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The map label for this gene is glyS

Identifier: 54020011

GI number: 54020011

Start: 70941

End: 72308

Strand: Direct

Name: glyS

Synonym: mhp061

Alternate gene names: 54020011

Gene position: 70941-72308 (Clockwise)

Preceding gene: 54020010

Following gene: 54020012

Centisome position: 7.95

GC content: 29.75

Gene sequence:

>1368_bases
ATGGCCAAAATTGAAAATTACAATTTTTTTATTAATCAACTACGGGAGCTAGGGTTTGTTTTTCCAAGTTCACAAATTTA
TGGTGGTCTGGCAAATTCGTATGATTATGGTCATCTTGGTGTGCTTTTAAGAAAAAATATTGAGAATTTTTGAGCTGATT
TTTTTGTTAATTCAAATCCTAATGCATTTTTTATTGATAGTAAAATTTTATTAAACCCGAAAGTTTGACAGGCATCTGGA
CACCTTGATAATTTTGTTGATTTATTAGTTGAAAATAAAATTAATAAAAAAAGATATCGTGTTGATCATCTTTTTGAAGA
ATTTTTTCCTGAGGTTGCATTTGAAAAATTATCTCAGGATGAAATTCGGGGTTATTTATCTCAAATTCAACTTTTGGAAA
ATACAAAAGTTGAATGAGCTAGCCCAAAAAAATTTAATTTACTTTTTCCAACCTATCAAGGCATAATCGAAGATGAAAAA
ACACTTTTATATTTAAGACCGGAGACAGCTCAGGGTATTTTTATAAATTTTAAAAATCTTTTGCGGACAACAAAAAATAG
TTTGCCCTTGATAATTGCTCAAGTAGGAAAATCTTTCCGAAATGAAATTTCCCCGGGAAATTTCATTTTTCGCACTCGTG
AGTTTGTACAACTAGAATTAGAAATTTTCTTAAAACCCGATCAATCAGAGAATTTTTTTCAAAATGAGATTGAAAAAATC
AAAAACTTTTTAAAAAAACTTGGTTTTGCGAGAAATTCAATCAGATTAAACTATCACAAAAAAGAAAAATTAGCTCATTA
TGCCAAGGCAACAGTTGACTTTGAATACAATTTTAATTTTGGGTGGGGTGAATTGATCGGAATTAGTAATCGTGGTGATT
ATGACCTCAAAAACCATAGTGAGAAAAGTGGCGAGAAGCTTGAATTTGTTGATTCAGCTACAGGAAAAAAATTTTTACCA
CACATTATCGAACCTTCGATGGGCCTTGATCGTTTAATGCTTGCGGTTTTAGAAGAATGTTTTTGTTTTGACAGTGTAAA
AAATCGCTATTTTTTAAAGTTACCATTTATTCTAAGTCCTTATAAGGTTGCAGTTTTGCCGCTTTTGAAAAAATTTAATT
TTTTAGCAGAAAAAATTTGAAAAGAATTAATTAGCCAAAAAATATCAGCAACACTAGTAACTTCCGGTTCAATTGGAAAA
AGATACTATCATCAAGATGTGATTGGGACGTATTTTTGTATTACAATTGACCAAAAATCGGTTGAAAATAGCATTGTAAC
ACTAAGATTTCGCGATACAACCGAGCAAAAAACACTAAAAATTGACGAAATAACTAAATTTATCAAGGAAAATTTTGTTA
ATGAATAG

Upstream 100 bases:

>100_bases
AATTTGAATCAATGTCGAAAAAAATGTCAGAAATTTCCACAAAAAATCTTAATCTTGACTCTTTTATTAAATAAAAACTA
ATAATTGTTAAGGATTGAAA

Downstream 100 bases:

>100_bases
ACAAGAAATTATAACACATATAATAAAAAATACCGATATTTACGACCTAATTTCAAAAAAAATAAATTTAAAACCAAAAG
GTCGAGATTCTTTTGTCGGT

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MAKIENYNFFINQLRELGFVFPSSQIYGGLANSYDYGHLGVLLRKNIENFWADFFVNSNPNAFFIDSKILLNPKVWQASG
HLDNFVDLLVENKINKKRYRVDHLFEEFFPEVAFEKLSQDEIRGYLSQIQLLENTKVEWASPKKFNLLFPTYQGIIEDEK
TLLYLRPETAQGIFINFKNLLRTTKNSLPLIIAQVGKSFRNEISPGNFIFRTREFVQLELEIFLKPDQSENFFQNEIEKI
KNFLKKLGFARNSIRLNYHKKEKLAHYAKATVDFEYNFNFGWGELIGISNRGDYDLKNHSEKSGEKLEFVDSATGKKFLP
HIIEPSMGLDRLMLAVLEECFCFDSVKNRYFLKLPFILSPYKVAVLPLLKKFNFLAEKIWKELISQKISATLVTSGSIGK
RYYHQDVIGTYFCITIDQKSVENSIVTLRFRDTTEQKTLKIDEITKFIKENFVNE

Sequences:

>Translated_455_residues
MAKIENYNFFINQLRELGFVFPSSQIYGGLANSYDYGHLGVLLRKNIENF*ADFFVNSNPNAFFIDSKILLNPKV*QASG
HLDNFVDLLVENKINKKRYRVDHLFEEFFPEVAFEKLSQDEIRGYLSQIQLLENTKVE*ASPKKFNLLFPTYQGIIEDEK
TLLYLRPETAQGIFINFKNLLRTTKNSLPLIIAQVGKSFRNEISPGNFIFRTREFVQLELEIFLKPDQSENFFQNEIEKI
KNFLKKLGFARNSIRLNYHKKEKLAHYAKATVDFEYNFNFGWGELIGISNRGDYDLKNHSEKSGEKLEFVDSATGKKFLP
HIIEPSMGLDRLMLAVLEECFCFDSVKNRYFLKLPFILSPYKVAVLPLLKKFNFLAEKI*KELISQKISATLVTSGSIGK
RYYHQDVIGTYFCITIDQKSVENSIVTLRFRDTTEQKTLKIDEITKFIKENFVNE
>Mature_454_residues
AKIENYNFFINQLRELGFVFPSSQIYGGLANSYDYGHLGVLLRKNIENF*ADFFVNSNPNAFFIDSKILLNPKV*QASGH
LDNFVDLLVENKINKKRYRVDHLFEEFFPEVAFEKLSQDEIRGYLSQIQLLENTKVE*ASPKKFNLLFPTYQGIIEDEKT
LLYLRPETAQGIFINFKNLLRTTKNSLPLIIAQVGKSFRNEISPGNFIFRTREFVQLELEIFLKPDQSENFFQNEIEKIK
NFLKKLGFARNSIRLNYHKKEKLAHYAKATVDFEYNFNFGWGELIGISNRGDYDLKNHSEKSGEKLEFVDSATGKKFLPH
IIEPSMGLDRLMLAVLEECFCFDSVKNRYFLKLPFILSPYKVAVLPLLKKFNFLAEKI*KELISQKISATLVTSGSIGKR
YYHQDVIGTYFCITIDQKSVENSIVTLRFRDTTEQKTLKIDEITKFIKENFVNE

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=340, Percent_Identity=30.5882352941176, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17554996, Length=383, Percent_Identity=28.4595300261097, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32564541, Length=383, Percent_Identity=28.4595300261097, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325338, Length=358, Percent_Identity=28.7709497206704, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319597, Length=211, Percent_Identity=36.4928909952607, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24664462, Length=345, Percent_Identity=29.8550724637681, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21357965, Length=345, Percent_Identity=29.8550724637681, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 52406; Mature: 52275

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIENYNFFINQLRELGFVFPSSQIYGGLANSYDYGHLGVLLRKNIENFADFFVNSNPN
CCEECCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
AFFIDSKILLNPKVQASGHLDNFVDLLVENKINKKRYRVDHLFEEFFPEVAFEKLSQDEI
EEEEECEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
RGYLSQIQLLENTKVEASPKKFNLLFPTYQGIIEDEKTLLYLRPETAQGIFINFKNLLRT
HHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCCCEEEEECCCCCCEEEEEHHHHHHH
TKNSLPLIIAQVGKSFRNEISPGNFIFRTREFVQLELEIFLKPDQSENFFQNEIEKIKNF
HCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHEEEEEEEEECCCCCCCHHHHHHHHHHHH
LKKLGFARNSIRLNYHKKEKLAHYAKATVDFEYNFNFGWGELIGISNRGDYDLKNHSEKS
HHHHCCCCCCEEEEEHHHHHHHHHHHEEEEEEEECCCCCHHEEEECCCCCCCCCCCCCCC
GEKLEFVDSATGKKFLPHIIEPSMGLDRLMLAVLEECFCFDSVKNRYFLKLPFILSPYKV
CCEEEEHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEECCHHH
AVLPLLKKFNFLAEKIKELISQKISATLVTSGSIGKRYYHQDVIGTYFCITIDQKSVENS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCEEEEEEECCCCCCCC
IVTLRFRDTTEQKTLKIDEITKFIKENFVNE
EEEEEEECCCCHHHEEHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKIENYNFFINQLRELGFVFPSSQIYGGLANSYDYGHLGVLLRKNIENFADFFVNSNPN
CEECCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
AFFIDSKILLNPKVQASGHLDNFVDLLVENKINKKRYRVDHLFEEFFPEVAFEKLSQDEI
EEEEECEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
RGYLSQIQLLENTKVEASPKKFNLLFPTYQGIIEDEKTLLYLRPETAQGIFINFKNLLRT
HHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCCCEEEEECCCCCCEEEEEHHHHHHH
TKNSLPLIIAQVGKSFRNEISPGNFIFRTREFVQLELEIFLKPDQSENFFQNEIEKIKNF
HCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHEEEEEEEEECCCCCCCHHHHHHHHHHHH
LKKLGFARNSIRLNYHKKEKLAHYAKATVDFEYNFNFGWGELIGISNRGDYDLKNHSEKS
HHHHCCCCCCEEEEEHHHHHHHHHHHEEEEEEEECCCCCHHEEEECCCCCCCCCCCCCCC
GEKLEFVDSATGKKFLPHIIEPSMGLDRLMLAVLEECFCFDSVKNRYFLKLPFILSPYKV
CCEEEEHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEECCHHH
AVLPLLKKFNFLAEKIKELISQKISATLVTSGSIGKRYYHQDVIGTYFCITIDQKSVENS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCEEEEEEECCCCCCCC
IVTLRFRDTTEQKTLKIDEITKFIKENFVNE
EEEEEEECCCCHHHEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA