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The map label for this gene is moeA [C]

Identifier: 51894041

GI number: 51894041

Start: 3129276

End: 3131201

Strand: Reverse

Name: moeA [C]

Synonym: STH2905

Alternate gene names: 51894041

Gene position: 3131201-3129276 (Counterclockwise)

Preceding gene: 51894042

Following gene: 51894040

Centisome position: 87.8

GC content: 70.92

Gene sequence:

>1926_bases
ATGAGCACGCGCAAGATCTACCTGGAATCGCTGCCCCGCGACGAGGCGCTGAGCCGGTTGCTCCGTGCGCTCGACCAGGC
CGGGTGGGGACCGCAGCGGGAGGTCATCCCCACCGACGAGGCGCTGGGCCGCATCACCTGCGAACCCGTGCGGGCCCGCA
TCTCTGCCCCGCATTACAACGCCGCCGCCGTGGACGGTATCGCCGTCAAGGCCAGCGACACCTTCGGCGCCACCGAGACG
GCGCCGCGGATCCTCACCATCGGCGAGCAGGCCTTCTGGGTCGACACCGGCGACCCGCTGCCGCCCGGGTGCGACGCGGT
GATCATGGTGGAGCACGTCAACCTGCTGGACGACGGCCACCACCAGGGCGCCCGCTGCGAGATCCTGGCGCCGGTCGCCC
CGTGGCAGGACGTGCGGCAGATCGGCGAAGACGTGGTGGCCACCGAGATCCTGCTGCCCGAGGGGCACGTCATCCGTCCG
CAGGACCTGGGCGCCCTGCTGGCGGCCGGGATCCTGGAGGTGCCGGTGGTGCGCAGGCCGCGGGTGACGTTCATCCCGAC
GGGCACGGAGATCGTCGAGCCCAAGGCGGATCCGGCTGAGGGCGAGATCATCGAGTTCAACTCCCGGGTCATCCTCTCCC
TGGTGCGGGAGTGGGGCGGCGAGCCGGTGCGGCACCCCATCGTGCGGGACGACTACGACCTCATCCGGCGGGCCGTGCGG
GAGGCCGTCGCCCGGTCGGACATCGTCATCGTCAACGCCGGCTCCTCCGCCGGCAGCGAAGACTACACCGTACATGTGTT
GAAGGAGCTGGGGCAGGTACTCGCCCACGGCGTCGCCGTCCGCCCCGGCAAGCCGGTGATGCTGGGCCTCATCGACGGCA
AGCCCTTCGTCGGGTTGCCCGGCTACCCGGTCTCCACGTGGTTGACGGCGGACCTCTTCGTCAAGCCGCTGGTCTTCCGG
GCGCAGGGCCTGCCGGTGCCCGAGCGGGAGACGGTGCGGGCTTCCCTGGCCAGGCGGATCACCTCGCCCATGGGGGTCGA
GGAGTTCGTGCGGGTGAAGCTGGGCCGCGTGGGCGAGCGGCTGGTGGCCACGCCCATCAGCCGGGGCGCCGCGGTGATCA
CCTCGCTGGTGCGGGCCGACGGGCTGCTGGTCGTCCCCGCGGACCGGGAGGGCATCGGCGAGGGCACCGAGGTGACGGTG
GAGCTGCTCCGGCCGCTGCGCGACATTCAGGAGACCGTGGTGGTCATCGGCTCCCACGACACCTCGCTGGACCTGATGGG
CTCCTGGCTGCGCCGCAAGGGCGGTTACTACCTCTCCAGCGCCCACGTGGGCTCCCAGGGCGGACTGCTGGCCCTGAAGC
GGGGCGAGGCGCACATGGCCGGCGTCCACCTGCTGGACACGGATACGGGCGAGTGCAATACGTCCTACGTGCGCAAGTAC
CTGGGCAGGCCCGCGCTCCTGGTGCTGCTGGCCCGGCGGGAGCAGGGGTTCATCGTGCCGAAGGGCAACCCGAAGGGGAT
CGGGTCGTTCCGCGACCTGGCCCGGCCGGACGTGCGGTTCGTCAACCGGCAGCGGGGGGCCGGCACCCGTCTGCTCCTGG
ATTTCCACCTGCGGCAGGAGGGGATCTCTCCGGAGCAGGTGCAGGGCTACCGGTGGGAGCTGTTCACGCACCTGAATGTC
GCCCAGGCCGTGAAGGCGGGCGACGCCGACACAGGACTGGGCATCCGCTCAGCTGCACAGGCGCTGGACCTGGACTTCGT
GCCCGTGGCCTGGGAAGAGTACGAGCTTTGCATCCCAGCGGAACTGGAGGAGCACCCCGGTGTCCAGGCGGTGCTGAGCC
TCCTGCGCGATCCCGAGTTCCTGAAGGCTGTGGAGGCGCTGGGCGGCTATGACTGCAGCGACTCCGGCCGGATCCGTCGG
GTCTGA

Upstream 100 bases:

>100_bases
GCCTGATCTCGACTCTCGTGCGGGCGGACGGGTTCCTCATCATCCCCTCGGCCCGCGAGGGACTGCTGGCCGGCGACACG
GTGGAGGTGGAGGTCCTGGC

Downstream 100 bases:

>100_bases
CCGAAAGAAAGGGGGCGGTACCCCGTGATCGACCAGTGGGGCCGCAAAGTCAACTACATGCGCATCTCCGTGACCGACCG
CTGCAACCTTCGCTGCGTCT

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSTRKIYLESLPRDEALSRLLRALDQAGWGPQREVIPTDEALGRITCEPVRARISAPHYNAAAVDGIAVKASDTFGATET
APRILTIGEQAFWVDTGDPLPPGCDAVIMVEHVNLLDDGHHQGARCEILAPVAPWQDVRQIGEDVVATEILLPEGHVIRP
QDLGALLAAGILEVPVVRRPRVTFIPTGTEIVEPKADPAEGEIIEFNSRVILSLVREWGGEPVRHPIVRDDYDLIRRAVR
EAVARSDIVIVNAGSSAGSEDYTVHVLKELGQVLAHGVAVRPGKPVMLGLIDGKPFVGLPGYPVSTWLTADLFVKPLVFR
AQGLPVPERETVRASLARRITSPMGVEEFVRVKLGRVGERLVATPISRGAAVITSLVRADGLLVVPADREGIGEGTEVTV
ELLRPLRDIQETVVVIGSHDTSLDLMGSWLRRKGGYYLSSAHVGSQGGLLALKRGEAHMAGVHLLDTDTGECNTSYVRKY
LGRPALLVLLARREQGFIVPKGNPKGIGSFRDLARPDVRFVNRQRGAGTRLLLDFHLRQEGISPEQVQGYRWELFTHLNV
AQAVKAGDADTGLGIRSAAQALDLDFVPVAWEEYELCIPAELEEHPGVQAVLSLLRDPEFLKAVEALGGYDCSDSGRIRR
V

Sequences:

>Translated_641_residues
MSTRKIYLESLPRDEALSRLLRALDQAGWGPQREVIPTDEALGRITCEPVRARISAPHYNAAAVDGIAVKASDTFGATET
APRILTIGEQAFWVDTGDPLPPGCDAVIMVEHVNLLDDGHHQGARCEILAPVAPWQDVRQIGEDVVATEILLPEGHVIRP
QDLGALLAAGILEVPVVRRPRVTFIPTGTEIVEPKADPAEGEIIEFNSRVILSLVREWGGEPVRHPIVRDDYDLIRRAVR
EAVARSDIVIVNAGSSAGSEDYTVHVLKELGQVLAHGVAVRPGKPVMLGLIDGKPFVGLPGYPVSTWLTADLFVKPLVFR
AQGLPVPERETVRASLARRITSPMGVEEFVRVKLGRVGERLVATPISRGAAVITSLVRADGLLVVPADREGIGEGTEVTV
ELLRPLRDIQETVVVIGSHDTSLDLMGSWLRRKGGYYLSSAHVGSQGGLLALKRGEAHMAGVHLLDTDTGECNTSYVRKY
LGRPALLVLLARREQGFIVPKGNPKGIGSFRDLARPDVRFVNRQRGAGTRLLLDFHLRQEGISPEQVQGYRWELFTHLNV
AQAVKAGDADTGLGIRSAAQALDLDFVPVAWEEYELCIPAELEEHPGVQAVLSLLRDPEFLKAVEALGGYDCSDSGRIRR
V
>Mature_640_residues
STRKIYLESLPRDEALSRLLRALDQAGWGPQREVIPTDEALGRITCEPVRARISAPHYNAAAVDGIAVKASDTFGATETA
PRILTIGEQAFWVDTGDPLPPGCDAVIMVEHVNLLDDGHHQGARCEILAPVAPWQDVRQIGEDVVATEILLPEGHVIRPQ
DLGALLAAGILEVPVVRRPRVTFIPTGTEIVEPKADPAEGEIIEFNSRVILSLVREWGGEPVRHPIVRDDYDLIRRAVRE
AVARSDIVIVNAGSSAGSEDYTVHVLKELGQVLAHGVAVRPGKPVMLGLIDGKPFVGLPGYPVSTWLTADLFVKPLVFRA
QGLPVPERETVRASLARRITSPMGVEEFVRVKLGRVGERLVATPISRGAAVITSLVRADGLLVVPADREGIGEGTEVTVE
LLRPLRDIQETVVVIGSHDTSLDLMGSWLRRKGGYYLSSAHVGSQGGLLALKRGEAHMAGVHLLDTDTGECNTSYVRKYL
GRPALLVLLARREQGFIVPKGNPKGIGSFRDLARPDVRFVNRQRGAGTRLLLDFHLRQEGISPEQVQGYRWELFTHLNVA
QAVKAGDADTGLGIRSAAQALDLDFVPVAWEEYELCIPAELEEHPGVQAVLSLLRDPEFLKAVEALGGYDCSDSGRIRRV

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=321, Percent_Identity=33.0218068535826, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI10880983, Length=321, Percent_Identity=33.0218068535826, Blast_Score=149, Evalue=1e-35,
Organism=Escherichia coli, GI1787049, Length=372, Percent_Identity=31.4516129032258, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=348, Percent_Identity=29.0229885057471, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562606, Length=356, Percent_Identity=23.314606741573, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136978, Length=362, Percent_Identity=27.6243093922652, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=362, Percent_Identity=27.6243093922652, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 69729; Mature: 69598

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRKIYLESLPRDEALSRLLRALDQAGWGPQREVIPTDEALGRITCEPVRARISAPHYN
CCCCEEHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEECHHHHHHCCCCCCC
AAAVDGIAVKASDTFGATETAPRILTIGEQAFWVDTGDPLPPGCDAVIMVEHVNLLDDGH
CEECCCEEEEECCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCEEEEEEEEHHHCCCC
HQGARCEILAPVAPWQDVRQIGEDVVATEILLPEGHVIRPQDLGALLAAGILEVPVVRRP
CCCCEEEEEECCCCHHHHHHHHHHHHHHEEECCCCCEECHHHHHHHHHHHHHHCCCCCCC
RVTFIPTGTEIVEPKADPAEGEIIEFNSRVILSLVREWGGEPVRHPIVRDDYDLIRRAVR
CEEEEECCCCEECCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
EAVARSDIVIVNAGSSAGSEDYTVHVLKELGQVLAHGVAVRPGKPVMLGLIDGKPFVGLP
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCEECCC
GYPVSTWLTADLFVKPLVFRAQGLPVPERETVRASLARRITSPMGVEEFVRVKLGRVGER
CCCHHHHEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
LVATPISRGAAVITSLVRADGLLVVPADREGIGEGTEVTVELLRPLRDIQETVVVIGSHD
HHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCC
TSLDLMGSWLRRKGGYYLSSAHVGSQGGLLALKRGEAHMAGVHLLDTDTGECNTSYVRKY
CCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCHHHHHHH
LGRPALLVLLARREQGFIVPKGNPKGIGSFRDLARPDVRFVNRQRGAGTRLLLDFHLRQE
HCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEEHHHC
GISPEQVQGYRWELFTHLNVAQAVKAGDADTGLGIRSAAQALDLDFVPVAWEEYELCIPA
CCCHHHHCCEEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEECCCCCCCEEECC
ELEEHPGVQAVLSLLRDPEFLKAVEALGGYDCSDSGRIRRV
CCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
STRKIYLESLPRDEALSRLLRALDQAGWGPQREVIPTDEALGRITCEPVRARISAPHYN
CCCEEHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEECHHHHHHCCCCCCC
AAAVDGIAVKASDTFGATETAPRILTIGEQAFWVDTGDPLPPGCDAVIMVEHVNLLDDGH
CEECCCEEEEECCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCEEEEEEEEHHHCCCC
HQGARCEILAPVAPWQDVRQIGEDVVATEILLPEGHVIRPQDLGALLAAGILEVPVVRRP
CCCCEEEEEECCCCHHHHHHHHHHHHHHEEECCCCCEECHHHHHHHHHHHHHHCCCCCCC
RVTFIPTGTEIVEPKADPAEGEIIEFNSRVILSLVREWGGEPVRHPIVRDDYDLIRRAVR
CEEEEECCCCEECCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
EAVARSDIVIVNAGSSAGSEDYTVHVLKELGQVLAHGVAVRPGKPVMLGLIDGKPFVGLP
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCEECCC
GYPVSTWLTADLFVKPLVFRAQGLPVPERETVRASLARRITSPMGVEEFVRVKLGRVGER
CCCHHHHEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
LVATPISRGAAVITSLVRADGLLVVPADREGIGEGTEVTVELLRPLRDIQETVVVIGSHD
HHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCC
TSLDLMGSWLRRKGGYYLSSAHVGSQGGLLALKRGEAHMAGVHLLDTDTGECNTSYVRKY
CCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCHHHHHHH
LGRPALLVLLARREQGFIVPKGNPKGIGSFRDLARPDVRFVNRQRGAGTRLLLDFHLRQE
HCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEEHHHC
GISPEQVQGYRWELFTHLNVAQAVKAGDADTGLGIRSAAQALDLDFVPVAWEEYELCIPA
CCCHHHHCCEEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEECCCCCCCEEECC
ELEEHPGVQAVLSLLRDPEFLKAVEALGGYDCSDSGRIRRV
CCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]