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The map label for this gene is thrB

Identifier: 51893694

GI number: 51893694

Start: 2741706

End: 2742680

Strand: Reverse

Name: thrB

Synonym: STH2556

Alternate gene names: 51893694

Gene position: 2742680-2741706 (Counterclockwise)

Preceding gene: 51893695

Following gene: 51893690

Centisome position: 76.91

GC content: 73.95

Gene sequence:

>975_bases
ATGGTCAGGGTCAGCGTGCCGGCGACCAGCGCCAACCTGGGGCCGGGGTTCGACACCCTGGGCGTGGCGCTGGAGCTTCG
CAACGTGATCGAGATGGACGAGACGGGCATCGACGACGTGGTCATCGAGGTGGAGGGGGCCGGGGCGGGCGCCCTGGAGG
ACCCGGGGCGCAACATGGTCTACCAGGCCGCCCGCCTGGTCTTTCAGCGGCTGGGCTACGAGCCCAACGGGCTGCTCATC
CGGGAGAAGGTGGCCATCCCGGTGGCGCGGGGCATGGGCTCCTCCGCCGCCGCGATCGTCGGCGGGCTGGTGGCCGCCAA
CGCCCTGGTGCAGAAGCGGACCGGCGGTCCCGGGCTCGACCGGGAGGAGCTGTTGCGCATGGCGGTGGCCATCGAGGGCC
ACCCGGACAACGTAACGCCAGCGCTGCTGGGCGGCTTCACCGTGTCGTGCATGGACCCGGACCGGGGGCCGCTGTACCTG
TGCTTTCCGCCGCCCCGGGGGCTGCGGGCCGTGGTCGTCATGCCCGAGGTGCAGATCAAGGGCCGGAAGACCGAGCAGTC
CCGGGGCGTCCTGCCCGCGCAGGTGAGCCTCCGGGACGCCGTCTACAACCTGAACCGCACCGCCCTCTTGGTGGCGGCGG
TGGCCCAGGGGCGCACGGACCTGCTCCGGGTGGCGATGCAGGACCGGCTGCACCAGCCCTACCGGGCCGCGCTGGTCCCC
GGCATGCGGTCGGTCTTCGAGGCCGCGCTCAGCGCCGGGGCGCTGGGCGTAGCGCTCTCGGGCGCCGGGCCCAGCGTCAT
CGCCCTCGTCGCCGAGTCCGCCGAGCCGGTGGCGCTGGCGATGGAGGCCGCCTTCCAGTGGGCGGGCAGCAACGCCCGGT
CGCTGACGATGGACCTGGCCCGGGAAGGGGCCCGGGTGCTGTCCGGGCCGGGCCGTGAGCAGGACATGCTGGACCGGCCG
CCGCACTGGGGTTGA

Upstream 100 bases:

>100_bases
GACCCCGACACGGCCATCCGGGTTTCGCCGCTGCCTGAGAAGCTGCCCGCCGACTACGGCCGGCTGGAGCGGCTGATCCT
CTCCGGGAGCTGAGCCCGCC

Downstream 100 bases:

>100_bases
GGAGACGGGACGAACGGATGCGACGAGTCCAGGGTGCGTGGGCACCCTGGACTCGTCGCATGATGGCGGGGACTGCCCGG
GGCACACGTGCGCCGCTCCC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MVRVSVPATSANLGPGFDTLGVALELRNVIEMDETGIDDVVIEVEGAGAGALEDPGRNMVYQAARLVFQRLGYEPNGLLI
REKVAIPVARGMGSSAAAIVGGLVAANALVQKRTGGPGLDREELLRMAVAIEGHPDNVTPALLGGFTVSCMDPDRGPLYL
CFPPPRGLRAVVVMPEVQIKGRKTEQSRGVLPAQVSLRDAVYNLNRTALLVAAVAQGRTDLLRVAMQDRLHQPYRAALVP
GMRSVFEAALSAGALGVALSGAGPSVIALVAESAEPVALAMEAAFQWAGSNARSLTMDLAREGARVLSGPGREQDMLDRP
PHWG

Sequences:

>Translated_324_residues
MVRVSVPATSANLGPGFDTLGVALELRNVIEMDETGIDDVVIEVEGAGAGALEDPGRNMVYQAARLVFQRLGYEPNGLLI
REKVAIPVARGMGSSAAAIVGGLVAANALVQKRTGGPGLDREELLRMAVAIEGHPDNVTPALLGGFTVSCMDPDRGPLYL
CFPPPRGLRAVVVMPEVQIKGRKTEQSRGVLPAQVSLRDAVYNLNRTALLVAAVAQGRTDLLRVAMQDRLHQPYRAALVP
GMRSVFEAALSAGALGVALSGAGPSVIALVAESAEPVALAMEAAFQWAGSNARSLTMDLAREGARVLSGPGREQDMLDRP
PHWG
>Mature_324_residues
MVRVSVPATSANLGPGFDTLGVALELRNVIEMDETGIDDVVIEVEGAGAGALEDPGRNMVYQAARLVFQRLGYEPNGLLI
REKVAIPVARGMGSSAAAIVGGLVAANALVQKRTGGPGLDREELLRMAVAIEGHPDNVTPALLGGFTVSCMDPDRGPLYL
CFPPPRGLRAVVVMPEVQIKGRKTEQSRGVLPAQVSLRDAVYNLNRTALLVAAVAQGRTDLLRVAMQDRLHQPYRAALVP
GMRSVFEAALSAGALGVALSGAGPSVIALVAESAEPVALAMEAAFQWAGSNARSLTMDLAREGARVLSGPGREQDMLDRP
PHWG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=310, Percent_Identity=31.6129032258064, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321814, Length=360, Percent_Identity=30.8333333333333, Blast_Score=153, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_SYMTH (Q67LA5)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076385.1
- ProteinModelPortal:   Q67LA5
- SMR:   Q67LA5
- GeneID:   2980478
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2556
- NMPDR:   fig|292459.1.peg.2446
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- BioCyc:   STHE292459:STH2556-MONOMER
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 34023; Mature: 34023

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVSVPATSANLGPGFDTLGVALELRNVIEMDETGIDDVVIEVEGAGAGALEDPGRNMV
CEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHH
YQAARLVFQRLGYEPNGLLIREKVAIPVARGMGSSAAAIVGGLVAANALVQKRTGGPGLD
HHHHHHHHHHHCCCCCCEEEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
REELLRMAVAIEGHPDNVTPALLGGFTVSCMDPDRGPLYLCFPPPRGLRAVVVMPEVQIK
HHHHHHHHHEECCCCCCCCHHHHCCEEEEEECCCCCCEEEECCCCCCCEEEEEECCEEEC
GRKTEQSRGVLPAQVSLRDAVYNLNRTALLVAAVAQGRTDLLRVAMQDRLHQPYRAALVP
CCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
GMRSVFEAALSAGALGVALSGAGPSVIALVAESAEPVALAMEAAFQWAGSNARSLTMDLA
HHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHH
REGARVLSGPGREQDMLDRPPHWG
HCCHHHHCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MVRVSVPATSANLGPGFDTLGVALELRNVIEMDETGIDDVVIEVEGAGAGALEDPGRNMV
CEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHH
YQAARLVFQRLGYEPNGLLIREKVAIPVARGMGSSAAAIVGGLVAANALVQKRTGGPGLD
HHHHHHHHHHHCCCCCCEEEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
REELLRMAVAIEGHPDNVTPALLGGFTVSCMDPDRGPLYLCFPPPRGLRAVVVMPEVQIK
HHHHHHHHHEECCCCCCCCHHHHCCEEEEEECCCCCCEEEECCCCCCCEEEEEECCEEEC
GRKTEQSRGVLPAQVSLRDAVYNLNRTALLVAAVAQGRTDLLRVAMQDRLHQPYRAALVP
CCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
GMRSVFEAALSAGALGVALSGAGPSVIALVAESAEPVALAMEAAFQWAGSNARSLTMDLA
HHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHH
REGARVLSGPGREQDMLDRPPHWG
HCCHHHHCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA