Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 51893695

GI number: 51893695

Start: 2742688

End: 2743887

Strand: Reverse

Name: thrC [H]

Synonym: STH2557

Alternate gene names: 51893695

Gene position: 2743887-2742688 (Counterclockwise)

Preceding gene: 51893696

Following gene: 51893694

Centisome position: 76.94

GC content: 73.08

Gene sequence:

>1200_bases
ATGGCCCGCTGGCACGGTGTCATCCGGCAGTACCAACGTTTTCTGCCCGTGAGCGAGAGGACCCCGGTGGTGACGCTGCT
GGAGGGCAACACCCCGCTGGTGCCGGCGCCCCGGCTGGGGGCGGAGCTGGGGCTCGATCTCTACCTGAAGTTCGAGGGGC
TGAACCCCACCGGCTCCTTCAAGGACCGGGGGATGACCCTCGCCATGTCCAAGGCGGTCGAGGCGGGGGCGAAGGCGGTG
ATCTGCGCCTCCACCGGCAACACCAGCGCCTCCGCGGCGGCCTACGCCGCCCGGGCGGGGCTGCCCTGCTACGTCGTCAT
CCCCGACGGCGCGGTCGCCATGGGCAAGCTCGCCCAGGCGCTGATGTACGGCGCCCGCACGATTCAGATCGAGGGCAACT
TCGACGACGGGCTCCGGCTGGTGCGCCGCCTGACCCAGGAGCACCCGGAGATCGCGCTGGTCAACTCGGTCAACCCGTAC
CGGCTCCAGGGGCAGAAGACCGCCGCCTTCGAGGTGGTGGACGCCCTGGGGGGCTACCCCGATTTCCTGGCGATCCCGGT
GGGCAACGCCGGCAACATCACCGCCTACTGGATGGGCTTCCAGGAGTACGCCGCCGCCGGCGTGGGCGCCGTCGAGTCCT
GTAGCTCCAGCGGGGCGCCTGCGGGGGCCCTCCTGCCCCGCATGCTGGGCTTCCAGGCGGCAGGGGCGGCGCCGCTGGTG
CACGGCGGCGAGGTGGAGGACCCGCAGACGGTGGGCACGGCCATCAGGATCGGCCGCCCAGCCAGCCGCGCCGGGGCGCT
GGCCGCGGCCCGGGAGTCGGGCGGGGCGTTCTGGGCGGTGACGGACGAGGAGATGCTGGCGGCCTACCGCCGGCTGGCGG
CGACCGAGGGCATCTTCGCTGAGCCCGCCTCCTGCGCCTCCGTGGCCGGGCTGATCAAGCTGTGCCGGCTCGGGTACTTC
GAGGGGCGCACCGGCAGTGCCGGCGATGTGTCCGGGGTCGGCGGTTTCATCGACGGCGTGCCCGCCCCGGTGCCGACCCA
CCGGCCCTTCACTGGCCGGGGCGGCCGGCCCAAGGTCGTCGCCGTACTGACCGGACACGGGCTCAAGGACCCCGACACGG
CCATCCGGGTTTCGCCGCTGCCTGAGAAGCTGCCCGCCGACTACGGCCGGCTGGAGCGGCTGATCCTCTCCGGGAGCTGA

Upstream 100 bases:

>100_bases
CACACCATGTACGCCGTCCTGCGGCGGGAATGGGCGCAGGCCTGAAGCGGATTCGGGCGCAGTCTGTGGGGATGGGATCG
TTCTGGACGGAGGTGTGCGC

Downstream 100 bases:

>100_bases
GCCCGCCATGGTCAGGGTCAGCGTGCCGGCGACCAGCGCCAACCTGGGGCCGGGGTTCGACACCCTGGGCGTGGCGCTGG
AGCTTCGCAACGTGATCGAG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MARWHGVIRQYQRFLPVSERTPVVTLLEGNTPLVPAPRLGAELGLDLYLKFEGLNPTGSFKDRGMTLAMSKAVEAGAKAV
ICASTGNTSASAAAYAARAGLPCYVVIPDGAVAMGKLAQALMYGARTIQIEGNFDDGLRLVRRLTQEHPEIALVNSVNPY
RLQGQKTAAFEVVDALGGYPDFLAIPVGNAGNITAYWMGFQEYAAAGVGAVESCSSSGAPAGALLPRMLGFQAAGAAPLV
HGGEVEDPQTVGTAIRIGRPASRAGALAAARESGGAFWAVTDEEMLAAYRRLAATEGIFAEPASCASVAGLIKLCRLGYF
EGRTGSAGDVSGVGGFIDGVPAPVPTHRPFTGRGGRPKVVAVLTGHGLKDPDTAIRVSPLPEKLPADYGRLERLILSGS

Sequences:

>Translated_399_residues
MARWHGVIRQYQRFLPVSERTPVVTLLEGNTPLVPAPRLGAELGLDLYLKFEGLNPTGSFKDRGMTLAMSKAVEAGAKAV
ICASTGNTSASAAAYAARAGLPCYVVIPDGAVAMGKLAQALMYGARTIQIEGNFDDGLRLVRRLTQEHPEIALVNSVNPY
RLQGQKTAAFEVVDALGGYPDFLAIPVGNAGNITAYWMGFQEYAAAGVGAVESCSSSGAPAGALLPRMLGFQAAGAAPLV
HGGEVEDPQTVGTAIRIGRPASRAGALAAARESGGAFWAVTDEEMLAAYRRLAATEGIFAEPASCASVAGLIKLCRLGYF
EGRTGSAGDVSGVGGFIDGVPAPVPTHRPFTGRGGRPKVVAVLTGHGLKDPDTAIRVSPLPEKLPADYGRLERLILSGS
>Mature_398_residues
ARWHGVIRQYQRFLPVSERTPVVTLLEGNTPLVPAPRLGAELGLDLYLKFEGLNPTGSFKDRGMTLAMSKAVEAGAKAVI
CASTGNTSASAAAYAARAGLPCYVVIPDGAVAMGKLAQALMYGARTIQIEGNFDDGLRLVRRLTQEHPEIALVNSVNPYR
LQGQKTAAFEVVDALGGYPDFLAIPVGNAGNITAYWMGFQEYAAAGVGAVESCSSSGAPAGALLPRMLGFQAAGAAPLVH
GGEVEDPQTVGTAIRIGRPASRAGALAAARESGGAFWAVTDEEMLAAYRRLAATEGIFAEPASCASVAGLIKLCRLGYFE
GRTGSAGDVSGVGGFIDGVPAPVPTHRPFTGRGGRPKVVAVLTGHGLKDPDTAIRVSPLPEKLPADYGRLERLILSGS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=211, Percent_Identity=32.7014218009479, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI2367138, Length=184, Percent_Identity=32.6086956521739, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322631, Length=286, Percent_Identity=26.5734265734266, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 41417; Mature: 41286

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARWHGVIRQYQRFLPVSERTPVVTLLEGNTPLVPAPRLGAELGLDLYLKFEGLNPTGSF
CCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHCCCEEEEEEECCCCCCCC
KDRGMTLAMSKAVEAGAKAVICASTGNTSASAAAYAARAGLPCYVVIPDGAVAMGKLAQA
CCCCEEEEHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LMYGARTIQIEGNFDDGLRLVRRLTQEHPEIALVNSVNPYRLQGQKTAAFEVVDALGGYP
HHHCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCC
DFLAIPVGNAGNITAYWMGFQEYAAAGVGAVESCSSSGAPAGALLPRMLGFQAAGAAPLV
CEEEEECCCCCCEEEEEECHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC
HGGEVEDPQTVGTAIRIGRPASRAGALAAARESGGAFWAVTDEEMLAAYRRLAATEGIFA
CCCCCCCCHHHCCEEEECCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCC
EPASCASVAGLIKLCRLGYFEGRTGSAGDVSGVGGFIDGVPAPVPTHRPFTGRGGRPKVV
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEE
AVLTGHGLKDPDTAIRVSPLPEKLPADYGRLERLILSGS
EEEECCCCCCCCCEEEECCCCHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
ARWHGVIRQYQRFLPVSERTPVVTLLEGNTPLVPAPRLGAELGLDLYLKFEGLNPTGSF
CHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHCCCEEEEEEECCCCCCCC
KDRGMTLAMSKAVEAGAKAVICASTGNTSASAAAYAARAGLPCYVVIPDGAVAMGKLAQA
CCCCEEEEHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LMYGARTIQIEGNFDDGLRLVRRLTQEHPEIALVNSVNPYRLQGQKTAAFEVVDALGGYP
HHHCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCC
DFLAIPVGNAGNITAYWMGFQEYAAAGVGAVESCSSSGAPAGALLPRMLGFQAAGAAPLV
CEEEEECCCCCCEEEEEECHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC
HGGEVEDPQTVGTAIRIGRPASRAGALAAARESGGAFWAVTDEEMLAAYRRLAATEGIFA
CCCCCCCCHHHCCEEEECCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCC
EPASCASVAGLIKLCRLGYFEGRTGSAGDVSGVGGFIDGVPAPVPTHRPFTGRGGRPKVV
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEE
AVLTGHGLKDPDTAIRVSPLPEKLPADYGRLERLILSGS
EEEECCCCCCCCCEEEECCCCHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]