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The map label for this gene is tdh

Identifier: 51893011

GI number: 51893011

Start: 2013575

End: 2014630

Strand: Reverse

Name: tdh

Synonym: STH1873

Alternate gene names: 51893011

Gene position: 2014630-2013575 (Counterclockwise)

Preceding gene: 51893013

Following gene: 51893010

Centisome position: 56.49

GC content: 67.8

Gene sequence:

>1056_bases
GTGGCAGAAACGATGCGTGCTTTGCGAAAACTGGAAGCTGGTCCTGGCGCGACACTGCAGGAGGTTCCGATCCCGACCAT
CGGCCCCCGCGACGTCCTGGTGAAGGTCCGGGCGGCCTCGATCTGCGGCACGGACTACCACATCTACACCTGGGATCCGT
GGTCCGCGGGCCGGGTGAAGCCGCCGCTCACCATTGGGCACGAGCTGGCCGGTGAGGTGGTGGCCGTCGGCCGCGAGGTC
ACCGCATGCAAGGTGGGCGACTACGTCTCTGCCGAAACGCACATTGTTTGCAACCGCTGTCCCCGCTGCCACATGGGGGA
GTACCACCTCTGCGAGAACACGAAGATCCTGGGGGTGGACACGGACGGCGCCTTCGCCGAGTACGTCGCGGTGCCGGAGC
AGAACATCTGGGTGAACGACAAGGACATCCCCTTTGAGCTGCAGTCGATTCAGGAGCCGCTGGGCAACGCGGTCCACACG
GCCCTGAACGGCGACCTCACCGCCCGGTCCGTGCTGATCACCGGCTGCGGCCCCATCGGCATCATGTCGGTCCCCGTGGC
CAAGATGGCCGGCGCGGAGATCGTGATGGCGATGGACATCAACGAATACCGGCTGCAGCTGGCGGGCCAGCTGGGGGCCG
ACGTGCTCATCAACCCCACGAAGCAGGATCCGGTCGAGGTGGTGCGCAGCTACACCCGCGGCTACGGCGCCGACGTGGTG
CTGGAGATGTCGGGTAACCCCACCGCCATCCGGCAGGGGCTGAAGGCCGCCCGCAACGGCGCCCGCATCTCGCTCCTCGG
TCTGCCCGGCCGGCCGCTGGAGCTGGACCTGGCAGCGGACGTGATCATGCGGGGCCTGGTGCTGCAGGGCATCACCGGCC
GCCGGATGTGGCAGACCTGGTATCAGGTGCGTTCCCTCTACCGGGCCGGGCTGGCGGAGCGGCTGCGGCCGCTGGTGACG
CACCGGATGCCGCTGGAGCAGATCGACGCCGCCATGGAGCTCATGGGTTCCGGCCAGAGCGGCAAGATAGTGCTGGTGCC
TGACCTGAAGGCGTGA

Upstream 100 bases:

>100_bases
CCCTTGCGACTGCTCGCGCAAGTGATATACAGTAGTGAGGGGTAGCCATCAAACCTCCCTGCGGCATCCATGCCCGCGGG
GCAAAAGAAGGTGGGCAGCC

Downstream 100 bases:

>100_bases
TTTCCCGCAGAGGAGGTCAATGCGGATGGCTCTGACGGACTTTCTCGTGGAAGAGCTCAACGGCCTGAAGCAGGCCGGGC
TCTACCGGCCCCTGAAGGAG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MAETMRALRKLEAGPGATLQEVPIPTIGPRDVLVKVRAASICGTDYHIYTWDPWSAGRVKPPLTIGHELAGEVVAVGREV
TACKVGDYVSAETHIVCNRCPRCHMGEYHLCENTKILGVDTDGAFAEYVAVPEQNIWVNDKDIPFELQSIQEPLGNAVHT
ALNGDLTARSVLITGCGPIGIMSVPVAKMAGAEIVMAMDINEYRLQLAGQLGADVLINPTKQDPVEVVRSYTRGYGADVV
LEMSGNPTAIRQGLKAARNGARISLLGLPGRPLELDLAADVIMRGLVLQGITGRRMWQTWYQVRSLYRAGLAERLRPLVT
HRMPLEQIDAAMELMGSGQSGKIVLVPDLKA

Sequences:

>Translated_351_residues
MAETMRALRKLEAGPGATLQEVPIPTIGPRDVLVKVRAASICGTDYHIYTWDPWSAGRVKPPLTIGHELAGEVVAVGREV
TACKVGDYVSAETHIVCNRCPRCHMGEYHLCENTKILGVDTDGAFAEYVAVPEQNIWVNDKDIPFELQSIQEPLGNAVHT
ALNGDLTARSVLITGCGPIGIMSVPVAKMAGAEIVMAMDINEYRLQLAGQLGADVLINPTKQDPVEVVRSYTRGYGADVV
LEMSGNPTAIRQGLKAARNGARISLLGLPGRPLELDLAADVIMRGLVLQGITGRRMWQTWYQVRSLYRAGLAERLRPLVT
HRMPLEQIDAAMELMGSGQSGKIVLVPDLKA
>Mature_350_residues
AETMRALRKLEAGPGATLQEVPIPTIGPRDVLVKVRAASICGTDYHIYTWDPWSAGRVKPPLTIGHELAGEVVAVGREVT
ACKVGDYVSAETHIVCNRCPRCHMGEYHLCENTKILGVDTDGAFAEYVAVPEQNIWVNDKDIPFELQSIQEPLGNAVHTA
LNGDLTARSVLITGCGPIGIMSVPVAKMAGAEIVMAMDINEYRLQLAGQLGADVLINPTKQDPVEVVRSYTRGYGADVVL
EMSGNPTAIRQGLKAARNGARISLLGLPGRPLELDLAADVIMRGLVLQGITGRRMWQTWYQVRSLYRAGLAERLRPLVTH
RMPLEQIDAAMELMGSGQSGKIVLVPDLKA

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=31.7647058823529, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI156523966, Length=365, Percent_Identity=25.2054794520548, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=27.5956284153005, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71565154, Length=380, Percent_Identity=27.3684210526316, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=25.4189944134078, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI34577061, Length=361, Percent_Identity=27.1468144044321, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=27.9005524861878, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71743840, Length=363, Percent_Identity=25.8953168044077, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=363, Percent_Identity=25.8953168044077, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=44.4767441860465, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=27.4725274725275, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1787863, Length=338, Percent_Identity=29.2899408284024, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788073, Length=260, Percent_Identity=31.9230769230769, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082125, Length=349, Percent_Identity=32.0916905444126, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788407, Length=339, Percent_Identity=28.9085545722714, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI226510992, Length=251, Percent_Identity=31.0756972111554, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786825, Length=387, Percent_Identity=27.390180878553, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=26.791277258567, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786552, Length=380, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=330, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=278, Percent_Identity=33.8129496402878, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=246, Percent_Identity=32.1138211382114, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25146526, Length=354, Percent_Identity=25.9887005649718, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=366, Percent_Identity=25.6830601092896, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=25.3687315634218, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=293, Percent_Identity=25.938566552901, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=284, Percent_Identity=26.056338028169, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=323, Percent_Identity=24.4582043343653, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=328, Percent_Identity=30.4878048780488, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=383, Percent_Identity=28.9817232375979, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=324, Percent_Identity=29.320987654321, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=324, Percent_Identity=29.320987654321, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=27.0777479892761, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323961, Length=303, Percent_Identity=29.7029702970297, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=276, Percent_Identity=29.7101449275362, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=384, Percent_Identity=25.78125, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=352, Percent_Identity=26.1363636363636, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=257, Percent_Identity=30.3501945525292, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=215, Percent_Identity=31.6279069767442, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=28.2352941176471, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737897, Length=335, Percent_Identity=27.4626865671642, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=26.8817204301075, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_SYMTH (Q67N85)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075702.1
- ProteinModelPortal:   Q67N85
- SMR:   Q67N85
- GeneID:   2979657
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1873
- NMPDR:   fig|292459.1.peg.1807
- HOGENOM:   HBG753318
- OMA:   TGQAHIC
- ProtClustDB:   PRK05396
- BioCyc:   STHE292459:STH1873-MONOMER
- BRENDA:   1.1.1.103
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 38051; Mature: 37919

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETMRALRKLEAGPGATLQEVPIPTIGPRDVLVKVRAASICGTDYHIYTWDPWSAGRVK
CCHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHEEEEEEHEECCCCCEEEEECCCCCCCCC
PPLTIGHELAGEVVAVGREVTACKVGDYVSAETHIVCNRCPRCHMGEYHLCENTKILGVD
CCCEECHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCCEEEECCCEEEEEC
TDGAFAEYVAVPEQNIWVNDKDIPFELQSIQEPLGNAVHTALNGDLTARSVLITGCGPIG
CCCCHHHEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
IMSVPVAKMAGAEIVMAMDINEYRLQLAGQLGADVLINPTKQDPVEVVRSYTRGYGADVV
CHHCCHHHHCCCEEEEEECCHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCEEE
LEMSGNPTAIRQGLKAARNGARISLLGLPGRPLELDLAADVIMRGLVLQGITGRRMWQTW
EEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHH
YQVRSLYRAGLAERLRPLVTHRMPLEQIDAAMELMGSGQSGKIVLVPDLKA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEECCCCC
>Mature Secondary Structure 
AETMRALRKLEAGPGATLQEVPIPTIGPRDVLVKVRAASICGTDYHIYTWDPWSAGRVK
CHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHEEEEEEHEECCCCCEEEEECCCCCCCCC
PPLTIGHELAGEVVAVGREVTACKVGDYVSAETHIVCNRCPRCHMGEYHLCENTKILGVD
CCCEECHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCCEEEECCCEEEEEC
TDGAFAEYVAVPEQNIWVNDKDIPFELQSIQEPLGNAVHTALNGDLTARSVLITGCGPIG
CCCCHHHEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
IMSVPVAKMAGAEIVMAMDINEYRLQLAGQLGADVLINPTKQDPVEVVRSYTRGYGADVV
CHHCCHHHHCCCEEEEEECCHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCEEE
LEMSGNPTAIRQGLKAARNGARISLLGLPGRPLELDLAADVIMRGLVLQGITGRRMWQTW
EEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHH
YQVRSLYRAGLAERLRPLVTHRMPLEQIDAAMELMGSGQSGKIVLVPDLKA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA