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The map label for this gene is moaA [H]

Identifier: 51894040

GI number: 51894040

Start: 3128262

End: 3129251

Strand: Reverse

Name: moaA [H]

Synonym: STH2904

Alternate gene names: 51894040

Gene position: 3129251-3128262 (Counterclockwise)

Preceding gene: 51894041

Following gene: 51894039

Centisome position: 87.75

GC content: 67.98

Gene sequence:

>990_bases
GTGATCGACCAGTGGGGCCGCAAAGTCAACTACATGCGCATCTCCGTGACCGACCGCTGCAACCTTCGCTGCGTCTACTG
CATGCCCCTGACCGGTGTCAAGCTGGGACCGCACGACGAGTACCTCCGCTACGAGGAGATTCTGCGCGTCGTCAAGGCCG
CGGTCGGCCTGGGGATCGACCGCATCCGCGTGACAGGCGGCGAGCCGCTGGTGCGCCAGGGCATCGTGGAGTTCCTGGCG
CAGTTGAAGCCCCTGGGCGTGACCGACCTCTCGCTCTCCACCAACGGCCTGCTCTTCGCCCCGATGGCGAAGGACCTGAA
GGCCGCGGGGGTCGACCGCGTGAACATTTCCCTGGACACGCTGCGCCCCGACCGCTTCACGAAGATTGCCCGGCTGAGCG
GCAGCCCGGCCCAGGTGTTGGAGGCGGCGGAGGCCGCGCTGGAACTGGGCATGGAGCCGGTGAAGCTGAACATGGTGGTC
ATCCGCGGCTGGAACGACGACGAGATCGGCGACATGGCCCGGCTGACTCTGGATCGGCCGATCCACGTGCGCTACATCGA
GGTCATGCCCTTCTCGGAAGGCTATCAGTTCACCTGGGAGAACCTGGTCCCCGCGGCCGAGATGCGGGAGCGGCTGCTGG
ACGAGTTCGGCGACCTGGAGCCGGTGCGCGGGGGCGTCCGGGGCAACGGGCCCGCCAAGTACTGGCGGCTGCCCGGCGCC
AAGGGCACGGTGGGCTTCATCTCGGCCGTCACCGAGTGCTTCTGCGCGGAGTGCAACCGCATCCGGCTGTCGGCTGACGG
CAAGGTCAACCCCTGCCTGGGCCACGTCCACGAGGTGGACCTGAAGCCGGTGATCCGCGACCCGGAGAAGACCGATGACG
ATCTGCGGAACGCCCTGGCGGACGCGATCCTGCGCAAGCCCCGGGAGCACAACTTCGACGACGCCGAGTCGGACTACGTC
CTGCGGGTCATGCACGGCATCGGCGGGTAG

Upstream 100 bases:

>100_bases
TCCCGAGTTCCTGAAGGCTGTGGAGGCGCTGGGCGGCTATGACTGCAGCGACTCCGGCCGGATCCGTCGGGTCTGACCGA
AAGAAAGGGGGCGGTACCCC

Downstream 100 bases:

>100_bases
CCGCGAAAGGGGTGCGACATGAGCAACATCAACCACGCAGATGCGCCGCGGCATGGGACGGACGAGCGCGGGGACAACGC
GCAGCTCGCCGGCCAGACCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MIDQWGRKVNYMRISVTDRCNLRCVYCMPLTGVKLGPHDEYLRYEEILRVVKAAVGLGIDRIRVTGGEPLVRQGIVEFLA
QLKPLGVTDLSLSTNGLLFAPMAKDLKAAGVDRVNISLDTLRPDRFTKIARLSGSPAQVLEAAEAALELGMEPVKLNMVV
IRGWNDDEIGDMARLTLDRPIHVRYIEVMPFSEGYQFTWENLVPAAEMRERLLDEFGDLEPVRGGVRGNGPAKYWRLPGA
KGTVGFISAVTECFCAECNRIRLSADGKVNPCLGHVHEVDLKPVIRDPEKTDDDLRNALADAILRKPREHNFDDAESDYV
LRVMHGIGG

Sequences:

>Translated_329_residues
MIDQWGRKVNYMRISVTDRCNLRCVYCMPLTGVKLGPHDEYLRYEEILRVVKAAVGLGIDRIRVTGGEPLVRQGIVEFLA
QLKPLGVTDLSLSTNGLLFAPMAKDLKAAGVDRVNISLDTLRPDRFTKIARLSGSPAQVLEAAEAALELGMEPVKLNMVV
IRGWNDDEIGDMARLTLDRPIHVRYIEVMPFSEGYQFTWENLVPAAEMRERLLDEFGDLEPVRGGVRGNGPAKYWRLPGA
KGTVGFISAVTECFCAECNRIRLSADGKVNPCLGHVHEVDLKPVIRDPEKTDDDLRNALADAILRKPREHNFDDAESDYV
LRVMHGIGG
>Mature_329_residues
MIDQWGRKVNYMRISVTDRCNLRCVYCMPLTGVKLGPHDEYLRYEEILRVVKAAVGLGIDRIRVTGGEPLVRQGIVEFLA
QLKPLGVTDLSLSTNGLLFAPMAKDLKAAGVDRVNISLDTLRPDRFTKIARLSGSPAQVLEAAEAALELGMEPVKLNMVV
IRGWNDDEIGDMARLTLDRPIHVRYIEVMPFSEGYQFTWENLVPAAEMRERLLDEFGDLEPVRGGVRGNGPAKYWRLPGA
KGTVGFISAVTECFCAECNRIRLSADGKVNPCLGHVHEVDLKPVIRDPEKTDDDLRNALADAILRKPREHNFDDAESDYV
LRVMHGIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=330, Percent_Identity=40.9090909090909, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI22027536, Length=330, Percent_Identity=40.9090909090909, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI1786999, Length=331, Percent_Identity=30.8157099697885, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32566329, Length=331, Percent_Identity=37.4622356495468, Blast_Score=216, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI32566331, Length=312, Percent_Identity=37.5, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17561210, Length=331, Percent_Identity=36.5558912386707, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28574490, Length=311, Percent_Identity=42.1221864951768, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI28574488, Length=311, Percent_Identity=42.1221864951768, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36666; Mature: 36666

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQWGRKVNYMRISVTDRCNLRCVYCMPLTGVKLGPHDEYLRYEEILRVVKAAVGLGID
CCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCE
RIRVTGGEPLVRQGIVEFLAQLKPLGVTDLSLSTNGLLFAPMAKDLKAAGVDRVNISLDT
EEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHHHHCCCCEEEEEEEC
LRPDRFTKIARLSGSPAQVLEAAEAALELGMEPVKLNMVVIRGWNDDEIGDMARLTLDRP
CCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHEECCC
IHVRYIEVMPFSEGYQFTWENLVPAAEMRERLLDEFGDLEPVRGGVRGNGPAKYWRLPGA
EEEEEEEEEECCCCCEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCC
KGTVGFISAVTECFCAECNRIRLSADGKVNPCLGHVHEVDLKPVIRDPEKTDDDLRNALA
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCEECCCCCCCCCCCCCHHHHHHHHH
DAILRKPREHNFDDAESDYVLRVMHGIGG
HHHHHCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MIDQWGRKVNYMRISVTDRCNLRCVYCMPLTGVKLGPHDEYLRYEEILRVVKAAVGLGID
CCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCE
RIRVTGGEPLVRQGIVEFLAQLKPLGVTDLSLSTNGLLFAPMAKDLKAAGVDRVNISLDT
EEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHHHHCCCCEEEEEEEC
LRPDRFTKIARLSGSPAQVLEAAEAALELGMEPVKLNMVVIRGWNDDEIGDMARLTLDRP
CCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHEECCC
IHVRYIEVMPFSEGYQFTWENLVPAAEMRERLLDEFGDLEPVRGGVRGNGPAKYWRLPGA
EEEEEEEEEECCCCCEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCC
KGTVGFISAVTECFCAECNRIRLSADGKVNPCLGHVHEVDLKPVIRDPEKTDDDLRNALA
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCEECCCCCCCCCCCCCHHHHHHHHH
DAILRKPREHNFDDAESDYVLRVMHGIGG
HHHHHCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA