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The map label for this gene is mtlD

Identifier: 52784327

GI number: 52784327

Start: 512816

End: 513955

Strand: Direct

Name: mtlD

Synonym: BLi00507

Alternate gene names: 52784327

Gene position: 512816-513955 (Clockwise)

Preceding gene: 52784326

Following gene: 52784328

Centisome position: 12.14

GC content: 52.37

Gene sequence:

>1140_bases
ATGATTGCACTGCATTTCGGTGCGGGGAACATCGGCCGCGGATTTATCGGAGCCTTGCTCTGCAAATCGGGGTATGATGT
CGTGTTCGCCGATGTAAATGATGCCGTGATCAATGAACTGAACGATAAGGGCCGCTATACCGTCGAAATGGCCGATGCCG
GAAGGAAGCAGGAAACGATCGGACCGGTCCGGGCGATCAACAGTGCGACCCAGCTTGACGAATTGTATGATTTGATAGCG
AAAGCCGACCTTGTCACCACAGCGGTAGGCCCGGCGGTGCTTAAATTGATCGCAGAGCCGATTGCAGAAGGTTTGAAGCG
TCGGATGAAAATAAACAAGCAGCCTTTAAATATTATAGCTTGCGAGAATATGATCGGGGGCAGCGCTCATCTTCGCGAGG
AAATTTTCGCCCGCTTAACTGAAACGGAGCGCGCCGCAATCAGCGATTCAGTCGGCTTTCCGAACTCGGCAGTCGACAGA
ATCGTGCCGATCCAGCACCATGATGATCCGTTGAAAGTAACGGTGGAGCCTTTTTTCGAATGGGCCGTTGATCAAACGGA
ATTCGCCGGAAAAGTGCCGGATATTGAAGGTGTGACATATGTAGCGGATCTTGCGCCATTCATCGAAAGAAAGCTGTTTA
CGGTCAATACCGGACACGCCATGGCGGCGTATGCCGGCTATAAGAAAGGTTTGAAGACGATAAAAGACGCCATTCATCAT
CCGGAGGTCCGCCAAACGGTGGCAGGCGCGCTAGAAGAAACAGGCCGGTACCTTGTCCAAACATACGATTTTACACAGGA
AGAGCACCGGGCATATATGACAAAAATTATCGGCCGCTTTGAGAATGAATGCCTGTCAGACGATGTCACCCGTGTGGCCA
GGTCGCCGCTTCGCAAGCTTGGCAGGGATGACCGTCTTGTCGGCCCGGCCCGGAAGCTTTGCGATCTCGGCTTTGAACCT
GTCCGCCTTGCAGAAGGCATTGCCCTGGCGCTGCAGTTTGATTGTGCCGATGATCCGGAAGCCGTTCAGCTTCAAAGCAT
GATCGCTGAAAAAGGCTATGCCGGCGTGCTTCGCGACGTATGCGGACTCGAAGAGGATCATTCTTTATTCAAACTGGTAA
TCAGCCATTTGAAAGCATAG

Upstream 100 bases:

>100_bases
AGATTGCGATTGTCTGCTCAGAAGCGGACAATGTCGAACGGATCATCAATGCGAAAAATGAAGACGAGTTAATGGCGGTT
TTTGAAGAAGGTGACCAGGT

Downstream 100 bases:

>100_bases
CTTTAGATAGAATCGGGAGAGGGCGGCAGCCGGGCGGGGGCTGCCGAAAACAGAATGTATGAACAGGGCGGCGCAGATGC
AACCTAATCTAGAAACATCA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MIALHFGAGNIGRGFIGALLCKSGYDVVFADVNDAVINELNDKGRYTVEMADAGRKQETIGPVRAINSATQLDELYDLIA
KADLVTTAVGPAVLKLIAEPIAEGLKRRMKINKQPLNIIACENMIGGSAHLREEIFARLTETERAAISDSVGFPNSAVDR
IVPIQHHDDPLKVTVEPFFEWAVDQTEFAGKVPDIEGVTYVADLAPFIERKLFTVNTGHAMAAYAGYKKGLKTIKDAIHH
PEVRQTVAGALEETGRYLVQTYDFTQEEHRAYMTKIIGRFENECLSDDVTRVARSPLRKLGRDDRLVGPARKLCDLGFEP
VRLAEGIALALQFDCADDPEAVQLQSMIAEKGYAGVLRDVCGLEEDHSLFKLVISHLKA

Sequences:

>Translated_379_residues
MIALHFGAGNIGRGFIGALLCKSGYDVVFADVNDAVINELNDKGRYTVEMADAGRKQETIGPVRAINSATQLDELYDLIA
KADLVTTAVGPAVLKLIAEPIAEGLKRRMKINKQPLNIIACENMIGGSAHLREEIFARLTETERAAISDSVGFPNSAVDR
IVPIQHHDDPLKVTVEPFFEWAVDQTEFAGKVPDIEGVTYVADLAPFIERKLFTVNTGHAMAAYAGYKKGLKTIKDAIHH
PEVRQTVAGALEETGRYLVQTYDFTQEEHRAYMTKIIGRFENECLSDDVTRVARSPLRKLGRDDRLVGPARKLCDLGFEP
VRLAEGIALALQFDCADDPEAVQLQSMIAEKGYAGVLRDVCGLEEDHSLFKLVISHLKA
>Mature_379_residues
MIALHFGAGNIGRGFIGALLCKSGYDVVFADVNDAVINELNDKGRYTVEMADAGRKQETIGPVRAINSATQLDELYDLIA
KADLVTTAVGPAVLKLIAEPIAEGLKRRMKINKQPLNIIACENMIGGSAHLREEIFARLTETERAAISDSVGFPNSAVDR
IVPIQHHDDPLKVTVEPFFEWAVDQTEFAGKVPDIEGVTYVADLAPFIERKLFTVNTGHAMAAYAGYKKGLKTIKDAIHH
PEVRQTVAGALEETGRYLVQTYDFTQEEHRAYMTKIIGRFENECLSDDVTRVARSPLRKLGRDDRLVGPARKLCDLGFEP
VRLAEGIALALQFDCADDPEAVQLQSMIAEKGYAGVLRDVCGLEEDHSLFKLVISHLKA

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=47.3821989528796, Blast_Score=343, Evalue=9e-96,
Organism=Escherichia coli, GI1788497, Length=284, Percent_Identity=27.112676056338, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787823, Length=284, Percent_Identity=27.112676056338, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790779, Length=250, Percent_Identity=28.4, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324401, Length=212, Percent_Identity=27.8301886792453, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320765, Length=212, Percent_Identity=27.8301886792453, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_BACLD (Q65NA1)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_077741.1
- RefSeq:   YP_090156.1
- ProteinModelPortal:   Q65NA1
- STRING:   Q65NA1
- EnsemblBacteria:   EBBACT00000058126
- EnsemblBacteria:   EBBACT00000060591
- GeneID:   3030175
- GeneID:   3098227
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00507
- KEGG:   bli:BL02815
- NMPDR:   fig|279010.5.peg.593
- eggNOG:   COG0246
- GeneTree:   EBGT00050000001216
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- BioCyc:   BLIC279010-1:BLI00507-MONOMER
- BioCyc:   BLIC279010:BL02815-MONOMER
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 41676; Mature: 41676

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALHFGAGNIGRGFIGALLCKSGYDVVFADVNDAVINELNDKGRYTVEMADAGRKQETI
CEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCEEEEECCCCCCHHHH
GPVRAINSATQLDELYDLIAKADLVTTAVGPAVLKLIAEPIAEGLKRRMKINKQPLNIIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CENMIGGSAHLREEIFARLTETERAAISDSVGFPNSAVDRIVPIQHHDDPLKVTVEPFFE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCEEEHHHHHH
WAVDQTEFAGKVPDIEGVTYVADLAPFIERKLFTVNTGHAMAAYAGYKKGLKTIKDAIHH
HHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHCC
PEVRQTVAGALEETGRYLVQTYDFTQEEHRAYMTKIIGRFENECLSDDVTRVARSPLRKL
CHHHHHHHHHHHHCCHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRDDRLVGPARKLCDLGFEPVRLAEGIALALQFDCADDPEAVQLQSMIAEKGYAGVLRDV
CCCCCCCCHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHH
CGLEEDHSLFKLVISHLKA
HCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIALHFGAGNIGRGFIGALLCKSGYDVVFADVNDAVINELNDKGRYTVEMADAGRKQETI
CEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCEEEEECCCCCCHHHH
GPVRAINSATQLDELYDLIAKADLVTTAVGPAVLKLIAEPIAEGLKRRMKINKQPLNIIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CENMIGGSAHLREEIFARLTETERAAISDSVGFPNSAVDRIVPIQHHDDPLKVTVEPFFE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCEEEHHHHHH
WAVDQTEFAGKVPDIEGVTYVADLAPFIERKLFTVNTGHAMAAYAGYKKGLKTIKDAIHH
HHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHCC
PEVRQTVAGALEETGRYLVQTYDFTQEEHRAYMTKIIGRFENECLSDDVTRVARSPLRKL
CHHHHHHHHHHHHCCHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRDDRLVGPARKLCDLGFEPVRLAEGIALALQFDCADDPEAVQLQSMIAEKGYAGVLRDV
CCCCCCCCHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHH
CGLEEDHSLFKLVISHLKA
HCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA