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The map label for this gene is arsM [C]

Identifier: 51893507

GI number: 51893507

Start: 2558854

End: 2559690

Strand: Reverse

Name: arsM [C]

Synonym: STH2369

Alternate gene names: 51893507

Gene position: 2559690-2558854 (Counterclockwise)

Preceding gene: 51893508

Following gene: 51893506

Centisome position: 71.78

GC content: 69.41

Gene sequence:

>837_bases
GTGTGGATGGACGCGCACGCGCTGCGTGAGATGGTACGGAAGCGCTATGCCGAAGCGGCCCGGGGTTCCGCCGCCGGCTC
GGCGGGCGGGTGCTGTGCTCCGGAGCCAAAGGGGGATGACCTCCTGGTGGTGAGCGGCTGTTGCTGCGGCAGCGGGGCCG
GGGGGGAGGAGCTGGGGAGGGTCCTCGGGTACTCCGACGACGAACTGGCCGCGGCGCCCGCAGGCGCAGACCTTGGTCTG
GGATGCGGCAACCCGCAGGCGATCGCGAGCCTGAAGCCGGGCGAGACGGTGCTGGACCTGGGGAGCGGGGCCGGGTTCGA
CTGCTTCCTCGCCGCACGCCAGGTTGGGGAGAGCGGCAGGGTGATCGGGGTGGACATGACGCCCGAGATGCTGGCTCGGG
CCCGCGAGAACGCCCGCAAGGGCGGATTCGCCAACGTCGAGTTCCGCCTCGGCGAGATCGAACACCTGCCGGTGGCGGAC
GAGAGCGTGGACGTGATCATCTCCAACTGCGTGATCAACCTCTCGCCGGAGAAGGAGCAGGTGTTCCGGGAGGCCTTCCG
GGTTCTGCGGCCCGGCGGCCGGATTGCGGTGGCCGACATGGTAAGCCTCGCCCCGCTTCCGCCCGAGGTCAGGGAGGACC
TGGCCCTTTACGCCGGATGCGTGGCGGGCGTGGCCACGGTTGGCGAGTTGCGGACCATGCTCACGGAGGCTGGCTTTGTC
GACATCGTCATCCGGCCCAAAGATAGCGAGCAGTTGTTGGAAGCCTGGGGAGCCGGCGAGTCCTTGAAGAACCAGGTGTT
CTCGGCGACCATCGAGGCGCGGAAGCCGACCGCGTGA

Upstream 100 bases:

>100_bases
AAGCCGGACGTCGGTTGTCGTCGTTGGAGCCGCTGACCCGGGGGCGCTGCCGGCCGGGAGGCGGCTTCGGGCATGGGGGC
TGCAGGAAATCAGAGGAGGG

Downstream 100 bases:

>100_bases
GATGAACGAGCCCTGCGGCGCACGCAGGGCTCTTGCTGTCGCAGGGGGCTACCGGATGCTCTCGGCCAGTCGGACCAGGT
CGGTACCTTCCGGCCCCGGA

Product: arsenite S-adenosylmethyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MWMDAHALREMVRKRYAEAARGSAAGSAGGCCAPEPKGDDLLVVSGCCCGSGAGGEELGRVLGYSDDELAAAPAGADLGL
GCGNPQAIASLKPGETVLDLGSGAGFDCFLAARQVGESGRVIGVDMTPEMLARARENARKGGFANVEFRLGEIEHLPVAD
ESVDVIISNCVINLSPEKEQVFREAFRVLRPGGRIAVADMVSLAPLPPEVREDLALYAGCVAGVATVGELRTMLTEAGFV
DIVIRPKDSEQLLEAWGAGESLKNQVFSATIEARKPTA

Sequences:

>Translated_278_residues
MWMDAHALREMVRKRYAEAARGSAAGSAGGCCAPEPKGDDLLVVSGCCCGSGAGGEELGRVLGYSDDELAAAPAGADLGL
GCGNPQAIASLKPGETVLDLGSGAGFDCFLAARQVGESGRVIGVDMTPEMLARARENARKGGFANVEFRLGEIEHLPVAD
ESVDVIISNCVINLSPEKEQVFREAFRVLRPGGRIAVADMVSLAPLPPEVREDLALYAGCVAGVATVGELRTMLTEAGFV
DIVIRPKDSEQLLEAWGAGESLKNQVFSATIEARKPTA
>Mature_278_residues
MWMDAHALREMVRKRYAEAARGSAAGSAGGCCAPEPKGDDLLVVSGCCCGSGAGGEELGRVLGYSDDELAAAPAGADLGL
GCGNPQAIASLKPGETVLDLGSGAGFDCFLAARQVGESGRVIGVDMTPEMLARARENARKGGFANVEFRLGEIEHLPVAD
ESVDVIISNCVINLSPEKEQVFREAFRVLRPGGRIAVADMVSLAPLPPEVREDLALYAGCVAGVATVGELRTMLTEAGFV
DIVIRPKDSEQLLEAWGAGESLKNQVFSATIEARKPTA

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI109389364, Length=152, Percent_Identity=40.7894736842105, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI48994983, Length=111, Percent_Identity=36.036036036036, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR005149
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08241 Methyltransf_11; PF03551 PadR [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 28989; Mature: 28989

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWMDAHALREMVRKRYAEAARGSAAGSAGGCCAPEPKGDDLLVVSGCCCGSGAGGEELGR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHH
VLGYSDDELAAAPAGADLGLGCGNPQAIASLKPGETVLDLGSGAGFDCFLAARQVGESGR
HHCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCEEEECCCCCCHHHHHHHHHCCCCCC
VIGVDMTPEMLARARENARKGGFANVEFRLGEIEHLPVADESVDVIISNCVINLSPEKEQ
EEEECCCHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCHHHEEEEEEEEECCCCHHH
VFREAFRVLRPGGRIAVADMVSLAPLPPEVREDLALYAGCVAGVATVGELRTMLTEAGFV
HHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
DIVIRPKDSEQLLEAWGAGESLKNQVFSATIEARKPTA
EEEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MWMDAHALREMVRKRYAEAARGSAAGSAGGCCAPEPKGDDLLVVSGCCCGSGAGGEELGR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHH
VLGYSDDELAAAPAGADLGLGCGNPQAIASLKPGETVLDLGSGAGFDCFLAARQVGESGR
HHCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCEEEECCCCCCHHHHHHHHHCCCCCC
VIGVDMTPEMLARARENARKGGFANVEFRLGEIEHLPVADESVDVIISNCVINLSPEKEQ
EEEECCCHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCHHHEEEEEEEEECCCCHHH
VFREAFRVLRPGGRIAVADMVSLAPLPPEVREDLALYAGCVAGVATVGELRTMLTEAGFV
HHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
DIVIRPKDSEQLLEAWGAGESLKNQVFSATIEARKPTA
EEEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2155856 [H]