Click here to switch to the map view.

The map label for this gene is sdhB [H]

Identifier: 51894309

GI number: 51894309

Start: 3380944

End: 3381699

Strand: Reverse

Name: sdhB [H]

Synonym: STH3174

Alternate gene names: 51894309

Gene position: 3381699-3380944 (Counterclockwise)

Preceding gene: 51894310

Following gene: 51894305

Centisome position: 94.83

GC content: 66.01

Gene sequence:

>756_bases
GTGGCCGATCAGAGGAAGTTCATCGAACTCCGCATCAGGCGGCAGGAGGCACCGGATAAGCCCTTCTACTGGGAGGAGTT
CCGCATCCCGTACCGCCCCGGCATGAACGTCATCGCCTGCCTGATGGAGATCCAGCGCAACCCGGTCAACGCCGAGGGCA
AGCGCACCACGCCGGTGGTCTGGGACTCCAACTGCCTGGAGGAGGTCTGCGGCGCCTGCTCGATGGTGATCAACGGCAAG
GCCCGCCAGGCCTGCTCCGCCCTGGTCGACAACCTGACGCAGCCGATCGTGCTGGAGCCGCTGAAGTCGTTCCCCCTGGT
CCGGGACCTCATGGTGGACCGCTCCCGCATGTTCGAGGCGCTGAAGCGCGTGAAGGCGTGGATCCCCATCGACGGTACCC
ACGACCTCGGCCCCGGGCCGCGCCAGTCGCCCGCCGACCAGGAGTGGATGTATAAGCTGTCGGAGTGCATGACCTGCGGC
TGCTGCATGGAGGCGTGCCCCAACTACAACGAGAAAACCGACTTCATCGGTCCCGCGCCGATCTCCCAGGTGCGGCTGTT
CAACGCCCATCCGACGGGCAAGATGCACGCCCACGAGCGGCTGGAGGCCCTGATGGGCCCGGGCGGCATCATGGAGTGCG
GCAGCGCCCAGAACTGCGTGCGGGCCTGCCCGAAGGGGATTCCGCTCACCACCTCCATCGCCGAGATCCAGCGGCAGCTC
ACCGTGTACGCCGTTAAGAAGATGTTCATGCAGTAG

Upstream 100 bases:

>100_bases
CACCGAGGACGGGCCGGAGCTGTTCTACCAGCCGGTCGACATCACTCACATCCAGCCCCGCAAGCGGGACTACTCGAGCA
AGTAAGGGGGTACGGGAACC

Downstream 100 bases:

>100_bases
CGACGAAAGCGGGTTCGCCGGCCCTTCCGCGGGGTGGCGAACCCGCTCTCTTGTACCTAACATTACGGTGCGACGAGGCC
GCTCCAGTTCAGGTACAGCA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MADQRKFIELRIRRQEAPDKPFYWEEFRIPYRPGMNVIACLMEIQRNPVNAEGKRTTPVVWDSNCLEEVCGACSMVINGK
ARQACSALVDNLTQPIVLEPLKSFPLVRDLMVDRSRMFEALKRVKAWIPIDGTHDLGPGPRQSPADQEWMYKLSECMTCG
CCMEACPNYNEKTDFIGPAPISQVRLFNAHPTGKMHAHERLEALMGPGGIMECGSAQNCVRACPKGIPLTTSIAEIQRQL
TVYAVKKMFMQ

Sequences:

>Translated_251_residues
MADQRKFIELRIRRQEAPDKPFYWEEFRIPYRPGMNVIACLMEIQRNPVNAEGKRTTPVVWDSNCLEEVCGACSMVINGK
ARQACSALVDNLTQPIVLEPLKSFPLVRDLMVDRSRMFEALKRVKAWIPIDGTHDLGPGPRQSPADQEWMYKLSECMTCG
CCMEACPNYNEKTDFIGPAPISQVRLFNAHPTGKMHAHERLEALMGPGGIMECGSAQNCVRACPKGIPLTTSIAEIQRQL
TVYAVKKMFMQ
>Mature_250_residues
ADQRKFIELRIRRQEAPDKPFYWEEFRIPYRPGMNVIACLMEIQRNPVNAEGKRTTPVVWDSNCLEEVCGACSMVINGKA
RQACSALVDNLTQPIVLEPLKSFPLVRDLMVDRSRMFEALKRVKAWIPIDGTHDLGPGPRQSPADQEWMYKLSECMTCGC
CMEACPNYNEKTDFIGPAPISQVRLFNAHPTGKMHAHERLEALMGPGGIMECGSAQNCVRACPKGIPLTTSIAEIQRQLT
VYAVKKMFMQ

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=247, Percent_Identity=29.1497975708502, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1790596, Length=222, Percent_Identity=29.7297297297297, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786943, Length=181, Percent_Identity=32.5966850828729, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533915, Length=186, Percent_Identity=29.5698924731183, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322987, Length=200, Percent_Identity=27.5, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17137106, Length=248, Percent_Identity=28.6290322580645, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643156, Length=188, Percent_Identity=30.3191489361702, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28323; Mature: 28192

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
10.8 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
10.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQRKFIELRIRRQEAPDKPFYWEEFRIPYRPGMNVIACLMEIQRNPVNAEGKRTTPVV
CCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
WDSNCLEEVCGACSMVINGKARQACSALVDNLTQPIVLEPLKSFPLVRDLMVDRSRMFEA
ECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHH
LKRVKAWIPIDGTHDLGPGPRQSPADQEWMYKLSECMTCGCCMEACPNYNEKTDFIGPAP
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ISQVRLFNAHPTGKMHAHERLEALMGPGGIMECGSAQNCVRACPKGIPLTTSIAEIQRQL
HHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHH
TVYAVKKMFMQ
HHHHHHHHHCC
>Mature Secondary Structure 
ADQRKFIELRIRRQEAPDKPFYWEEFRIPYRPGMNVIACLMEIQRNPVNAEGKRTTPVV
CCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
WDSNCLEEVCGACSMVINGKARQACSALVDNLTQPIVLEPLKSFPLVRDLMVDRSRMFEA
ECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHH
LKRVKAWIPIDGTHDLGPGPRQSPADQEWMYKLSECMTCGCCMEACPNYNEKTDFIGPAP
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ISQVRLFNAHPTGKMHAHERLEALMGPGGIMECGSAQNCVRACPKGIPLTTSIAEIQRQL
HHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHH
TVYAVKKMFMQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3114423 [H]