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The map label for this gene is sucD2 [H]

Identifier: 51893670

GI number: 51893670

Start: 2716405

End: 2717277

Strand: Reverse

Name: sucD2 [H]

Synonym: STH2532

Alternate gene names: 51893670

Gene position: 2717277-2716405 (Counterclockwise)

Preceding gene: 51893671

Following gene: 51893669

Centisome position: 76.2

GC content: 66.9

Gene sequence:

>873_bases
ATGGCGGTCATCATCGACAGGAACACGCGTGCAATCGTTCAGGGCATCACAGGTTCGCAGGGCCAGTTCCACACCGGCCA
GATGCTGGCCTTCGGCACCAACATCGTCGGCGGCGTGAACTTCAAGAAGGCGGGCCAGCAGGTCCAGGGCGTGCCGGTGT
TCGCCACGGTCCACGAGGCCGTGGAGAAGACCGGGGCCAACGCTTCGGTGATGTTCGTGCCCGCGCCCGGCGTGAAGGAC
GCCGCTTTCGAGGCCATCCACGCGGGCATCAAGGTGCTGGTGCTCATCCCCGAGCACGTGCCGACGCAGGAGACCATGGA
GATCATGGCCTACGCCAAGCGGCACGGCGTGCGCGTCATCGGCCCCAATACCTTCGGCATCATCTCGCCCGGCGAGAAGT
GCAAGCTGGGGATCATGCCGAACCACATCTACAAGCCCGGTCCCGTGGGCATCGTGGCCCGCTCGGGAACCCTGTCCTAT
GAGATTGCCTTCAACCTCTCCAACGCCGGTCTGGGCCAGACCACGGTCATCGGCATGGGCGGCGACCGGGTGATCGGCAC
CAACTTCGTCGACGCCCTGGAGCTGTTCAACGCCGACCCCGCCACCGAGGCGATCGTCATGGTCGGCGAGATCGGCGGCA
TCCAGGAGGAGCTGGCCGCGGAGTACATCAAGCAGCACGTGCGCAAGCCGGTGGTGGCCTACCTGGCCGGCAAGTCGGCG
CCCCCCGGGAAGCGCATGGGTCACGCGGGCGCCATCATCGAGGGCAACCGGGGCACGTACCAGTCCAAGGTGGAGGCCCT
CACCGCCGCGGGCGTCAAGGTTGCCGCCCTGCCGTGGGAGATCGTCGACCTGGTGCGCGAGGCGCTGAAGTAG

Upstream 100 bases:

>100_bases
GGAGATCCTGGCGGAGGCGGGCATCCAGGCGTACACCGACATGGGCGAGGCCGCGAAGGCCGCGGTCGAGGCTGCCTACG
GCAAGGGGGCGTAGCAGAGC

Downstream 100 bases:

>100_bases
GGGCGCACGCGGCGGGCAAGAGCCGCGGGGACAATAAGGGCGATGGCCGTTCGGGGGCAGCAGCGCATCGGCTGCTGCCC
CGTTGCTGTTGCCCCGGCCC

Product: succinyl-CoA synthetase alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha 2; SCS-alpha 2 [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MAVIIDRNTRAIVQGITGSQGQFHTGQMLAFGTNIVGGVNFKKAGQQVQGVPVFATVHEAVEKTGANASVMFVPAPGVKD
AAFEAIHAGIKVLVLIPEHVPTQETMEIMAYAKRHGVRVIGPNTFGIISPGEKCKLGIMPNHIYKPGPVGIVARSGTLSY
EIAFNLSNAGLGQTTVIGMGGDRVIGTNFVDALELFNADPATEAIVMVGEIGGIQEELAAEYIKQHVRKPVVAYLAGKSA
PPGKRMGHAGAIIEGNRGTYQSKVEALTAAGVKVAALPWEIVDLVREALK

Sequences:

>Translated_290_residues
MAVIIDRNTRAIVQGITGSQGQFHTGQMLAFGTNIVGGVNFKKAGQQVQGVPVFATVHEAVEKTGANASVMFVPAPGVKD
AAFEAIHAGIKVLVLIPEHVPTQETMEIMAYAKRHGVRVIGPNTFGIISPGEKCKLGIMPNHIYKPGPVGIVARSGTLSY
EIAFNLSNAGLGQTTVIGMGGDRVIGTNFVDALELFNADPATEAIVMVGEIGGIQEELAAEYIKQHVRKPVVAYLAGKSA
PPGKRMGHAGAIIEGNRGTYQSKVEALTAAGVKVAALPWEIVDLVREALK
>Mature_289_residues
AVIIDRNTRAIVQGITGSQGQFHTGQMLAFGTNIVGGVNFKKAGQQVQGVPVFATVHEAVEKTGANASVMFVPAPGVKDA
AFEAIHAGIKVLVLIPEHVPTQETMEIMAYAKRHGVRVIGPNTFGIISPGEKCKLGIMPNHIYKPGPVGIVARSGTLSYE
IAFNLSNAGLGQTTVIGMGGDRVIGTNFVDALELFNADPATEAIVMVGEIGGIQEELAAEYIKQHVRKPVVAYLAGKSAP
PGKRMGHAGAIIEGNRGTYQSKVEALTAAGVKVAALPWEIVDLVREALK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=284, Percent_Identity=50.3521126760563, Blast_Score=227, Evalue=8e-60,
Organism=Homo sapiens, GI38569421, Length=298, Percent_Identity=29.5302013422819, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI38569423, Length=297, Percent_Identity=29.6296296296296, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786949, Length=290, Percent_Identity=55.5172413793103, Blast_Score=318, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17550194, Length=282, Percent_Identity=50, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=49.3150684931507, Blast_Score=253, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI17557344, Length=255, Percent_Identity=32.9411764705882, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=256, Percent_Identity=33.203125, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=284, Percent_Identity=44.3661971830986, Blast_Score=225, Evalue=7e-60,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=46.551724137931, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI28574296, Length=282, Percent_Identity=47.8723404255319, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI281363477, Length=239, Percent_Identity=31.7991631799163, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363475, Length=239, Percent_Identity=31.7991631799163, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281363473, Length=239, Percent_Identity=31.7991631799163, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30468; Mature: 30337

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIIDRNTRAIVQGITGSQGQFHTGQMLAFGTNIVGGVNFKKAGQQVQGVPVFATVHEA
CEEEEECCCEEEEECCCCCCCCCCCCCEEEECCCEECCCCHHHCCCHHCCCCHHHHHHHH
VEKTGANASVMFVPAPGVKDAAFEAIHAGIKVLVLIPEHVPTQETMEIMAYAKRHGVRVI
HHHCCCCCEEEEEECCCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEE
GPNTFGIISPGEKCKLGIMPNHIYKPGPVGIVARSGTLSYEIAFNLSNAGLGQTTVIGMG
CCCCEEEECCCCCEEEECCCCCCCCCCCEEEEEECCEEEEEEEEEECCCCCCCEEEEECC
GDRVIGTNFVDALELFNADPATEAIVMVGEIGGIQEELAAEYIKQHVRKPVVAYLAGKSA
CCEEECCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCHHEEECCCCCC
PPGKRMGHAGAIIEGNRGTYQSKVEALTAAGVKVAALPWEIVDLVREALK
CCCCCCCCCCCEEECCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
AVIIDRNTRAIVQGITGSQGQFHTGQMLAFGTNIVGGVNFKKAGQQVQGVPVFATVHEA
EEEEECCCEEEEECCCCCCCCCCCCCEEEECCCEECCCCHHHCCCHHCCCCHHHHHHHH
VEKTGANASVMFVPAPGVKDAAFEAIHAGIKVLVLIPEHVPTQETMEIMAYAKRHGVRVI
HHHCCCCCEEEEEECCCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEE
GPNTFGIISPGEKCKLGIMPNHIYKPGPVGIVARSGTLSYEIAFNLSNAGLGQTTVIGMG
CCCCEEEECCCCCEEEECCCCCCCCCCCEEEEEECCEEEEEEEEEECCCCCCCEEEEECC
GDRVIGTNFVDALELFNADPATEAIVMVGEIGGIQEELAAEYIKQHVRKPVVAYLAGKSA
CCEEECCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCHHEEECCCCCC
PPGKRMGHAGAIIEGNRGTYQSKVEALTAAGVKVAALPWEIVDLVREALK
CCCCCCCCCCCEEECCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]