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The map label for this gene is fadE [H]

Identifier: 51894146

GI number: 51894146

Start: 3227761

End: 3229530

Strand: Reverse

Name: fadE [H]

Synonym: STH3010

Alternate gene names: 51894146

Gene position: 3229530-3227761 (Counterclockwise)

Preceding gene: 51894147

Following gene: 51894145

Centisome position: 90.56

GC content: 66.78

Gene sequence:

>1770_bases
ATGTCTGAGACCGCTTCCAACGTGGTCAAGGGAGGCTCCTTCCTGCTCTCCCAGGCAAGCCCCGACCAGGTCTTCACCCC
CGAGGACCTGTCGGAGGAGCAGCGGATGATCGGCAGCACGGCCCGCGAGTTCTCCGAGAAGGTGCTCGCGCGACTGCACG
AGATCGAACAGGATAAGCCCTTCCACTCCCGGCCCCTGCTGCGCGAGCTGGGCGAGCTGGGCCTTCTGGGGCTGGAGATT
CCCGAGGAATATGGCGGGATGGGGCTCGACAAGGTGACGGCTACCGTGGCGACGGAGGAGTACTCCCGGGCCGGATCCTT
CGCCATCACCATCGGGGCCCACACCGGCATCGGCTCCCTGCCCATCGTCTACTTCGGCACGCCCGAGCAGAAGGCCAAGT
ACCTGCCCAAGCTGGCGACCGGTGAGTGGGTCGCGGCCTACGCCCTCACCGAGCCCAACGCCGGCTCCGACGCCCTGGGC
GCCCGCACCACCGCGAGGCTGTCCGAGGACGGCAAGTACTGGATCCTGAACGGCACCAAGCAGTGGATCACCAACGCCGG
CTTCGCGGACGTGTTCGTCGTCTACGCCAAGGTCGACGGCGAGAAGTTCTCGGCCTTCATCGTCGAGCGCAACTTCCCCG
GCGTTTCCATCGGCCCCGAGGAGAAGAAGATGGGCCTGCACGCCTCCTCCACCTGCTCGCTCATCCTGGAGGACGCCAAG
GTGCCCGTGGAGAACCTGCTTGGCGAGATCGGCAAGGGGCACGTCATCGCCTTCAACATCCTGAACATCGGCCGCTGGAA
GCTGGGCGCCGGCACGGTGGGATCCAGCAAGATGGTCCTGGCCACCTCCATCGAGTACGCCAAGACCCGCAAGCAGTTCG
GCAAGCCCATCGCCGAACTGCGGGCCATCCAGCAGAAGCTGGCCGACATGGCCGTGCGCACCTATGTGACCGAGTCCATG
GGCTACCGGACCGCCGGCCTGCTGGACAGCAGCCTGAGCGACCTGGATCCCAACGCCGACATGCGCGAGGTGGGCAAGCG
GCTCGAGGAGTACGCGATGGAGTGCTCCATCATGAAGGTCTTCGGCTCCGAGGCCTTCGACTTCGTCGCCGACGAGGGCG
TGCAGATCCACGGCGGCTACGGGTTCATGGACGAGTACGCGGTCAGCATGGCCTACCGGGACAGCCGCATCAACCGCATC
TTCGAAGGCACCAACGAGATCAACCGGCTGCTCATCCCGGGCACCCTGGTCCGCCGGGCGATGAAGGGCCAGCTGCCCAT
CATGCAGGCGATGGCCGGGCTGCAGGACGAGCTGATGAGCCTCACGCCGTACGAGGAGTCGGACGAGCCGCTGGCCCAGG
AGCTGTTCATGATCGACCGGGCCCGGAAGGTCTTCCTCATGCTGGCCGGCCTGGGCGTGCAGAAGTACCAGATGGCCCTG
GAGCACGAGCAGGAGCTGCTGCTCGGGGTGGCGGACATCGCCATCGAGATTTACGCCATGGAGTCGGCGGTCCTGCGGGC
GCTGAAGGCCGTGAAGCGCGGGCAGCCGGGGCTGAAGGTGGAGATGGCCACCGTGTACTGCCAGGAGGCCTTCGAGCGGA
TCGCCGCCACCGCCCGCACCCTGCTGCCGGCGGTGGAGGAGGACGGCGATACCCTGCGGACCCAGCTCTCCATGCTCCGG
CGGCTGACCCGGTACACGCCGGCCAACACCGTGGCGCTGAAGCGGAAGATCGCCGAGCGGCTCCTGGAGAAGGGCGACTA
CGTCTGCTGA

Upstream 100 bases:

>100_bases
CCTCGGCCGGCGGAGGCCCGTGTCGGGCCCCTCCCCGGGGTTGGAGGCCATTCTCACCCCTCATCACTCACCGCCCTCAG
CTGAAAAAGGAGGTACCGGA

Downstream 100 bases:

>100_bases
GGTGCGCAGCCGCCGCAGGCCTGATCAGGCTGTACGGAGCAGCGGATAACGGACGGGGGAGCGGCCATGCCGCTCCCCCG
TCGTTACGCGGGATGGTTCT

Product: acetyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MSETASNVVKGGSFLLSQASPDQVFTPEDLSEEQRMIGSTAREFSEKVLARLHEIEQDKPFHSRPLLRELGELGLLGLEI
PEEYGGMGLDKVTATVATEEYSRAGSFAITIGAHTGIGSLPIVYFGTPEQKAKYLPKLATGEWVAAYALTEPNAGSDALG
ARTTARLSEDGKYWILNGTKQWITNAGFADVFVVYAKVDGEKFSAFIVERNFPGVSIGPEEKKMGLHASSTCSLILEDAK
VPVENLLGEIGKGHVIAFNILNIGRWKLGAGTVGSSKMVLATSIEYAKTRKQFGKPIAELRAIQQKLADMAVRTYVTESM
GYRTAGLLDSSLSDLDPNADMREVGKRLEEYAMECSIMKVFGSEAFDFVADEGVQIHGGYGFMDEYAVSMAYRDSRINRI
FEGTNEINRLLIPGTLVRRAMKGQLPIMQAMAGLQDELMSLTPYEESDEPLAQELFMIDRARKVFLMLAGLGVQKYQMAL
EHEQELLLGVADIAIEIYAMESAVLRALKAVKRGQPGLKVEMATVYCQEAFERIAATARTLLPAVEEDGDTLRTQLSMLR
RLTRYTPANTVALKRKIAERLLEKGDYVC

Sequences:

>Translated_589_residues
MSETASNVVKGGSFLLSQASPDQVFTPEDLSEEQRMIGSTAREFSEKVLARLHEIEQDKPFHSRPLLRELGELGLLGLEI
PEEYGGMGLDKVTATVATEEYSRAGSFAITIGAHTGIGSLPIVYFGTPEQKAKYLPKLATGEWVAAYALTEPNAGSDALG
ARTTARLSEDGKYWILNGTKQWITNAGFADVFVVYAKVDGEKFSAFIVERNFPGVSIGPEEKKMGLHASSTCSLILEDAK
VPVENLLGEIGKGHVIAFNILNIGRWKLGAGTVGSSKMVLATSIEYAKTRKQFGKPIAELRAIQQKLADMAVRTYVTESM
GYRTAGLLDSSLSDLDPNADMREVGKRLEEYAMECSIMKVFGSEAFDFVADEGVQIHGGYGFMDEYAVSMAYRDSRINRI
FEGTNEINRLLIPGTLVRRAMKGQLPIMQAMAGLQDELMSLTPYEESDEPLAQELFMIDRARKVFLMLAGLGVQKYQMAL
EHEQELLLGVADIAIEIYAMESAVLRALKAVKRGQPGLKVEMATVYCQEAFERIAATARTLLPAVEEDGDTLRTQLSMLR
RLTRYTPANTVALKRKIAERLLEKGDYVC
>Mature_588_residues
SETASNVVKGGSFLLSQASPDQVFTPEDLSEEQRMIGSTAREFSEKVLARLHEIEQDKPFHSRPLLRELGELGLLGLEIP
EEYGGMGLDKVTATVATEEYSRAGSFAITIGAHTGIGSLPIVYFGTPEQKAKYLPKLATGEWVAAYALTEPNAGSDALGA
RTTARLSEDGKYWILNGTKQWITNAGFADVFVVYAKVDGEKFSAFIVERNFPGVSIGPEEKKMGLHASSTCSLILEDAKV
PVENLLGEIGKGHVIAFNILNIGRWKLGAGTVGSSKMVLATSIEYAKTRKQFGKPIAELRAIQQKLADMAVRTYVTESMG
YRTAGLLDSSLSDLDPNADMREVGKRLEEYAMECSIMKVFGSEAFDFVADEGVQIHGGYGFMDEYAVSMAYRDSRINRIF
EGTNEINRLLIPGTLVRRAMKGQLPIMQAMAGLQDELMSLTPYEESDEPLAQELFMIDRARKVFLMLAGLGVQKYQMALE
HEQELLLGVADIAIEIYAMESAVLRALKAVKRGQPGLKVEMATVYCQEAFERIAATARTLLPAVEEDGDTLRTQLSMLRR
LTRYTPANTVALKRKIAERLLEKGDYVC

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=600, Percent_Identity=36, Blast_Score=336, Evalue=4e-92,
Organism=Homo sapiens, GI76496475, Length=569, Percent_Identity=36.3796133567663, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI4557235, Length=569, Percent_Identity=36.3796133567663, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI4557233, Length=401, Percent_Identity=35.9102244389027, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI226958412, Length=392, Percent_Identity=35.7142857142857, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI226958414, Length=352, Percent_Identity=35.7954545454545, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI7656849, Length=393, Percent_Identity=33.0788804071247, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI187960098, Length=403, Percent_Identity=35.2357320099256, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4557231, Length=403, Percent_Identity=35.2357320099256, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4501859, Length=411, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4501857, Length=402, Percent_Identity=34.0796019900498, Blast_Score=199, Evalue=8e-51,
Organism=Homo sapiens, GI4503943, Length=421, Percent_Identity=33.2541567695962, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI7669494, Length=397, Percent_Identity=34.0050377833753, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI48976061, Length=417, Percent_Identity=26.378896882494, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI211971008, Length=417, Percent_Identity=26.378896882494, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38505218, Length=308, Percent_Identity=23.3766233766234, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87081958, Length=389, Percent_Identity=31.8766066838046, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1786223, Length=400, Percent_Identity=27.25, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI87081702, Length=444, Percent_Identity=25.6756756756757, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082384, Length=329, Percent_Identity=25.2279635258359, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985184, Length=546, Percent_Identity=36.8131868131868, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71985192, Length=368, Percent_Identity=39.4021739130435, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17538396, Length=423, Percent_Identity=33.806146572104, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=386, Percent_Identity=33.6787564766839, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17569725, Length=396, Percent_Identity=35.8585858585859, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17534899, Length=405, Percent_Identity=35.3086419753086, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17506239, Length=384, Percent_Identity=33.8541666666667, Blast_Score=212, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17570075, Length=361, Percent_Identity=32.9639889196676, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17533517, Length=360, Percent_Identity=33.6111111111111, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=38.1974248927039, Blast_Score=168, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17534353, Length=390, Percent_Identity=32.0512820512821, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=250, Percent_Identity=37.6, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71982178, Length=284, Percent_Identity=34.1549295774648, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17505929, Length=394, Percent_Identity=28.1725888324873, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=394, Percent_Identity=27.6649746192893, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=26.7489711934156, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=403, Percent_Identity=25.3101736972705, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=403, Percent_Identity=25.3101736972705, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363737, Length=590, Percent_Identity=33.728813559322, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21356377, Length=401, Percent_Identity=36.6583541147132, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24646207, Length=399, Percent_Identity=37.0927318295739, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24660351, Length=416, Percent_Identity=35.5769230769231, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21355753, Length=392, Percent_Identity=35.7142857142857, Blast_Score=222, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24666513, Length=384, Percent_Identity=32.5520833333333, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI19920834, Length=398, Percent_Identity=30.4020100502513, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24652780, Length=504, Percent_Identity=23.2142857142857, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550141, Length=394, Percent_Identity=23.6040609137056, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221473076, Length=394, Percent_Identity=23.6040609137056, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 64813; Mature: 64682

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETASNVVKGGSFLLSQASPDQVFTPEDLSEEQRMIGSTAREFSEKVLARLHEIEQDKP
CCCCHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FHSRPLLRELGELGLLGLEIPEEYGGMGLDKVTATVATEEYSRAGSFAITIGAHTGIGSL
CCCCHHHHHHHHCCEEEEECCHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
PIVYFGTPEQKAKYLPKLATGEWVAAYALTEPNAGSDALGARTTARLSEDGKYWILNGTK
CEEEECCCHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCCEEEECCCH
QWITNAGFADVFVVYAKVDGEKFSAFIVERNFPGVSIGPEEKKMGLHASSTCSLILEDAK
HHHCCCCCHHEEEEEEEECCCCEEEEEEECCCCCCCCCCCHHHCCCCCCCHHHHEECCCC
VPVENLLGEIGKGHVIAFNILNIGRWKLGAGTVGSSKMVLATSIEYAKTRKQFGKPIAEL
CCHHHHHHHCCCCCEEEEEEEECCCEEECCCCCCCCCEEEEECHHHHHHHHHHCCCHHHH
RAIQQKLADMAVRTYVTESMGYRTAGLLDSSLSDLDPNADMREVGKRLEEYAMECSIMKV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGSEAFDFVADEGVQIHGGYGFMDEYAVSMAYRDSRINRIFEGTNEINRLLIPGTLVRRA
HCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCEEECCHHHHHHH
MKGQLPIMQAMAGLQDELMSLTPYEESDEPLAQELFMIDRARKVFLMLAGLGVQKYQMAL
HHCCCHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EHEQELLLGVADIAIEIYAMESAVLRALKAVKRGQPGLKVEMATVYCQEAFERIAATART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LLPAVEEDGDTLRTQLSMLRRLTRYTPANTVALKRKIAERLLEKGDYVC
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SETASNVVKGGSFLLSQASPDQVFTPEDLSEEQRMIGSTAREFSEKVLARLHEIEQDKP
CCCHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FHSRPLLRELGELGLLGLEIPEEYGGMGLDKVTATVATEEYSRAGSFAITIGAHTGIGSL
CCCCHHHHHHHHCCEEEEECCHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
PIVYFGTPEQKAKYLPKLATGEWVAAYALTEPNAGSDALGARTTARLSEDGKYWILNGTK
CEEEECCCHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCCEEEECCCH
QWITNAGFADVFVVYAKVDGEKFSAFIVERNFPGVSIGPEEKKMGLHASSTCSLILEDAK
HHHCCCCCHHEEEEEEEECCCCEEEEEEECCCCCCCCCCCHHHCCCCCCCHHHHEECCCC
VPVENLLGEIGKGHVIAFNILNIGRWKLGAGTVGSSKMVLATSIEYAKTRKQFGKPIAEL
CCHHHHHHHCCCCCEEEEEEEECCCEEECCCCCCCCCEEEEECHHHHHHHHHHCCCHHHH
RAIQQKLADMAVRTYVTESMGYRTAGLLDSSLSDLDPNADMREVGKRLEEYAMECSIMKV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGSEAFDFVADEGVQIHGGYGFMDEYAVSMAYRDSRINRIFEGTNEINRLLIPGTLVRRA
HCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCEEECCHHHHHHH
MKGQLPIMQAMAGLQDELMSLTPYEESDEPLAQELFMIDRARKVFLMLAGLGVQKYQMAL
HHCCCHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EHEQELLLGVADIAIEIYAMESAVLRALKAVKRGQPGLKVEMATVYCQEAFERIAATART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LLPAVEEDGDTLRTQLSMLRRLTRYTPANTVALKRKIAERLLEKGDYVC
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]