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The map label for this gene is leuD [H]

Identifier: 51893253

GI number: 51893253

Start: 2257441

End: 2258019

Strand: Reverse

Name: leuD [H]

Synonym: STH2115

Alternate gene names: 51893253

Gene position: 2258019-2257441 (Counterclockwise)

Preceding gene: 51893254

Following gene: 51893252

Centisome position: 63.32

GC content: 67.53

Gene sequence:

>579_bases
GTGCCGCTGGACCGGGTGAACGTGGACACCGACCAGATCATCCCCAAGCAGTTCCTGAAGCGCATCGAGCGGACCGGGTT
CGGCCAGTTCCTGTTCCACGACTGGCGCTACCTGCCGGACGGCTCGCCCAATCCCGAGTTCGTGCTCAACCGGCCGCAGT
ACGCCGGCGCGACCATCCTGATCGCCGGCCGGAACTTCGGCTCGGGTTCGTCCCGGGAGCATGCCCCGTGGGCGCTCAGC
GACTACGGCTTCCGCGCGATCATCGCGCCGTCGTTCGCGGATATCTTCTACAATAACTGTTTCCAGAACGGCCTCCTGCC
GGTGGTGCTGCCCGAGGAGGCCGTGGCCGAGCTCATGCGGCGGGCGCAGGAGCCGGGGTATCGGCTCACGGTCGATCTGG
AGCGGTGCGTGGTGGAGGACGATGCGGGCTTCCGGGTGGACTTCGCCATCGACGCGTTCCGGAGGCACCGGATGCTGCAC
GGGCTGGACGACATCGGCCTGACGCTGCAATATGAAGACGAGATTGCGGCGTACGAAGCCCGGCGCCCGGCGTGGCTGCC
GACGACACCCGCACGGTAG

Upstream 100 bases:

>100_bases
CGGCCGCGGCCATCGCCGGCCACTTCGTCGACGTGCGTGAACTCCTGGCGGAAGGGGGTGCGGCCCGGTGAGGCCCTTCA
CACGGGAGACGGGGCTGGCG

Downstream 100 bases:

>100_bases
GGTGCCGGTGCCGTTCGGGACGCCATCGTGCCCCGTGCCGGTTGGCTGGAGAGGGCGGAGGCGCCGGCCTCCGCCCTTCG
TCGCGGCGCGGGCTGACCGC

Product: 3-isopropylmalate dehydratase small subunit

Products: NA

Alternate protein names: Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MPLDRVNVDTDQIIPKQFLKRIERTGFGQFLFHDWRYLPDGSPNPEFVLNRPQYAGATILIAGRNFGSGSSREHAPWALS
DYGFRAIIAPSFADIFYNNCFQNGLLPVVLPEEAVAELMRRAQEPGYRLTVDLERCVVEDDAGFRVDFAIDAFRRHRMLH
GLDDIGLTLQYEDEIAAYEARRPAWLPTTPAR

Sequences:

>Translated_192_residues
MPLDRVNVDTDQIIPKQFLKRIERTGFGQFLFHDWRYLPDGSPNPEFVLNRPQYAGATILIAGRNFGSGSSREHAPWALS
DYGFRAIIAPSFADIFYNNCFQNGLLPVVLPEEAVAELMRRAQEPGYRLTVDLERCVVEDDAGFRVDFAIDAFRRHRMLH
GLDDIGLTLQYEDEIAAYEARRPAWLPTTPAR
>Mature_191_residues
PLDRVNVDTDQIIPKQFLKRIERTGFGQFLFHDWRYLPDGSPNPEFVLNRPQYAGATILIAGRNFGSGSSREHAPWALSD
YGFRAIIAPSFADIFYNNCFQNGLLPVVLPEEAVAELMRRAQEPGYRLTVDLERCVVEDDAGFRVDFAIDAFRRHRMLHG
LDDIGLTLQYEDEIAAYEARRPAWLPTTPAR

Specific function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate [H]

COG id: COG0066

COG function: function code E; 3-isopropylmalate dehydratase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leuD family. LeuD type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786258, Length=190, Percent_Identity=61.0526315789474, Blast_Score=226, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6321429, Length=187, Percent_Identity=50.8021390374332, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004431
- InterPro:   IPR012305
- InterPro:   IPR015937
- InterPro:   IPR015928
- InterPro:   IPR000573 [H]

Pfam domain/function: PF00694 Aconitase_C [H]

EC number: =4.2.1.33 [H]

Molecular weight: Translated: 21931; Mature: 21800

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDRVNVDTDQIIPKQFLKRIERTGFGQFLFHDWRYLPDGSPNPEFVLNRPQYAGATIL
CCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCEECCCCCCCCCEEECCCCCCCEEEE
IAGRNFGSGSSREHAPWALSDYGFRAIIAPSFADIFYNNCFQNGLLPVVLPEEAVAELMR
EEECCCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHCCCEEEEECHHHHHHHHH
RAQEPGYRLTVDLERCVVEDDAGFRVDFAIDAFRRHRMLHGLDDIGLTLQYEDEIAAYEA
HHCCCCCEEEEEHHHEEEECCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHC
RRPAWLPTTPAR
CCCCCCCCCCCC
>Mature Secondary Structure 
PLDRVNVDTDQIIPKQFLKRIERTGFGQFLFHDWRYLPDGSPNPEFVLNRPQYAGATIL
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCEECCCCCCCCCEEECCCCCCCEEEE
IAGRNFGSGSSREHAPWALSDYGFRAIIAPSFADIFYNNCFQNGLLPVVLPEEAVAELMR
EEECCCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHCCCEEEEECHHHHHHHHH
RAQEPGYRLTVDLERCVVEDDAGFRVDFAIDAFRRHRMLHGLDDIGLTLQYEDEIAAYEA
HHCCCCCEEEEEHHHEEEECCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHC
RRPAWLPTTPAR
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA