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The map label for this gene is mutM

Identifier: 54026154

GI number: 54026154

Start: 4331980

End: 4332864

Strand: Reverse

Name: mutM

Synonym: nfa41830

Alternate gene names: 54026154

Gene position: 4332864-4331980 (Counterclockwise)

Preceding gene: 54026155

Following gene: 54026153

Centisome position: 71.96

GC content: 72.2

Gene sequence:

>885_bases
GTGCCCGAACTTCCCGAGGTCGAGGTCGTCCGGCGTGGGCTGGCCGAGCATGTCGCCGGCCGTGTCGTCGGCGCCGTCAC
CATCACCCACCCGCGTTCGGTACGCAGGCATCTCGCGGGTTCGGCCGATCTGGCCGCCCGGATGACCGGGCGCCGGGTGC
GCGCCGCGCAGCGTCGCGGCAAGTACCTGTGGCTCACCTTCGACGAGCCGGGCGCCGCCGACGAGACCGCGCTGGACGCC
GCGCTCGTGGTGCACCTGGGCATGAGCGGTCAGATGCTGGTACAGCCCGCCGCCGCGCCCGTGGAGAAGCATGCGCACAT
CCGCGCCGCGCTCGACGACGGCAGCGAGTTGCGGTTCGTCGACCAGCGCACCTTCGGCGGCTGGGCGCTCGCGCCGCTGG
CCGAGGTGGACGGTTCGCTGGTGCCCGAGCCGGTCGCCCACATCGCCCGCGATCCGCTCGACCCGCGCTTCGACGCCGAG
TCCGTGGTCGCCGCGATCCGGGCCAAGAATTCCGAGATCAAGCGCGTGCTGCTGGACCAGACCGTGGTGTCGGGCATCGG
CAACATCTACGCCGACGAGTCGCTGTGGCGGGCGGGGATCAACGGCAACCGGCTCGCGTCCGGCCTCACCCGCCCCGCGG
TGCGCAGGCTGCTCGCCGAGGTGCGGGCGGTGATGCTGGAGGCCTTGGCGGCGGGCGGCACCTCCTTCGACGCGCTGTAT
GTCAACGTCAACGGGCAGTCCGGCTACTTCGAACGCGCACTGGCGGTCTACGGCAGGCAGGACGAGCCGTGCCGCCGGTG
CGGCGCGCCGATCGTGCGCGAGAAGTTCATGAACCGATCGTCGTATTCCTGCCCGCGCTGTCAGCCGAGGCCTCGCCGCC
GCTGA

Upstream 100 bases:

>100_bases
GGCGGCCGCGCCTACGGGCAAGGGGTCGGGCGCTCGAAGAAGGAAGCCGAGCAGAAGGCCGCGGGCGCCGCCTACCAGGC
GCTGACCGCCGAATCCTGAC

Downstream 100 bases:

>100_bases
GCTTCGCGCGTTACCGTTGCCTCGGGTGGTCCGGTGCGTTCGCCGGATCGTCGGAGGAAGGACACCATGCGCAAGCTCAC
CTACTACGTCGCGTCGACGA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MPELPEVEVVRRGLAEHVAGRVVGAVTITHPRSVRRHLAGSADLAARMTGRRVRAAQRRGKYLWLTFDEPGAADETALDA
ALVVHLGMSGQMLVQPAAAPVEKHAHIRAALDDGSELRFVDQRTFGGWALAPLAEVDGSLVPEPVAHIARDPLDPRFDAE
SVVAAIRAKNSEIKRVLLDQTVVSGIGNIYADESLWRAGINGNRLASGLTRPAVRRLLAEVRAVMLEALAAGGTSFDALY
VNVNGQSGYFERALAVYGRQDEPCRRCGAPIVREKFMNRSSYSCPRCQPRPRRR

Sequences:

>Translated_294_residues
MPELPEVEVVRRGLAEHVAGRVVGAVTITHPRSVRRHLAGSADLAARMTGRRVRAAQRRGKYLWLTFDEPGAADETALDA
ALVVHLGMSGQMLVQPAAAPVEKHAHIRAALDDGSELRFVDQRTFGGWALAPLAEVDGSLVPEPVAHIARDPLDPRFDAE
SVVAAIRAKNSEIKRVLLDQTVVSGIGNIYADESLWRAGINGNRLASGLTRPAVRRLLAEVRAVMLEALAAGGTSFDALY
VNVNGQSGYFERALAVYGRQDEPCRRCGAPIVREKFMNRSSYSCPRCQPRPRRR
>Mature_293_residues
PELPEVEVVRRGLAEHVAGRVVGAVTITHPRSVRRHLAGSADLAARMTGRRVRAAQRRGKYLWLTFDEPGAADETALDAA
LVVHLGMSGQMLVQPAAAPVEKHAHIRAALDDGSELRFVDQRTFGGWALAPLAEVDGSLVPEPVAHIARDPLDPRFDAES
VVAAIRAKNSEIKRVLLDQTVVSGIGNIYADESLWRAGINGNRLASGLTRPAVRRLLAEVRAVMLEALAAGGTSFDALYV
NVNGQSGYFERALAVYGRQDEPCRRCGAPIVREKFMNRSSYSCPRCQPRPRRR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=290, Percent_Identity=37.9310344827586, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI1786932, Length=303, Percent_Identity=24.7524752475248, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_NOCFA (Q5YS09)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_120396.1
- ProteinModelPortal:   Q5YS09
- SMR:   Q5YS09
- GeneID:   3111311
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa41830
- NMPDR:   fig|247156.1.peg.4033
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BioCyc:   NFAR247156:NFA41830-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32054; Mature: 31923

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 279-279 BINDING 104-104 BINDING 123-123 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLAEHVAGRVVGAVTITHPRSVRRHLAGSADLAARMTGRRVRAAQRRG
CCCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
KYLWLTFDEPGAADETALDAALVVHLGMSGQMLVQPAAAPVEKHAHIRAALDDGSELRFV
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHEEEECCCCCCEEEE
DQRTFGGWALAPLAEVDGSLVPEPVAHIARDPLDPRFDAESVVAAIRAKNSEIKRVLLDQ
ECCCCCCEEECHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
TVVSGIGNIYADESLWRAGINGNRLASGLTRPAVRRLLAEVRAVMLEALAAGGTSFDALY
HHHHHHHHHHCCHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VNVNGQSGYFERALAVYGRQDEPCRRCGAPIVREKFMNRSSYSCPRCQPRPRRR
EEECCCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLAEHVAGRVVGAVTITHPRSVRRHLAGSADLAARMTGRRVRAAQRRG
CCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
KYLWLTFDEPGAADETALDAALVVHLGMSGQMLVQPAAAPVEKHAHIRAALDDGSELRFV
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHEEEECCCCCCEEEE
DQRTFGGWALAPLAEVDGSLVPEPVAHIARDPLDPRFDAESVVAAIRAKNSEIKRVLLDQ
ECCCCCCEEECHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
TVVSGIGNIYADESLWRAGINGNRLASGLTRPAVRRLLAEVRAVMLEALAAGGTSFDALY
HHHHHHHHHHCCHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VNVNGQSGYFERALAVYGRQDEPCRRCGAPIVREKFMNRSSYSCPRCQPRPRRR
EEECCCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA