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The map label for this gene is fadA [H]

Identifier: 51894147

GI number: 51894147

Start: 3229685

End: 3230863

Strand: Reverse

Name: fadA [H]

Synonym: STH3011

Alternate gene names: 51894147

Gene position: 3230863-3229685 (Counterclockwise)

Preceding gene: 51894148

Following gene: 51894146

Centisome position: 90.6

GC content: 68.87

Gene sequence:

>1179_bases
TTGCGCGAGGCAGTGATTGTGACCGGCGTCCGAACGGCGCTGGGGAAGGCGCCGCGGGGCTCACTGCGCCATGTGCGGCC
GGAGGACCTGGCAGCGACGGTTATTAAGGAAGCGATTGCGCGCACGCCCGGGCTGGATCCCGCAGCCGTAGAGGACGTGG
TGCTGGGCTGCGCGTTCCCGGAGGGGGAGCAGGGGCTGAACATCGCCCGCAACGCCGCCATCCGCGCCGGGCTGCCCACC
TCGGTTCCCGGCTTCACCATCAACCGGTTCTGCTCGTCGGGCCTGAACGCGATCGCCATCGCGGCCAACGCGGTCATGGC
CGGCAACCTGGATATCGCGATCGCCGGCGGCGTCGAGTCGATGAGCCGGGTGCCGATGGGCGGCCACACGCCCCGGCCGC
ACCCGGAGGTGGTGGAGAGCTATCCGCAGCTCTACATGTCCATGGGCCACACGGCCGAGGTCGTCTGCGCCCGGTACAAC
GTGAGCCGGGAGGACATGGACGCGTTTGCCCTGGCGTCCCACCGGAAGGCCGCCGCGGCCATCGACGCCGGCAAGTTCAA
GGACGAGATCGTCCCGATCACCGTCAAGGAGCGGGTTTTCGACGGCAAGCGGGTCGTGGAGAAGGAGTTCGTGTTCGACA
CCGACGAGGGCGTGCGGCGCGACACCTCGATGGAGGCCCTGGCCAAGCTGCGGCCTGCGTTCTCGGCCAATGGCAACGTC
ACGGCCGGCAACTCCAGCCAGACCACCGATGGCGCCGCCGCCGTGGTGGTGATGTCGGCCGAGAAGGCGCAGGAGATGGG
TCTGAAGCCCCTGGCGATCTTCCGCTCCTTCGCCGTGGGCGGCGTCGATCCGGAGGTGATGGGCATTGGCCCCGTGGTGG
CGGTGCCCAAGGCGCTGAAGCAGGCGGGCATCACCTTGGCGGATGTCGATCTGATCGAGCTGAACGAGGCGTTTGCTTCC
CAGTCCTTGGCCGTGATCCGGAAGCTCGAAATGGACCCGGACAAGGTGAACGTCAACGGCGGCGCCATCGCGCTCGGCCA
CCCGCTGGGCTGCTCCGGCGCACGGCTCACGGTCACCATCATGCACGAGGCTCGGCGCCGCAAGGCCAGGTACGGGCTCG
TGACGATGTGCGTCGGCGGAGGGATGGGGGCCGCCGGGGTGCTCGAGTTCGTGCACTAG

Upstream 100 bases:

>100_bases
GGCGTTCCTCAGCCTCCTGGGCACCAAGAAGACTCAGGAGCGCATGGCCCATCTGCTGAAGACCGGCAAGCCGCTGCGGA
ACTAGGGAGGTGGCGACGAG

Downstream 100 bases:

>100_bases
GCAGCGCCGGGCGCAGGGCTCGGACTGCAGGCCGCCCCTGAAGCGGTATGGGCTCCTCGGCCGGCGGAGGCCCGTGTCGG
GCCCCTCCCCGGGGTTGGAG

Product: acetyl-CoA acyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MREAVIVTGVRTALGKAPRGSLRHVRPEDLAATVIKEAIARTPGLDPAAVEDVVLGCAFPEGEQGLNIARNAAIRAGLPT
SVPGFTINRFCSSGLNAIAIAANAVMAGNLDIAIAGGVESMSRVPMGGHTPRPHPEVVESYPQLYMSMGHTAEVVCARYN
VSREDMDAFALASHRKAAAAIDAGKFKDEIVPITVKERVFDGKRVVEKEFVFDTDEGVRRDTSMEALAKLRPAFSANGNV
TAGNSSQTTDGAAAVVVMSAEKAQEMGLKPLAIFRSFAVGGVDPEVMGIGPVVAVPKALKQAGITLADVDLIELNEAFAS
QSLAVIRKLEMDPDKVNVNGGAIALGHPLGCSGARLTVTIMHEARRRKARYGLVTMCVGGGMGAAGVLEFVH

Sequences:

>Translated_392_residues
MREAVIVTGVRTALGKAPRGSLRHVRPEDLAATVIKEAIARTPGLDPAAVEDVVLGCAFPEGEQGLNIARNAAIRAGLPT
SVPGFTINRFCSSGLNAIAIAANAVMAGNLDIAIAGGVESMSRVPMGGHTPRPHPEVVESYPQLYMSMGHTAEVVCARYN
VSREDMDAFALASHRKAAAAIDAGKFKDEIVPITVKERVFDGKRVVEKEFVFDTDEGVRRDTSMEALAKLRPAFSANGNV
TAGNSSQTTDGAAAVVVMSAEKAQEMGLKPLAIFRSFAVGGVDPEVMGIGPVVAVPKALKQAGITLADVDLIELNEAFAS
QSLAVIRKLEMDPDKVNVNGGAIALGHPLGCSGARLTVTIMHEARRRKARYGLVTMCVGGGMGAAGVLEFVH
>Mature_392_residues
MREAVIVTGVRTALGKAPRGSLRHVRPEDLAATVIKEAIARTPGLDPAAVEDVVLGCAFPEGEQGLNIARNAAIRAGLPT
SVPGFTINRFCSSGLNAIAIAANAVMAGNLDIAIAGGVESMSRVPMGGHTPRPHPEVVESYPQLYMSMGHTAEVVCARYN
VSREDMDAFALASHRKAAAAIDAGKFKDEIVPITVKERVFDGKRVVEKEFVFDTDEGVRRDTSMEALAKLRPAFSANGNV
TAGNSSQTTDGAAAVVVMSAEKAQEMGLKPLAIFRSFAVGGVDPEVMGIGPVVAVPKALKQAGITLADVDLIELNEAFAS
QSLAVIRKLEMDPDKVNVNGGAIALGHPLGCSGARLTVTIMHEARRRKARYGLVTMCVGGGMGAAGVLEFVH

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=46.1734693877551, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=38.7096774193548, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=40.6091370558376, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=37.593984962406, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4504327, Length=438, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=34.1902313624679, Blast_Score=185, Evalue=5e-47,
Organism=Escherichia coli, GI48994986, Length=395, Percent_Identity=46.5822784810127, Blast_Score=334, Evalue=6e-93,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=45.9657701711491, Blast_Score=317, Evalue=6e-88,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=46.6334164588529, Blast_Score=314, Evalue=5e-87,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=47.029702970297, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1788683, Length=435, Percent_Identity=35.1724137931034, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=398, Percent_Identity=39.9497487437186, Blast_Score=270, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=36.0902255639098, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=403, Percent_Identity=34.7394540942928, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17551802, Length=408, Percent_Identity=32.843137254902, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.2977099236641, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=40, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=36.7245657568238, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655093, Length=402, Percent_Identity=41.044776119403, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI17648125, Length=399, Percent_Identity=40.6015037593985, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=39.2947103274559, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=33.4101382488479, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41061; Mature: 41061

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00052 RIBOSOMAL_S7 ; PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVTGVRTALGKAPRGSLRHVRPEDLAATVIKEAIARTPGLDPAAVEDVVLGCAFP
CCCEEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
EGEQGLNIARNAAIRAGLPTSVPGFTINRFCSSGLNAIAIAANAVMAGNLDIAIAGGVES
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECEEEECCCCEEEECCHHH
MSRVPMGGHTPRPHPEVVESYPQLYMSMGHTAEVVCARYNVSREDMDAFALASHRKAAAA
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHCCHHHHH
IDAGKFKDEIVPITVKERVFDGKRVVEKEFVFDTDEGVRRDTSMEALAKLRPAFSANGNV
HCCCCCCCCEEEEEEHHHHCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHCCCCCCCCCE
TAGNSSQTTDGAAAVVVMSAEKAQEMGLKPLAIFRSFAVGGVDPEVMGIGPVVAVPKALK
ECCCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
QAGITLADVDLIELNEAFASQSLAVIRKLEMDPDKVNVNGGAIALGHPLGCSGARLTVTI
HCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCCEEEEEE
MHEARRRKARYGLVTMCVGGGMGAAGVLEFVH
HHHHHHHHHHCCEEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure
MREAVIVTGVRTALGKAPRGSLRHVRPEDLAATVIKEAIARTPGLDPAAVEDVVLGCAFP
CCCEEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
EGEQGLNIARNAAIRAGLPTSVPGFTINRFCSSGLNAIAIAANAVMAGNLDIAIAGGVES
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECEEEECCCCEEEECCHHH
MSRVPMGGHTPRPHPEVVESYPQLYMSMGHTAEVVCARYNVSREDMDAFALASHRKAAAA
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHCCHHHHH
IDAGKFKDEIVPITVKERVFDGKRVVEKEFVFDTDEGVRRDTSMEALAKLRPAFSANGNV
HCCCCCCCCEEEEEEHHHHCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHCCCCCCCCCE
TAGNSSQTTDGAAAVVVMSAEKAQEMGLKPLAIFRSFAVGGVDPEVMGIGPVVAVPKALK
ECCCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
QAGITLADVDLIELNEAFASQSLAVIRKLEMDPDKVNVNGGAIALGHPLGCSGARLTVTI
HCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCCEEEEEE
MHEARRRKARYGLVTMCVGGGMGAAGVLEFVH
HHHHHHHHHHCCEEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]