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The map label for this gene is bfmBAA [H]

Identifier: 51893300

GI number: 51893300

Start: 2305742

End: 2306800

Strand: Reverse

Name: bfmBAA [H]

Synonym: STH2162

Alternate gene names: 51893300

Gene position: 2306800-2305742 (Counterclockwise)

Preceding gene: 51893301

Following gene: 51893299

Centisome position: 64.69

GC content: 70.82

Gene sequence:

>1059_bases
GTGCAGGCGGTGGATTTCCAGGTGAGTGAGCATCGAGACGGGAGGGGGAGAGCGATGAAGGAAGCGACCATGGCCCGGCA
TGAGGCCCTGGGGCTGACGGCGGACCAGGTGCGGGAGATGTACTACTACATGCTGCTCACCCGCCGGCTGGACGAGCGGC
TGTGGCTCTTGCAGCGGGGGGGCAAGATCCCGTTCGTCATCTCGCCGCAGGGGCAGGAGGCGGCCCAGGTGGGGGCGGCG
TTCGCCTTCCGCCGGCGGCAGGACTGGTTCACGCCCTACTACCGGGATCTGGGGGTCAACCTGGTGGTGGGGGTGACGCC
CCGGGAAGTGATGCTGAGCGCCTTTGCCCGGGGCGCCGACCCGGCGTCCGGCGGCAAGCAGATGCCGTCCCACTGGGGGA
ACCGGCCGCTCAACATCGTGTCCGGCTCCAGCCCGGTGACGACCCAGGTCCTGCACGCGGTGGGGATCGCCCAGGCGGCC
AGGATGCGGGGCGACGACGTGGTGGTCTACACCGCCTGCGGCGAGGGCTCGTCCAACCAGGGCGACTTCCACGAGGCCCT
GAACTGGGCGGGGCTGCACAAGCTGCCGGTGATCTTCATGGTCCAGAACAACGAGTACGCGATCTCCGTGCCCCTGAGCC
AGCAGGTGGCGGGCGGCTCGGTGGCGGCCCGCGGGCGGGGGTACGGTATGCCCGGGGTGGAGGTGGACGGGACGGACGTG
CTGGCGGTCTACGAGGTCGTGAAGGAGGCCCACGAGCGCGCCCGGCGGGGCGAGGGGCCGACGCTGATCGAGGCCCGCTG
CATCCGGATCACGTCCCACTCCTCGGACGACGACCAGCGGCGCTACCGGGACCCGGAGGAGATCGCGGCCGTGCAGGTCC
GGGACCCCATCCGGAAGGCGCGCCAGTACCTGTTCGAACACGGGCTGATGGACGAAGCGGCCGAGCAGGAGCTGGAGCGG
AAGGTGGCGGCCATCGTGGACGACGCGACCGACTGGGCGGAGGCCCAGCCGTACGCCGCCCCGGAAGAGGCCCTGCGCCA
CGTGTACAAGGAGGGATGA

Upstream 100 bases:

>100_bases
TCGCGGTGGAGGGGCGCGCGATCCACATGTAGGCGATTCTCCTGCAGAAGACCGGCCTGCAGGCGGTGGAAGGCTGGTGA
CGGACCGGCCGTCCGCTCCC

Downstream 100 bases:

>100_bases
GCCGATGCCGGTGATGAACCTGGTGGAGGCCGTGCGCGACGCGCTGCGCACCGAGATGCGCCGCGACCCCGACGTCTGGA
TCGTGGGGGAGGACGTCGGG

Product: branched-chain alpha-keto acid dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MQAVDFQVSEHRDGRGRAMKEATMARHEALGLTADQVREMYYYMLLTRRLDERLWLLQRGGKIPFVISPQGQEAAQVGAA
FAFRRRQDWFTPYYRDLGVNLVVGVTPREVMLSAFARGADPASGGKQMPSHWGNRPLNIVSGSSPVTTQVLHAVGIAQAA
RMRGDDVVVYTACGEGSSNQGDFHEALNWAGLHKLPVIFMVQNNEYAISVPLSQQVAGGSVAARGRGYGMPGVEVDGTDV
LAVYEVVKEAHERARRGEGPTLIEARCIRITSHSSDDDQRRYRDPEEIAAVQVRDPIRKARQYLFEHGLMDEAAEQELER
KVAAIVDDATDWAEAQPYAAPEEALRHVYKEG

Sequences:

>Translated_352_residues
MQAVDFQVSEHRDGRGRAMKEATMARHEALGLTADQVREMYYYMLLTRRLDERLWLLQRGGKIPFVISPQGQEAAQVGAA
FAFRRRQDWFTPYYRDLGVNLVVGVTPREVMLSAFARGADPASGGKQMPSHWGNRPLNIVSGSSPVTTQVLHAVGIAQAA
RMRGDDVVVYTACGEGSSNQGDFHEALNWAGLHKLPVIFMVQNNEYAISVPLSQQVAGGSVAARGRGYGMPGVEVDGTDV
LAVYEVVKEAHERARRGEGPTLIEARCIRITSHSSDDDQRRYRDPEEIAAVQVRDPIRKARQYLFEHGLMDEAAEQELER
KVAAIVDDATDWAEAQPYAAPEEALRHVYKEG
>Mature_352_residues
MQAVDFQVSEHRDGRGRAMKEATMARHEALGLTADQVREMYYYMLLTRRLDERLWLLQRGGKIPFVISPQGQEAAQVGAA
FAFRRRQDWFTPYYRDLGVNLVVGVTPREVMLSAFARGADPASGGKQMPSHWGNRPLNIVSGSSPVTTQVLHAVGIAQAA
RMRGDDVVVYTACGEGSSNQGDFHEALNWAGLHKLPVIFMVQNNEYAISVPLSQQVAGGSVAARGRGYGMPGVEVDGTDV
LAVYEVVKEAHERARRGEGPTLIEARCIRITSHSSDDDQRRYRDPEEIAAVQVRDPIRKARQYLFEHGLMDEAAEQELER
KVAAIVDDATDWAEAQPYAAPEEALRHVYKEG

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=321, Percent_Identity=37.3831775700935, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI258645172, Length=321, Percent_Identity=37.0716510903427, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=33.6538461538462, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4505685, Length=312, Percent_Identity=33.0128205128205, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291084742, Length=312, Percent_Identity=33.0128205128205, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291084744, Length=284, Percent_Identity=33.0985915492958, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI291084757, Length=171, Percent_Identity=35.672514619883, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI86563355, Length=317, Percent_Identity=37.5394321766561, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI86563357, Length=317, Percent_Identity=37.5394321766561, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17536047, Length=325, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32564172, Length=325, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321026, Length=320, Percent_Identity=30, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21355903, Length=289, Percent_Identity=37.7162629757785, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24639744, Length=311, Percent_Identity=32.7974276527331, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28571106, Length=311, Percent_Identity=32.7974276527331, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24639740, Length=311, Percent_Identity=32.7974276527331, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24639746, Length=272, Percent_Identity=33.0882352941176, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24639748, Length=323, Percent_Identity=29.7213622291022, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 39077; Mature: 39077

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAVDFQVSEHRDGRGRAMKEATMARHEALGLTADQVREMYYYMLLTRRLDERLWLLQRG
CCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKIPFVISPQGQEAAQVGAAFAFRRRQDWFTPYYRDLGVNLVVGVTPREVMLSAFARGAD
CCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEECCHHHHHHHHHHCCCC
PASGGKQMPSHWGNRPLNIVSGSSPVTTQVLHAVGIAQAARMRGDDVVVYTACGEGSSNQ
CCCCCCCCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GDFHEALNWAGLHKLPVIFMVQNNEYAISVPLSQQVAGGSVAARGRGYGMPGVEVDGTDV
CCHHHHHHHCCCCCCCEEEEEECCCEEEECCCHHHHCCCCEEECCCCCCCCCCEECCCHH
LAVYEVVKEAHERARRGEGPTLIEARCIRITSHSSDDDQRRYRDPEEIAAVQVRDPIRKA
HHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHH
RQYLFEHGLMDEAAEQELERKVAAIVDDATDWAEAQPYAAPEEALRHVYKEG
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQAVDFQVSEHRDGRGRAMKEATMARHEALGLTADQVREMYYYMLLTRRLDERLWLLQRG
CCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKIPFVISPQGQEAAQVGAAFAFRRRQDWFTPYYRDLGVNLVVGVTPREVMLSAFARGAD
CCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEECCHHHHHHHHHHCCCC
PASGGKQMPSHWGNRPLNIVSGSSPVTTQVLHAVGIAQAARMRGDDVVVYTACGEGSSNQ
CCCCCCCCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GDFHEALNWAGLHKLPVIFMVQNNEYAISVPLSQQVAGGSVAARGRGYGMPGVEVDGTDV
CCHHHHHHHCCCCCCCEEEEEECCCEEEECCCHHHHCCCCEEECCCCCCCCCCEECCCHH
LAVYEVVKEAHERARRGEGPTLIEARCIRITSHSSDDDQRRYRDPEEIAAVQVRDPIRKA
HHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHH
RQYLFEHGLMDEAAEQELERKVAAIVDDATDWAEAQPYAAPEEALRHVYKEG
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]