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The map label for this gene is aceK

Identifier: 53718013

GI number: 53718013

Start: 402273

End: 404084

Strand: Reverse

Name: aceK

Synonym: BPSL0373

Alternate gene names: 53718013

Gene position: 404084-402273 (Counterclockwise)

Preceding gene: 53718015

Following gene: 53718012

Centisome position: 9.92

GC content: 63.91

Gene sequence:

>1812_bases
ATGAATCACTTTCCCAAACTGCTGTCCTCGCAGATCGGCTTCGACGTCGCGCAGACGATCCTCGAGAACTTCGATCGCCA
CTACCGGATCTTCCGCGAAGCGGCCGTCGAAGCGAAGGACCTGTTCGAGCGCGCGGACTGGCACGGGCTGCAGCGGCTCG
CGCGCGAGCGCATCACGTCGTACGACGACCGCGTGCGCGAATGCGTCGAGCTGCTCGAGGACGAGTACGACGCGGAGAAC
ATCGACAACGAAGTCTGGCCGCAGATCAAGCTGCATTACATCGGCCTGCTCACGTCGCACCGCCAGCCCGAATGCGCGGA
GACGTTCTTCAATTCGGTGTGCTGCAAGATCCTGCACCGCGCGTACTTCAACAACGATTTCATCTTCGTGCGCCCGGCGA
TCTCGACCGAATACATCGAGAACGACGAGCCCGCCGCGAAGCCCACGTACCGCGCGTACTATCCGGGCAGCGAGGGGCTC
GCCGCGACGCTCGAGCGGATCGTCACGAACTTCCAGCTCAATCCGCCGTTCGAGGATCTCGAGCGCGACATCGCGTGCAT
CATGCAGGCGATCCACGACGAGTTCGGCGCGTTCGACGAAGCGGTGAATTTCCAGATCCACGTGCTGTCGTCGCTGTTCT
ACCGGAACAAGACCGCGTACGTCGTCGGCCGCATCATCAACGGCGACCGCGTGCTGCCGTTCGCGGTGCCGATCCGCCAC
GCGCGCGCGGGCATCCTCGCGCTCGACACCGTGCTCCTGCGCCGCGACCAGTTGAAGATCATCTTCAGCTTCTCGCACTC
GTATTTCCTCGTCGACATGAACGTGCCCTCCGCGTATGTGCAGTTCCTGCGCTCGATCATGCCGGGCAAGCCGAAGGCGG
AGATCTACACGTCGGTCGGCCTGCAGAAGCAGGGCAAGAACCTGTTCTATCGCGACCTGCTGCATCACCTGTCGCATTCG
AGCGACCGCTTCATCGTCGCGCCCGGCATCAAGGGGCTCGTGATGCTCGTGTTCACGCTGCCGTCGTTCCCGTACGTGTT
CAAGATGATCAAGGATCACTTCCCGCCGCCGAAGGACACGACGCGCGAGCAGATCATGGCCAAGTACCTGCTCGTCAAGC
GCCACGACCGTCTCGGCCGGATGGCCGACACGCTCGAATACTCGAGCGTCGCGCTGCCGCTCGCGCGGCTCGACGACGCG
CTCGTGCGCGAGCTCGAAAAGGAAGTGCCGTCGCTGATCGAATACGAGGGCGAGAACCTCGTCATCAAGCACCTGTACAT
CGAGCGCCGGATGGTGCCGCTCAACCTGTATCTGCAAAACGGCAGCGATGCCGAGATCGAGCACGGCGTGCGCGAATACG
GCAATGCGGTGAAGGAGCTGATGCAGGCCAACATCTTCCCCGGCGACATGCTGTACAAGAACTTCGGCGTGACGCGCCAC
GGGCGCGTCGTGTTCTACGACTACGACGAGATCGAATACCTGACCGACTGCAACGTGCGCCGCGTGCCGCCGCCGCGCAA
CGACGAAGACGAGATGTCGGGCGAGCCGTGGTACACGGTCGGCCCGCACGACATCTTCCCCGAAACCTACGCGCCGTTCC
TGCTCGGCGACCCGCGCGTGCGCGAGCACTTCCTCGCGCATCACGCGGATTTCTTCGATCCGCAGCTCTGGCAGGACAGC
AAGGACCGCCTGCTGCGCGGCGAGCTGCCCGATTTCTTCGCCTACGAGCCGGCGCTGCGCTTTTGCATCCGCTATCCGGA
GCGCTTCGCGCCGGGCGACGCGGCCGACGGCGGCAAGCTCGCCGCCGCGTGA

Upstream 100 bases:

>100_bases
GGCCGCGCCCGCCGCCTGCGCCGAATCGCCCCGCGCTCGCTAAAGCGGGCCCGCGCGGCGCTAAAATGGCATGAGCTTTT
CGCCCGTGAGCCCGCGCACG

Downstream 100 bases:

>100_bases
GCCGCGCCCGCCCCGCGCTCGAACGCCCCTTTTTTCATCCCACTGAACCGACTTGAGATGAACAAGAACGACCATCCGCT
CTCCCATCTGTTCGACAACA

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITSYDDRVRECVELLEDEYDAEN
IDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGL
AATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRH
ARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDTTREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDA
LVRELEKEVPSLIEYEGENLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDS
KDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKLAAA

Sequences:

>Translated_603_residues
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITSYDDRVRECVELLEDEYDAEN
IDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGL
AATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRH
ARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDTTREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDA
LVRELEKEVPSLIEYEGENLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDS
KDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKLAAA
>Mature_603_residues
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITSYDDRVRECVELLEDEYDAEN
IDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGL
AATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRH
ARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDTTREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDA
LVRELEKEVPSLIEYEGENLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDS
KDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKLAAA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family

Homologues:

Organism=Escherichia coli, GI1790446, Length=572, Percent_Identity=42.1328671328671, Blast_Score=463, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACEK_BURM7 (A3MNH1)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001081807.1
- GeneID:   4894218
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_2279
- TIGR:   BMA10247_2279
- HOGENOM:   HBG298593
- OMA:   RMTPLNI
- ProtClustDB:   PRK02946
- BioCyc:   BMAL320389:BMA10247_2279-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00747
- InterPro:   IPR010452
- PIRSF:   PIRSF000719
- ProDom:   PD043552

Pfam domain/function: PF06315 AceK

EC number: =2.7.11.5

Molecular weight: Translated: 69894; Mature: 69894

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: ACT_SITE 383-383 BINDING 348-348

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITS
CCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YDDRVRECVELLEDEYDAENIDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCHHCCCCHHCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHH
AYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDL
HHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
ERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRH
HHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEHHHHH
ARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVG
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDT
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGENL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRH
EEEEEEHHCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRV
CEEEEEECCCHHHHHCCCCCCCCCCCCCCHHCCCCCCEECCCHHCCCCCCCCCCCCCHHH
REHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKL
HHHHHHHHCCCCCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCCCC
AAA
CCC
>Mature Secondary Structure
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITS
CCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YDDRVRECVELLEDEYDAENIDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCHHCCCCHHCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHH
AYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDL
HHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
ERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRH
HHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEHHHHH
ARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVG
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDT
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGENL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRH
EEEEEEHHCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRV
CEEEEEECCCHHHHHCCCCCCCCCCCCCCHHCCCCCCEECCCHHCCCCCCCCCCCCCHHH
REHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKL
HHHHHHHHCCCCCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCCCC
AAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA