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The map label for this gene is hcaR [H]

Identifier: 54026093

GI number: 54026093

Start: 4271218

End: 4272195

Strand: Reverse

Name: hcaR [H]

Synonym: nfa41220

Alternate gene names: 54026093

Gene position: 4272195-4271218 (Counterclockwise)

Preceding gene: 54026096

Following gene: 54026091

Centisome position: 70.95

GC content: 71.88

Gene sequence:

>978_bases
ATGAGCCGGTACGCCTCGATCGATCCCACCCGCTTGCGCTGGTTCGCGGAGGTCGCCGAACAGCTGCACTTCACGCGCGC
GGCCAAGACGCTCGGGATCGCGCGGCAACGGCTCAGCGCCACCGTCATCGAGCTGGAGAACGAACTCGGGGTGCGGCTGT
TCGTGCCCGGGGCGCAGCCCACGCAGTTGACCGAGGACGGCGCGGACCTGCTTCGGGCCGCCCGCGAAATCCTGTCCACC
CCAGCGGAATCCGAGCCGGAGGTCCGCACGCCGGAACGGTTGCGGGTGGGCTTCGTGCCGGGTGTGACGGTGTCGAAGTG
GGAGCGGATCTGGGGCGAGCGGTTCCCGGACACGCCGCTCGAGACCGTGCCGATCGCCGCCGCCGAACAGCGCGCGGCGC
TCGACGACGGCCGGGTCGACATGTGCTTCGTGCGCCAGCCGATCGAGCGTGACGGGCTCGGCGTGATCCCGCTCTATCGT
GAGCTGCCGGTGGTGGTCGTGCCGAAGGAGCACGAGATCTCGCTGTTCGACGAGGTGAGCGTGGCCGATCTGGCGGGCGA
GCGGCTCCAGGACGCCGCGGACATCGACCAGGCCGCGGTCGTGCTCGAGATGGTCGCCGCCGGTGTCGGGCCCGCCATCG
TGCCGCATTCCATCGCCCGGCTGCACGCGCGCCGTGACCTGGTGTACCGGACCGTGACCGATCATCCCGACACCGAGATC
GCGCTGGCCTGGCCGAGCGAGCGGACCACCGTGCTGGTGGAGGAGTTCATCGGCGTGGTGCGCGGACGATCGGCCCGGAG
TTCACGCGGGCCCTCGGGACCGGCGGCGAACGCGAAATCCACGGGAAAACAGGCCGCGGGAAAACAGGCCGCGGGGAAGA
AGGGTGCGGGAAAGAAGGGTGCGGCGACGGGCGCCGAGAAGGCCGCGTCGCCGCGCGCGGGTGCCCGGCGCGGAAGCGCC
GGGCGGCGGGGCCGCTGA

Upstream 100 bases:

>100_bases
AGCGGCTTCATCATCTGCGATTTCTGCTCCGGACTCACCGCAACAGCCTAGCGGGCGGCGGGGGCCGCTCCCGCGCCGCC
CGTGCAATACGCTGGCTGGA

Downstream 100 bases:

>100_bases
GCGGCGACTAGCGCGGCTTGCGGCGGTAGATCCAGTCGTAACCGATGATCGCGAAGATCGCCAGGGCGAAGCCGACCAGG
AAGATGTTCTCGATGTTGCC

Product: putative transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSRYASIDPTRLRWFAEVAEQLHFTRAAKTLGIARQRLSATVIELENELGVRLFVPGAQPTQLTEDGADLLRAAREILST
PAESEPEVRTPERLRVGFVPGVTVSKWERIWGERFPDTPLETVPIAAAEQRAALDDGRVDMCFVRQPIERDGLGVIPLYR
ELPVVVVPKEHEISLFDEVSVADLAGERLQDAADIDQAAVVLEMVAAGVGPAIVPHSIARLHARRDLVYRTVTDHPDTEI
ALAWPSERTTVLVEEFIGVVRGRSARSSRGPSGPAANAKSTGKQAAGKQAAGKKGAGKKGAATGAEKAASPRAGARRGSA
GRRGR

Sequences:

>Translated_325_residues
MSRYASIDPTRLRWFAEVAEQLHFTRAAKTLGIARQRLSATVIELENELGVRLFVPGAQPTQLTEDGADLLRAAREILST
PAESEPEVRTPERLRVGFVPGVTVSKWERIWGERFPDTPLETVPIAAAEQRAALDDGRVDMCFVRQPIERDGLGVIPLYR
ELPVVVVPKEHEISLFDEVSVADLAGERLQDAADIDQAAVVLEMVAAGVGPAIVPHSIARLHARRDLVYRTVTDHPDTEI
ALAWPSERTTVLVEEFIGVVRGRSARSSRGPSGPAANAKSTGKQAAGKQAAGKKGAGKKGAATGAEKAASPRAGARRGSA
GRRGR
>Mature_324_residues
SRYASIDPTRLRWFAEVAEQLHFTRAAKTLGIARQRLSATVIELENELGVRLFVPGAQPTQLTEDGADLLRAAREILSTP
AESEPEVRTPERLRVGFVPGVTVSKWERIWGERFPDTPLETVPIAAAEQRAALDDGRVDMCFVRQPIERDGLGVIPLYRE
LPVVVVPKEHEISLFDEVSVADLAGERLQDAADIDQAAVVLEMVAAGVGPAIVPHSIARLHARRDLVYRTVTDHPDTEIA
LAWPSERTTVLVEEFIGVVRGRSARSSRGPSGPAANAKSTGKQAAGKQAAGKKGAGKKGAATGAEKAASPRAGARRGSAG
RRGR

Specific function: Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=25.9515570934256, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787879, Length=278, Percent_Identity=25.8992805755396, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367136, Length=283, Percent_Identity=25.0883392226148, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790262, Length=232, Percent_Identity=25.4310344827586, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34991; Mature: 34860

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYASIDPTRLRWFAEVAEQLHFTRAAKTLGIARQRLSATVIELENELGVRLFVPGAQP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCC
TQLTEDGADLLRAAREILSTPAESEPEVRTPERLRVGFVPGVTVSKWERIWGERFPDTPL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEECCCCCHHHHHHHHHHCCCCCCCC
ETVPIAAAEQRAALDDGRVDMCFVRQPIERDGLGVIPLYRELPVVVVPKEHEISLFDEVS
CCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEHHHCCCEEEECCCCCCCHHHHHH
VADLAGERLQDAADIDQAAVVLEMVAAGVGPAIVPHSIARLHARRDLVYRTVTDHPDTEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEE
ALAWPSERTTVLVEEFIGVVRGRSARSSRGPSGPAANAKSTGKQAAGKQAAGKKGAGKKG
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCHHHHCHHHCCCCCCCCCC
AATGAEKAASPRAGARRGSAGRRGR
CCCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRYASIDPTRLRWFAEVAEQLHFTRAAKTLGIARQRLSATVIELENELGVRLFVPGAQP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCC
TQLTEDGADLLRAAREILSTPAESEPEVRTPERLRVGFVPGVTVSKWERIWGERFPDTPL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEECCCCCHHHHHHHHHHCCCCCCCC
ETVPIAAAEQRAALDDGRVDMCFVRQPIERDGLGVIPLYRELPVVVVPKEHEISLFDEVS
CCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEHHHCCCEEEECCCCCCCHHHHHH
VADLAGERLQDAADIDQAAVVLEMVAAGVGPAIVPHSIARLHARRDLVYRTVTDHPDTEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEE
ALAWPSERTTVLVEEFIGVVRGRSARSSRGPSGPAANAKSTGKQAAGKQAAGKKGAGKKG
EEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCHHHHCHHHCCCCCCCCCC
AATGAEKAASPRAGARRGSAGRRGR
CCCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 9603882 [H]