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The map label for this gene is drrB [H]

Identifier: 54026083

GI number: 54026083

Start: 4261701

End: 4262585

Strand: Reverse

Name: drrB [H]

Synonym: nfa41120

Alternate gene names: 54026083

Gene position: 4262585-4261701 (Counterclockwise)

Preceding gene: 54026087

Following gene: 54026082

Centisome position: 70.79

GC content: 76.27

Gene sequence:

>885_bases
ATGCGCGCCGTGACCGACCGGACCCGTCTGCCGGGAGACCGCCGCCGCCCGGCGCACCGTGCGACGCAGCCCAACCGAGT
GGTCCTGCCGTCGCGGCCGCACCCGTCGGCCGCGGCGCAGTGGTGGACGCTCACCGCCCGGCTGCTGCGTCCGTCGTTGC
GCAACGGGGAGGTCCTCACCGCGGTGCTCGCCCCGACGGTGTTCACGCTGGGCTTCTACGTGCCGATGAACGCGGTGATG
GCGGCCTACGGGCACGGGCTGAGCAGCTACGCGCAGTTCCTGCTGCCGATGATCGTGATGCAGGCGGTCGCGTTCTGCGC
GGTGTCGGCGGCGCACCGGGCCGCGGTGGACGCCAGGGCCGGACTCGACGAACGCCTGCGCACGCTGCCGTTGCCCCGGC
TGGTGCCGCCCGCGGCCCGGCTCGCCGCCGCGCTGTACCGCGGCGGCATCGCCGGGGCGGCCGCGTTGGTGTGCGGCGGG
GTGATCGGCGCGCGGTTCTTCGGGCCGTGGTGGCAGACCGGGGGCTTCCTGCTGCTCGCGCTCGCCGTCGGCGCGGTCCT
GAGCCTCGGCGCCGACCTGCTGGGCAGCCTCTCGGCCGGCCCCGAGGCGACGACGCAGCTGCTGGCGCTGCCGCAGCTGA
TCCTCGGTCTGGTGTCCACCGGGTTGGCCCCCGCCGAGCACTTCCCGCCGTGGCTGGCCGGATTCGCCGCGCACCAACCG
GTGTCGGCCTTCGTCGACGCGTTGCGCGCGCTGGCGGGCGACGCCACCGGGGCGGCGGGCACGATCGGCTGGTCGACGCT
GGGTCCCGCGGTGGCGTGGATCCTCGGGCTGGGTGCGGTGTTCGGCGCGGGTGCGGTGTTCGTCGCGAGGCGGGGCGGGC
GGTGA

Upstream 100 bases:

>100_bases
ATGCGCTCGCCGCGACCGGTTTTCGCGTGCGCCGACGAGAACGGCACCCGGCCCGACCAGTGCGGATGAACCAGGCGCGA
GCGCCGCGCGTGTATTCGGG

Downstream 100 bases:

>100_bases
GGGATGCGCACCGAACCCCCCGTGGTCACCGGCCCCACCGAGACCGTGGCGCTGCTCGGGGGCCAGAGCGTGCTGCACAC
GCGCAGGTTGCTGCTGCGCG

Product: putative ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRAVTDRTRLPGDRRRPAHRATQPNRVVLPSRPHPSAAAQWWTLTARLLRPSLRNGEVLTAVLAPTVFTLGFYVPMNAVM
AAYGHGLSSYAQFLLPMIVMQAVAFCAVSAAHRAAVDARAGLDERLRTLPLPRLVPPAARLAAALYRGGIAGAAALVCGG
VIGARFFGPWWQTGGFLLLALAVGAVLSLGADLLGSLSAGPEATTQLLALPQLILGLVSTGLAPAEHFPPWLAGFAAHQP
VSAFVDALRALAGDATGAAGTIGWSTLGPAVAWILGLGAVFGAGAVFVARRGGR

Sequences:

>Translated_294_residues
MRAVTDRTRLPGDRRRPAHRATQPNRVVLPSRPHPSAAAQWWTLTARLLRPSLRNGEVLTAVLAPTVFTLGFYVPMNAVM
AAYGHGLSSYAQFLLPMIVMQAVAFCAVSAAHRAAVDARAGLDERLRTLPLPRLVPPAARLAAALYRGGIAGAAALVCGG
VIGARFFGPWWQTGGFLLLALAVGAVLSLGADLLGSLSAGPEATTQLLALPQLILGLVSTGLAPAEHFPPWLAGFAAHQP
VSAFVDALRALAGDATGAAGTIGWSTLGPAVAWILGLGAVFGAGAVFVARRGGR
>Mature_294_residues
MRAVTDRTRLPGDRRRPAHRATQPNRVVLPSRPHPSAAAQWWTLTARLLRPSLRNGEVLTAVLAPTVFTLGFYVPMNAVM
AAYGHGLSSYAQFLLPMIVMQAVAFCAVSAAHRAAVDARAGLDERLRTLPLPRLVPPAARLAAALYRGGIAGAAALVCGG
VIGARFFGPWWQTGGFLLLALAVGAVLSLGADLLGSLSAGPEATTQLLALPQLILGLVSTGLAPAEHFPPWLAGFAAHQP
VSAFVDALRALAGDATGAAGTIGWSTLGPAVAWILGLGAVFGAGAVFVARRGGR

Specific function: Part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004377 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 30408; Mature: 30408

Theoretical pI: Translated: 12.03; Mature: 12.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVTDRTRLPGDRRRPAHRATQPNRVVLPSRPHPSAAAQWWTLTARLLRPSLRNGEVLT
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
AVLAPTVFTLGFYVPMNAVMAAYGHGLSSYAQFLLPMIVMQAVAFCAVSAAHRAAVDARA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLDERLRTLPLPRLVPPAARLAAALYRGGIAGAAALVCGGVIGARFFGPWWQTGGFLLLA
CHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LAVGAVLSLGADLLGSLSAGPEATTQLLALPQLILGLVSTGLAPAEHFPPWLAGFAAHQP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCC
VSAFVDALRALAGDATGAAGTIGWSTLGPAVAWILGLGAVFGAGAVFVARRGGR
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEECCCCC
>Mature Secondary Structure
MRAVTDRTRLPGDRRRPAHRATQPNRVVLPSRPHPSAAAQWWTLTARLLRPSLRNGEVLT
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
AVLAPTVFTLGFYVPMNAVMAAYGHGLSSYAQFLLPMIVMQAVAFCAVSAAHRAAVDARA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLDERLRTLPLPRLVPPAARLAAALYRGGIAGAAALVCGGVIGARFFGPWWQTGGFLLLA
CHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LAVGAVLSLGADLLGSLSAGPEATTQLLALPQLILGLVSTGLAPAEHFPPWLAGFAAHQP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCC
VSAFVDALRALAGDATGAAGTIGWSTLGPAVAWILGLGAVFGAGAVFVARRGGR
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]