Click here to switch to the map view.

The map label for this gene is lip2 [H]

Identifier: 51893263

GI number: 51893263

Start: 2270294

End: 2271232

Strand: Reverse

Name: lip2 [H]

Synonym: STH2125

Alternate gene names: 51893263

Gene position: 2271232-2270294 (Counterclockwise)

Preceding gene: 51893266

Following gene: 51893260

Centisome position: 63.69

GC content: 71.25

Gene sequence:

>939_bases
ATGCCGCTGGCCAGAGAAGCGGAGGCCTTCCTGAAGCAGCTCGCCGAAGCCGGTGGCCCGGCGCTCAACGAGCTGTCCCC
CGCGGATGCCCGGAAGATGACCGAGCAGATGGCGGCGTTCGGCGGCGATGCCGAGCCGGTGGCCGGTGTGGTGGACCGGA
CCGTGCCGGGGCCCGCAGGGAAGATTCCCGTCCGCATTTACACGCCGGCGGGGGAGGGGCCGTTCCCGGTGCTGCTCTAC
TTCCACGGGGGCGGCTGGGTGCTCGGCAGCCCCGACACCGTGCACGCCACCTGCGCCCTGCTGGCCAACAGGGCCGGGGC
CGTGGTGGTGTCGGTGGACTACCGGCTGGCGCCGGAGCACAAGTTCCCGGCGGCGGCGGAGGACTGCTACGCCGCGACCG
TGTGGGTGGCCGAGAATGCCCGGACCATCGGCGGCGACCCGCGGCGCATCGCGGTGGCCGGTGACAGCGCCGGCGGCAAC
CTGGCGGCGGTGGTCTCACTCATGGCCCGGGACAAGGGCTATCCGGACCTGGCCTACCAGGTGCTAATCTACCCGGTGAC
CGATCACAACTTCGATACCCCGTCCTACCGGGAAAACGGGAACGACTACTTCCTGACCACGGCCATGATGCAGTGGTTCT
GGGACCATTACATCCGGAGCGAGGCGGATGGCAGGGACTGGCGGGCCTCGCCCCTGCAGGCGGCCGACGTGTCCGGCCTG
CCCCCGGCCTTCGTGATCACCGCCGAGTACGACCCGCTGCGGGACGAGGGGGAGGCGTACGCCCGCAAGCTGATCGAGGC
CGGCAGCGCCGTCACCGTCAAGCGGTACCTCGGCCAGATCCACGGCTTCTGCACGCTGCTGGGCGCCATGCCCGCCGGCA
GGCAGGCCTTGGAGGATGCGGCGGCCCACCTCCGCCTGGCCTTCGCCGCCCGTGAGTAG

Upstream 100 bases:

>100_bases
GCGGATTCGCCCACGAATTGCCACTCCTTCCAGTGAATATCCATCTACCGGGCGTGTCCGAAGCCACGCCCCACGTCAGG
ACAGAAAGGGGAGGAGATTC

Downstream 100 bases:

>100_bases
CGGCCCGGCGGAAAGGGGGCAGGGCCCCGTGGTACGAACAGGCGGCAGGTTGAGACGCAGACCCGGGGCCGCAAGGCCCC
GGGTCGAGCTGTGTGCCGGT

Product: putative lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MPLAREAEAFLKQLAEAGGPALNELSPADARKMTEQMAAFGGDAEPVAGVVDRTVPGPAGKIPVRIYTPAGEGPFPVLLY
FHGGGWVLGSPDTVHATCALLANRAGAVVVSVDYRLAPEHKFPAAAEDCYAATVWVAENARTIGGDPRRIAVAGDSAGGN
LAAVVSLMARDKGYPDLAYQVLIYPVTDHNFDTPSYRENGNDYFLTTAMMQWFWDHYIRSEADGRDWRASPLQAADVSGL
PPAFVITAEYDPLRDEGEAYARKLIEAGSAVTVKRYLGQIHGFCTLLGAMPAGRQALEDAAAHLRLAFAARE

Sequences:

>Translated_312_residues
MPLAREAEAFLKQLAEAGGPALNELSPADARKMTEQMAAFGGDAEPVAGVVDRTVPGPAGKIPVRIYTPAGEGPFPVLLY
FHGGGWVLGSPDTVHATCALLANRAGAVVVSVDYRLAPEHKFPAAAEDCYAATVWVAENARTIGGDPRRIAVAGDSAGGN
LAAVVSLMARDKGYPDLAYQVLIYPVTDHNFDTPSYRENGNDYFLTTAMMQWFWDHYIRSEADGRDWRASPLQAADVSGL
PPAFVITAEYDPLRDEGEAYARKLIEAGSAVTVKRYLGQIHGFCTLLGAMPAGRQALEDAAAHLRLAFAARE
>Mature_311_residues
PLAREAEAFLKQLAEAGGPALNELSPADARKMTEQMAAFGGDAEPVAGVVDRTVPGPAGKIPVRIYTPAGEGPFPVLLYF
HGGGWVLGSPDTVHATCALLANRAGAVVVSVDYRLAPEHKFPAAAEDCYAATVWVAENARTIGGDPRRIAVAGDSAGGNL
AAVVSLMARDKGYPDLAYQVLIYPVTDHNFDTPSYRENGNDYFLTTAMMQWFWDHYIRSEADGRDWRASPLQAADVSGLP
PAFVITAEYDPLRDEGEAYARKLIEAGSAVTVKRYLGQIHGFCTLLGAMPAGRQALEDAAAHLRLAFAARE

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=309, Percent_Identity=29.4498381877023, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI68299767, Length=302, Percent_Identity=31.4569536423841, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI61966717, Length=284, Percent_Identity=28.5211267605634, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI206597554, Length=156, Percent_Identity=42.9487179487179, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI68051721, Length=172, Percent_Identity=36.6279069767442, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI157041237, Length=250, Percent_Identity=28.4, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226423947, Length=180, Percent_Identity=35.5555555555556, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI21328446, Length=159, Percent_Identity=32.7044025157233, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI226423952, Length=128, Percent_Identity=38.28125, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI226423950, Length=128, Percent_Identity=38.28125, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786682, Length=254, Percent_Identity=32.6771653543307, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17567059, Length=301, Percent_Identity=30.8970099667774, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17540028, Length=143, Percent_Identity=35.6643356643357, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=140, Percent_Identity=36.4285714285714, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI72001146, Length=123, Percent_Identity=37.3983739837398, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533410, Length=91, Percent_Identity=37.3626373626374, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115533412, Length=91, Percent_Identity=37.3626373626374, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24656084, Length=149, Percent_Identity=32.8859060402685, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24656076, Length=149, Percent_Identity=32.8859060402685, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI20130169, Length=149, Percent_Identity=32.8859060402685, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 33376; Mature: 33245

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01174 LIPASE_GDXG_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLAREAEAFLKQLAEAGGPALNELSPADARKMTEQMAAFGGDAEPVAGVVDRTVPGPAG
CCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
KIPVRIYTPAGEGPFPVLLYFHGGGWVLGSPDTVHATCALLANRAGAVVVSVDYRLAPEH
CCCEEEECCCCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHCCCCEEEEEEEEEECCCC
KFPAAAEDCYAATVWVAENARTIGGDPRRIAVAGDSAGGNLAAVVSLMARDKGYPDLAYQ
CCCCCCCCCEEEEEEEECCCEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEE
VLIYPVTDHNFDTPSYRENGNDYFLTTAMMQWFWDHYIRSEADGRDWRASPLQAADVSGL
EEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PPAFVITAEYDPLRDEGEAYARKLIEAGSAVTVKRYLGQIHGFCTLLGAMPAGRQALEDA
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AAHLRLAFAARE
HHHEEHEEEECC
>Mature Secondary Structure 
PLAREAEAFLKQLAEAGGPALNELSPADARKMTEQMAAFGGDAEPVAGVVDRTVPGPAG
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
KIPVRIYTPAGEGPFPVLLYFHGGGWVLGSPDTVHATCALLANRAGAVVVSVDYRLAPEH
CCCEEEECCCCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHCCCCEEEEEEEEEECCCC
KFPAAAEDCYAATVWVAENARTIGGDPRRIAVAGDSAGGNLAAVVSLMARDKGYPDLAYQ
CCCCCCCCCEEEEEEEECCCEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEE
VLIYPVTDHNFDTPSYRENGNDYFLTTAMMQWFWDHYIRSEADGRDWRASPLQAADVSGL
EEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PPAFVITAEYDPLRDEGEAYARKLIEAGSAVTVKRYLGQIHGFCTLLGAMPAGRQALEDA
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AAHLRLAFAARE
HHHEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]