKDDAGASDDHASLLEALGVDVRPDLLRLALTHRSYAYENGGLPTNERLEFLGDSVLGLSITERLYHEHPDKSEGEL
AKLRASVVNMHALAEVARGLGEGGLGAHLLLGKGEELTGGRDKPSILADGMESLLGAVHLQHGIDVARGVVLRLFADLLE
RGPRMGAGLDWKTSLQELTAERGLGVPSYEISSTGPDHDKEFTATTVIGGRAYGQGVGRSKKEAEQKAAGAAYQALTAES
>Mature_239_residues
TASKDDAGASDDHASLLEALGVDVRPDLLRLALTHRSYAYENGGLPTNERLEFLGDSVLGLSITERLYHEHPDKSEGELA
KLRASVVNMHALAEVARGLGEGGLGAHLLLGKGEELTGGRDKPSILADGMESLLGAVHLQHGIDVARGVVLRLFADLLER
GPRMGAGLDWKTSLQELTAERGLGVPSYEISSTGPDHDKEFTATTVIGGRAYGQGVGRSKKEAEQKAAGAAYQALTAES

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=32.1888412017167, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=32.1888412017167, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788920, Length=198, Percent_Identity=39.3939393939394, Blast_Score=112, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17137682, Length=218, Percent_Identity=29.3577981651376, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_NOCFA (Q5YS08)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_120397.1
- ProteinModelPortal:   Q5YS08
- SMR:   Q5YS08
- GeneID:   3111461
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa41840
- NMPDR:   fig|247156.1.peg.4034
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   NFAR247156:NFA41840-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25347; Mature: 25216

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASKDDAGASDDHASLLEALGVDVRPDLLRLALTHRSYAYENGGLPTNERLEFLGDSVL
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHH
GLSITERLYHEHPDKSEGELAKLRASVVNMHALAEVARGLGEGGLGAHLLLGKGEELTGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
RDKPSILADGMESLLGAVHLQHGIDVARGVVLRLFADLLERGPRMGAGLDWKTSLQELTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ERGLGVPSYEISSTGPDHDKEFTATTVIGGRAYGQGVGRSKKEAEQKAAGAAYQALTAES
HHCCCCCCCCCCCCCCCCCCCEEHHEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TASKDDAGASDDHASLLEALGVDVRPDLLRLALTHRSYAYENGGLPTNERLEFLGDSVL
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHH
GLSITERLYHEHPDKSEGELAKLRASVVNMHALAEVARGLGEGGLGAHLLLGKGEELTGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
RDKPSILADGMESLLGAVHLQHGIDVARGVVLRLFADLLERGPRMGAGLDWKTSLQELTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ERGLGVPSYEISSTGPDHDKEFTATTVIGGRAYGQGVGRSKKEAEQKAAGAAYQALTAES
HHCCCCCCCCCCCCCCCCCCCEEHHEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA