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The map label for this gene is grdA [H]

Identifier: 51894005

GI number: 51894005

Start: 3092533

End: 3093000

Strand: Reverse

Name: grdA [H]

Synonym: STH2869

Alternate gene names: 51894005

Gene position: 3093000-3092533 (Counterclockwise)

Preceding gene: 51894006

Following gene: 51894004

Centisome position: 86.73

GC content: 66.45

Gene sequence:

>468_bases
ATGGAACTGAAGGGGAAGAAGGCGATCATCCTCGGCGACCGGGACGGCATCCCGGGTCCGGCCCTGGAGGCCTGCGTCCG
CAGCGCCGGCGCCGAGGTGGTCTTCGCCTCCACGGAGTGCTTCGTCTGAACGAGCGCAGGGGCCATGGACATGGAGAACC
AGCGCAGGGTCAAGGAGCTGGCTGAGAAGTATCCCAAGGAGGACCTCGTGGTCATCCTGGGCGGCGCCGAGGCCGAGGCC
TCGGGGCTGGCGGCGGAGACGGTCAGCAACGGCGACCCCGCCTGGGCCGGTCCACTGGCCGGAGTCCAGTTGGGACTCAA
GGCGTACCACATCTTCGAGCCCGAGATCAAGGAGCAGATCGATCCCAACGTCTACGAGGAGCAGGTCTCCCTGATGGAGA
TGGTGCTGGACGTGGAGGCGATCGTCCAGGAGGTCCGCTCGATCCGCGAGAAGTACGCCGCCTGGTAA

Upstream 100 bases:

>100_bases
AGATCCAGGTGATCACCGGCGCGACCAACGAGCTGGGCTTCTCCCGCCTGTCGGCCAGGACCATTTGAGGCTTTCTACTG
TCTGTAAAGGAAGTGAGAGC

Downstream 100 bases:

>100_bases
AGGGGGGTCACACGTGCGGATTGTGCATTACCTGAACCAGTTCTTCGGTGGAATCGGAGGTGAGGAGCACGCCGGCGTGC
GGCCCGAGGTACGCCCCGGC

Product: glycine/sarcosine/betaine reductase complex protein A

Products: NA

Alternate protein names: Selenoprotein PA; Thioredoxin reductase complex selenoprotein A [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MELKGKKAIILGDRDGIPGPALEACVRSAGAEVVFASTECFVUTSAGAMDMENQRRVKELAEKYPKEDLVVILGGAEAEA
SGLAAETVSNGDPAWAGPLAGVQLGLKAYHIFEPEIKEQIDPNVYEEQVSLMEMVLDVEAIVQEVRSIREKYAAW

Sequences:

>Translated_155_residues
MELKGKKAIILGDRDGIPGPALEACVRSAGAEVVFASTECFV*TSAGAMDMENQRRVKELAEKYPKEDLVVILGGAEAEA
SGLAAETVSNGDPAWAGPLAGVQLGLKAYHIFEPEIKEQIDPNVYEEQVSLMEMVLDVEAIVQEVRSIREKYAAW
>Mature_155_residues
MELKGKKAIILGDRDGIPGPALEACVRSAGAEVVFASTECFV*TSAGAMDMENQRRVKELAEKYPKEDLVVILGGAEAEA
SGLAAETVSNGDPAWAGPLAGVQLGLKAYHIFEPEIKEQIDPNVYEEQVSLMEMVLDVEAIVQEVRSIREKYAAW

Specific function: In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a c

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the grdA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006812 [H]

Pfam domain/function: PF04723 GRDA [H]

EC number: =1.21.4.2; =1.21.4.3; =1.21.4.4 [H]

Molecular weight: Translated: 16618; Mature: 16618

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKGKKAIILGDRDGIPGPALEACVRSAGAEVVFASTECFVTSAGAMDMENQRRVKELA
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCCCCHHHHHHHHHH
EKYPKEDLVVILGGAEAEASGLAAETVSNGDPAWAGPLAGVQLGLKAYHIFEPEIKEQID
HHCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHEEEECCHHHHHCC
PNVYEEQVSLMEMVLDVEAIVQEVRSIREKYAAW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELKGKKAIILGDRDGIPGPALEACVRSAGAEVVFASTECFVTSAGAMDMENQRRVKELA
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCCCCHHHHHHHHHH
EKYPKEDLVVILGGAEAEASGLAAETVSNGDPAWAGPLAGVQLGLKAYHIFEPEIKEQID
HHCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHEEEECCHHHHHCC
PNVYEEQVSLMEMVLDVEAIVQEVRSIREKYAAW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA