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The map label for this gene is ffh

Identifier: 54020010

GI number: 54020010

Start: 69592

End: 70914

Strand: Direct

Name: ffh

Synonym: mhp060

Alternate gene names: 54020010

Gene position: 69592-70914 (Clockwise)

Preceding gene: 54020009

Following gene: 54020011

Centisome position: 7.8

GC content: 30.91

Gene sequence:

>1323_bases
ATGCTAGAATTTTTAACTAATCGAATTCAGTCATCCTTAAAAAAATTACAAAAATCCTTAACAATTAATGAAAGTGATTT
AGTAGAAATAACACGTGAAATCCGGCTTGCCTTACTTGAAGCTGATGTTAATTTGTTGGTGGTTAAAGATTTTATATCTA
AAGTTAAAACCCAAGTCTTAAAGCAAGGTTTGACTTCAAAATTAAACCCACAGCAAGAATTTCTAAAAATTTTACATCAA
AATTTAGTAGAAATTCTTGGAATTAATTCAAAATCAATTAATTTTAACAAAACTCCTACTATAATAATGTTAGTTGGCCT
TCAAGGTTCTGGGAAAACAACAACCGCTGCAAAATTAGCAGTTTTTGCAAGGCAAAAAAAATTAGCAAAAAAAATTTTAC
TAGTTGCTTGTGATACTTATAGACCAGCTGCAATCGATCAATTAAAACAGTTAGGAAAACAGGTTTTAATTGAGGTGTTT
TATGTTGAGAAATCACCAGTTCAAATTGCAAAAGAGGCCCTAATTTATAGTAAAAACAATGATTTTGATCTTGTAATTTT
CGATACGGCTGGCCGGCTTTCAATCAACGAAGAATTAATGAATGAGCTTTCAGAAATTAAAGAAAATATTAAACCTGATC
AAATTTTATTTATTCTTGATGCACTTTCAGGTCAAGACATTATCAATGTTGCTCAAATTTTCAACCAGAAAATTAACCTC
ACAGGAGCAATTATTACAAAATTAGACTCAAATGCGCGCGCAGGTGCCGCGCTTTCAATAACGCATTTACTTAAAATTCC
GGTTTTGCTCCTCGGGACAGGTGAAAAAATTTCTGCTCTTGAACTTTTTCATCCAAATAGGATGGCCGATCGAATTTTAG
GAATGGGGGATGTAAGGTCACTTTTAGAGCAAGCAGAGGAAAATATTGACAAAAAAACAGTAAAAAAATTATCTCATCGA
ATGTTTTCTGGCCAGTTTGATTTAAATGATCTTTTAAATAGTCTAGCCCAGATTCAGAAAATCGGAAAATTTTCAAAAAT
TATTAAAATGATACCAGGTTTATCAGGAAAAATTGATCAAAGTCAAATAGATGAAGTTGAGAAAAAGATGAAGGTCTATA
AAATTTTGATTTCTTCAATGACAATTGAGGAAAGAAAAAAACCAAAAATTTTAAAAAATCCCTCGCGTCGAAGTCGAATT
TTGCGTGGTTCTGGAAGGTCAAGTGCTGAATTTAACCGTTTAATTAATGAATTTGAATCAATGTCGAAAAAAATGTCAGA
AATTTCCACAAAAAATCTTAATCTTGACTCTTTTATTAAATAA

Upstream 100 bases:

>100_bases
ATTTCAGAAAAAATAGAAAAATTATCAAACTAAAAATCTGAAGAGGGGTATAAAATTTTTCCTTTAAAAATAGGAAAAAT
TTTGTATTTTTTATAAACAA

Downstream 100 bases:

>100_bases
AAACTAATAATTGTTAAGGATTGAAAATGGCCAAAATTGAAAATTACAATTTTTTTATTAATCAACTACGGGAGCTAGGG
TTTGTTTTTCCAAGTTCACA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MLEFLTNRIQSSLKKLQKSLTINESDLVEITREIRLALLEADVNLLVVKDFISKVKTQVLKQGLTSKLNPQQEFLKILHQ
NLVEILGINSKSINFNKTPTIIMLVGLQGSGKTTTAAKLAVFARQKKLAKKILLVACDTYRPAAIDQLKQLGKQVLIEVF
YVEKSPVQIAKEALIYSKNNDFDLVIFDTAGRLSINEELMNELSEIKENIKPDQILFILDALSGQDIINVAQIFNQKINL
TGAIITKLDSNARAGAALSITHLLKIPVLLLGTGEKISALELFHPNRMADRILGMGDVRSLLEQAEENIDKKTVKKLSHR
MFSGQFDLNDLLNSLAQIQKIGKFSKIIKMIPGLSGKIDQSQIDEVEKKMKVYKILISSMTIEERKKPKILKNPSRRSRI
LRGSGRSSAEFNRLINEFESMSKKMSEISTKNLNLDSFIK

Sequences:

>Translated_440_residues
MLEFLTNRIQSSLKKLQKSLTINESDLVEITREIRLALLEADVNLLVVKDFISKVKTQVLKQGLTSKLNPQQEFLKILHQ
NLVEILGINSKSINFNKTPTIIMLVGLQGSGKTTTAAKLAVFARQKKLAKKILLVACDTYRPAAIDQLKQLGKQVLIEVF
YVEKSPVQIAKEALIYSKNNDFDLVIFDTAGRLSINEELMNELSEIKENIKPDQILFILDALSGQDIINVAQIFNQKINL
TGAIITKLDSNARAGAALSITHLLKIPVLLLGTGEKISALELFHPNRMADRILGMGDVRSLLEQAEENIDKKTVKKLSHR
MFSGQFDLNDLLNSLAQIQKIGKFSKIIKMIPGLSGKIDQSQIDEVEKKMKVYKILISSMTIEERKKPKILKNPSRRSRI
LRGSGRSSAEFNRLINEFESMSKKMSEISTKNLNLDSFIK
>Mature_440_residues
MLEFLTNRIQSSLKKLQKSLTINESDLVEITREIRLALLEADVNLLVVKDFISKVKTQVLKQGLTSKLNPQQEFLKILHQ
NLVEILGINSKSINFNKTPTIIMLVGLQGSGKTTTAAKLAVFARQKKLAKKILLVACDTYRPAAIDQLKQLGKQVLIEVF
YVEKSPVQIAKEALIYSKNNDFDLVIFDTAGRLSINEELMNELSEIKENIKPDQILFILDALSGQDIINVAQIFNQKINL
TGAIITKLDSNARAGAALSITHLLKIPVLLLGTGEKISALELFHPNRMADRILGMGDVRSLLEQAEENIDKKTVKKLSHR
MFSGQFDLNDLLNSLAQIQKIGKFSKIIKMIPGLSGKIDQSQIDEVEKKMKVYKILISSMTIEERKKPKILKNPSRRSRI
LRGSGRSSAEFNRLINEFESMSKKMSEISTKNLNLDSFIK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=443, Percent_Identity=35.4401805869075, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI226371618, Length=384, Percent_Identity=35.15625, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI89061728, Length=162, Percent_Identity=35.1851851851852, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI23308697, Length=306, Percent_Identity=25.4901960784314, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI295424842, Length=282, Percent_Identity=26.9503546099291, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1788963, Length=429, Percent_Identity=41.2587412587413, Blast_Score=340, Evalue=9e-95,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=32.6771653543307, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17539958, Length=442, Percent_Identity=33.0316742081448, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=30.6930693069307, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=412, Percent_Identity=34.4660194174757, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=213, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17647949, Length=453, Percent_Identity=32.8918322295806, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24641198, Length=225, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49439; Mature: 49439

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFLTNRIQSSLKKLQKSLTINESDLVEITREIRLALLEADVNLLVVKDFISKVKTQVL
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KQGLTSKLNPQQEFLKILHQNLVEILGINSKSINFNKTPTIIMLVGLQGSGKTTTAAKLA
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHH
VFARQKKLAKKILLVACDTYRPAAIDQLKQLGKQVLIEVFYVEKSPVQIAKEALIYSKNN
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHEECCC
DFDLVIFDTAGRLSINEELMNELSEIKENIKPDQILFILDALSGQDIINVAQIFNQKINL
CEEEEEEECCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
TGAIITKLDSNARAGAALSITHLLKIPVLLLGTGEKISALELFHPNRMADRILGMGDVRS
HHHHHEEECCCCCCCHHHHHHHHHHCCCCEECCCCCCCCEECCCCHHHHHHHCCHHHHHH
LLEQAEENIDKKTVKKLSHRMFSGQFDLNDLLNSLAQIQKIGKFSKIIKMIPGLSGKIDQ
HHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SQIDEVEKKMKVYKILISSMTIEERKKPKILKNPSRRSRILRGSGRSSAEFNRLINEFES
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHH
MSKKMSEISTKNLNLDSFIK
HHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MLEFLTNRIQSSLKKLQKSLTINESDLVEITREIRLALLEADVNLLVVKDFISKVKTQVL
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KQGLTSKLNPQQEFLKILHQNLVEILGINSKSINFNKTPTIIMLVGLQGSGKTTTAAKLA
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHH
VFARQKKLAKKILLVACDTYRPAAIDQLKQLGKQVLIEVFYVEKSPVQIAKEALIYSKNN
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHEECCC
DFDLVIFDTAGRLSINEELMNELSEIKENIKPDQILFILDALSGQDIINVAQIFNQKINL
CEEEEEEECCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
TGAIITKLDSNARAGAALSITHLLKIPVLLLGTGEKISALELFHPNRMADRILGMGDVRS
HHHHHEEECCCCCCCHHHHHHHHHHCCCCEECCCCCCCCEECCCCHHHHHHHCCHHHHHH
LLEQAEENIDKKTVKKLSHRMFSGQFDLNDLLNSLAQIQKIGKFSKIIKMIPGLSGKIDQ
HHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SQIDEVEKKMKVYKILISSMTIEERKKPKILKNPSRRSRILRGSGRSSAEFNRLINEFES
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHH
MSKKMSEISTKNLNLDSFIK
HHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1280809 [H]