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The map label for this gene is dxr

Identifier: 54026091

GI number: 54026091

Start: 4269657

End: 4270841

Strand: Reverse

Name: dxr

Synonym: nfa41200

Alternate gene names: 54026091

Gene position: 4270841-4269657 (Counterclockwise)

Preceding gene: 54026093

Following gene: 54026090

Centisome position: 70.93

GC content: 72.32

Gene sequence:

>1185_bases
GTGCGCCCGCCGTCGCGGTGTCCGGGCATGCGCCACAATGACGGGGTGTCCGACATCGTGAGAGTCCTGCTGCTGGGCAG
CACCGGATCCATTGGTACCCAGGCGCTGGAGGTCATCGCGGCCAACCCCGACAAGTTCGAGGTGGTCGGGTTGGCCGCGC
GCGGCGGCAATCCGGCCCTGCTCGCCGAGCAGATGGCCGCCACCGGCACCCGCAATGTCGCGGTGGCCGATCCGGCGGCG
GGCGCGGCGTTGGACATCAAGCTGGCCGGGCCGCACGCCGTGACCGAACTGGTACGCCGCACCGAGGCGGACGTGGTGCT
CAACGCGCTGGTCGGTTCGCTCGGCCTGGAACCCACCCTCGCGACGCTGACAGCGGGCACCCGGCTCGCCCTGGCCAACA
AGGAATCACTGGTCGCGGGCGGGTCGCTGGTGACCCGCGCGGCCGCCCCCGGCCAGATCGTGCCGGTCGACTCCGAGCAC
TCGGCGCTGGCGCAGTGCCTGCGCGGCGGCCGCGCCGACGAGGTGGACCGGCTGGTCCTCACCGCCTCCGGCGGCCCCTT
CCGCGGCTGGACCGCACAGATGCTGGAGTCGGTGAATCCCGAGGCGGCGAAGGCGCACCCGACCTGGTCGATGGGGCTGA
TGAACACGCTGAACTCGGCGTCGCTGGTGAACAAGGGGCTCGAACTCATCGAGACCCACCTGCTGTTCGGTATTCCGTAC
GACCGCATCGACGTCACGGTGCACCCGCAGTCGATCGTGCATTCGATGGTCACCTTCGTGGACGGCTCGACGCTGGCCCA
GGCCAGCCCGCCGGACATGAAGCTACCCATCGCGCTCGCGCTCGGCTGGCCGGACCGGGTGCCCGGCGCGGCCGCGGCCT
GCGATTTCAGCACCGCCTCGACCTGGACCTTCGAGCCGGTCGACACCGAGGTGTTCCCGGCCGTCGAGCTGGCCAGGCAG
GCCGGGCAGGCGGGCGGCAGCGTCACCGCGGTGTACAACGCCGCCAACGAGGTCGCGGTGCAGGCGTTCCTGGACGGGCG
GATCCGCTTTCCCGAGATCGTGCGCACGGTCGCCCGGGCGGTGGAGGCGGCCGACCGGTGGCGCGCCGAACCGGAGACGG
TCGAGGACGTGCTGGCCGCCGACCGCTGGGCCCGGGGTCGGGCCGCCGAACTCGTCGGAGCGTGA

Upstream 100 bases:

>100_bases
CGATCGCTCCTTTGTCGGGTACCGAAGGGACGGTACGCAGTCGGCTTGCTGCCGCATATCGTGACATACGACGCCGCGTC
GTTGGAAGTCGGCCCCGGCC

Downstream 100 bases:

>100_bases
GGGAATCGGCGCGCCGACCGGGCCCGCCCTGGCAGACTGGGTGAGGGCCGGGGGAGCGGACCGATAGTGTGGTCGGGTGC
TCGCGGCCGTACGGCGCGCG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRPPSRCPGMRHNDGVSDIVRVLLLGSTGSIGTQALEVIAANPDKFEVVGLAARGGNPALLAEQMAATGTRNVAVADPAA
GAALDIKLAGPHAVTELVRRTEADVVLNALVGSLGLEPTLATLTAGTRLALANKESLVAGGSLVTRAAAPGQIVPVDSEH
SALAQCLRGGRADEVDRLVLTASGGPFRGWTAQMLESVNPEAAKAHPTWSMGLMNTLNSASLVNKGLELIETHLLFGIPY
DRIDVTVHPQSIVHSMVTFVDGSTLAQASPPDMKLPIALALGWPDRVPGAAAACDFSTASTWTFEPVDTEVFPAVELARQ
AGQAGGSVTAVYNAANEVAVQAFLDGRIRFPEIVRTVARAVEAADRWRAEPETVEDVLAADRWARGRAAELVGA

Sequences:

>Translated_394_residues
MRPPSRCPGMRHNDGVSDIVRVLLLGSTGSIGTQALEVIAANPDKFEVVGLAARGGNPALLAEQMAATGTRNVAVADPAA
GAALDIKLAGPHAVTELVRRTEADVVLNALVGSLGLEPTLATLTAGTRLALANKESLVAGGSLVTRAAAPGQIVPVDSEH
SALAQCLRGGRADEVDRLVLTASGGPFRGWTAQMLESVNPEAAKAHPTWSMGLMNTLNSASLVNKGLELIETHLLFGIPY
DRIDVTVHPQSIVHSMVTFVDGSTLAQASPPDMKLPIALALGWPDRVPGAAAACDFSTASTWTFEPVDTEVFPAVELARQ
AGQAGGSVTAVYNAANEVAVQAFLDGRIRFPEIVRTVARAVEAADRWRAEPETVEDVLAADRWARGRAAELVGA
>Mature_394_residues
MRPPSRCPGMRHNDGVSDIVRVLLLGSTGSIGTQALEVIAANPDKFEVVGLAARGGNPALLAEQMAATGTRNVAVADPAA
GAALDIKLAGPHAVTELVRRTEADVVLNALVGSLGLEPTLATLTAGTRLALANKESLVAGGSLVTRAAAPGQIVPVDSEH
SALAQCLRGGRADEVDRLVLTASGGPFRGWTAQMLESVNPEAAKAHPTWSMGLMNTLNSASLVNKGLELIETHLLFGIPY
DRIDVTVHPQSIVHSMVTFVDGSTLAQASPPDMKLPIALALGWPDRVPGAAAACDFSTASTWTFEPVDTEVFPAVELARQ
AGQAGGSVTAVYNAANEVAVQAFLDGRIRFPEIVRTVARAVEAADRWRAEPETVEDVLAADRWARGRAAELVGA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=387, Percent_Identity=40.0516795865633, Blast_Score=244, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_NOCFA (Q5YS72)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_120333.1
- ProteinModelPortal:   Q5YS72
- SMR:   Q5YS72
- GeneID:   3109765
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa41200
- NMPDR:   fig|247156.1.peg.3977
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   NFAR247156:NFA41200-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41055; Mature: 41055

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: BINDING 134-134 BINDING 159-159 BINDING 183-183 BINDING 206-206 BINDING 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPPSRCPGMRHNDGVSDIVRVLLLGSTGSIGTQALEVIAANPDKFEVVGLAARGGNPAL
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHEEECCCCCEEEEEEEECCCCHHH
LAEQMAATGTRNVAVADPAAGAALDIKLAGPHAVTELVRRTEADVVLNALVGSLGLEPTL
HHHHHHHCCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ATLTAGTRLALANKESLVAGGSLVTRAAAPGQIVPVDSEHSALAQCLRGGRADEVDRLVL
HHHCCCCEEEEECCCCEEECCCHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCCCEEEE
TASGGPFRGWTAQMLESVNPEAAKAHPTWSMGLMNTLNSASLVNKGLELIETHLLFGIPY
EECCCCCCCHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DRIDVTVHPQSIVHSMVTFVDGSTLAQASPPDMKLPIALALGWPDRVPGAAAACDFSTAS
CCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHCCCCCCCC
TWTFEPVDTEVFPAVELARQAGQAGGSVTAVYNAANEVAVQAFLDGRIRFPEIVRTVARA
CEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHH
VEAADRWRAEPETVEDVLAADRWARGRAAELVGA
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure
MRPPSRCPGMRHNDGVSDIVRVLLLGSTGSIGTQALEVIAANPDKFEVVGLAARGGNPAL
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHEEECCCCCEEEEEEEECCCCHHH
LAEQMAATGTRNVAVADPAAGAALDIKLAGPHAVTELVRRTEADVVLNALVGSLGLEPTL
HHHHHHHCCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ATLTAGTRLALANKESLVAGGSLVTRAAAPGQIVPVDSEHSALAQCLRGGRADEVDRLVL
HHHCCCCEEEEECCCCEEECCCHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCCCEEEE
TASGGPFRGWTAQMLESVNPEAAKAHPTWSMGLMNTLNSASLVNKGLELIETHLLFGIPY
EECCCCCCCHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DRIDVTVHPQSIVHSMVTFVDGSTLAQASPPDMKLPIALALGWPDRVPGAAAACDFSTAS
CCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHCCCCCCCC
TWTFEPVDTEVFPAVELARQAGQAGGSVTAVYNAANEVAVQAFLDGRIRFPEIVRTVARA
CEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHH
VEAADRWRAEPETVEDVLAADRWARGRAAELVGA
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA