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The map label for this gene is ffh [H]

Identifier: 54026131

GI number: 54026131

Start: 4306663

End: 4308225

Strand: Reverse

Name: ffh [H]

Synonym: nfa41600

Alternate gene names: 54026131

Gene position: 4308225-4306663 (Counterclockwise)

Preceding gene: 54026132

Following gene: 54026130

Centisome position: 71.55

GC content: 69.42

Gene sequence:

>1563_bases
GTGTTCGAATCCCTGTCCGACCGGCTTACCGGTGCCCTGAAGGATCTGCGCGGTAAGGGGCGTCTGTCACCGGCCGACAT
CGACGCCACGTGCCGGGAGATCCGGTTGGCCCTGCTCGAGGCCGACGTCGCGCTGCCCGTGGTGCGCGGTTTCATCGCCA
GGATCAAGGAGCGCGCGAAGGGCGCGGAGGTCTCCGCGGCGCTGAATCCCGCCCAGCAGGTCGTCAAGATCGTCAACGAG
GAACTCGTCGGCATCCTCGGCGGCGAGACCCGCAGGCTCAACCTGGCCAAGACCCCGCCGACGGTGATCATGCTCGCCGG
TCTGCAGGGCGCCGGTAAGACGACGCTGGCGGGCAAGCTCGCGAAATACCTGAAGGGGCAGGGACATCAGCCCTTGCTGG
TGGCCTGCGACCTGCAGCGCCCCGGCGCCGTCACCCAGCTCCAGGTGGTCGGCGAGCGCGCGGGCGTGCCCGTCTTCGCC
CCGCACCCGGGCACCTCGGTGGGCGGCGGGGAGAACCCGCTGGGCATCACCGCGGCCGACCCGGTCGAGGTCGCGCGCGG
CGGCGTCGCCGAGGCCCGCAACAAGCAGTACGACATCGTCATCGTCGACACCGCGGGCCGCCTCGGCATCGACGAGGAGC
TGATGCGCCAGGCCGCGAGCATCCGCGACGCCGTCCAGCCGGACGAGACGCTGTTCGTGCTCGACGCCATGATCGGTCAG
GACGCGGTGACCACCGCCGAAGCCTTCCGCGACGGCGTCGGCTTCACCGGCGTGGTGCTCACCAAGCTCGACGGCGACGC
CCGCGGCGGTGCGGCGCTGTCGGTGCGCAACGTCACCGGCGCGCCGATCATGTTCGCCTCCACCGGTGAGAAGCTCGAGG
ACTTCGACGTCTTCCACCCGGACCGGATGGCCAGCCGCATCCTGGGCATGGGTGACGTGCTCACCCTCATCGAGCAGGCC
GAACAGGTCTACGACGCGCAGCAGGCCGAGGAGGCGGCGCGCAAGATCGGCAGCGGCGAACTCACGCTGGAGGACTTCCT
CGAGCAGATGCTCGCCATCCGCAAGATGGGCCCGATCGGCAATCTGCTGGGCATGCTGCCGGGCGCGGGTCAGATGAAGG
ACGTGCTCGCCCAGGTCGACGACAAGCAGCTCGACCGGGTGCAGGCGATCATCCGTGGCATGACCCCCGCCGAGCGGGCC
AACCCCAAGATCATCAACGCCTCCCGGCGCCTGCGCATCGCCAACGGCTCCGGTGTCACGGTCTCGGAGGTCAACCAGCT
GGTCGACCGGTTCTTCGAGGCCAAGAAGATGATGGCGATGATGGGCCGCCAGATGGGCATGCCCGGCTCGCGCCGCAACG
CCAAGAAGGGCAAGAAGGGCAAGAAGGGCGGTCGCGGCCCCACCCCGCCGAAGGTGCGCGGCGGATTCCCGGGCATGCCC
GCCGGAATGCCGGGGATGCCCGCCGGGATGCCCGACATCTCCAACATGCCCGCGGGTCTCAACGAGCTGCCGCCGGGGCT
GGAGAACTTCGATCTGTCGAAGCTGAAGTTCCCGAAGAAGTAG

Upstream 100 bases:

>100_bases
GCCGAATAGCCGCTGCTCGGCGCACCGCGTGCGCGCAGGCCCGGGTGACCCCATTACGCTGGGAGATAATTGACGTCACT
CGAGATCAGGAGCGCGATCG

Downstream 100 bases:

>100_bases
GCGCCCGGCCCGACTCGCGGCGCCCGAGCGCCACCCGCAGGCGGCGCGAACGGGACAGAATGGGACTCGCGAGCCTCGCC
GCGGCACCGCGGCGGCGCAC

Product: putative signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MFESLSDRLTGALKDLRGKGRLSPADIDATCREIRLALLEADVALPVVRGFIARIKERAKGAEVSAALNPAQQVVKIVNE
ELVGILGGETRRLNLAKTPPTVIMLAGLQGAGKTTLAGKLAKYLKGQGHQPLLVACDLQRPGAVTQLQVVGERAGVPVFA
PHPGTSVGGGENPLGITAADPVEVARGGVAEARNKQYDIVIVDTAGRLGIDEELMRQAASIRDAVQPDETLFVLDAMIGQ
DAVTTAEAFRDGVGFTGVVLTKLDGDARGGAALSVRNVTGAPIMFASTGEKLEDFDVFHPDRMASRILGMGDVLTLIEQA
EQVYDAQQAEEAARKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMKDVLAQVDDKQLDRVQAIIRGMTPAERA
NPKIINASRRLRIANGSGVTVSEVNQLVDRFFEAKKMMAMMGRQMGMPGSRRNAKKGKKGKKGGRGPTPPKVRGGFPGMP
AGMPGMPAGMPDISNMPAGLNELPPGLENFDLSKLKFPKK

Sequences:

>Translated_520_residues
MFESLSDRLTGALKDLRGKGRLSPADIDATCREIRLALLEADVALPVVRGFIARIKERAKGAEVSAALNPAQQVVKIVNE
ELVGILGGETRRLNLAKTPPTVIMLAGLQGAGKTTLAGKLAKYLKGQGHQPLLVACDLQRPGAVTQLQVVGERAGVPVFA
PHPGTSVGGGENPLGITAADPVEVARGGVAEARNKQYDIVIVDTAGRLGIDEELMRQAASIRDAVQPDETLFVLDAMIGQ
DAVTTAEAFRDGVGFTGVVLTKLDGDARGGAALSVRNVTGAPIMFASTGEKLEDFDVFHPDRMASRILGMGDVLTLIEQA
EQVYDAQQAEEAARKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMKDVLAQVDDKQLDRVQAIIRGMTPAERA
NPKIINASRRLRIANGSGVTVSEVNQLVDRFFEAKKMMAMMGRQMGMPGSRRNAKKGKKGKKGGRGPTPPKVRGGFPGMP
AGMPGMPAGMPDISNMPAGLNELPPGLENFDLSKLKFPKK
>Mature_520_residues
MFESLSDRLTGALKDLRGKGRLSPADIDATCREIRLALLEADVALPVVRGFIARIKERAKGAEVSAALNPAQQVVKIVNE
ELVGILGGETRRLNLAKTPPTVIMLAGLQGAGKTTLAGKLAKYLKGQGHQPLLVACDLQRPGAVTQLQVVGERAGVPVFA
PHPGTSVGGGENPLGITAADPVEVARGGVAEARNKQYDIVIVDTAGRLGIDEELMRQAASIRDAVQPDETLFVLDAMIGQ
DAVTTAEAFRDGVGFTGVVLTKLDGDARGGAALSVRNVTGAPIMFASTGEKLEDFDVFHPDRMASRILGMGDVLTLIEQA
EQVYDAQQAEEAARKIGSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMKDVLAQVDDKQLDRVQAIIRGMTPAERA
NPKIINASRRLRIANGSGVTVSEVNQLVDRFFEAKKMMAMMGRQMGMPGSRRNAKKGKKGKKGGRGPTPPKVRGGFPGMP
AGMPGMPAGMPDISNMPAGLNELPPGLENFDLSKLKFPKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=447, Percent_Identity=32.8859060402685, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=33.6760925449871, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI89061728, Length=147, Percent_Identity=41.4965986394558, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI23308697, Length=312, Percent_Identity=30.4487179487179, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI295424842, Length=312, Percent_Identity=30.4487179487179, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1788963, Length=434, Percent_Identity=50.4608294930876, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1789874, Length=278, Percent_Identity=35.2517985611511, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=434, Percent_Identity=30.8755760368664, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI193206261, Length=303, Percent_Identity=30.03300330033, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=484, Percent_Identity=33.0578512396694, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6320498, Length=217, Percent_Identity=32.258064516129, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=30.561797752809, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24641198, Length=323, Percent_Identity=27.5541795665635, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 55112; Mature: 55112

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSDRLTGALKDLRGKGRLSPADIDATCREIRLALLEADVALPVVRGFIARIKERAK
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEVSAALNPAQQVVKIVNEELVGILGGETRRLNLAKTPPTVIMLAGLQGAGKTTLAGKL
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHH
AKYLKGQGHQPLLVACDLQRPGAVTQLQVVGERAGVPVFAPHPGTSVGGGENPLGITAAD
HHHHCCCCCCCEEEEECCCCCCCCHHHEEHHHHCCCCEECCCCCCCCCCCCCCCCCCCCC
PVEVARGGVAEARNKQYDIVIVDTAGRLGIDEELMRQAASIRDAVQPDETLFVLDAMIGQ
HHHHHCCCHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHCC
DAVTTAEAFRDGVGFTGVVLTKLDGDARGGAALSVRNVTGAPIMFASTGEKLEDFDVFHP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEECCCCCHHHCCCCCH
DRMASRILGMGDVLTLIEQAEQVYDAQQAEEAARKIGSGELTLEDFLEQMLAIRKMGPIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHH
NLLGMLPGAGQMKDVLAQVDDKQLDRVQAIIRGMTPAERANPKIINASRRLRIANGSGVT
HHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCEECCCCEEEEECCCCCC
VSEVNQLVDRFFEAKKMMAMMGRQMGMPGSRRNAKKGKKGKKGGRGPTPPKVRGGFPGMP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AGMPGMPAGMPDISNMPAGLNELPPGLENFDLSKLKFPKK
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHCCCCCC
>Mature Secondary Structure
MFESLSDRLTGALKDLRGKGRLSPADIDATCREIRLALLEADVALPVVRGFIARIKERAK
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEVSAALNPAQQVVKIVNEELVGILGGETRRLNLAKTPPTVIMLAGLQGAGKTTLAGKL
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHH
AKYLKGQGHQPLLVACDLQRPGAVTQLQVVGERAGVPVFAPHPGTSVGGGENPLGITAAD
HHHHCCCCCCCEEEEECCCCCCCCHHHEEHHHHCCCCEECCCCCCCCCCCCCCCCCCCCC
PVEVARGGVAEARNKQYDIVIVDTAGRLGIDEELMRQAASIRDAVQPDETLFVLDAMIGQ
HHHHHCCCHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHCC
DAVTTAEAFRDGVGFTGVVLTKLDGDARGGAALSVRNVTGAPIMFASTGEKLEDFDVFHP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEECCCCCHHHCCCCCH
DRMASRILGMGDVLTLIEQAEQVYDAQQAEEAARKIGSGELTLEDFLEQMLAIRKMGPIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHH
NLLGMLPGAGQMKDVLAQVDDKQLDRVQAIIRGMTPAERANPKIINASRRLRIANGSGVT
HHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCEECCCCEEEEECCCCCC
VSEVNQLVDRFFEAKKMMAMMGRQMGMPGSRRNAKKGKKGKKGGRGPTPPKVRGGFPGMP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AGMPGMPAGMPDISNMPAGLNELPPGLENFDLSKLKFPKK
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]