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The map label for this gene is tipA [H]

Identifier: 51893322

GI number: 51893322

Start: 2339889

End: 2340617

Strand: Reverse

Name: tipA [H]

Synonym: STH2184

Alternate gene names: 51893322

Gene position: 2340617-2339889 (Counterclockwise)

Preceding gene: 51893325

Following gene: 51893321

Centisome position: 65.63

GC content: 68.59

Gene sequence:

>729_bases
TTGAACCGGCGTGGCTGGAAGATCGGTGAGCTGGCCCGGCGGGTCGGCATCACGGTGCGGACTCTCCACCACTACGATCA
CATCGGCCTGCTGTCGCCTTCCTCCAGTACCGAGGCGGGACACCGGGTCTACTCGGACGCCGACGTGCGCAGGCTGCTTT
CCATCATCTCGCTGAAGCGGCTGGGGTTCTCGCTGCGCGAGATCAAGGTGCTGCTCAGCGATGCCGCCGAGGATCCCCGG
GCGATGCTGCAGGTCCAGCTGGCCCGGCTGGACGAGCAGATCGCGGCGCTGACGGAGGTGCGCGCGCACGTGCAGCGCCT
GCACGATCACCTGGAGGTCGGCGGGTCGGTGGCCATCGAGGAGCTGATGGCCGTGGCCCATGCGCTGACGCTGACCGGGA
GCCCGCATTTCCGCCGGGATGAGGTCGAACAGGTGCGTCAGAAGTACCTGGGATTGGATCCCGCGGTCCGGCGGGAGCTG
TTCGAGACCGGCCGGCGGCTGGTGGCCGAGTTCCGCCGGTACTTCGACGCGGGGATCGCTCCTGACGCCCCCGCTGTCAC
CGCCCTGGCGCGGCGCTGGAAGGAGGTCACCGGCGCGCTCCTGCCCGCCGGTGAACCGCTGACGCAGGCCGCCGAGCAGT
ATTATCGGGACAACCCTGACGCCGGGCTGCTCTACGGCATGGACGTCGACTTGTACCGCTACATCAAGCAGGCGGCTTCG
CGCGTGTAA

Upstream 100 bases:

>100_bases
CCACCGAGTATAGAACCTGACGTTGCGTCAGGTTCAAGCCCCGTCCGCACGGGCGCGCACCGGAAGGGAGGCCGGGGCAG
ACCGAAAGGGGGCAGGGTTC

Downstream 100 bases:

>100_bases
ATGGGAAGGCGGCCCGGGCGAGGGGGTGGGGGCCAGCATGGAGGTGACCCCGGCTGCACGACCGATCCGGGCGTCGCGCA
GGCGGCTCCTGGAGGCACGG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MNRRGWKIGELARRVGITVRTLHHYDHIGLLSPSSSTEAGHRVYSDADVRRLLSIISLKRLGFSLREIKVLLSDAAEDPR
AMLQVQLARLDEQIAALTEVRAHVQRLHDHLEVGGSVAIEELMAVAHALTLTGSPHFRRDEVEQVRQKYLGLDPAVRREL
FETGRRLVAEFRRYFDAGIAPDAPAVTALARRWKEVTGALLPAGEPLTQAAEQYYRDNPDAGLLYGMDVDLYRYIKQAAS
RV

Sequences:

>Translated_242_residues
MNRRGWKIGELARRVGITVRTLHHYDHIGLLSPSSSTEAGHRVYSDADVRRLLSIISLKRLGFSLREIKVLLSDAAEDPR
AMLQVQLARLDEQIAALTEVRAHVQRLHDHLEVGGSVAIEELMAVAHALTLTGSPHFRRDEVEQVRQKYLGLDPAVRREL
FETGRRLVAEFRRYFDAGIAPDAPAVTALARRWKEVTGALLPAGEPLTQAAEQYYRDNPDAGLLYGMDVDLYRYIKQAAS
RV
>Mature_242_residues
MNRRGWKIGELARRVGITVRTLHHYDHIGLLSPSSSTEAGHRVYSDADVRRLLSIISLKRLGFSLREIKVLLSDAAEDPR
AMLQVQLARLDEQIAALTEVRAHVQRLHDHLEVGGSVAIEELMAVAHALTLTGSPHFRRDEVEQVRQKYLGLDPAVRREL
FETGRRLVAEFRRYFDAGIAPDAPAVTALARRWKEVTGALLPAGEPLTQAAEQYYRDNPDAGLLYGMDVDLYRYIKQAAS
RV

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=111, Percent_Identity=31.5315315315315, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 27227; Mature: 27227

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRGWKIGELARRVGITVRTLHHYDHIGLLSPSSSTEAGHRVYSDADVRRLLSIISLKR
CCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHH
LGFSLREIKVLLSDAAEDPRAMLQVQLARLDEQIAALTEVRAHVQRLHDHLEVGGSVAIE
HCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELMAVAHALTLTGSPHFRRDEVEQVRQKYLGLDPAVRRELFETGRRLVAEFRRYFDAGIA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDAPAVTALARRWKEVTGALLPAGEPLTQAAEQYYRDNPDAGLLYGMDVDLYRYIKQAAS
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHH
RV
CC
>Mature Secondary Structure
MNRRGWKIGELARRVGITVRTLHHYDHIGLLSPSSSTEAGHRVYSDADVRRLLSIISLKR
CCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHH
LGFSLREIKVLLSDAAEDPRAMLQVQLARLDEQIAALTEVRAHVQRLHDHLEVGGSVAIE
HCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELMAVAHALTLTGSPHFRRDEVEQVRQKYLGLDPAVRRELFETGRRLVAEFRRYFDAGIA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDAPAVTALARRWKEVTGALLPAGEPLTQAAEQYYRDNPDAGLLYGMDVDLYRYIKQAAS
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHH
RV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]