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The map label for this gene is thrC [H]

Identifier: 52787105

GI number: 52787105

Start: 3259136

End: 3260203

Strand: Reverse

Name: thrC [H]

Synonym: BLi03413

Alternate gene names: 52787105

Gene position: 3260203-3259136 (Counterclockwise)

Preceding gene: 52787106

Following gene: 52787104

Centisome position: 77.21

GC content: 50.66

Gene sequence:

>1068_bases
TTGGAGCTAATGTGGAAAGGACTCATCCATCAATATAAAGAATATTTGCCAGTAACGGACAAAACACCGGAATTGACGCT
GAACGAGGGAAATACCCCGCTTATTTATCTGCAAAACCTTTCGAAAAAGCTCGGAATCGAGCTTTATGTCAAGACGGAGG
GTGTCAACCCTACAGGCTCCTTTAAAGACCGCGGGATGGTCATGGCGGTCGCCAAGGCGAAAGAAGAAGGCAATGACACG
ATCATGTGCGCTTCGACCGGCAATACGTCGGCTGCTGCGGCGGCTTATGCGGCCCGCGCCAACATGAAGTGCATCGTCAT
TATTCCAGACGGCAAAATCGCCTTCGGAAAATTGGCCCAAGCCGTCATGTACGGCGCAGAAATCATTGCGATCGACGGAA
ACTTCGACGATGCCCTGAAAATGGTGCGCAGCATTTGCGAGAAAGAGCCGATTGCGCTGGTCAACTCTGTGAATCCATAC
CGGATTGAAGGACAGAAAACCGCTTCCTTTGAAATTTGTGAACAGCTGGGCGAAGCGCCTGATATCCTAGCGATTCCTGT
CGGAAATGCCGGTAATATAACGGCTTACTGGAAAGGCTTTAAAGAGTATCATGAGAAAAACGGCACAGGCCTGCCGGTCA
TGAAGGGTTTTCAGGCGGAAGGCGCGGCCCCGATTGTCAAAAACAAAGTAATTGAAAAGCCGGAAACCGTTGCGACAGCG
ATCAGAATCGGAAATCCGGCTAGCTGGGATAAAGCGGTCAACGCTGCAAAAGAATCGAACGGTAAAATCGATGCAGTGTC
AGACGAGGAGATTCTCCACGCTTATCAGCTCCTGGCAAGAGAAGAAGGCGTATTTGCAGAACCGGGATCATGCGCATCCA
TTGCGGGCGTGCTGAAACAGCTGCAAACGAAAGAGATTCAGCCGGGTGCGAAAGTGGTTGCCGTCTTAACCGGAAACGGC
CTGAAAGATCCGAACACAGCCGTTGATGTGTCGCAGATCAAACCTGTCACACTGCCGACAGACGAAGAAGCTATTCTCGA
ACACTTAAAAGGAGCCGCTCGTGTATGA

Upstream 100 bases:

>100_bases
ATCATACGTCAGAAGAGGATTTTACGGATATCCTGCAAAAGCTGAACGATCTTGAGGTTGTTCATCAGGTGAAAAGCACT
TATCGAGTAGAAGGGAACGG

Downstream 100 bases:

>100_bases
CTGAGGCTGACATGCTGTTTTCCGTTACGGTTCCCGGAAGCACGGCCAATCTTGGCCCGGGCTTTGATTCAGTCGGCATG
GCGCTGTCCCGCTATTTAAG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MELMWKGLIHQYKEYLPVTDKTPELTLNEGNTPLIYLQNLSKKLGIELYVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDT
IMCASTGNTSAAAAAYAARANMKCIVIIPDGKIAFGKLAQAVMYGAEIIAIDGNFDDALKMVRSICEKEPIALVNSVNPY
RIEGQKTASFEICEQLGEAPDILAIPVGNAGNITAYWKGFKEYHEKNGTGLPVMKGFQAEGAAPIVKNKVIEKPETVATA
IRIGNPASWDKAVNAAKESNGKIDAVSDEEILHAYQLLAREEGVFAEPGSCASIAGVLKQLQTKEIQPGAKVVAVLTGNG
LKDPNTAVDVSQIKPVTLPTDEEAILEHLKGAARV

Sequences:

>Translated_355_residues
MELMWKGLIHQYKEYLPVTDKTPELTLNEGNTPLIYLQNLSKKLGIELYVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDT
IMCASTGNTSAAAAAYAARANMKCIVIIPDGKIAFGKLAQAVMYGAEIIAIDGNFDDALKMVRSICEKEPIALVNSVNPY
RIEGQKTASFEICEQLGEAPDILAIPVGNAGNITAYWKGFKEYHEKNGTGLPVMKGFQAEGAAPIVKNKVIEKPETVATA
IRIGNPASWDKAVNAAKESNGKIDAVSDEEILHAYQLLAREEGVFAEPGSCASIAGVLKQLQTKEIQPGAKVVAVLTGNG
LKDPNTAVDVSQIKPVTLPTDEEAILEHLKGAARV
>Mature_355_residues
MELMWKGLIHQYKEYLPVTDKTPELTLNEGNTPLIYLQNLSKKLGIELYVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDT
IMCASTGNTSAAAAAYAARANMKCIVIIPDGKIAFGKLAQAVMYGAEIIAIDGNFDDALKMVRSICEKEPIALVNSVNPY
RIEGQKTASFEICEQLGEAPDILAIPVGNAGNITAYWKGFKEYHEKNGTGLPVMKGFQAEGAAPIVKNKVIEKPETVATA
IRIGNPASWDKAVNAAKESNGKIDAVSDEEILHAYQLLAREEGVFAEPGSCASIAGVLKQLQTKEIQPGAKVVAVLTGNG
LKDPNTAVDVSQIKPVTLPTDEEAILEHLKGAARV

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=312, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI295821200, Length=312, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4557415, Length=312, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI2367138, Length=310, Percent_Identity=27.741935483871, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786185, Length=276, Percent_Identity=25.7246376811594, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=320, Percent_Identity=27.1875, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24643623, Length=197, Percent_Identity=30.4568527918782, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129101, Length=197, Percent_Identity=30.4568527918782, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 38012; Mature: 38012

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELMWKGLIHQYKEYLPVTDKTPELTLNEGNTPLIYLQNLSKKLGIELYVKTEGVNPTGS
CCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCHHHCCEEEEEEECCCCCCCC
FKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCIVIIPDGKIAFGKLAQ
CCCCCEEEEEEEHHCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
AVMYGAEIIAIDGNFDDALKMVRSICEKEPIALVNSVNPYRIEGQKTASFEICEQLGEAP
HHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCC
DILAIPVGNAGNITAYWKGFKEYHEKNGTGLPVMKGFQAEGAAPIVKNKVIEKPETVATA
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHE
IRIGNPASWDKAVNAAKESNGKIDAVSDEEILHAYQLLAREEGVFAEPGSCASIAGVLKQ
EECCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LQTKEIQPGAKVVAVLTGNGLKDPNTAVDVSQIKPVTLPTDEEAILEHLKGAARV
HHHHCCCCCCEEEEEEECCCCCCCCCEEEHHHCCCEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MELMWKGLIHQYKEYLPVTDKTPELTLNEGNTPLIYLQNLSKKLGIELYVKTEGVNPTGS
CCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCHHHCCEEEEEEECCCCCCCC
FKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCIVIIPDGKIAFGKLAQ
CCCCCEEEEEEEHHCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
AVMYGAEIIAIDGNFDDALKMVRSICEKEPIALVNSVNPYRIEGQKTASFEICEQLGEAP
HHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCC
DILAIPVGNAGNITAYWKGFKEYHEKNGTGLPVMKGFQAEGAAPIVKNKVIEKPETVATA
CEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHE
IRIGNPASWDKAVNAAKESNGKIDAVSDEEILHAYQLLAREEGVFAEPGSCASIAGVLKQ
EECCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LQTKEIQPGAKVVAVLTGNGLKDPNTAVDVSQIKPVTLPTDEEAILEHLKGAARV
HHHHCCCCCCEEEEEEECCCCCCCCCEEEHHHCCCEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3098560; 9384377; 3139660 [H]