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The map label for this gene is vanR [H]

Identifier: 52140648

GI number: 52140648

Start: 4692836

End: 4693534

Strand: Reverse

Name: vanR [H]

Synonym: BCZK4605

Alternate gene names: 52140648

Gene position: 4693534-4692836 (Counterclockwise)

Preceding gene: 52140649

Following gene: 52140650

Centisome position: 88.54

GC content: 38.63

Gene sequence:

>699_bases
ATGAAGCGCATTTCAATTTTAATAGCGGATGATGAGGCAGAAATTGCTGATTTAATTGAGATACATTTAGAAAAAGAAGG
GTACCACGTCGTGAAAGCAGCTGATGGAGAAGAGGCAATTCATATTATTGAAACGCAGCCAATCGATTTAGTGGTTTTAG
ATATTATGATGCCAAAAATGGATGGGTATGAGGTGACGCGCCAAATTCGAGCGAAGCATCATATGCCAATCATTTTCTTG
AGTGCGAAAACTTCGGACTTTGATAAGGTGACAGGTCTTGTATTAGGTGCAGATGATTATATGACGAAACCTTTTACGCC
GATTGAATTAGTTGCGCGTGTAAATGCACAATTACGCCGATTTCTTACGTTAAATCAGCCGAAAGTAGCGGAGAATAAAT
CTGCTTTAGAGGTAGGCGGGGTCGTGATTGATCCTGAGCGAAGAACAGTAAATGTGTACGGAGAACAAGTTGAATTAACA
CCGAAAGAGTTTGATATTTTATATTTATTAGCGAGCCATCCGAAGAAAGTGTACAATGTAGAAAATATTTTTCAGCAAGT
ATGGGCAGATGATTATTATGAAGGCGGAAATACAGTTATGGTACATATTCGTACGTTGCGGAAAAAGCTTGGGGAGGATA
AAAGAAAAGATAAGCTAATAAAAACAGTTTGGGGAGTAGGGTATACTTTCAATGGGTAA

Upstream 100 bases:

>100_bases
TATAATTTTATTTACAAAGGTTACTCTAACGGGTAACCTTTTCGTATTGTACAAATGGGATAGACTAGTTTACAATCGAG
CGTATAAAAGGGGGAGTAAA

Downstream 100 bases:

>100_bases
AAAGATGAGAAGTTTTCGCTCAAAGATGGTTATGCTATTTGCGTTAAGTATGCTATTTGCTGGTGGCGTAACGTATATCA
TTTATGAAGGGTTACGGATC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKMDGYEVTRQIRAKHHMPIIFL
SAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRRFLTLNQPKVAENKSALEVGGVVIDPERRTVNVYGEQVELT
PKEFDILYLLASHPKKVYNVENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG

Sequences:

>Translated_232_residues
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKMDGYEVTRQIRAKHHMPIIFL
SAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRRFLTLNQPKVAENKSALEVGGVVIDPERRTVNVYGEQVELT
PKEFDILYLLASHPKKVYNVENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG
>Mature_232_residues
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKMDGYEVTRQIRAKHHMPIIFL
SAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRRFLTLNQPKVAENKSALEVGGVVIDPERRTVNVYGEQVELT
PKEFDILYLLASHPKKVYNVENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=36.6812227074236, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=41.0714285714286, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=35.6828193832599, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=32.7433628318584, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.0396475770925, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=35.3711790393013, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=31.7596566523605, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=35.8407079646018, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=32.3008849557522, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=32.2033898305085, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=31.25, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=31.8965517241379, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=29.3859649122807, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788713, Length=106, Percent_Identity=37.7358490566038, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790299, Length=130, Percent_Identity=32.3076923076923, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788550, Length=124, Percent_Identity=32.258064516129, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=33.0097087378641, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=106, Percent_Identity=34.9056603773585, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26436; Mature: 26436

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKM
CCEEEEEEECCCHHHHHHHHHEECCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCC
DGYEVTRQIRAKHHMPIIFLSAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRR
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FLTLNQPKVAENKSALEVGGVVIDPERRTVNVYGEQVELTPKEFDILYLLASHPKKVYNV
HCCCCCCCCCCCCCCEEECCEEECCCCCEEEEECCEEEECCCCEEEEEEEECCCHHHHHH
ENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG
HHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKM
CCEEEEEEECCCHHHHHHHHHEECCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCC
DGYEVTRQIRAKHHMPIIFLSAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRR
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FLTLNQPKVAENKSALEVGGVVIDPERRTVNVYGEQVELTPKEFDILYLLASHPKKVYNV
HCCCCCCCCCCCCCCEEECCEEECCCCCEEEEECCEEEECCCCEEEEEEEECCCHHHHHH
ENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG
HHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]