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The map label for this gene is mtlR [H]

Identifier: 52784328

GI number: 52784328

Start: 514236

End: 516314

Strand: Direct

Name: mtlR [H]

Synonym: BLi00508

Alternate gene names: 52784328

Gene position: 514236-516314 (Clockwise)

Preceding gene: 52784327

Following gene: 52784329

Centisome position: 12.18

GC content: 47.91

Gene sequence:

>2079_bases
ATGTATATGACAGCAAGGGAACAAAAACTAATGAAATACCTTTTGCATCAAAACCGTTATGTCAAAGTCAATGAAATTGC
CGGCTATATAGAAGTCAGCACAAGAACGGTCCACCGCGAGCTCAAAGCGGTTAAATCCGTTCTGGACAAGTACAGGCTTC
AGCTTGATAAGCAGCCGGGAAAAGGCTTGAAACTGGTCGGAGCCTACAGAGACAAACAGCGGCTTCTTGAAGATCTGTCC
CGGGACAGTCATGTCGAATACAGTGCCGATGAACGAAAGCTTTTGATTTTATGCGCGATGCTTGAAACGGGAGAGCCGAT
CAAGCTTTATACAATTGCCCATGACTTGCAGGTGACGGCGGCAACGATCAGCAACGATCTTGACGAGCTGGAGAAGTGGA
TCGCTCCATTCGGCCTTTCGCTGATCAGAAAAAGAGGCTACGGTATAGAGCTGAGGGGGCCGGAGGACGCCAAGCGGAAA
ATCGTCGGAAACTTGATGGCCGACAAGCTCGATGTTCAGCAGTTTCTGGAAACGATCGAAATGAATATTAAAGGCAAGAA
CGAAGCGCCGGAGAAAATATTCGGTGTCGTCAGCCGGGGGAAATTGCTGAAAGCGGAAAAAGTGCTGTTTCAGATGAAAG
AAAAGTATGGACTTTCTCTTTCCGACAGTGCATACATCGCTCTGGTCGTCCACTTGACGTTTGCGATCGAGCGGATACAG
CTCGGTGAAATGATCAATATGAATGAAGAAGAATTGACGGATCTGAAGCGTACGAAAGAGTTTGAACTGGCGCTTGCGCT
TGCAAAGGCGCTTGAAGATGCGTTTCACGTGAAGATACCCGAAGCTGAGGCGGGGTATATTACGATGCATTTAAGAAGCG
CCAACAAAAGCTTCAAAATCGACTACAGAGCGGAAGATATCGAGCTGGATACTGCGCTCAGAACGAAAAAGCTGATCGAT
TTCATCTCGCAAAAAACGGGCATGAATTTAACCGGCAATCATTCGCTTTATGAAGGATTAATCGCCCACCTTGAACCGGC
GATCATCCGGATCAAAGAAAAGATGTCGGTGCATAATCCGTTAACAGAGCAGGTCAAAAAAGATTATTTTCTCCTATATA
TGGCCATAGAGGAAGGCGTCGAAATATTTTTCCCGGAAATCCGGTTTCCAGATGAAGAAATTGCTTTTATCGTCCTTCAC
TTTGGATCGGCGCTTGAGATGAGCAAACAAAAAGTAGACATCAACGCGCTCGTGATTTGTTCGAGCGGAATCGGTTCATC
AAAGATGCTGGCCTCGCGGTTGAAAAAAGAGCTTCCTGAAATCGCTTCCTTTGAGATATCCTCTCTGATGGAACTGAAGA
CGAAAAACACTGATGCCTTTGACATCATCGTTTCAACCGTGCCGATCCCATATGAAAACATTGACTGCGTCACCGTCAGT
CCGCTCCTTGACACGGAAGATGTGAAACAGATCAAACACCAGCTCACCCGAAAAATCCCGCTCATCCTTCGGAAAAAGCG
GATGGCGCCCAAAAAACCGGAGCCGTTTCCAGATATGCTTCAGATTGCGCGGAAAATCGGCCATTACGCGGCCGGCATTC
AACATATACTGAGCCATTTTACGGTTGAAACGATGGAAGCTGAATCAAGCCTGGAACATACGGTCAAACGGATTTGCGGA
ACCCTGGAAGATCAAGGCCTGGTTAAGGATGCAGGGCAGATGGCGGATGGACTGATGAAAAGAGAAGCACAGGGTGGCCT
CGGAATTCCCGGAACAACCTTCGCGCTGTTTCATTTAAAAAGTGAAGCGGCCGCGGTTCCCCTCTTTAAAGCTTATGATC
TGTCCAAACCGTTCGAGATCAAAGGGATGGACGGAAGCGCCATGAAGATGATGCGGATGCTCATCATGCTGGCGCCGGCC
GATCTGTCTCCGGAAGGTTCCGAGATTCTGAGCTTCATCAGCTCTTCGATGATAGAAAGTGATGAGAGCATAAAAGCATA
CCAGACCGGAGACCGCGAGCAGCTGTACGGCATGCTGAACGTGCTGTTTCACCGGTTTATACAGGATAAAGAGTGGTGA

Upstream 100 bases:

>100_bases
TTTTTTGACAGCGTTTTATGATAGGGATACCGTTTCAACCGCCGGAACCCCTTTCACCCCCCCCCCCCCGCAAAAACGAC
AACACCGGAGGCGGCGTTTT

Downstream 100 bases:

>100_bases
GAGCCCCGGGTTAACCCGGGGCTTTCTTCATTTTTATCGCACATGGTCATGTTTAAACAAAAATTTCTCCGGTTAAAAGT
CTAGTAACATCAGCTAAAGG

Product: hypothetical protein

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 692; Mature: 692

Protein sequence:

>692_residues
MYMTAREQKLMKYLLHQNRYVKVNEIAGYIEVSTRTVHRELKAVKSVLDKYRLQLDKQPGKGLKLVGAYRDKQRLLEDLS
RDSHVEYSADERKLLILCAMLETGEPIKLYTIAHDLQVTAATISNDLDELEKWIAPFGLSLIRKRGYGIELRGPEDAKRK
IVGNLMADKLDVQQFLETIEMNIKGKNEAPEKIFGVVSRGKLLKAEKVLFQMKEKYGLSLSDSAYIALVVHLTFAIERIQ
LGEMINMNEEELTDLKRTKEFELALALAKALEDAFHVKIPEAEAGYITMHLRSANKSFKIDYRAEDIELDTALRTKKLID
FISQKTGMNLTGNHSLYEGLIAHLEPAIIRIKEKMSVHNPLTEQVKKDYFLLYMAIEEGVEIFFPEIRFPDEEIAFIVLH
FGSALEMSKQKVDINALVICSSGIGSSKMLASRLKKELPEIASFEISSLMELKTKNTDAFDIIVSTVPIPYENIDCVTVS
PLLDTEDVKQIKHQLTRKIPLILRKKRMAPKKPEPFPDMLQIARKIGHYAAGIQHILSHFTVETMEAESSLEHTVKRICG
TLEDQGLVKDAGQMADGLMKREAQGGLGIPGTTFALFHLKSEAAAVPLFKAYDLSKPFEIKGMDGSAMKMMRMLIMLAPA
DLSPEGSEILSFISSSMIESDESIKAYQTGDREQLYGMLNVLFHRFIQDKEW

Sequences:

>Translated_692_residues
MYMTAREQKLMKYLLHQNRYVKVNEIAGYIEVSTRTVHRELKAVKSVLDKYRLQLDKQPGKGLKLVGAYRDKQRLLEDLS
RDSHVEYSADERKLLILCAMLETGEPIKLYTIAHDLQVTAATISNDLDELEKWIAPFGLSLIRKRGYGIELRGPEDAKRK
IVGNLMADKLDVQQFLETIEMNIKGKNEAPEKIFGVVSRGKLLKAEKVLFQMKEKYGLSLSDSAYIALVVHLTFAIERIQ
LGEMINMNEEELTDLKRTKEFELALALAKALEDAFHVKIPEAEAGYITMHLRSANKSFKIDYRAEDIELDTALRTKKLID
FISQKTGMNLTGNHSLYEGLIAHLEPAIIRIKEKMSVHNPLTEQVKKDYFLLYMAIEEGVEIFFPEIRFPDEEIAFIVLH
FGSALEMSKQKVDINALVICSSGIGSSKMLASRLKKELPEIASFEISSLMELKTKNTDAFDIIVSTVPIPYENIDCVTVS
PLLDTEDVKQIKHQLTRKIPLILRKKRMAPKKPEPFPDMLQIARKIGHYAAGIQHILSHFTVETMEAESSLEHTVKRICG
TLEDQGLVKDAGQMADGLMKREAQGGLGIPGTTFALFHLKSEAAAVPLFKAYDLSKPFEIKGMDGSAMKMMRMLIMLAPA
DLSPEGSEILSFISSSMIESDESIKAYQTGDREQLYGMLNVLFHRFIQDKEW
>Mature_692_residues
MYMTAREQKLMKYLLHQNRYVKVNEIAGYIEVSTRTVHRELKAVKSVLDKYRLQLDKQPGKGLKLVGAYRDKQRLLEDLS
RDSHVEYSADERKLLILCAMLETGEPIKLYTIAHDLQVTAATISNDLDELEKWIAPFGLSLIRKRGYGIELRGPEDAKRK
IVGNLMADKLDVQQFLETIEMNIKGKNEAPEKIFGVVSRGKLLKAEKVLFQMKEKYGLSLSDSAYIALVVHLTFAIERIQ
LGEMINMNEEELTDLKRTKEFELALALAKALEDAFHVKIPEAEAGYITMHLRSANKSFKIDYRAEDIELDTALRTKKLID
FISQKTGMNLTGNHSLYEGLIAHLEPAIIRIKEKMSVHNPLTEQVKKDYFLLYMAIEEGVEIFFPEIRFPDEEIAFIVLH
FGSALEMSKQKVDINALVICSSGIGSSKMLASRLKKELPEIASFEISSLMELKTKNTDAFDIIVSTVPIPYENIDCVTVS
PLLDTEDVKQIKHQLTRKIPLILRKKRMAPKKPEPFPDMLQIARKIGHYAAGIQHILSHFTVETMEAESSLEHTVKRICG
TLEDQGLVKDAGQMADGLMKREAQGGLGIPGTTFALFHLKSEAAAVPLFKAYDLSKPFEIKGMDGSAMKMMRMLIMLAPA
DLSPEGSEILSFISSSMIESDESIKAYQTGDREQLYGMLNVLFHRFIQDKEW

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 78370; Mature: 78370

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMTAREQKLMKYLLHQNRYVKVNEIAGYIEVSTRTVHRELKAVKSVLDKYRLQLDKQPG
CCCCHHHHHHHHHHHCCCCEEEEEHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KGLKLVGAYRDKQRLLEDLSRDSHVEYSADERKLLILCAMLETGEPIKLYTIAHDLQVTA
CCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHCCCCCEEEEEEEECCEEHH
ATISNDLDELEKWIAPFGLSLIRKRGYGIELRGPEDAKRKIVGNLMADKLDVQQFLETIE
HHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MNIKGKNEAPEKIFGVVSRGKLLKAEKVLFQMKEKYGLSLSDSAYIALVVHLTFAIERIQ
HCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LGEMINMNEEELTDLKRTKEFELALALAKALEDAFHVKIPEAEAGYITMHLRSANKSFKI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCEEE
DYRAEDIELDTALRTKKLIDFISQKTGMNLTGNHSLYEGLIAHLEPAIIRIKEKMSVHNP
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCC
LTEQVKKDYFLLYMAIEEGVEIFFPEIRFPDEEIAFIVLHFGSALEMSKQKVDINALVIC
HHHHHCCCCEEEEEEHHCCCCEEECCCCCCCHHHEEEEEECCCHHHHHHHEECEEEEEEE
SSGIGSSKMLASRLKKELPEIASFEISSLMELKTKNTDAFDIIVSTVPIPYENIDCVTVS
ECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEC
PLLDTEDVKQIKHQLTRKIPLILRKKRMAPKKPEPFPDMLQIARKIGHYAAGIQHILSHF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TVETMEAESSLEHTVKRICGTLEDQGLVKDAGQMADGLMKREAQGGLGIPGTTFALFHLK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEEC
SEAAAVPLFKAYDLSKPFEIKGMDGSAMKMMRMLIMLAPADLSPEGSEILSFISSSMIES
CCCCCCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DESIKAYQTGDREQLYGMLNVLFHRFIQDKEW
CCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYMTAREQKLMKYLLHQNRYVKVNEIAGYIEVSTRTVHRELKAVKSVLDKYRLQLDKQPG
CCCCHHHHHHHHHHHCCCCEEEEEHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KGLKLVGAYRDKQRLLEDLSRDSHVEYSADERKLLILCAMLETGEPIKLYTIAHDLQVTA
CCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHCCCCCEEEEEEEECCEEHH
ATISNDLDELEKWIAPFGLSLIRKRGYGIELRGPEDAKRKIVGNLMADKLDVQQFLETIE
HHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MNIKGKNEAPEKIFGVVSRGKLLKAEKVLFQMKEKYGLSLSDSAYIALVVHLTFAIERIQ
HCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LGEMINMNEEELTDLKRTKEFELALALAKALEDAFHVKIPEAEAGYITMHLRSANKSFKI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCEEE
DYRAEDIELDTALRTKKLIDFISQKTGMNLTGNHSLYEGLIAHLEPAIIRIKEKMSVHNP
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCC
LTEQVKKDYFLLYMAIEEGVEIFFPEIRFPDEEIAFIVLHFGSALEMSKQKVDINALVIC
HHHHHCCCCEEEEEEHHCCCCEEECCCCCCCHHHEEEEEECCCHHHHHHHEECEEEEEEE
SSGIGSSKMLASRLKKELPEIASFEISSLMELKTKNTDAFDIIVSTVPIPYENIDCVTVS
ECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEC
PLLDTEDVKQIKHQLTRKIPLILRKKRMAPKKPEPFPDMLQIARKIGHYAAGIQHILSHF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TVETMEAESSLEHTVKRICGTLEDQGLVKDAGQMADGLMKREAQGGLGIPGTTFALFHLK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEEC
SEAAAVPLFKAYDLSKPFEIKGMDGSAMKMMRMLIMLAPADLSPEGSEILSFISSSMIES
CCCCCCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DESIKAYQTGDREQLYGMLNVLFHRFIQDKEW
CCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]