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The map label for this gene is bfmBAB [H]

Identifier: 51893299

GI number: 51893299

Start: 2304754

End: 2305737

Strand: Reverse

Name: bfmBAB [H]

Synonym: STH2161

Alternate gene names: 51893299

Gene position: 2305737-2304754 (Counterclockwise)

Preceding gene: 51893300

Following gene: 51893298

Centisome position: 64.66

GC content: 68.6

Gene sequence:

>984_bases
ATGCCGGTGATGAACCTGGTGGAGGCCGTGCGCGACGCGCTGCGCACCGAGATGCGCCGCGACCCCGACGTCTGGATCGT
GGGGGAGGACGTCGGGAAGAAGGGCGGCGTCTTCGGGGCGACGCTGGGGCTCTACGACGAGTTCGGCCCCCAGCGGGTGA
TGGACTCGCCGCTCACCGAGTCGGCCATCGTCGGCGTGGGCATCGGGGCGGCGCTCTACGGCACCAAGCCCGTCTGCGAG
ATCCAGTTCGCCGACTTCATCTTCCCGGCGATGAACCAGATCGTCTCCGAGGCGGCCAAGATGCGCTACCGCTCCAACAG
CGCCTGGACGGTGCCGATGGTGATCCGGGCGCCCTTCGGCGGCGGGGTGCACGGCGGGCTGTACCACTCCCAGTCCGTGG
AGCAGTACTTCACCAACACCGCCGGCCTGAAGGTGGTGGTGCCGTCCACCCCGTACGACGCCAAGGGGCTGCTCATCTCG
GCCATCCGGGATCCCGACCCGGTGCTCTTCTTCGAACATAAGGGGCTCTACCGCGCGGTGAAGGGCGAGGTCCCCGAGGG
GGACTATACCATCCCCATCGGCAAGGCCGAGGTGAAGCGGGACGGCACCGACATCACCGTGATCACCTACGGCAAGGTGG
TCCACTTCTGCCTGGAGGCCGCCGAGCTGCTTGCCCGGGAGGGGTACGAGGCCCTGGTGCTGGACCTCAGAACCCTCCTG
CCCCTGGACCGGGAGGCGATCGTCGCCGCCGCCCGCAAGACCGGCAAGGTGCTGATCGCTCATGAGGCGGGCAAGACCCA
CGGCGTCGGCGCCGAGGTCGCGGCGATCATCGCCGAGGAGTGCCTCTTCGACCTGGACGCGCCGATCAAGCGGCTCTGCG
GCCCGGATGTCCCCGCCATGCCCTACGCCGGGCCGATGGAGAAGTTCTACATGCTGTCGACGGAGAAGTGCCTCGCGGCC
ATGCGGGAGCTGGCCCAGTTCTAG

Upstream 100 bases:

>100_bases
GTGGCGGCCATCGTGGACGACGCGACCGACTGGGCGGAGGCCCAGCCGTACGCCGCCCCGGAAGAGGCCCTGCGCCACGT
GTACAAGGAGGGATGAGCCG

Downstream 100 bases:

>100_bases
GCGAGGGGGGAACGCGCAATGGAGATCACCATGCCGCAGCTGGGCGAGTCGGTGACGGAAGGGACGATCAACCGGTGGCT
GGTGGCCCCCGGGGATGTGG

Product: branched-chain alpha-keto acid dehydrogenase E1 beta subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MPVMNLVEAVRDALRTEMRRDPDVWIVGEDVGKKGGVFGATLGLYDEFGPQRVMDSPLTESAIVGVGIGAALYGTKPVCE
IQFADFIFPAMNQIVSEAAKMRYRSNSAWTVPMVIRAPFGGGVHGGLYHSQSVEQYFTNTAGLKVVVPSTPYDAKGLLIS
AIRDPDPVLFFEHKGLYRAVKGEVPEGDYTIPIGKAEVKRDGTDITVITYGKVVHFCLEAAELLAREGYEALVLDLRTLL
PLDREAIVAAARKTGKVLIAHEAGKTHGVGAEVAAIIAEECLFDLDAPIKRLCGPDVPAMPYAGPMEKFYMLSTEKCLAA
MRELAQF

Sequences:

>Translated_327_residues
MPVMNLVEAVRDALRTEMRRDPDVWIVGEDVGKKGGVFGATLGLYDEFGPQRVMDSPLTESAIVGVGIGAALYGTKPVCE
IQFADFIFPAMNQIVSEAAKMRYRSNSAWTVPMVIRAPFGGGVHGGLYHSQSVEQYFTNTAGLKVVVPSTPYDAKGLLIS
AIRDPDPVLFFEHKGLYRAVKGEVPEGDYTIPIGKAEVKRDGTDITVITYGKVVHFCLEAAELLAREGYEALVLDLRTLL
PLDREAIVAAARKTGKVLIAHEAGKTHGVGAEVAAIIAEECLFDLDAPIKRLCGPDVPAMPYAGPMEKFYMLSTEKCLAA
MRELAQF
>Mature_326_residues
PVMNLVEAVRDALRTEMRRDPDVWIVGEDVGKKGGVFGATLGLYDEFGPQRVMDSPLTESAIVGVGIGAALYGTKPVCEI
QFADFIFPAMNQIVSEAAKMRYRSNSAWTVPMVIRAPFGGGVHGGLYHSQSVEQYFTNTAGLKVVVPSTPYDAKGLLISA
IRDPDPVLFFEHKGLYRAVKGEVPEGDYTIPIGKAEVKRDGTDITVITYGKVVHFCLEAAELLAREGYEALVLDLRTLLP
LDREAIVAAARKTGKVLIAHEAGKTHGVGAEVAAIIAEECLFDLDAPIKRLCGPDVPAMPYAGPMEKFYMLSTEKCLAAM
RELAQF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=46.0122699386503, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=46.0122699386503, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI156564403, Length=321, Percent_Identity=37.6947040498442, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI291084858, Length=321, Percent_Identity=36.1370716510903, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=44.954128440367, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17538422, Length=324, Percent_Identity=37.962962962963, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=40.6727828746177, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI160714832, Length=326, Percent_Identity=45.398773006135, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=45.398773006135, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI21358145, Length=308, Percent_Identity=41.8831168831169, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24650940, Length=308, Percent_Identity=41.8831168831169, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=36.6666666666667, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=36.6666666666667, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35481; Mature: 35349

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVMNLVEAVRDALRTEMRRDPDVWIVGEDVGKKGGVFGATLGLYDEFGPQRVMDSPLTE
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEHHHHHHHCCCHHHHCCCCCC
SAIVGVGIGAALYGTKPVCEIQFADFIFPAMNQIVSEAAKMRYRSNSAWTVPMVIRAPFG
HHEECCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGVHGGLYHSQSVEQYFTNTAGLKVVVPSTPYDAKGLLISAIRDPDPVLFFEHKGLYRAV
CCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCHHHHH
KGEVPEGDYTIPIGKAEVKRDGTDITVITYGKVVHFCLEAAELLAREGYEALVLDLRTLL
CCCCCCCCEEEECCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PLDREAIVAAARKTGKVLIAHEAGKTHGVGAEVAAIIAEECLFDLDAPIKRLCGPDVPAM
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
PYAGPMEKFYMLSTEKCLAAMRELAQF
CCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVMNLVEAVRDALRTEMRRDPDVWIVGEDVGKKGGVFGATLGLYDEFGPQRVMDSPLTE
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEHHHHHHHCCCHHHHCCCCCC
SAIVGVGIGAALYGTKPVCEIQFADFIFPAMNQIVSEAAKMRYRSNSAWTVPMVIRAPFG
HHEECCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGVHGGLYHSQSVEQYFTNTAGLKVVVPSTPYDAKGLLISAIRDPDPVLFFEHKGLYRAV
CCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCHHHHH
KGEVPEGDYTIPIGKAEVKRDGTDITVITYGKVVHFCLEAAELLAREGYEALVLDLRTLL
CCCCCCCCEEEECCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PLDREAIVAAARKTGKVLIAHEAGKTHGVGAEVAAIIAEECLFDLDAPIKRLCGPDVPAM
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
PYAGPMEKFYMLSTEKCLAAMRELAQF
CCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]