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The map label for this gene is folP [C]

Identifier: 51894323

GI number: 51894323

Start: 3395537

End: 3396379

Strand: Reverse

Name: folP [C]

Synonym: STH3188

Alternate gene names: 51894323

Gene position: 3396379-3395537 (Counterclockwise)

Preceding gene: 51894324

Following gene: 51894322

Centisome position: 95.24

GC content: 70.82

Gene sequence:

>843_bases
ATGTGGCGGATTTCCTGCCGGGGCCGCTCGCTGGAGCTGGGTACGCGCTCAGTGATCATGGGCATTCTGAACGTGACGCC
GGATTCGTTTTCCGACGGCGGCCGCTGGACGGACCCGGAACGGGCCGTGGCCCGCGCCCTGCACATGCTGGAGGAGGGCG
CGGACATCATCGACATCGGCGGCGAGTCGACCCGTCCGGGGTACGAGCCCGTCCCGGCCGACGAGGAGATGCGCCGGGTC
CTGCCGGTGATCGCGGCCCTGCGGCGGGCGGCGCCTGATGCCATCATCTCCGTGGACACGCAGAAGGCGGCGGTCGCAGA
GGCCGCCCTGGGCGCCGGGGCCGATATGATCAACGACATCTGGGGGCTGCAGGGCGATCCGGAGATGGTCCAGGTGGCGG
CGCGGTGGCAGTGCCCGGTGGTGGTGATGCACAACCAGCACGGCACCGAGTACCGGGAGCTGATGGGCGACATCAAGGCC
TTCTTCCGCCGGTCGCTGGCGCTGGCCGCCGCGGCCGGACTGCCCGGGGACCTGATCATCCTGGATCCCGGCGTAGGTTT
CGGCAAGACCCCTCTGCAGAACCTGGAGGTCATCCGGCGGCTGGGGGAGCTGCGGGAGCTGGACAGGCCCCTGCTCCTCG
GCGTCAGCCGCAAGTCGACCATCGGGAAGGTACTGGGCGGGCTGCCGCCGGAGGAACGGCTGGAGGGTACGGCGGCGGCG
GTGGCGATTGGTATCATGGGCGGCGCGGACATCCTCCGTGTACACGACGTGCGCGCCATGAAGCGGGTGGCGCAGGTGGC
CGACGCCATCGTGCGCCCCGGCCGCGGCGGCTTTGAGGGGTGA

Upstream 100 bases:

>100_bases
GGACCGGGCGCTGTTCGCTTCCGCAGGAAGGGAGAGGCGGAGGCCGGGGCGAATCCCTCCCCGGCCTTCGCACATTCAGA
GACGAGGTGACCTGAATCTC

Downstream 100 bases:

>100_bases
CGGCGGACGTGGATCGCATTGTGATTTCGGGCATGCGCTTTTACGCCTACCACGGCGTGTTGCCCGAGGAGACGCGCCTG
GGGCAGGAGTTCCTGGTGGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MWRISCRGRSLELGTRSVIMGILNVTPDSFSDGGRWTDPERAVARALHMLEEGADIIDIGGESTRPGYEPVPADEEMRRV
LPVIAALRRAAPDAIISVDTQKAAVAEAALGAGADMINDIWGLQGDPEMVQVAARWQCPVVVMHNQHGTEYRELMGDIKA
FFRRSLALAAAAGLPGDLIILDPGVGFGKTPLQNLEVIRRLGELRELDRPLLLGVSRKSTIGKVLGGLPPEERLEGTAAA
VAIGIMGGADILRVHDVRAMKRVAQVADAIVRPGRGGFEG

Sequences:

>Translated_280_residues
MWRISCRGRSLELGTRSVIMGILNVTPDSFSDGGRWTDPERAVARALHMLEEGADIIDIGGESTRPGYEPVPADEEMRRV
LPVIAALRRAAPDAIISVDTQKAAVAEAALGAGADMINDIWGLQGDPEMVQVAARWQCPVVVMHNQHGTEYRELMGDIKA
FFRRSLALAAAAGLPGDLIILDPGVGFGKTPLQNLEVIRRLGELRELDRPLLLGVSRKSTIGKVLGGLPPEERLEGTAAA
VAIGIMGGADILRVHDVRAMKRVAQVADAIVRPGRGGFEG
>Mature_280_residues
MWRISCRGRSLELGTRSVIMGILNVTPDSFSDGGRWTDPERAVARALHMLEEGADIIDIGGESTRPGYEPVPADEEMRRV
LPVIAALRRAAPDAIISVDTQKAAVAEAALGAGADMINDIWGLQGDPEMVQVAARWQCPVVVMHNQHGTEYRELMGDIKA
FFRRSLALAAAAGLPGDLIILDPGVGFGKTPLQNLEVIRRLGELRELDRPLLLGVSRKSTIGKVLGGLPPEERLEGTAAA
VAIGIMGGADILRVHDVRAMKRVAQVADAIVRPGRGGFEG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=276, Percent_Identity=40.5797101449275, Blast_Score=191, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=30.188679245283, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29989; Mature: 29989

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRISCRGRSLELGTRSVIMGILNVTPDSFSDGGRWTDPERAVARALHMLEEGADIIDIG
CEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECC
GESTRPGYEPVPADEEMRRVLPVIAALRRAAPDAIISVDTQKAAVAEAALGAGADMINDI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCHHHHHHH
WGLQGDPEMVQVAARWQCPVVVMHNQHGTEYRELMGDIKAFFRRSLALAAAAGLPGDLII
HCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LDPGVGFGKTPLQNLEVIRRLGELRELDRPLLLGVSRKSTIGKVLGGLPPEERLEGTAAA
ECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHH
VAIGIMGGADILRVHDVRAMKRVAQVADAIVRPGRGGFEG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MWRISCRGRSLELGTRSVIMGILNVTPDSFSDGGRWTDPERAVARALHMLEEGADIIDIG
CEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECC
GESTRPGYEPVPADEEMRRVLPVIAALRRAAPDAIISVDTQKAAVAEAALGAGADMINDI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCHHHHHHH
WGLQGDPEMVQVAARWQCPVVVMHNQHGTEYRELMGDIKAFFRRSLALAAAAGLPGDLII
HCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LDPGVGFGKTPLQNLEVIRRLGELRELDRPLLLGVSRKSTIGKVLGGLPPEERLEGTAAA
ECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHH
VAIGIMGGADILRVHDVRAMKRVAQVADAIVRPGRGGFEG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]