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The map label for this gene is thrB

Identifier: 52787104

GI number: 52787104

Start: 3258219

End: 3259139

Strand: Reverse

Name: thrB

Synonym: BLi03412

Alternate gene names: 52787104

Gene position: 3259139-3258219 (Counterclockwise)

Preceding gene: 52787105

Following gene: 52787103

Centisome position: 77.18

GC content: 52.01

Gene sequence:

>921_bases
ATGACTGAGGCTGACATGCTGTTTTCCGTTACGGTTCCCGGAAGCACGGCCAATCTTGGCCCGGGCTTTGATTCAGTCGG
CATGGCGCTGTCCCGCTATTTAAGACTGTCTGTTTTTCCTCATGATGAGTGGCGTTTTGAAGCTGAAACAGAAGTCGTAG
CGGGAATACCTGAAGGAACGGACAATTTAATTTACCAGGTGGCCAAACGGACCGCCGCACACTTCGGAAAAGAACTTCCG
CCAAGCCTTGTCAAAGTGTGGAGCGATATTCCGCTTGCGCGCGGTCTCGGCAGCAGCGCAGCCGCAATTGCCGCTGCGGT
TGAGCTGGCGAACGAACTTGCCGATTTGAAGCTTTCAGACCGCGAGAAACTTCATTTTGCGAGCCTTGAAGAAGGCCATC
CTGACAATGCCGGAGCATCGCTTTTCGGCGGGCTTGTCATCGGACTTCATGAGGAAGATGAAACAGAGATGGTTTCTATG
AAAGACATCGATTTGGATGTCGTCGTCGTCATTCCTTTTTATGAAGTGCTGACAAAAGATGCGCGGGATGTTCTTCCCGA
AAGCCTCTCTTATCCGAAAGCCGTGGAAGCAAGCGCGGTCAGCAATATGCTCGTCGCCGGACTGATGGCGAAAGATTGGA
AGCTTGTCGGCCGCATGATGCAAAAAGACCTCTTTCACCAGCCATACCGAAGGGCGCTCGTCCCTGAGCTTTCGAAAGTG
GAGCATGAAGCAGGCCAAAACGGCGCGTTCGGGACGGCTTTAAGCGGAGCCGGCCCGACGATCCTTTCCTTTATTGAAAA
AGGAAAAGGAGAGGCGCTGAGAAACCAGCTTGCGTCCAAGTTTCCGCACTGTGAGGTCGACTGCCTTTATGTCCCGGATA
CAGGCATTATCGTTGAAAGAAAATCAGTAAACAGTGTTTAA

Upstream 100 bases:

>100_bases
AAGATCCGAACACAGCCGTTGATGTGTCGCAGATCAAACCTGTCACACTGCCGACAGACGAAGAAGCTATTCTCGAACAC
TTAAAAGGAGCCGCTCGTGT

Downstream 100 bases:

>100_bases
CGAAAAAAGAGCTTTTTCGGCTCTTTTTTTGTTTGCCTTCAAAACAAGGATTTTTATTTAGGAAGTCGAAGTAGTATGGC
AAACAGACATGAGGAGGAGA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTEADMLFSVTVPGSTANLGPGFDSVGMALSRYLRLSVFPHDEWRFEAETEVVAGIPEGTDNLIYQVAKRTAAHFGKELP
PSLVKVWSDIPLARGLGSSAAAIAAAVELANELADLKLSDREKLHFASLEEGHPDNAGASLFGGLVIGLHEEDETEMVSM
KDIDLDVVVVIPFYEVLTKDARDVLPESLSYPKAVEASAVSNMLVAGLMAKDWKLVGRMMQKDLFHQPYRRALVPELSKV
EHEAGQNGAFGTALSGAGPTILSFIEKGKGEALRNQLASKFPHCEVDCLYVPDTGIIVERKSVNSV

Sequences:

>Translated_306_residues
MTEADMLFSVTVPGSTANLGPGFDSVGMALSRYLRLSVFPHDEWRFEAETEVVAGIPEGTDNLIYQVAKRTAAHFGKELP
PSLVKVWSDIPLARGLGSSAAAIAAAVELANELADLKLSDREKLHFASLEEGHPDNAGASLFGGLVIGLHEEDETEMVSM
KDIDLDVVVVIPFYEVLTKDARDVLPESLSYPKAVEASAVSNMLVAGLMAKDWKLVGRMMQKDLFHQPYRRALVPELSKV
EHEAGQNGAFGTALSGAGPTILSFIEKGKGEALRNQLASKFPHCEVDCLYVPDTGIIVERKSVNSV
>Mature_305_residues
TEADMLFSVTVPGSTANLGPGFDSVGMALSRYLRLSVFPHDEWRFEAETEVVAGIPEGTDNLIYQVAKRTAAHFGKELPP
SLVKVWSDIPLARGLGSSAAAIAAAVELANELADLKLSDREKLHFASLEEGHPDNAGASLFGGLVIGLHEEDETEMVSMK
DIDLDVVVVIPFYEVLTKDARDVLPESLSYPKAVEASAVSNMLVAGLMAKDWKLVGRMMQKDLFHQPYRRALVPELSKVE
HEAGQNGAFGTALSGAGPTILSFIEKGKGEALRNQLASKFPHCEVDCLYVPDTGIIVERKSVNSV

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=277, Percent_Identity=25.2707581227437, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321814, Length=338, Percent_Identity=28.9940828402367, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_BACLD (Q65FC4)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_080509.1
- RefSeq:   YP_092933.1
- HSSP:   Q58504
- ProteinModelPortal:   Q65FC4
- SMR:   Q65FC4
- STRING:   Q65FC4
- EnsemblBacteria:   EBBACT00000055356
- EnsemblBacteria:   EBBACT00000060707
- GeneID:   3027602
- GeneID:   3099765
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03412
- KEGG:   bli:BL02135
- NMPDR:   fig|279010.5.peg.3658
- eggNOG:   COG0083
- GeneTree:   EBGT00050000000874
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   BLIC279010-1:BLI03412-MONOMER
- BioCyc:   BLIC279010:BL02135-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33064; Mature: 32933

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEADMLFSVTVPGSTANLGPGFDSVGMALSRYLRLSVFPHDEWRFEAETEVVAGIPEGT
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEECCCCCH
DNLIYQVAKRTAAHFGKELPPSLVKVWSDIPLARGLGSSAAAIAAAVELANELADLKLSD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
REKLHFASLEEGHPDNAGASLFGGLVIGLHEEDETEMVSMKDIDLDVVVVIPFYEVLTKD
CHHHEECCCCCCCCCCCCHHHHCCEEEEECCCCCCCEEEEECCCEEEEEEEHHHHHHHHH
ARDVLPESLSYPKAVEASAVSNMLVAGLMAKDWKLVGRMMQKDLFHQPYRRALVPELSKV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHEAGQNGAFGTALSGAGPTILSFIEKGKGEALRNQLASKFPHCEVDCLYVPDTGIIVER
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEC
KSVNSV
CCCCCC
>Mature Secondary Structure 
TEADMLFSVTVPGSTANLGPGFDSVGMALSRYLRLSVFPHDEWRFEAETEVVAGIPEGT
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEECCCCCH
DNLIYQVAKRTAAHFGKELPPSLVKVWSDIPLARGLGSSAAAIAAAVELANELADLKLSD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
REKLHFASLEEGHPDNAGASLFGGLVIGLHEEDETEMVSMKDIDLDVVVVIPFYEVLTKD
CHHHEECCCCCCCCCCCCHHHHCCEEEEECCCCCCCEEEEECCCEEEEEEEHHHHHHHHH
ARDVLPESLSYPKAVEASAVSNMLVAGLMAKDWKLVGRMMQKDLFHQPYRRALVPELSKV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHEAGQNGAFGTALSGAGPTILSFIEKGKGEALRNQLASKFPHCEVDCLYVPDTGIIVER
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEC
KSVNSV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA