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The map label for this gene is folB [H]

Identifier: 51894322

GI number: 51894322

Start: 3395163

End: 3395528

Strand: Reverse

Name: folB [H]

Synonym: STH3187

Alternate gene names: 51894322

Gene position: 3395528-3395163 (Counterclockwise)

Preceding gene: 51894323

Following gene: 51894321

Centisome position: 95.22

GC content: 68.31

Gene sequence:

>366_bases
GTGGATCGCATTGTGATTTCGGGCATGCGCTTTTACGCCTACCACGGCGTGTTGCCCGAGGAGACGCGCCTGGGGCAGGA
GTTCCTGGTGGACGCGGAGCTCTACCTGGACCTGCAGGCTGCGGGGCAGGAGGACGACATCCGGCAGACGGTGCACTACG
GGAAGGTCTACCAGACGGTGAAGGCGATCGTGGAGGGCACCCCGTTCAAGCTGATCGAGGCCGTGGCGGAGCGGGTGGCC
GCCGAGGTGCTGGCCCAGTACCGCAACGTGGAGGCCGTGACCATCCGGGTGCACAAGCCGCGGGCGCCGATCCCGGGCGC
CCTGGGCGGCGTGATGGTGGAGATCCAGAGGAGGCGTGGCCGGTGA

Upstream 100 bases:

>100_bases
TCCTCCGTGTACACGACGTGCGCGCCATGAAGCGGGTGGCGCAGGTGGCCGACGCCATCGTGCGCCCCGGCCGCGGCGGC
TTTGAGGGGTGACGGCGGAC

Downstream 100 bases:

>100_bases
CCACCGCGTACCTTTCGCTGGGGGCGAACATCGGCGACCCGGAGGGACAGCTGGTCTCGGCCCTGCGCCGGCTGGCGTCC
GCCCCAGGGACCAGCCTGGC

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MDRIVISGMRFYAYHGVLPEETRLGQEFLVDAELYLDLQAAGQEDDIRQTVHYGKVYQTVKAIVEGTPFKLIEAVAERVA
AEVLAQYRNVEAVTIRVHKPRAPIPGALGGVMVEIQRRRGR

Sequences:

>Translated_121_residues
MDRIVISGMRFYAYHGVLPEETRLGQEFLVDAELYLDLQAAGQEDDIRQTVHYGKVYQTVKAIVEGTPFKLIEAVAERVA
AEVLAQYRNVEAVTIRVHKPRAPIPGALGGVMVEIQRRRGR
>Mature_121_residues
MDRIVISGMRFYAYHGVLPEETRLGQEFLVDAELYLDLQAAGQEDDIRQTVHYGKVYQTVKAIVEGTPFKLIEAVAERVA
AEVLAQYRNVEAVTIRVHKPRAPIPGALGGVMVEIQRRRGR

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=114, Percent_Identity=34.2105263157895, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13621; Mature: 13621

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIVISGMRFYAYHGVLPEETRLGQEFLVDAELYLDLQAAGQEDDIRQTVHYGKVYQTV
CCCEEECCHHEEHHCCCCCCHHHCCHHHEECHHHEEEEECCCCCHHHHHHHHHHHHHHHH
KAIVEGTPFKLIEAVAERVAAEVLAQYRNVEAVTIRVHKPRAPIPGALGGVMVEIQRRRG
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCC
R
C
>Mature Secondary Structure
MDRIVISGMRFYAYHGVLPEETRLGQEFLVDAELYLDLQAAGQEDDIRQTVHYGKVYQTV
CCCEEECCHHEEHHCCCCCCHHHCCHHHEECHHHEEEEECCCCCHHHHHHHHHHHHHHHH
KAIVEGTPFKLIEAVAERVAAEVLAQYRNVEAVTIRVHKPRAPIPGALGGVMVEIQRRRG
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]