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The map label for this gene is adhC [C]

Identifier: 54025852

GI number: 54025852

Start: 4095022

End: 4096128

Strand: Reverse

Name: adhC [C]

Synonym: nfa38820

Alternate gene names: 54025852

Gene position: 4096128-4095022 (Counterclockwise)

Preceding gene: 54025853

Following gene: 54025851

Centisome position: 68.03

GC content: 72.63

Gene sequence:

>1107_bases
ATGAGGATTCGTGGGGCGGTCCTGGAGCGGATCGCGGCGCCGGCCCCGTTCGCCGAGTCGGCGCCGATCAACGTGTGTGA
GCTCGAGCTGGGCGAGCCCGGGCCCGGTGAGTTGCTGGTGCGTATCGAAGCGGCCGGGCTGTGTCATTCGGACCTGTCGG
TGGTGGACGGCAACCGGGTGCGGCCGGTGCCGATGCTGCTCGGGCACGAGGCCGCGGGCCGGGTCGAGGCGGTGGGTCCG
GGGGACAGCGATGTCGCGGTCGGGCAGCGCGTGGTGATGACGTTCCTGCCGCGCTGCGGTGAGTGCGCGGGCTGTGCCAG
CCAGGGCCGGATGCCGTGTGTGCCGGGCAGTGTCGCCAACAACGCCGGGGAGCTGCTTGGTGGCGGTCGCCGGCTGATCC
GCGACGGTGCGCCGGTGCATCACCACCTGGGTGTGTCGGCGTTCGCCACGCATGCGGTGGTGGACCGACGGTCGGTGGTG
CCGGTGCCCGACGACGTGCCGCCCGAGGTGGCCGCGGTCTTGGGGTGCGCGGTGCTCACCGGTGGTGGCGCGCTGTTGAA
TTCGGCGAAACCGGGTCCGGCGGACCGGATCATGGTGGTCGGGCTGGGCGGTGTCGGCATGGCAGCGGTGCTGGTCGCGG
TGTCGTTGGGTGCGCCGGAGGTCATCGCGGTGGACACCGTGCCCGAGAAACTGGCGCTGGCACGGGAATTGGGGGCGAGC
GCGGCCTACACCCCGGCCGAGGTGGCCGAGCGGGGAATCGTGGCGGAAGTGGTCGTCGAGGCCGCGGGCAATGTGCGCGC
CTTCGAGACCGCCGTCGCGGCCACGGCCGCGGGCGGTACCACGGTGACGGTGGGTCTGCCCGCACCCGACGCGCGTGCCA
GCATCGCCCCGCTGGGTCTGGTCGCACAGGGCCGGTCCATCGTCGGCAGCTACCTTGGCTCCGCGGTGCCCGCCCGCGAC
ATTCCCGAGTACGTGCGGATGTGGCGCGCGGGCACACTGCCGGTGGAGCGGCTCGTCTCCGCGCACATCGGGCTCGACGA
GATCAACCGGGCGATGGACGAACTCGCCGCCGGCCACGCGCTGCGCCAGGTGATCGTCTTCGACTGA

Upstream 100 bases:

>100_bases
CGCCTCGACGTGGCCTGAGCACACCCGGTGGTGTCCGGCCGCGGGACCGATTCGGCGGGGGCGATGCCCGCCCGCCGGGC
CGGGCGGTAGCGTCGGGGGA

Downstream 100 bases:

>100_bases
GGACGGGGCCGCGCCGGCCCGCGGGCGCCGCTCGATAGGCTTGCCACCACATCGGCGAGACGAGGAGGTGCGGTGACCAT
TCGGGTCGGAGTGCTGGGAG

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MRIRGAVLERIAAPAPFAESAPINVCELELGEPGPGELLVRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGRVEAVGP
GDSDVAVGQRVVMTFLPRCGECAGCASQGRMPCVPGSVANNAGELLGGGRRLIRDGAPVHHHLGVSAFATHAVVDRRSVV
PVPDDVPPEVAAVLGCAVLTGGGALLNSAKPGPADRIMVVGLGGVGMAAVLVAVSLGAPEVIAVDTVPEKLALARELGAS
AAYTPAEVAERGIVAEVVVEAAGNVRAFETAVAATAAGGTTVTVGLPAPDARASIAPLGLVAQGRSIVGSYLGSAVPARD
IPEYVRMWRAGTLPVERLVSAHIGLDEINRAMDELAAGHALRQVIVFD

Sequences:

>Translated_368_residues
MRIRGAVLERIAAPAPFAESAPINVCELELGEPGPGELLVRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGRVEAVGP
GDSDVAVGQRVVMTFLPRCGECAGCASQGRMPCVPGSVANNAGELLGGGRRLIRDGAPVHHHLGVSAFATHAVVDRRSVV
PVPDDVPPEVAAVLGCAVLTGGGALLNSAKPGPADRIMVVGLGGVGMAAVLVAVSLGAPEVIAVDTVPEKLALARELGAS
AAYTPAEVAERGIVAEVVVEAAGNVRAFETAVAATAAGGTTVTVGLPAPDARASIAPLGLVAQGRSIVGSYLGSAVPARD
IPEYVRMWRAGTLPVERLVSAHIGLDEINRAMDELAAGHALRQVIVFD
>Mature_368_residues
MRIRGAVLERIAAPAPFAESAPINVCELELGEPGPGELLVRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGRVEAVGP
GDSDVAVGQRVVMTFLPRCGECAGCASQGRMPCVPGSVANNAGELLGGGRRLIRDGAPVHHHLGVSAFATHAVVDRRSVV
PVPDDVPPEVAAVLGCAVLTGGGALLNSAKPGPADRIMVVGLGGVGMAAVLVAVSLGAPEVIAVDTVPEKLALARELGAS
AAYTPAEVAERGIVAEVVVEAAGNVRAFETAVAATAAGGTTVTVGLPAPDARASIAPLGLVAQGRSIVGSYLGSAVPARD
IPEYVRMWRAGTLPVERLVSAHIGLDEINRAMDELAAGHALRQVIVFD

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=379, Percent_Identity=33.7730870712401, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI4501933, Length=379, Percent_Identity=33.509234828496, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4501929, Length=379, Percent_Identity=32.1899736147757, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=30.2702702702703, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=30.2702702702703, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI71565152, Length=386, Percent_Identity=30.5699481865285, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI156523966, Length=381, Percent_Identity=30.1837270341207, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=29.2682926829268, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI4501939, Length=373, Percent_Identity=30.5630026809651, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=32.3204419889503, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1788407, Length=331, Percent_Identity=27.190332326284, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=367, Percent_Identity=25.0681198910082, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081918, Length=287, Percent_Identity=33.7979094076655, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790045, Length=359, Percent_Identity=24.7910863509749, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=24.5125348189415, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788075, Length=359, Percent_Identity=25.3481894150418, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082401, Length=352, Percent_Identity=27.5568181818182, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790718, Length=286, Percent_Identity=26.5734265734266, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI226510992, Length=269, Percent_Identity=28.6245353159851, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=22.7138643067847, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=27.7372262773723, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=28.7598944591029, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71997431, Length=381, Percent_Identity=28.3464566929134, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=29.0697674418605, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17562876, Length=349, Percent_Identity=24.6418338108883, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=362, Percent_Identity=28.4530386740331, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=308, Percent_Identity=26.9480519480519, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=374, Percent_Identity=28.8770053475936, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319258, Length=329, Percent_Identity=24.6200607902736, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=293, Percent_Identity=30.0341296928328, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=308, Percent_Identity=30.1948051948052, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=27.4924471299094, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=317, Percent_Identity=28.0757097791798, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=363, Percent_Identity=25.8953168044077, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=27.8637770897833, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=317, Percent_Identity=23.0283911671924, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=30.9782608695652, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI17137530, Length=213, Percent_Identity=26.7605633802817, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737897, Length=337, Percent_Identity=25.2225519287834, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37284; Mature: 37284

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRGAVLERIAAPAPFAESAPINVCELELGEPGPGELLVRIEAAGLCHSDLSVVDGNRV
CCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCEEECCCCC
RPVPMLLGHEAAGRVEAVGPGDSDVAVGQRVVMTFLPRCGECAGCASQGRMPCVPGSVAN
CCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHCHHHCCCCCCCCCHHHC
NAGELLGGGRRLIRDGAPVHHHLGVSAFATHAVVDRRSVVPVPDDVPPEVAAVLGCAVLT
CCHHHHCCCHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHC
GGGALLNSAKPGPADRIMVVGLGGVGMAAVLVAVSLGAPEVIAVDTVPEKLALARELGAS
CCCHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCC
AAYTPAEVAERGIVAEVVVEAAGNVRAFETAVAATAAGGTTVTVGLPAPDARASIAPLGL
CCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHH
VAQGRSIVGSYLGSAVPARDIPEYVRMWRAGTLPVERLVSAHIGLDEINRAMDELAAGHA
HHCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LRQVIVFD
HHHHEECC
>Mature Secondary Structure
MRIRGAVLERIAAPAPFAESAPINVCELELGEPGPGELLVRIEAAGLCHSDLSVVDGNRV
CCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCEEECCCCC
RPVPMLLGHEAAGRVEAVGPGDSDVAVGQRVVMTFLPRCGECAGCASQGRMPCVPGSVAN
CCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHCHHHCCCCCCCCCHHHC
NAGELLGGGRRLIRDGAPVHHHLGVSAFATHAVVDRRSVVPVPDDVPPEVAAVLGCAVLT
CCHHHHCCCHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHC
GGGALLNSAKPGPADRIMVVGLGGVGMAAVLVAVSLGAPEVIAVDTVPEKLALARELGAS
CCCHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCC
AAYTPAEVAERGIVAEVVVEAAGNVRAFETAVAATAAGGTTVTVGLPAPDARASIAPLGL
CCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHH
VAQGRSIVGSYLGSAVPARDIPEYVRMWRAGTLPVERLVSAHIGLDEINRAMDELAAGHA
HHCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LRQVIVFD
HHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]