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The map label for this gene is drrC [H]

Identifier: 54026082

GI number: 54026082

Start: 4260873

End: 4261697

Strand: Reverse

Name: drrC [H]

Synonym: nfa41110

Alternate gene names: 54026082

Gene position: 4261697-4260873 (Counterclockwise)

Preceding gene: 54026083

Following gene: 54026080

Centisome position: 70.78

GC content: 74.67

Gene sequence:

>825_bases
ATGCGCACCGAACCCCCCGTGGTCACCGGCCCCACCGAGACCGTGGCGCTGCTCGGGGGCCAGAGCGTGCTGCACACGCG
CAGGTTGCTGCTGCGCGTCGCGCGCGACCCGCAGACCGTGGTCGCGACGGTGGTGTTCCCCGCCGGGCTGCTGATGGTGC
TGAACGCGGTCACCGGGCGCCAGGTGTCGGCGTTCGCCGGGGCGAGTGCGCTCTACGGGACGGTGCCGATGGTCGCGCTG
GTCGCGGCGATGTCCGGGTCGGTGGCCGGCGCCGTCGCGCTCGGGCGGGAGCGCGACGCGGGGTTGCCCGCCCGGTTCTG
GGTGCTGCCGGTACACCGCGGCGCCGATCCGCTGGCGCGGCTGCTCGCCGAAGCCGCGCGCATCCTGGTGGCGACCGCGG
TGATGGTGATCGTCGGTGTCCTGCTCGGATTCCGGTTCCAGCAGGGGGTGCTGGCCGGCGTCGTGTTCCTGGCGGTGCCG
CTGGTGTTCGGGCTGGGGTTCGCGACGATGGTGTTCGCGGCGGCGATGGTCACCACGCGCACCGCCTTCGTCGAGGCGGT
GTCGCTGCTGTCCTCGCTGCTGATGTTCTTCAGCACCGGTTTCGTGCCGCTCGCGGCGTATCCGGCGTGGGCGCGCCCGC
TCGTCGCCCATCAGCCGCTGACCCAGGCGATCGACGCGATGCGGGGACTGTCGCTCGGCGGCCCCGTGCGCGGCCCGCTG
CTGGCGACACTGGCCTGGTCGGTGGGCGCGTTCGCGGTGTTCGCGGGCCCGGCCCTGCGCGGATATCGCCGTGCCGCCCG
GTCCGGCGCCGGTGGCGGCGCGTGA

Upstream 100 bases:

>100_bases
CTGGTCGACGCTGGGTCCCGCGGTGGCGTGGATCCTCGGGCTGGGTGCGGTGTTCGGCGCGGGTGCGGTGTTCGTCGCGA
GGCGGGGCGGGCGGTGAGGG

Downstream 100 bases:

>100_bases
CCCGGGGAGTCCTCAGCGCATGGTCGCGGCGGCCGACTCGATCAGCCCCACCGAATCACGCGGGCTCAACGCCATCGCGC
GCAGCTGATCGAAGATCACC

Product: putative ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MRTEPPVVTGPTETVALLGGQSVLHTRRLLLRVARDPQTVVATVVFPAGLLMVLNAVTGRQVSAFAGASALYGTVPMVAL
VAAMSGSVAGAVALGRERDAGLPARFWVLPVHRGADPLARLLAEAARILVATAVMVIVGVLLGFRFQQGVLAGVVFLAVP
LVFGLGFATMVFAAAMVTTRTAFVEAVSLLSSLLMFFSTGFVPLAAYPAWARPLVAHQPLTQAIDAMRGLSLGGPVRGPL
LATLAWSVGAFAVFAGPALRGYRRAARSGAGGGA

Sequences:

>Translated_274_residues
MRTEPPVVTGPTETVALLGGQSVLHTRRLLLRVARDPQTVVATVVFPAGLLMVLNAVTGRQVSAFAGASALYGTVPMVAL
VAAMSGSVAGAVALGRERDAGLPARFWVLPVHRGADPLARLLAEAARILVATAVMVIVGVLLGFRFQQGVLAGVVFLAVP
LVFGLGFATMVFAAAMVTTRTAFVEAVSLLSSLLMFFSTGFVPLAAYPAWARPLVAHQPLTQAIDAMRGLSLGGPVRGPL
LATLAWSVGAFAVFAGPALRGYRRAARSGAGGGA
>Mature_274_residues
MRTEPPVVTGPTETVALLGGQSVLHTRRLLLRVARDPQTVVATVVFPAGLLMVLNAVTGRQVSAFAGASALYGTVPMVAL
VAAMSGSVAGAVALGRERDAGLPARFWVLPVHRGADPLARLLAEAARILVATAVMVIVGVLLGFRFQQGVLAGVVFLAVP
LVFGLGFATMVFAAAMVTTRTAFVEAVSLLSSLLMFFSTGFVPLAAYPAWARPLVAHQPLTQAIDAMRGLSLGGPVRGPL
LATLAWSVGAFAVFAGPALRGYRRAARSGAGGGA

Specific function: Probably part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525
- InterPro:   IPR004377
- InterPro:   IPR005943 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 28166; Mature: 28166

Theoretical pI: Translated: 12.29; Mature: 12.29

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTEPPVVTGPTETVALLGGQSVLHTRRLLLRVARDPQTVVATVVFPAGLLMVLNAVTGR
CCCCCCCEECCCHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
QVSAFAGASALYGTVPMVALVAAMSGSVAGAVALGRERDAGLPARFWVLPVHRGADPLAR
HHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHH
LLAEAARILVATAVMVIVGVLLGFRFQQGVLAGVVFLAVPLVFGLGFATMVFAAAMVTTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAFVEAVSLLSSLLMFFSTGFVPLAAYPAWARPLVAHQPLTQAIDAMRGLSLGGPVRGPL
HHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHCHHHHCCHHHHHHHHHHCCCCCCCCCHHH
LATLAWSVGAFAVFAGPALRGYRRAARSGAGGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRTEPPVVTGPTETVALLGGQSVLHTRRLLLRVARDPQTVVATVVFPAGLLMVLNAVTGR
CCCCCCCEECCCHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
QVSAFAGASALYGTVPMVALVAAMSGSVAGAVALGRERDAGLPARFWVLPVHRGADPLAR
HHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHH
LLAEAARILVATAVMVIVGVLLGFRFQQGVLAGVVFLAVPLVFGLGFATMVFAAAMVTTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAFVEAVSLLSSLLMFFSTGFVPLAAYPAWARPLVAHQPLTQAIDAMRGLSLGGPVRGPL
HHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHCHHHHCCHHHHHHHHHHCCCCCCCCCHHH
LATLAWSVGAFAVFAGPALRGYRRAARSGAGGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]