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The map label for this gene is sucC [H]

Identifier: 51893671

GI number: 51893671

Start: 2717284

End: 2718405

Strand: Reverse

Name: sucC [H]

Synonym: STH2533

Alternate gene names: 51893671

Gene position: 2718405-2717284 (Counterclockwise)

Preceding gene: 51893672

Following gene: 51893670

Centisome position: 76.23

GC content: 67.2

Gene sequence:

>1122_bases
ATGAAGCTGTACGAGTACCTGGCCAAGCAGATGTTTGCTGAGCACGGCGTCCCCACGGGGAACGGCATTCTCTGCACCAC
GCCTGAGGAGGCGGAGGAGGCCGCGCGCAAGATCGGTCCGTGCGCCATCAAGGCGCAGGTCCTCGTCGGCGGCCGGGGCA
AGGCCGGCGGCATCAAGCTGGCCAATACGCCGGAGGAAGCACGGGAGCGGGCCCGGGAGATCCTGGGCATGAACCTGAAG
GGGTACATCGTGGACAAGGTCCTGGTCGATCCCCAGATTAAGATCGAGAAGGAGTACTACGTCTCGATTACCCTGGACGG
CATGGCCAAGAAGCCGCTGGTCATGGCTTCCGAGTACGGCGGCGTGGAGATCGAGTCGGTCCCGCACGACAAGATCGTCT
TCGAGCACATCGATATCGAGACGGGGCTCCTGCCGTTCCAGGCCCGGGAGATCGCCCGGAAGATCAACCTCACTGGCGAC
CTCGCCGATCAGTTCGTGCGGATCCTGACCGGCCTCTACCAGGCCTTCCGCAAGTACGATGCCGAGCTGGTGGAGATCAA
CCCGCTCGCGCTGACCGACGGCGGCACGCGGCTCATCGCCGCCGACGGCCGCTTCAACGTGGAGGACGACGCCCTCTTCC
GTCACCCCGAGTTCCCGCGGGTGGAGGAGGGCACCGAGCTGGAGAAGAAGGTGCGCGCCATCGGCCTCGCCTTCGTGCAG
CTGGACGGCGACATCGCGGTGATGGCCAACGGCGCCGGCATGGCGATGGGCACCCTCGATACCCTGGCGTACTACGGCGG
CCGGCCGGCCAACTTCCTGGATGCCGGCGGCGGCTCCGGCGTGGAGCCCACGGCCCAGGCCTTCGACGCGCTCCTGGGGA
CCAAGCCCAAGGCCATCTTCGTCAACATCTTCGGCGGTATCACCCGCTGCGACCTGGTGGCGGAGGCCATCGTGCAGGTG
AAGAAGGCGAAGGGCATCGACGTGCCGCTGGTCGTCCGCATGGTGGGCACCAACGACGTCCGCGGCCGGGAGATCCTGGC
GGAGGCGGGCATCCAGGCGTACACCGACATGGGCGAGGCCGCGAAGGCCGCGGTCGAGGCTGCCTACGGCAAGGGGGCGT
AG

Upstream 100 bases:

>100_bases
ATGCGATTTCCAACAGGAGTTTATCTGTGGTAGAATTCGTTGGAGCGTATTGGATTCGGCGCACCATCACCAAGCATCGC
ATTCACCTGGAGGTGGGCGG

Downstream 100 bases:

>100_bases
CAGAGCATGGCGGTCATCATCGACAGGAACACGCGTGCAATCGTTCAGGGCATCACAGGTTCGCAGGGCCAGTTCCACAC
CGGCCAGATGCTGGCCTTCG

Product: succinyl-CoA synthetase beta subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKLYEYLAKQMFAEHGVPTGNGILCTTPEEAEEAARKIGPCAIKAQVLVGGRGKAGGIKLANTPEEARERAREILGMNLK
GYIVDKVLVDPQIKIEKEYYVSITLDGMAKKPLVMASEYGGVEIESVPHDKIVFEHIDIETGLLPFQAREIARKINLTGD
LADQFVRILTGLYQAFRKYDAELVEINPLALTDGGTRLIAADGRFNVEDDALFRHPEFPRVEEGTELEKKVRAIGLAFVQ
LDGDIAVMANGAGMAMGTLDTLAYYGGRPANFLDAGGGSGVEPTAQAFDALLGTKPKAIFVNIFGGITRCDLVAEAIVQV
KKAKGIDVPLVVRMVGTNDVRGREILAEAGIQAYTDMGEAAKAAVEAAYGKGA

Sequences:

>Translated_373_residues
MKLYEYLAKQMFAEHGVPTGNGILCTTPEEAEEAARKIGPCAIKAQVLVGGRGKAGGIKLANTPEEARERAREILGMNLK
GYIVDKVLVDPQIKIEKEYYVSITLDGMAKKPLVMASEYGGVEIESVPHDKIVFEHIDIETGLLPFQAREIARKINLTGD
LADQFVRILTGLYQAFRKYDAELVEINPLALTDGGTRLIAADGRFNVEDDALFRHPEFPRVEEGTELEKKVRAIGLAFVQ
LDGDIAVMANGAGMAMGTLDTLAYYGGRPANFLDAGGGSGVEPTAQAFDALLGTKPKAIFVNIFGGITRCDLVAEAIVQV
KKAKGIDVPLVVRMVGTNDVRGREILAEAGIQAYTDMGEAAKAAVEAAYGKGA
>Mature_373_residues
MKLYEYLAKQMFAEHGVPTGNGILCTTPEEAEEAARKIGPCAIKAQVLVGGRGKAGGIKLANTPEEARERAREILGMNLK
GYIVDKVLVDPQIKIEKEYYVSITLDGMAKKPLVMASEYGGVEIESVPHDKIVFEHIDIETGLLPFQAREIARKINLTGD
LADQFVRILTGLYQAFRKYDAELVEINPLALTDGGTRLIAADGRFNVEDDALFRHPEFPRVEEGTELEKKVRAIGLAFVQ
LDGDIAVMANGAGMAMGTLDTLAYYGGRPANFLDAGGGSGVEPTAQAFDALLGTKPKAIFVNIFGGITRCDLVAEAIVQV
KKAKGIDVPLVVRMVGTNDVRGREILAEAGIQAYTDMGEAAKAAVEAAYGKGA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=391, Percent_Identity=35.8056265984655, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI157779135, Length=375, Percent_Identity=36.2666666666667, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI294862256, Length=361, Percent_Identity=36.5650969529086, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1786948, Length=389, Percent_Identity=43.1876606683805, Blast_Score=271, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17567829, Length=364, Percent_Identity=38.1868131868132, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17539378, Length=395, Percent_Identity=32.9113924050633, Blast_Score=202, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6321683, Length=393, Percent_Identity=36.6412213740458, Blast_Score=239, Evalue=7e-64,
Organism=Drosophila melanogaster, GI161078106, Length=394, Percent_Identity=37.0558375634518, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24645208, Length=394, Percent_Identity=37.0558375634518, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI281361397, Length=394, Percent_Identity=36.8020304568528, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI281361395, Length=394, Percent_Identity=36.8020304568528, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI21356231, Length=395, Percent_Identity=35.4430379746835, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 40059; Mature: 40059

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYEYLAKQMFAEHGVPTGNGILCTTPEEAEEAARKIGPCAIKAQVLVGGRGKAGGIKL
CCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEE
ANTPEEARERAREILGMNLKGYIVDKVLVDPQIKIEKEYYVSITLDGMAKKPLVMASEYG
CCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEEEEEEECCCCCCCEEEEECCC
GVEIESVPHDKIVFEHIDIETGLLPFQAREIARKINLTGDLADQFVRILTGLYQAFRKYD
CEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
AELVEINPLALTDGGTRLIAADGRFNVEDDALFRHPEFPRVEEGTELEKKVRAIGLAFVQ
CEEEEECCEEEECCCCEEEEECCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHEEEEEE
LDGDIAVMANGAGMAMGTLDTLAYYGGRPANFLDAGGGSGVEPTAQAFDALLGTKPKAIF
ECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCEEE
VNIFGGITRCDLVAEAIVQVKKAKGIDVPLVVRMVGTNDVRGREILAEAGIQAYTDMGEA
EEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHH
AKAAVEAAYGKGA
HHHHHHHHCCCCC
>Mature Secondary Structure
MKLYEYLAKQMFAEHGVPTGNGILCTTPEEAEEAARKIGPCAIKAQVLVGGRGKAGGIKL
CCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEE
ANTPEEARERAREILGMNLKGYIVDKVLVDPQIKIEKEYYVSITLDGMAKKPLVMASEYG
CCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEEEEEEECCCCCCCEEEEECCC
GVEIESVPHDKIVFEHIDIETGLLPFQAREIARKINLTGDLADQFVRILTGLYQAFRKYD
CEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
AELVEINPLALTDGGTRLIAADGRFNVEDDALFRHPEFPRVEEGTELEKKVRAIGLAFVQ
CEEEEECCEEEECCCCEEEEECCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHEEEEEE
LDGDIAVMANGAGMAMGTLDTLAYYGGRPANFLDAGGGSGVEPTAQAFDALLGTKPKAIF
ECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCEEE
VNIFGGITRCDLVAEAIVQVKKAKGIDVPLVVRMVGTNDVRGREILAEAGIQAYTDMGEA
EEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHH
AKAAVEAAYGKGA
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA