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The map label for this gene is grdE [H]

Identifier: 51894006

GI number: 51894006

Start: 3093033

End: 3094337

Strand: Reverse

Name: grdE [H]

Synonym: STH2870

Alternate gene names: 51894006

Gene position: 3094337-3093033 (Counterclockwise)

Preceding gene: 51894007

Following gene: 51894005

Centisome position: 86.77

GC content: 68.51

Gene sequence:

>1305_bases
GTGAGGAGGCGAAGGGCCATGAAGCTGGAACTGGGCCGCATCTACATCCGCGACGTGCGCTTCGGCGAGACCACCCGGGT
GGAGGGCGGCGTCCTCACCGTGAACCGGGAGGAGCTCGCAAACCTGCTCCTGCAGGACGAGCGGCTGACCGCCGTGGAGC
TGGACATCGCCCGCCCCGGCGAGTCGGTGCGGATCATCCCGGTCAAGGACGTCATCGAGCCCCTGGTCAAGGTCTCGGGC
CCCGGTGGTGTCTTCCCCGGGTTCATCGGGAAGGTGGAGACGGTGGGCGAGGGTCGCACCCACGTGCTGAAGGGCTGCGC
CGTCGTCACGACCGGCCGGATCGTCGGCTTCCAGGAGGGGCTGATCGACATGTCCGGCCCGGGCGCCGAGTACACCCCGT
TCTCCAAGCTCATCAACGTGACGGTGCACTGCACCCCGCGCGAGGGGCTGACCCAGCACGAGCACGAGGCCGCCCTGCGG
CTGGCGGGGCTGAAGGCCGCCGCCTATCTGGGCGAGGCGGGCCGCCACGCCGAGCCGGACGAGGTGGTCACCTACGAGCA
CCTGCCCCTGCCCGAGGCCATCGCCCGGTACCCGGACCTGCCGAAGGTGGTCTACGTGTACATGCTTCAGTCCCAGGGGC
TGCTGCACGACACCTACGTCTACGGCGTGGACGCCAAGCGGATCCTGCCGACCCTGATCTCCCCGACCGAGGTCTTCGAC
GGCGCGATCGTCAGCGGCAACTGCGTCTCCGCCTGCGACAAGAACACCACCTACCACCACCAGAACTCGCCGGTGATCGA
GGACCTGTACGCCCGCCACGGCAAGGACATCAACTTCCTCGGGGTGGTCATCACCAACGAGAACGTGACCCTGGCGGACA
AGGAGCGCTCCTCCAGCTACGCGGCCAAGCTGGTCCGGATGCTGGGGGCCGACGGCGCCATCGTCACCGAGGAGGGGTTC
GGCAACCCCGACACCGACCTGATGATGAACTGCCGGAAGCTGGAGGAGAAGGGCATCAAGACGGTGCTGATCACCGACGA
GTACGCCGGGCGCGACGGCGGATCCCAGTCGCTGGCCGACGCCACGCCGCACGCCGACGCCGTGGTGACCGCCGGCAACG
CCAACGCCGTGGTCGTGCTGCCGCCCATGGAGAAGGTCATCGGCTACCCCGAGCAGGTGAACGTCATCGCCGGCGGCTGG
GAAGGATCCCTCAGGCCCGACGGCTCCATCGAGGCCGAGATCCAGGTGATCACCGGCGCGACCAACGAGCTGGGCTTCTC
CCGCCTGTCGGCCAGGACCATTTGA

Upstream 100 bases:

>100_bases
CGACGTTCCTCTTCTTCCGGGACGGGGAGAAGGTGGCCGAGCTGGCCGGGCCCGAGGCGTGCACGGCGGAGGCCATCGAG
GCCGAGCTGCAGCGGCTGGT

Downstream 100 bases:

>100_bases
GGCTTTCTACTGTCTGTAAAGGAAGTGAGAGCATGGAACTGAAGGGGAAGAAGGCGATCATCCTCGGCGACCGGGACGGC
ATCCCGGGTCCGGCCCTGGA

Product: glycine reductase proprotein

Products: NA

Alternate protein names: Selenoprotein PB alpha/beta [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRRRRAMKLELGRIYIRDVRFGETTRVEGGVLTVNREELANLLLQDERLTAVELDIARPGESVRIIPVKDVIEPLVKVSG
PGGVFPGFIGKVETVGEGRTHVLKGCAVVTTGRIVGFQEGLIDMSGPGAEYTPFSKLINVTVHCTPREGLTQHEHEAALR
LAGLKAAAYLGEAGRHAEPDEVVTYEHLPLPEAIARYPDLPKVVYVYMLQSQGLLHDTYVYGVDAKRILPTLISPTEVFD
GAIVSGNCVSACDKNTTYHHQNSPVIEDLYARHGKDINFLGVVITNENVTLADKERSSSYAAKLVRMLGADGAIVTEEGF
GNPDTDLMMNCRKLEEKGIKTVLITDEYAGRDGGSQSLADATPHADAVVTAGNANAVVVLPPMEKVIGYPEQVNVIAGGW
EGSLRPDGSIEAEIQVITGATNELGFSRLSARTI

Sequences:

>Translated_434_residues
MRRRRAMKLELGRIYIRDVRFGETTRVEGGVLTVNREELANLLLQDERLTAVELDIARPGESVRIIPVKDVIEPLVKVSG
PGGVFPGFIGKVETVGEGRTHVLKGCAVVTTGRIVGFQEGLIDMSGPGAEYTPFSKLINVTVHCTPREGLTQHEHEAALR
LAGLKAAAYLGEAGRHAEPDEVVTYEHLPLPEAIARYPDLPKVVYVYMLQSQGLLHDTYVYGVDAKRILPTLISPTEVFD
GAIVSGNCVSACDKNTTYHHQNSPVIEDLYARHGKDINFLGVVITNENVTLADKERSSSYAAKLVRMLGADGAIVTEEGF
GNPDTDLMMNCRKLEEKGIKTVLITDEYAGRDGGSQSLADATPHADAVVTAGNANAVVVLPPMEKVIGYPEQVNVIAGGW
EGSLRPDGSIEAEIQVITGATNELGFSRLSARTI
>Mature_434_residues
MRRRRAMKLELGRIYIRDVRFGETTRVEGGVLTVNREELANLLLQDERLTAVELDIARPGESVRIIPVKDVIEPLVKVSG
PGGVFPGFIGKVETVGEGRTHVLKGCAVVTTGRIVGFQEGLIDMSGPGAEYTPFSKLINVTVHCTPREGLTQHEHEAALR
LAGLKAAAYLGEAGRHAEPDEVVTYEHLPLPEAIARYPDLPKVVYVYMLQSQGLLHDTYVYGVDAKRILPTLISPTEVFD
GAIVSGNCVSACDKNTTYHHQNSPVIEDLYARHGKDINFLGVVITNENVTLADKERSSSYAAKLVRMLGADGAIVTEEGF
GNPDTDLMMNCRKLEEKGIKTVLITDEYAGRDGGSQSLADATPHADAVVTAGNANAVVVLPPMEKVIGYPEQVNVIAGGW
EGSLRPDGSIEAEIQVITGATNELGFSRLSARTI

Specific function: In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB- activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated seleno

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016585
- InterPro:   IPR015417 [H]

Pfam domain/function: PF09338 Gly_reductase [H]

EC number: =1.21.4.2 [H]

Molecular weight: Translated: 46921; Mature: 46921

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRRAMKLELGRIYIRDVRFGETTRVEGGVLTVNREELANLLLQDERLTAVELDIARPG
CCCCCCCEEEECEEEEEEECCCCCEEECCCEEEECHHHHHHHHHCCCCEEEEEEEECCCC
ESVRIIPVKDVIEPLVKVSGPGGVFPGFIGKVETVGEGRTHVLKGCAVVTTGRIVGFQEG
CCEEEEEHHHHHHHHHEECCCCCCCCCHHCCEEECCCCCHHHHHCEEEEEECEEEEECCC
LIDMSGPGAEYTPFSKLINVTVHCTPREGLTQHEHEAALRLAGLKAAAYLGEAGRHAEPD
CEECCCCCCCCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EVVTYEHLPLPEAIARYPDLPKVVYVYMLQSQGLLHDTYVYGVDAKRILPTLISPTEVFD
CEEEEECCCCHHHHHHCCCCCHHEEEEEHHCCCCEEEEEEEECCHHHHHHHHCCCHHHHC
GAIVSGNCVSACDKNTTYHHQNSPVIEDLYARHGKDINFLGVVITNENVTLADKERSSSY
CEEECCCCHHHCCCCCCEECCCCCHHHHHHHHCCCCCEEEEEEEECCCEEEECCCCCHHH
AAKLVRMLGADGAIVTEEGFGNPDTDLMMNCRKLEEKGIKTVLITDEYAGRDGGSQSLAD
HHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
ATPHADAVVTAGNANAVVVLPPMEKVIGYPEQVNVIAGGWEGSLRPDGSIEAEIQVITGA
CCCCCCEEEECCCCCEEEEECCHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEECC
TNELGFSRLSARTI
CCCCCHHHHHCCCC
>Mature Secondary Structure
MRRRRAMKLELGRIYIRDVRFGETTRVEGGVLTVNREELANLLLQDERLTAVELDIARPG
CCCCCCCEEEECEEEEEEECCCCCEEECCCEEEECHHHHHHHHHCCCCEEEEEEEECCCC
ESVRIIPVKDVIEPLVKVSGPGGVFPGFIGKVETVGEGRTHVLKGCAVVTTGRIVGFQEG
CCEEEEEHHHHHHHHHEECCCCCCCCCHHCCEEECCCCCHHHHHCEEEEEECEEEEECCC
LIDMSGPGAEYTPFSKLINVTVHCTPREGLTQHEHEAALRLAGLKAAAYLGEAGRHAEPD
CEECCCCCCCCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EVVTYEHLPLPEAIARYPDLPKVVYVYMLQSQGLLHDTYVYGVDAKRILPTLISPTEVFD
CEEEEECCCCHHHHHHCCCCCHHEEEEEHHCCCCEEEEEEEECCHHHHHHHHCCCHHHHC
GAIVSGNCVSACDKNTTYHHQNSPVIEDLYARHGKDINFLGVVITNENVTLADKERSSSY
CEEECCCCHHHCCCCCCEECCCCCHHHHHHHHCCCCCEEEEEEEECCCEEEECCCCCHHH
AAKLVRMLGADGAIVTEEGFGNPDTDLMMNCRKLEEKGIKTVLITDEYAGRDGGSQSLAD
HHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
ATPHADAVVTAGNANAVVVLPPMEKVIGYPEQVNVIAGGWEGSLRPDGSIEAEIQVITGA
CCCCCCEEEECCCCCEEEEECCHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEECC
TNELGFSRLSARTI
CCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10091582; 8529639 [H]