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The map label for this gene is sdhA [H]

Identifier: 51894310

GI number: 51894310

Start: 3381715

End: 3383496

Strand: Reverse

Name: sdhA [H]

Synonym: STH3175

Alternate gene names: 51894310

Gene position: 3383496-3381715 (Counterclockwise)

Preceding gene: 51894311

Following gene: 51894309

Centisome position: 94.88

GC content: 65.6

Gene sequence:

>1782_bases
GTGCGACGCAATCTCATTGTCGTTGGCGGCGGTCTGGCCGGGCTGATGGCCGTCATCAAGGCTGCCGAGGCCGGGTTCCA
CGTCGACCTGATCTCCCTGGTCCCCGTCAAGCGTTCCCACTCTGTGTGCGCGCAGGGGGGCATCAATGGCGCGGTGAACA
CCAAGGGCGAGGGTGACTCTCCCTGGATCCACTTTGACGACACCATCTACGGCGGCGACTTCCTGGCCGATCAGCCGCCG
GTCAAGGCCATGTGTGAGGCGGCCCCGGGCATCATCTACCTCTTCGACCGGATGGGTGTGCCCTTCAACCGCACGCCGGA
GGGGCTGATCGACTTCCGGCGCTTCGGCGGCACCCTGTATCACCGCACCGCGTTCTCCGGCGGCTCCACCGGCCAGCAGC
TGCTGTACGCCCTGGACGAGCAGGTGCGCCGCCACGAGGTGGACGGCAAGGTCACCAAGTGGGAGGGGTGGGACTTCACC
GGTCTCGTGCTCCACGAGGGCCGGGTGGTCGGCTGCACCGCGCAGAACCTGCGCACCATGGAGTTCCGGGCGTTCAAGGC
CGACGCGGTCATCATGGCCACGGGCGGAATCGGCATGATCTTCGGCAAGTCCACCAACTCGGTGATCAATACCGGCTCCG
CCGCCGCGATCGTCTACCAGCAGGGTGCATGGTACGCCAACGGCGAGATGATCCAGGTGCACCCCACCGCCATCCCAGGC
GACGACAAGCTGCGGCTCATGTCGGAGTCGATCCGCGGCGAGGGCGGCCGCGTCTGGACCTACAAGGATGGCAAGCCCTG
GTATTTCCTCGAGGAGAAGTACCCCAAGTACGGCAATCTGGTCCCGCGCGACATCGCCACGCGCGAGATCTTCGACGTCT
GCGTCAACCAGAAGCTGGGCGTCGACGGCAAGAACATGGTCTACCTGGATGTGAGCCACATCCCGGCAGAGACCCTGCGC
CGGCGCATCGGCAACCTCATCGACATGTACATCAAGTTCGTCGGCGACGACCCCACCAAGGTGCCCATGAAGATCTTCCC
GGGGGTCCACTACAGCATGGGCGGCCTCTGGGCGGGCTACGAGAAGAAGGCCAACAACGACATGGACATCTCGAGCCCGA
AGAGCTTCATGACCAACATCCCCGGCCTCTACGCCGCCGGCGAGGCCTCGTTCCAGCATCACGGCGCCAACCGGCTCGGC
GCCAACTCGCTGGTCTCCTGCGTCTTTGACGGCATGGTGACCGGCCCTGCGGCCGTGAAGTACGTCCTGGGGCTCAACAC
CACCCCGGCCGAGGAGTTGCCCGAGTCGATTTTCGAGGCGGCCGTGCGGGAGGCCGAGGCCAAGTACCAGCGCATCCTGC
GCATGGACGGTCCCGAAAACCCCTACGTCCTGGCCGACGAACTGGGCAAGGTCATGACCGACAACGTCACCGTGGTGCGG
TACAACGCCAAGCTCCAGGAGACGCTCGTGAAGATCGCCGAGCTGAAGGAGCGGTACGAGCGGATCGGCGTACCCGACAC
CGGCAGCCACTCCAACCAGCCCGCTGTGTTCACCCGCTGGCTCCACGGCATGCTGGTCCTGGCGGAGGTCATCACCAAGG
GCGCGCTGGCCCGGAACGAGTCCCGCGGGGCGCACTACAAGCCCGAGTTCCCGGAGCGGGACGACGCGAACTGGCTGAAG
ACCACCATTGCCCGCCACACCGAGGACGGGCCGGAGCTGTTCTACCAGCCGGTCGACATCACTCACATCCAGCCCCGCAA
GCGGGACTACTCGAGCAAGTAA

Upstream 100 bases:

>100_bases
CCAGCGGGTCTCGAGCCTGGTCACGAACCTGCTGTTCGTGCTCGTCTCGGCAATGGGCCTCACCGCCCTGTTCGCATTCC
AGATGTAGGAGGGAACGGTC

Downstream 100 bases:

>100_bases
GGGGGTACGGGAACCGTGGCCGATCAGAGGAAGTTCATCGAACTCCGCATCAGGCGGCAGGAGGCACCGGATAAGCCCTT
CTACTGGGAGGAGTTCCGCA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MRRNLIVVGGGLAGLMAVIKAAEAGFHVDLISLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLADQPP
VKAMCEAAPGIIYLFDRMGVPFNRTPEGLIDFRRFGGTLYHRTAFSGGSTGQQLLYALDEQVRRHEVDGKVTKWEGWDFT
GLVLHEGRVVGCTAQNLRTMEFRAFKADAVIMATGGIGMIFGKSTNSVINTGSAAAIVYQQGAWYANGEMIQVHPTAIPG
DDKLRLMSESIRGEGGRVWTYKDGKPWYFLEEKYPKYGNLVPRDIATREIFDVCVNQKLGVDGKNMVYLDVSHIPAETLR
RRIGNLIDMYIKFVGDDPTKVPMKIFPGVHYSMGGLWAGYEKKANNDMDISSPKSFMTNIPGLYAAGEASFQHHGANRLG
ANSLVSCVFDGMVTGPAAVKYVLGLNTTPAEELPESIFEAAVREAEAKYQRILRMDGPENPYVLADELGKVMTDNVTVVR
YNAKLQETLVKIAELKERYERIGVPDTGSHSNQPAVFTRWLHGMLVLAEVITKGALARNESRGAHYKPEFPERDDANWLK
TTIARHTEDGPELFYQPVDITHIQPRKRDYSSK

Sequences:

>Translated_593_residues
MRRNLIVVGGGLAGLMAVIKAAEAGFHVDLISLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLADQPP
VKAMCEAAPGIIYLFDRMGVPFNRTPEGLIDFRRFGGTLYHRTAFSGGSTGQQLLYALDEQVRRHEVDGKVTKWEGWDFT
GLVLHEGRVVGCTAQNLRTMEFRAFKADAVIMATGGIGMIFGKSTNSVINTGSAAAIVYQQGAWYANGEMIQVHPTAIPG
DDKLRLMSESIRGEGGRVWTYKDGKPWYFLEEKYPKYGNLVPRDIATREIFDVCVNQKLGVDGKNMVYLDVSHIPAETLR
RRIGNLIDMYIKFVGDDPTKVPMKIFPGVHYSMGGLWAGYEKKANNDMDISSPKSFMTNIPGLYAAGEASFQHHGANRLG
ANSLVSCVFDGMVTGPAAVKYVLGLNTTPAEELPESIFEAAVREAEAKYQRILRMDGPENPYVLADELGKVMTDNVTVVR
YNAKLQETLVKIAELKERYERIGVPDTGSHSNQPAVFTRWLHGMLVLAEVITKGALARNESRGAHYKPEFPERDDANWLK
TTIARHTEDGPELFYQPVDITHIQPRKRDYSSK
>Mature_593_residues
MRRNLIVVGGGLAGLMAVIKAAEAGFHVDLISLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLADQPP
VKAMCEAAPGIIYLFDRMGVPFNRTPEGLIDFRRFGGTLYHRTAFSGGSTGQQLLYALDEQVRRHEVDGKVTKWEGWDFT
GLVLHEGRVVGCTAQNLRTMEFRAFKADAVIMATGGIGMIFGKSTNSVINTGSAAAIVYQQGAWYANGEMIQVHPTAIPG
DDKLRLMSESIRGEGGRVWTYKDGKPWYFLEEKYPKYGNLVPRDIATREIFDVCVNQKLGVDGKNMVYLDVSHIPAETLR
RRIGNLIDMYIKFVGDDPTKVPMKIFPGVHYSMGGLWAGYEKKANNDMDISSPKSFMTNIPGLYAAGEASFQHHGANRLG
ANSLVSCVFDGMVTGPAAVKYVLGLNTTPAEELPESIFEAAVREAEAKYQRILRMDGPENPYVLADELGKVMTDNVTVVR
YNAKLQETLVKIAELKERYERIGVPDTGSHSNQPAVFTRWLHGMLVLAEVITKGALARNESRGAHYKPEFPERDDANWLK
TTIARHTEDGPELFYQPVDITHIQPRKRDYSSK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=548, Percent_Identity=31.2043795620438, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=32.9289428076257, Blast_Score=268, Evalue=9e-73,
Organism=Escherichia coli, GI1786942, Length=555, Percent_Identity=33.1531531531532, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1788928, Length=573, Percent_Identity=27.0506108202443, Blast_Score=163, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17550100, Length=598, Percent_Identity=30.7692307692308, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17505833, Length=545, Percent_Identity=31.3761467889908, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71986328, Length=468, Percent_Identity=24.7863247863248, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322701, Length=554, Percent_Identity=32.8519855595668, Blast_Score=247, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6322416, Length=555, Percent_Identity=31.1711711711712, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24663005, Length=544, Percent_Identity=32.1691176470588, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI17137288, Length=543, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24655642, Length=543, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24655647, Length=543, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65573; Mature: 65573

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRNLIVVGGGLAGLMAVIKAAEAGFHVDLISLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLADQPPVKAMCEAAPGIIYLFDRMGVPFNRTPEGLIDFRRFGGTLY
CEEEECCEEECCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCEEE
HRTAFSGGSTGQQLLYALDEQVRRHEVDGKVTKWEGWDFTGLVLHEGRVVGCTAQNLRTM
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCEEEEEECCCCEEE
EFRAFKADAVIMATGGIGMIFGKSTNSVINTGSAAAIVYQQGAWYANGEMIQVHPTAIPG
EEEEEECCEEEEEECCEEEEEECCCCCEEECCCEEEEEEECCCEEECCCEEEEECCCCCC
DDKLRLMSESIRGEGGRVWTYKDGKPWYFLEEKYPKYGNLVPRDIATREIFDVCVNQKLG
CCHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VDGKNMVYLDVSHIPAETLRRRIGNLIDMYIKFVGDDPTKVPMKIFPGVHYSMGGLWAGY
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEECCCCEECCC
EKKANNDMDISSPKSFMTNIPGLYAAGEASFQHHGANRLGANSLVSCVFDGMVTGPAAVK
HHCCCCCCCCCCCHHHHHCCCCEEECCCCCHHHCCCCCCCHHHHHHHHHHHHCCCHHHEE
YVLGLNTTPAEELPESIFEAAVREAEAKYQRILRMDGPENPYVLADELGKVMTDNVTVVR
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCEEEEE
YNAKLQETLVKIAELKERYERIGVPDTGSHSNQPAVFTRWLHGMLVLAEVITKGALARNE
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SRGAHYKPEFPERDDANWLKTTIARHTEDGPELFYQPVDITHIQPRKRDYSSK
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHEECCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MRRNLIVVGGGLAGLMAVIKAAEAGFHVDLISLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLADQPPVKAMCEAAPGIIYLFDRMGVPFNRTPEGLIDFRRFGGTLY
CEEEECCEEECCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCEEE
HRTAFSGGSTGQQLLYALDEQVRRHEVDGKVTKWEGWDFTGLVLHEGRVVGCTAQNLRTM
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCEEEEEECCCCEEE
EFRAFKADAVIMATGGIGMIFGKSTNSVINTGSAAAIVYQQGAWYANGEMIQVHPTAIPG
EEEEEECCEEEEEECCEEEEEECCCCCEEECCCEEEEEEECCCEEECCCEEEEECCCCCC
DDKLRLMSESIRGEGGRVWTYKDGKPWYFLEEKYPKYGNLVPRDIATREIFDVCVNQKLG
CCHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VDGKNMVYLDVSHIPAETLRRRIGNLIDMYIKFVGDDPTKVPMKIFPGVHYSMGGLWAGY
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEECCCCEECCC
EKKANNDMDISSPKSFMTNIPGLYAAGEASFQHHGANRLGANSLVSCVFDGMVTGPAAVK
HHCCCCCCCCCCCHHHHHCCCCEEECCCCCHHHCCCCCCCHHHHHHHHHHHHCCCHHHEE
YVLGLNTTPAEELPESIFEAAVREAEAKYQRILRMDGPENPYVLADELGKVMTDNVTVVR
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCEEEEE
YNAKLQETLVKIAELKERYERIGVPDTGSHSNQPAVFTRWLHGMLVLAEVITKGALARNE
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
SRGAHYKPEFPERDDANWLKTTIARHTEDGPELFYQPVDITHIQPRKRDYSSK
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHEECCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]