Click here to switch to the map view.

The map label for this gene is hemH

Identifier: 54025445

GI number: 54025445

Start: 3684375

End: 3685433

Strand: Reverse

Name: hemH

Synonym: nfa34750

Alternate gene names: 54025445

Gene position: 3685433-3684375 (Counterclockwise)

Preceding gene: 54025446

Following gene: 54025442

Centisome position: 61.21

GC content: 72.99

Gene sequence:

>1059_bases
GTGGCCGTCGAGGCGCTGCTGCTGCTGTCCTTCGGCGGCCCGGAACGCCCCGAGGACGTGATGCCGTTCCTGGAGAACGT
CACCCGGGGCCGTGGGGTGCCGCGTGCCCGCCTCGAGGAGGTCGCCCAGCACTACCTGCACTTCGGCGGCGTCTCGCCGA
TCAACGCGCTCAACCGCGACATCATCGCCGGTGTCGAGCGCGAACTCGACGAGGCGGGCATCGACCTGCCGGTGTATTTC
GGCAACCGCAACTGGCATCCGATGGTCGAGGACACCGTCGCGGAGATGGCCCGCGACGGGGTGACCGGCGCCCTGGTCTT
CCCCACCTCGGCCTGGGGCGGCTACTCCGGGTGCCGCCAGTACCACGAGGACATCGAGCGGGCCAGGGCGGCCGTCGGCC
CCGCCGCCCCGCACCTGACCAAGCTGCGCCAGTACTTCGACCATCCGCTGTTGATCGAGGCGTTCGCCGACGCGATCCGC
GCCGCCCTGGAACGGCTGCCCGCGGATCGGCGTGACCGTGCCCGGCTGGTGTTCACCGCGCACTCGGTGCCGGTCGCCGC
CGACGCCGCGGCCGGTCCGCCCGCCGACGGCGGCGAGCTGTACAGCCGTCAGGTCGCCGATGCCGCCCGATTGTGCGCGG
CGGCAACGGGTTTCGCCGATCACGACCTGGTGTGGCAGTCCCGCTCCGGGCCGCCGCAGGTGCCGTGGCTCGAGCCCGAC
ATCGTCGACCATCTGGAGGACCTGGCGGGCCGGGGGGTGGACGCGGTCGTGGTGTGCCCGGTCGGCTTCGTCTCCGACCA
CCTCGAGGTCATCTGGGATCTGGACAACGAGGCGAAGGACAAGGCCGCCGAGCTCGGCATGGCGTTCGCGCGGGCGTCGA
CGCCGGGCACCGACCCGCGGTTCCCGCGGTTGGTGGTGGAGCTGATGCGTGAGCATCTGGACGGCCTGGCCCCGCGCAGG
CTGGGCGCCGAACCGGGCTACGGGTGCACCATCGACGGGATGCCGTGCGCGAGCGGATGCTGTGCGCCGCAACGCCGCCC
GGCGGCCGCGGGCCGCTGA

Upstream 100 bases:

>100_bases
TGCCCGCTACCACCGGTTCGATCATCTACGTCGACGGCGGTGCCAGCCACAACACCTGGTTCCCGGAGAACTGGTCGGCC
AACTGAGCGAAGGAGGACCC

Downstream 100 bases:

>100_bases
CCGGCGCTCACCGATCGCCTCATCCGCGCGCGGCCGCGTGTACCGCGACCAGCCGGGCGGCGCGGATGGCGTCCCACAGC
GGGCGCAGCAGATTCTCCTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MAVEALLLLSFGGPERPEDVMPFLENVTRGRGVPRARLEEVAQHYLHFGGVSPINALNRDIIAGVERELDEAGIDLPVYF
GNRNWHPMVEDTVAEMARDGVTGALVFPTSAWGGYSGCRQYHEDIERARAAVGPAAPHLTKLRQYFDHPLLIEAFADAIR
AALERLPADRRDRARLVFTAHSVPVAADAAAGPPADGGELYSRQVADAARLCAAATGFADHDLVWQSRSGPPQVPWLEPD
IVDHLEDLAGRGVDAVVVCPVGFVSDHLEVIWDLDNEAKDKAAELGMAFARASTPGTDPRFPRLVVELMREHLDGLAPRR
LGAEPGYGCTIDGMPCASGCCAPQRRPAAAGR

Sequences:

>Translated_352_residues
MAVEALLLLSFGGPERPEDVMPFLENVTRGRGVPRARLEEVAQHYLHFGGVSPINALNRDIIAGVERELDEAGIDLPVYF
GNRNWHPMVEDTVAEMARDGVTGALVFPTSAWGGYSGCRQYHEDIERARAAVGPAAPHLTKLRQYFDHPLLIEAFADAIR
AALERLPADRRDRARLVFTAHSVPVAADAAAGPPADGGELYSRQVADAARLCAAATGFADHDLVWQSRSGPPQVPWLEPD
IVDHLEDLAGRGVDAVVVCPVGFVSDHLEVIWDLDNEAKDKAAELGMAFARASTPGTDPRFPRLVVELMREHLDGLAPRR
LGAEPGYGCTIDGMPCASGCCAPQRRPAAAGR
>Mature_351_residues
AVEALLLLSFGGPERPEDVMPFLENVTRGRGVPRARLEEVAQHYLHFGGVSPINALNRDIIAGVERELDEAGIDLPVYFG
NRNWHPMVEDTVAEMARDGVTGALVFPTSAWGGYSGCRQYHEDIERARAAVGPAAPHLTKLRQYFDHPLLIEAFADAIRA
ALERLPADRRDRARLVFTAHSVPVAADAAAGPPADGGELYSRQVADAARLCAAATGFADHDLVWQSRSGPPQVPWLEPDI
VDHLEDLAGRGVDAVVVCPVGFVSDHLEVIWDLDNEAKDKAAELGMAFARASTPGTDPRFPRLVVELMREHLDGLAPRRL
GAEPGYGCTIDGMPCASGCCAPQRRPAAAGR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=26.969696969697, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI60499025, Length=330, Percent_Identity=26.969696969697, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324750, Length=337, Percent_Identity=24.9258160237389, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17864156, Length=333, Percent_Identity=26.4264264264264, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI45552018, Length=171, Percent_Identity=30.9941520467836, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651774, Length=262, Percent_Identity=25.5725190839695, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_NOCFA (Q5YU18)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_119687.1
- ProteinModelPortal:   Q5YU18
- SMR:   Q5YU18
- GeneID:   3109562
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa34750
- NMPDR:   fig|247156.1.peg.3394
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   PRK00035
- BioCyc:   NFAR247156:NFA34750-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 38014; Mature: 37883

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEALLLLSFGGPERPEDVMPFLENVTRGRGVPRARLEEVAQHYLHFGGVSPINALNRD
CCHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
IIAGVERELDEAGIDLPVYFGNRNWHPMVEDTVAEMARDGVTGALVFPTSAWGGYSGCRQ
HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
YHEDIERARAAVGPAAPHLTKLRQYFDHPLLIEAFADAIRAALERLPADRRDRARLVFTA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
HSVPVAADAAAGPPADGGELYSRQVADAARLCAAATGFADHDLVWQSRSGPPQVPWLEPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCHH
IVDHLEDLAGRGVDAVVVCPVGFVSDHLEVIWDLDNEAKDKAAELGMAFARASTPGTDPR
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCC
FPRLVVELMREHLDGLAPRRLGAEPGYGCTIDGMPCASGCCAPQRRPAAAGR
HHHHHHHHHHHHHHCCCCHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVEALLLLSFGGPERPEDVMPFLENVTRGRGVPRARLEEVAQHYLHFGGVSPINALNRD
CHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
IIAGVERELDEAGIDLPVYFGNRNWHPMVEDTVAEMARDGVTGALVFPTSAWGGYSGCRQ
HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
YHEDIERARAAVGPAAPHLTKLRQYFDHPLLIEAFADAIRAALERLPADRRDRARLVFTA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
HSVPVAADAAAGPPADGGELYSRQVADAARLCAAATGFADHDLVWQSRSGPPQVPWLEPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCHH
IVDHLEDLAGRGVDAVVVCPVGFVSDHLEVIWDLDNEAKDKAAELGMAFARASTPGTDPR
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCC
FPRLVVELMREHLDGLAPRRLGAEPGYGCTIDGMPCASGCCAPQRRPAAAGR
HHHHHHHHHHHHHHCCCCHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA