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The map label for this gene is menC [H]

Identifier: 52140649

GI number: 52140649

Start: 4693749

End: 4694855

Strand: Reverse

Name: menC [H]

Synonym: BCZK4606

Alternate gene names: 52140649

Gene position: 4694855-4693749 (Counterclockwise)

Preceding gene: 52140647

Following gene: 52140648

Centisome position: 88.57

GC content: 43.0

Gene sequence:

>1107_bases
GTGGAGATAAAAAAAGCGACACTTCATATAACGGAAATGCCACTCGTCATCCCGTTTGCTGCAAGCTACGGAACGTATGA
AAAGCGTGAAAGTATCGTCATTGAATTAGAAGATGAGGACGGGGACATTGGATTTGGCGAAGTCGTTGCATTTTCTGAAC
CGTGGTATACGGAAGAAACAGTGAAGACGGCGCTACATGTACTGCAAGACTTTTTATTACCAGATTTATTAAAGGCTGAA
ATTTCTCATCCGAATGAAGTGCCGAGTTTGTTCCAGCATATAAAAAGAAACCGAATGGCAAAGGCCGGAATTGAAGGGGC
TGTTTGGGATTTATATGCGAAGCGTCAAAAGAAATCATTAGCGACATTGCTTGGCGGAACGAAGTCTGAAATTGAAGTCG
GTGTTGTGATCGGGATCAATACGATTCCAGTTATGTTAAAACAAATTGAGAAGTATGCGGAAGAAGGATACGAGCGTTTT
AAGGTGAAAATAAAACCGGGGCATGATTATGAGTTATTGAAAGAAATTCGTAAAGAGTTTCCGCATATCCCGTTAATGGC
TGATGCAAATTCAGCGTATACATTAGCGGATACGGAGAGTCTGAAACGACTAGATGAATTCCAATTGATGATGATTGAGC
AACCGCTAGCAGATTACGATTTTCTCGATCATGCACAGCTACAGAAGAAGATTGAAACGCCAATTTGTTTGGACGAAAGT
ATCCATAGTTTAGAAGATGCGCGTGTTGCGATTACACTTGGCAGTTGCCAAATCGTTAACATTAAACCAGGGCGAGTAGG
CGGATTAACAGAATCAATCCAAATCCATAATTATTGTATGGAGCATAACATACCAGTTTGGTGCGGCGGTATGGTAGAGA
TGGGGATTTCACGAGCACAAAATGTTGCCCTCGCCTCATTGCCGAACTTTACGATTCCTGGCGATATATCCGCTTCTAGT
AGACATTGGGAGAAGGATATTATTTCGCCGGAAGTGACGCTTGAGCGCGGGAAAGTGATGGTGCCGCAAAGTGTTGATAC
TGAGTATAAAGTGGACCGCGGAAGGCTGGCGGAAATTACGAAGCAACGGATTGTTTTTGAGCGGTAA

Upstream 100 bases:

>100_bases
TAAAGTGCCGAAAAAAGCGTGGTTCTTAGAGGAATTACCACGAAATGCTTCGAAAAAATTGTTAAGACGAGAGTTAAGAC
AATTAGTGGAGGAGATGTAA

Downstream 100 bases:

>100_bases
GTGGAGTCTTTAAAATAGCGATAGGGTTTTGTCGTTAATTGTCGGTAAGTCGATATATTTCAATAATCGCCGATATAATT
CCAGTTATGGTCGATATATT

Product: N-acylamino acid racemase; O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MEIKKATLHITEMPLVIPFAASYGTYEKRESIVIELEDEDGDIGFGEVVAFSEPWYTEETVKTALHVLQDFLLPDLLKAE
ISHPNEVPSLFQHIKRNRMAKAGIEGAVWDLYAKRQKKSLATLLGGTKSEIEVGVVIGINTIPVMLKQIEKYAEEGYERF
KVKIKPGHDYELLKEIRKEFPHIPLMADANSAYTLADTESLKRLDEFQLMMIEQPLADYDFLDHAQLQKKIETPICLDES
IHSLEDARVAITLGSCQIVNIKPGRVGGLTESIQIHNYCMEHNIPVWCGGMVEMGISRAQNVALASLPNFTIPGDISASS
RHWEKDIISPEVTLERGKVMVPQSVDTEYKVDRGRLAEITKQRIVFER

Sequences:

>Translated_368_residues
MEIKKATLHITEMPLVIPFAASYGTYEKRESIVIELEDEDGDIGFGEVVAFSEPWYTEETVKTALHVLQDFLLPDLLKAE
ISHPNEVPSLFQHIKRNRMAKAGIEGAVWDLYAKRQKKSLATLLGGTKSEIEVGVVIGINTIPVMLKQIEKYAEEGYERF
KVKIKPGHDYELLKEIRKEFPHIPLMADANSAYTLADTESLKRLDEFQLMMIEQPLADYDFLDHAQLQKKIETPICLDES
IHSLEDARVAITLGSCQIVNIKPGRVGGLTESIQIHNYCMEHNIPVWCGGMVEMGISRAQNVALASLPNFTIPGDISASS
RHWEKDIISPEVTLERGKVMVPQSVDTEYKVDRGRLAEITKQRIVFER
>Mature_368_residues
MEIKKATLHITEMPLVIPFAASYGTYEKRESIVIELEDEDGDIGFGEVVAFSEPWYTEETVKTALHVLQDFLLPDLLKAE
ISHPNEVPSLFQHIKRNRMAKAGIEGAVWDLYAKRQKKSLATLLGGTKSEIEVGVVIGINTIPVMLKQIEKYAEEGYERF
KVKIKPGHDYELLKEIRKEFPHIPLMADANSAYTLADTESLKRLDEFQLMMIEQPLADYDFLDHAQLQKKIETPICLDES
IHSLEDARVAITLGSCQIVNIKPGRVGGLTESIQIHNYCMEHNIPVWCGGMVEMGISRAQNVALASLPNFTIPGDISASS
RHWEKDIISPEVTLERGKVMVPQSVDTEYKVDRGRLAEITKQRIVFER

Specific function: Converts SHCHC to OSB [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081876, Length=302, Percent_Identity=28.8079470198675, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354
- InterPro:   IPR010197 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.113 [H]

Molecular weight: Translated: 41560; Mature: 41560

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKKATLHITEMPLVIPFAASYGTYEKRESIVIELEDEDGDIGFGEVVAFSEPWYTEET
CCCCEEEEEEEECCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCHHH
VKTALHVLQDFLLPDLLKAEISHPNEVPSLFQHIKRNRMAKAGIEGAVWDLYAKRQKKSL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ATLLGGTKSEIEVGVVIGINTIPVMLKQIEKYAEEGYERFKVKIKPGHDYELLKEIRKEF
HHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHC
PHIPLMADANSAYTLADTESLKRLDEFQLMMIEQPLADYDFLDHAQLQKKIETPICLDES
CCCCEEECCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHH
IHSLEDARVAITLGSCQIVNIKPGRVGGLTESIQIHNYCMEHNIPVWCGGMVEMGISRAQ
HHHHCCCEEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHH
NVALASLPNFTIPGDISASSRHWEKDIISPEVTLERGKVMVPQSVDTEYKVDRGRLAEIT
CEEEECCCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCEECCCCCCCCEECCCCHHHHHH
KQRIVFER
HHHHCCCC
>Mature Secondary Structure
MEIKKATLHITEMPLVIPFAASYGTYEKRESIVIELEDEDGDIGFGEVVAFSEPWYTEET
CCCCEEEEEEEECCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCHHH
VKTALHVLQDFLLPDLLKAEISHPNEVPSLFQHIKRNRMAKAGIEGAVWDLYAKRQKKSL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ATLLGGTKSEIEVGVVIGINTIPVMLKQIEKYAEEGYERFKVKIKPGHDYELLKEIRKEF
HHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHC
PHIPLMADANSAYTLADTESLKRLDEFQLMMIEQPLADYDFLDHAQLQKKIETPICLDES
CCCCEEECCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHH
IHSLEDARVAITLGSCQIVNIKPGRVGGLTESIQIHNYCMEHNIPVWCGGMVEMGISRAQ
HHHHCCCEEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHH
NVALASLPNFTIPGDISASSRHWEKDIISPEVTLERGKVMVPQSVDTEYKVDRGRLAEIT
CEEEECCCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCEECCCCCCCCEECCCCHHHHHH
KQRIVFER
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10194342 [H]