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The map label for this gene is inhA [H]

Identifier: 54025446

GI number: 54025446

Start: 3685448

End: 3686284

Strand: Reverse

Name: inhA [H]

Synonym: nfa34760

Alternate gene names: 54025446

Gene position: 3686284-3685448 (Counterclockwise)

Preceding gene: 54025447

Following gene: 54025445

Centisome position: 61.22

GC content: 68.82

Gene sequence:

>837_bases
ATGGGCGGACTGCTCGAAGGCAAGACCATCCTGGTCACCGGCATCATCACCGACGCCTCCATCGCGTTCCACGCGGCGGC
GATGGCCCAGGAACAGGGCGCGAAGGTGATCATCACCGGTATCCCGGAGCGGCTGCGGCTCATCGACCGCATCGCCAAGC
GGCTGCCGAAGGAGGTTCCGCCCGCCATCGGTCTCGACGTCACCAACGAGGAGGACCTGGCCGGACTCGCGGACAAGATC
CGCGAGCTCGCGCCCGAGGGACTCGACGGTGTGCTGCACTCGATCGCCTTCGCACCGCGCACCCTGATGGGCCCGGAGGC
GCTGCCGTTCCTGGAGGGCCCCGGCCCGGACGCGGCCAAGGCGTTCGAGATCTCCGCGTGGAGCTACGCCTCGCTGGCCC
GCGCGGTGCTGCCGGTGATGAACGAGGGCGGCTCGCTGGTCGGCATGGACTTCGACCCGCGCACCGCCATGCCGTACTAC
AACTGGATGGGCGTGGCCAAGGCCGCGCTGGAGTCGGTGAACCGCTACGTCGCCCGCGAGGTCGGCACCGCCAAGAAGGT
CCGCTCCAACCTGATCGCCGCGGGCCCGATCAAGACGCTGGCCGCCAAGGCCATCGCGGGCACCGCCACCGACGACGCGG
CCAAGCTCAACCAGCTCAACATCTACTGGGACGGTGCCTCGCCGATCGGCTGGGATGTCGACGACCCGACCGCGGTGGCC
AAGTCCATCGTGGCGCTGTTGTCGGACTGGCTGCCCGCTACCACCGGTTCGATCATCTACGTCGACGGCGGTGCCAGCCA
CAACACCTGGTTCCCGGAGAACTGGTCGGCCAACTGA

Upstream 100 bases:

>100_bases
CGGCGCGGTGATCCCGGTCGACGGCGGCATGGGCATGGGCCACTAGTATCCCGCTGGCCCGCAGCAACGGACTTTCGACA
TCAGGAGAACCGAGAAACTC

Downstream 100 bases:

>100_bases
GCGAAGGAGGACCCGTGGCCGTCGAGGCGCTGCTGCTGCTGTCCTTCGGCGGCCCGGAACGCCCCGAGGACGTGATGCCG
TTCCTGGAGAACGTCACCCG

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MGGLLEGKTILVTGIITDASIAFHAAAMAQEQGAKVIITGIPERLRLIDRIAKRLPKEVPPAIGLDVTNEEDLAGLADKI
RELAPEGLDGVLHSIAFAPRTLMGPEALPFLEGPGPDAAKAFEISAWSYASLARAVLPVMNEGGSLVGMDFDPRTAMPYY
NWMGVAKAALESVNRYVAREVGTAKKVRSNLIAAGPIKTLAAKAIAGTATDDAAKLNQLNIYWDGASPIGWDVDDPTAVA
KSIVALLSDWLPATTGSIIYVDGGASHNTWFPENWSAN

Sequences:

>Translated_278_residues
MGGLLEGKTILVTGIITDASIAFHAAAMAQEQGAKVIITGIPERLRLIDRIAKRLPKEVPPAIGLDVTNEEDLAGLADKI
RELAPEGLDGVLHSIAFAPRTLMGPEALPFLEGPGPDAAKAFEISAWSYASLARAVLPVMNEGGSLVGMDFDPRTAMPYY
NWMGVAKAALESVNRYVAREVGTAKKVRSNLIAAGPIKTLAAKAIAGTATDDAAKLNQLNIYWDGASPIGWDVDDPTAVA
KSIVALLSDWLPATTGSIIYVDGGASHNTWFPENWSAN
>Mature_277_residues
GGLLEGKTILVTGIITDASIAFHAAAMAQEQGAKVIITGIPERLRLIDRIAKRLPKEVPPAIGLDVTNEEDLAGLADKIR
ELAPEGLDGVLHSIAFAPRTLMGPEALPFLEGPGPDAAKAFEISAWSYASLARAVLPVMNEGGSLVGMDFDPRTAMPYYN
WMGVAKAALESVNRYVAREVGTAKKVRSNLIAAGPIKTLAAKAIAGTATDDAAKLNQLNIYWDGASPIGWDVDDPTAVAK
SIVALLSDWLPATTGSIIYVDGGASHNTWFPENWSAN

Specific function: Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide [H]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=266, Percent_Identity=30.8270676691729, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR016040 [H]

Pfam domain/function: NA

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29358; Mature: 29227

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGLLEGKTILVTGIITDASIAFHAAAMAQEQGAKVIITGIPERLRLIDRIAKRLPKEVP
CCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCHHHCC
PAIGLDVTNEEDLAGLADKIRELAPEGLDGVLHSIAFAPRTLMGPEALPFLEGPGPDAAK
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCC
AFEISAWSYASLARAVLPVMNEGGSLVGMDFDPRTAMPYYNWMGVAKAALESVNRYVARE
EEEECCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGTAKKVRSNLIAAGPIKTLAAKAIAGTATDDAAKLNQLNIYWDGASPIGWDVDDPTAVA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHCEEEEEECCCCCCCCCCCCHHHHH
KSIVALLSDWLPATTGSIIYVDGGASHNTWFPENWSAN
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GGLLEGKTILVTGIITDASIAFHAAAMAQEQGAKVIITGIPERLRLIDRIAKRLPKEVP
CCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCHHHCC
PAIGLDVTNEEDLAGLADKIRELAPEGLDGVLHSIAFAPRTLMGPEALPFLEGPGPDAAK
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCC
AFEISAWSYASLARAVLPVMNEGGSLVGMDFDPRTAMPYYNWMGVAKAALESVNRYVARE
EEEECCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGTAKKVRSNLIAAGPIKTLAAKAIAGTATDDAAKLNQLNIYWDGASPIGWDVDDPTAVA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHCEEEEEECCCCCCCCCCCCHHHHH
KSIVALLSDWLPATTGSIIYVDGGASHNTWFPENWSAN
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8284673 [H]