| Definition | Bacillus licheniformis ATCC 14580, complete genome. |
|---|---|
| Accession | NC_006322 |
| Length | 4,222,645 |
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The map label for this gene is purH [H]
Identifier: 52784504
GI number: 52784504
Start: 707082
End: 708620
Strand: Direct
Name: purH [H]
Synonym: BLi00703
Alternate gene names: 52784504
Gene position: 707082-708620 (Clockwise)
Preceding gene: 52784503
Following gene: 52784505
Centisome position: 16.75
GC content: 50.88
Gene sequence:
>1539_bases ATGACGATCAAACGCGCATTAATCAGCGTATCTGATAAAACGAACATTGTCCCTTTTGTAAAAGAATTGACAGAGCTTGG CGTTGAAGTGATTTCAACAGGGGGCACAAGCAAACTTCTTCAGGAAAACGGCGTTGACGTCATCGGCATTTCTGAAGTGA CGGGCTTTCCCGAAATCATGGACGGCCGTCTGAAAACCCTTCATCCGAATATTCACGGCGGGCTTCTTGCCGTACGCGGC AACGAAAAGCACATGGCGCAGCTGAATGAGCAGGGTATCCAGCCAATCGACCTTGTCGTTGTCAATTTATATCCTTTTAA AGAAACGGTTTCTAAAGAAGATGTCACATTCGAAGAAGCGATTGAGAATATCGACATCGGCGGCCCCGGCATGCTTCGCG CTGCAGCGAAAAACCACCAGGACGTGGCGGTCATCGTCGATCCCCGCGATTACAGCCCTGTGCTGAACGACTTGAAAGAA AACGGCAGCGTCTCTCTTGAGAAAAAACGCGAGCTTGCGGCGAAGGTGTTCCGCCACACGGCAGCATATGACGCGTTGAT CGCTGACTATTTAACAAATGTAACCGGTGAAAAAGAGCCTGAACAGTTCACCGTCACTTTTGAGAAAAAACAATCGCTCC GCTACGGCGAAAATCCGCATCAGGAAGCAGTCTTTTATCAAAGCGCGCTCCCTGTCAAAGGGTCGATCGCTTCAGCTGAA CAGCTGCACGGAAAAGAGCTTTCCTACAACAACATCAAAGACGCGGATGCGGCACTTCAAATTGTCCGCGAGTTCACCGA GCCGGCTGCGGTTGCCGTCAAGCATATGAACCCTTGCGGCGTCGGGACGGGCAACACGATCGAAGAGGCGTTTAACAAAG CATACGCCGCTGACGAAACATCGATTTTCGGCGGCATCATCGCCCTGAACCGCGAAGTGGACAAAGCGACTGCTGAAACG CTTCACAAAATCTTTTTGGAAATCATTATCGCGCCGGCATTCAGCCAAGAAGCGCTTGATATTTTAACATCCAAGAAAAA CCTTCGCCTCTTGACCCTCGATGTCAATCAGCCTGTGAAAAACGAAAAACAGCTGACATCTGTTCAAGGCGGGCTCTTGA TTCAGGATCTGGATATGCACGGCTTTGACGACGCTGACATTACGATTCCGACGAAAAGGGAGCCGACCGAACAGGAATGG GCTGACCTGAAGCTTGCTTGGAAAGTCGTGAAGCACGTCAAATCGAATGCGATTGTCCTGGCAAAGGACGATATGACGAT CGGCGTCGGCGCCGGGCAAATGAACCGCGTCGGCTCGGCGAAAATCGCAATTGAGCAAGCCGGGGAGAAAGCAAAAGGAA GCGCGCTCGGATCAGATGCCTTCTTTCCGATGCCTGATACGGTCGAAGAAGCGGCTAAAGCCGGTGTGACGGCAATCATT CAGCCGGGCGGCTCGGTTCGTGATGAAGATTCAATTAAAAAAGCGGATGAATACGGGATCGCGATGGTGTTCACCGGAAT CCGCCATTTCAAACATTAA
Upstream 100 bases:
>100_bases CACTCGCGTCTCTTGAAGAAAAGATACACAAATTGGAGCATGAACTTTATCCCGAAGTAATCAAAGAGCTTCTTGAACTA AATGGCAGAGGTGAAAAGGA
Downstream 100 bases:
>100_bases GGGAGTGACCAGCGTGAACGTATTGATTATCGGCAGAGGCGGCAGGGAGCACACGCTCGCCTGGAAAGCGGCGCAAAGCC CTCTTGTCGGCACTGTATAT
Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Products: NA
Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]
Number of amino acids: Translated: 512; Mature: 511
Protein sequence:
>512_residues MTIKRALISVSDKTNIVPFVKELTELGVEVISTGGTSKLLQENGVDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRG NEKHMAQLNEQGIQPIDLVVVNLYPFKETVSKEDVTFEEAIENIDIGGPGMLRAAAKNHQDVAVIVDPRDYSPVLNDLKE NGSVSLEKKRELAAKVFRHTAAYDALIADYLTNVTGEKEPEQFTVTFEKKQSLRYGENPHQEAVFYQSALPVKGSIASAE QLHGKELSYNNIKDADAALQIVREFTEPAAVAVKHMNPCGVGTGNTIEEAFNKAYAADETSIFGGIIALNREVDKATAET LHKIFLEIIIAPAFSQEALDILTSKKNLRLLTLDVNQPVKNEKQLTSVQGGLLIQDLDMHGFDDADITIPTKREPTEQEW ADLKLAWKVVKHVKSNAIVLAKDDMTIGVGAGQMNRVGSAKIAIEQAGEKAKGSALGSDAFFPMPDTVEEAAKAGVTAII QPGGSVRDEDSIKKADEYGIAMVFTGIRHFKH
Sequences:
>Translated_512_residues MTIKRALISVSDKTNIVPFVKELTELGVEVISTGGTSKLLQENGVDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRG NEKHMAQLNEQGIQPIDLVVVNLYPFKETVSKEDVTFEEAIENIDIGGPGMLRAAAKNHQDVAVIVDPRDYSPVLNDLKE NGSVSLEKKRELAAKVFRHTAAYDALIADYLTNVTGEKEPEQFTVTFEKKQSLRYGENPHQEAVFYQSALPVKGSIASAE QLHGKELSYNNIKDADAALQIVREFTEPAAVAVKHMNPCGVGTGNTIEEAFNKAYAADETSIFGGIIALNREVDKATAET LHKIFLEIIIAPAFSQEALDILTSKKNLRLLTLDVNQPVKNEKQLTSVQGGLLIQDLDMHGFDDADITIPTKREPTEQEW ADLKLAWKVVKHVKSNAIVLAKDDMTIGVGAGQMNRVGSAKIAIEQAGEKAKGSALGSDAFFPMPDTVEEAAKAGVTAII QPGGSVRDEDSIKKADEYGIAMVFTGIRHFKH >Mature_511_residues TIKRALISVSDKTNIVPFVKELTELGVEVISTGGTSKLLQENGVDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGN EKHMAQLNEQGIQPIDLVVVNLYPFKETVSKEDVTFEEAIENIDIGGPGMLRAAAKNHQDVAVIVDPRDYSPVLNDLKEN GSVSLEKKRELAAKVFRHTAAYDALIADYLTNVTGEKEPEQFTVTFEKKQSLRYGENPHQEAVFYQSALPVKGSIASAEQ LHGKELSYNNIKDADAALQIVREFTEPAAVAVKHMNPCGVGTGNTIEEAFNKAYAADETSIFGGIIALNREVDKATAETL HKIFLEIIIAPAFSQEALDILTSKKNLRLLTLDVNQPVKNEKQLTSVQGGLLIQDLDMHGFDDADITIPTKREPTEQEWA DLKLAWKVVKHVKSNAIVLAKDDMTIGVGAGQMNRVGSAKIAIEQAGEKAKGSALGSDAFFPMPDTVEEAAKAGVTAIIQ PGGSVRDEDSIKKADEYGIAMVFTGIRHFKH
Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]
COG id: COG0138
COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the purH family [H]
Homologues:
Organism=Homo sapiens, GI20127454, Length=476, Percent_Identity=36.9747899159664, Blast_Score=271, Evalue=8e-73, Organism=Escherichia coli, GI1790439, Length=525, Percent_Identity=52.1904761904762, Blast_Score=542, Evalue=1e-155, Organism=Caenorhabditis elegans, GI71985564, Length=478, Percent_Identity=34.3096234309623, Blast_Score=261, Evalue=5e-70, Organism=Caenorhabditis elegans, GI71985574, Length=309, Percent_Identity=26.537216828479, Blast_Score=95, Evalue=7e-20, Organism=Saccharomyces cerevisiae, GI6323056, Length=477, Percent_Identity=37.9454926624738, Blast_Score=276, Evalue=4e-75, Organism=Saccharomyces cerevisiae, GI6323768, Length=479, Percent_Identity=35.9081419624217, Blast_Score=267, Evalue=4e-72, Organism=Drosophila melanogaster, GI24649832, Length=475, Percent_Identity=36.4210526315789, Blast_Score=271, Evalue=8e-73,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002695 - InterPro: IPR013982 - InterPro: IPR016193 - InterPro: IPR011607 [H]
Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]
EC number: =2.1.2.3; =3.5.4.10 [H]
Molecular weight: Translated: 55686; Mature: 55555
Theoretical pI: Translated: 5.05; Mature: 5.05
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTIKRALISVSDKTNIVPFVKELTELGVEVISTGGTSKLLQENGVDVIGISEVTGFPEIM CCHHHHHEEECCCCCCHHHHHHHHHCCHHEECCCCCHHHHHHCCCCEEEEHHHCCCHHHH DGRLKTLHPNIHGGLLAVRGNEKHMAQLNEQGIQPIDLVVVNLYPFKETVSKEDVTFEEA CCCCEEECCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCHHHCCCCCCCHHHH IENIDIGGPGMLRAAAKNHQDVAVIVDPRDYSPVLNDLKENGSVSLEKKRELAAKVFRHT HHHCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHH AAYDALIADYLTNVTGEKEPEQFTVTFEKKQSLRYGENPHQEAVFYQSALPVKGSIASAE HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHEEECCCCCCCCCCCCHH QLHGKELSYNNIKDADAALQIVREFTEPAAVAVKHMNPCGVGTGNTIEEAFNKAYAADET HHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCH SIFGGIIALNREVDKATAETLHKIFLEIIIAPAFSQEALDILTSKKNLRLLTLDVNQPVK HHHHEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCC NEKQLTSVQGGLLIQDLDMHGFDDADITIPTKREPTEQEWADLKLAWKVVKHVKSNAIVL CHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE AKDDMTIGVGAGQMNRVGSAKIAIEQAGEKAKGSALGSDAFFPMPDTVEEAAKAGVTAII EECCEEEEECCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEE QPGGSVRDEDSIKKADEYGIAMVFTGIRHFKH CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC >Mature Secondary Structure TIKRALISVSDKTNIVPFVKELTELGVEVISTGGTSKLLQENGVDVIGISEVTGFPEIM CHHHHHEEECCCCCCHHHHHHHHHCCHHEECCCCCHHHHHHCCCCEEEEHHHCCCHHHH DGRLKTLHPNIHGGLLAVRGNEKHMAQLNEQGIQPIDLVVVNLYPFKETVSKEDVTFEEA CCCCEEECCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCHHHCCCCCCCHHHH IENIDIGGPGMLRAAAKNHQDVAVIVDPRDYSPVLNDLKENGSVSLEKKRELAAKVFRHT HHHCCCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHH AAYDALIADYLTNVTGEKEPEQFTVTFEKKQSLRYGENPHQEAVFYQSALPVKGSIASAE HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHEEECCCCCCCCCCCCHH QLHGKELSYNNIKDADAALQIVREFTEPAAVAVKHMNPCGVGTGNTIEEAFNKAYAADET HHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCH SIFGGIIALNREVDKATAETLHKIFLEIIIAPAFSQEALDILTSKKNLRLLTLDVNQPVK HHHHEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCC NEKQLTSVQGGLLIQDLDMHGFDDADITIPTKREPTEQEWADLKLAWKVVKHVKSNAIVL CHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE AKDDMTIGVGAGQMNRVGSAKIAIEQAGEKAKGSALGSDAFFPMPDTVEEAAKAGVTAII EECCEEEEECCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEE QPGGSVRDEDSIKKADEYGIAMVFTGIRHFKH CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 3036807; 9384377; 8969499 [H]