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The map label for this gene is kbl [C]

Identifier: 51893010

GI number: 51893010

Start: 2012371

End: 2013549

Strand: Reverse

Name: kbl [C]

Synonym: STH1872

Alternate gene names: 51893010

Gene position: 2013549-2012371 (Counterclockwise)

Preceding gene: 51893011

Following gene: 51893008

Centisome position: 56.46

GC content: 68.02

Gene sequence:

>1179_bases
ATGGCTCTGACGGACTTTCTCGTGGAAGAGCTCAACGGCCTGAAGCAGGCCGGGCTCTACCGGCCCCTGAAGGAGCTGCA
GTCGCCCCAGCGCCCCCGGTCCATCATCGACGGGCGGGAGGTCATCAACCTCTCCAGCAACAACTACCTCGGCCTGGCCG
ACGACCCCCGCCTGAAGCAGGCGATGATCGAGGCCACTGAGGCGTACGGCGCCGGGTCCGGCGCGGTCCGGACCATCATC
GGCACCATGACGATCCACAACCAGCTCGAGCAGAAGCTGGCCGAGTTCAAGCACGTGGAGGCCGCCGTGGTCTTCCAGTC
GGGGTTCACCTGCAACTCCGGCGTGATCCCGGTTCTGGTGGGCGAGGGCGACGCCGTGATCTCCGACGAGCTGAACCACG
CGTCCATCATCGACGGGTGCAGGCTGTCCAAGGCGAAGATCCACCGCTACAAGCACGCCGACATGGACGACCTGGCCCGC
GTGCTGAAGGAGACCGACGGGCAGTACCGGCGCCGGCTGATCATCACCGACGGCGTGTTCTCCATGGACGGCGACATCGC
CCCGCTGCCGGACATCGTGGAGCTGGCCGAGAAGCACGGCTGCATGACCTACGTGGACGACGCCCACTCCTCCGGCGTGC
TGGGCAAGAACGGCCGCGGCTCCGTCAACCACTTCGGCCTGGACGGCCGGGTGACGGTGCAGGTGGGCACGCTGTCGAAG
GCCGTGGGCGTGCTGGGCGGCTACGTGGCCGGGCCGCGCGCCCTGATCGAACTGCTCTGGCACAAGGGCCGGCCGTTCCT
CTTCTCCACGTCCCATCCGCCGGGAGTGGCGGCGGCCTGCCTGAAGGCCATCGAGATCATGGAGCAGGAGCCGGAGCGGA
TCGACCGGCTGTGGGAGAACACCCGCTACTTCAAGGAGCGGCTTACCGAGTTGGGCTTCGACACCGGGAAGTCGGAGACG
CCGATCACCCCGGTGATCGTGGGCGACGAGGTCAAGGCGATGCAGCTGTCCGACCGGCTGCTGGAGGAGGGCGTTTTCGC
CCAGGGCATCGCCTTCCCGACGGTGCCGCGGGGCAAGGCCCGGGTCCGGACCATCGTCACCGCCGCTCACACGAAGGAGG
ACCTGGACGAGGCCCTGGCTGCCTTCGCGAAGGTGGGCCGGGAGCTCGGGCTCATCTAG

Upstream 100 bases:

>100_bases
ATCGACGCCGCCATGGAGCTCATGGGTTCCGGCCAGAGCGGCAAGATAGTGCTGGTGCCTGACCTGAAGGCGTGATTTCC
CGCAGAGGAGGTCAATGCGG

Downstream 100 bases:

>100_bases
TCCGGGATGCTGGTCGTGGTTTTCTGGCGCTTAGCCTGATCCCGGGACACGCGCAACCAGGGCGCCGCCTCAGCAGCGCC
CTGGTTGCGCGTGTGCGTCT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MALTDFLVEELNGLKQAGLYRPLKELQSPQRPRSIIDGREVINLSSNNYLGLADDPRLKQAMIEATEAYGAGSGAVRTII
GTMTIHNQLEQKLAEFKHVEAAVVFQSGFTCNSGVIPVLVGEGDAVISDELNHASIIDGCRLSKAKIHRYKHADMDDLAR
VLKETDGQYRRRLIITDGVFSMDGDIAPLPDIVELAEKHGCMTYVDDAHSSGVLGKNGRGSVNHFGLDGRVTVQVGTLSK
AVGVLGGYVAGPRALIELLWHKGRPFLFSTSHPPGVAAACLKAIEIMEQEPERIDRLWENTRYFKERLTELGFDTGKSET
PITPVIVGDEVKAMQLSDRLLEEGVFAQGIAFPTVPRGKARVRTIVTAAHTKEDLDEALAAFAKVGRELGLI

Sequences:

>Translated_392_residues
MALTDFLVEELNGLKQAGLYRPLKELQSPQRPRSIIDGREVINLSSNNYLGLADDPRLKQAMIEATEAYGAGSGAVRTII
GTMTIHNQLEQKLAEFKHVEAAVVFQSGFTCNSGVIPVLVGEGDAVISDELNHASIIDGCRLSKAKIHRYKHADMDDLAR
VLKETDGQYRRRLIITDGVFSMDGDIAPLPDIVELAEKHGCMTYVDDAHSSGVLGKNGRGSVNHFGLDGRVTVQVGTLSK
AVGVLGGYVAGPRALIELLWHKGRPFLFSTSHPPGVAAACLKAIEIMEQEPERIDRLWENTRYFKERLTELGFDTGKSET
PITPVIVGDEVKAMQLSDRLLEEGVFAQGIAFPTVPRGKARVRTIVTAAHTKEDLDEALAAFAKVGRELGLI
>Mature_391_residues
ALTDFLVEELNGLKQAGLYRPLKELQSPQRPRSIIDGREVINLSSNNYLGLADDPRLKQAMIEATEAYGAGSGAVRTIIG
TMTIHNQLEQKLAEFKHVEAAVVFQSGFTCNSGVIPVLVGEGDAVISDELNHASIIDGCRLSKAKIHRYKHADMDDLARV
LKETDGQYRRRLIITDGVFSMDGDIAPLPDIVELAEKHGCMTYVDDAHSSGVLGKNGRGSVNHFGLDGRVTVQVGTLSKA
VGVLGGYVAGPRALIELLWHKGRPFLFSTSHPPGVAAACLKAIEIMEQEPERIDRLWENTRYFKERLTELGFDTGKSETP
ITPVIVGDEVKAMQLSDRLLEEGVFAQGIAFPTVPRGKARVRTIVTAAHTKEDLDEALAAFAKVGRELGLI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=388, Percent_Identity=41.7525773195876, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI284448556, Length=414, Percent_Identity=39.1304347826087, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI4758668, Length=375, Percent_Identity=39.4666666666667, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI119220554, Length=371, Percent_Identity=37.466307277628, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI83977442, Length=363, Percent_Identity=31.6804407713499, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI83977440, Length=363, Percent_Identity=31.6804407713499, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI83977444, Length=363, Percent_Identity=31.6804407713499, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4502025, Length=363, Percent_Identity=31.404958677686, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI40316939, Length=363, Percent_Identity=31.404958677686, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI5454084, Length=383, Percent_Identity=30.2872062663185, Blast_Score=171, Evalue=7e-43,
Organism=Escherichia coli, GI1790046, Length=389, Percent_Identity=43.4447300771208, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=35.632183908046, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71994529, Length=391, Percent_Identity=44.5012787723785, Blast_Score=331, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=34.2391304347826, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=33.7874659400545, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17560912, Length=366, Percent_Identity=33.879781420765, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71982617, Length=316, Percent_Identity=29.746835443038, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71982625, Length=316, Percent_Identity=29.746835443038, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=34.2391304347826, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320438, Length=396, Percent_Identity=33.0808080808081, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=28.0898876404494, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24662918, Length=393, Percent_Identity=43.2569974554707, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI17137420, Length=345, Percent_Identity=35.6521739130435, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17136286, Length=375, Percent_Identity=35.7333333333333, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24653280, Length=341, Percent_Identity=28.4457478005865, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24653276, Length=341, Percent_Identity=28.4457478005865, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24653278, Length=341, Percent_Identity=28.4457478005865, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_SYMTH (Q67N86)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075701.1
- HSSP:   P0AB77
- ProteinModelPortal:   Q67N86
- SMR:   Q67N86
- GeneID:   2979606
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1872
- NMPDR:   fig|292459.1.peg.1806
- HOGENOM:   HBG649839
- OMA:   AGHEREH
- ProtClustDB:   PRK06939
- BioCyc:   STHE292459:STH1872-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR13693:SF15
- TIGRFAMs:   TIGR00858
- TIGRFAMs:   TIGR01825

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 42720; Mature: 42589

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 21-21 BINDING 133-133 BINDING 181-181 BINDING 354-354

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTDFLVEELNGLKQAGLYRPLKELQSPQRPRSIIDGREVINLSSNNYLGLADDPRLKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEECCCCEECCCCCHHHHH
AMIEATEAYGAGSGAVRTIIGTMTIHNQLEQKLAEFKHVEAAVVFQSGFTCNSGVIPVLV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEE
GEGDAVISDELNHASIIDGCRLSKAKIHRYKHADMDDLARVLKETDGQYRRRLIITDGVF
CCCCEEECCCCCCHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHEEEEEECCEE
SMDGDIAPLPDIVELAEKHGCMTYVDDAHSSGVLGKNGRGSVNHFGLDGRVTVQVGTLSK
ECCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCEECCCCEEEEEECCHHH
AVGVLGGYVAGPRALIELLWHKGRPFLFSTSHPPGVAAACLKAIEIMEQEPERIDRLWEN
HHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
TRYFKERLTELGFDTGKSETPITPVIVGDEVKAMQLSDRLLEEGVFAQGIAFPTVPRGKA
HHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCH
RVRTIVTAAHTKEDLDEALAAFAKVGRELGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALTDFLVEELNGLKQAGLYRPLKELQSPQRPRSIIDGREVINLSSNNYLGLADDPRLKQ
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEECCCCEECCCCCHHHHH
AMIEATEAYGAGSGAVRTIIGTMTIHNQLEQKLAEFKHVEAAVVFQSGFTCNSGVIPVLV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEE
GEGDAVISDELNHASIIDGCRLSKAKIHRYKHADMDDLARVLKETDGQYRRRLIITDGVF
CCCCEEECCCCCCHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHEEEEEECCEE
SMDGDIAPLPDIVELAEKHGCMTYVDDAHSSGVLGKNGRGSVNHFGLDGRVTVQVGTLSK
ECCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCEECCCCEEEEEECCHHH
AVGVLGGYVAGPRALIELLWHKGRPFLFSTSHPPGVAAACLKAIEIMEQEPERIDRLWEN
HHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
TRYFKERLTELGFDTGKSETPITPVIVGDEVKAMQLSDRLLEEGVFAQGIAFPTVPRGKA
HHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCH
RVRTIVTAAHTKEDLDEALAAFAKVGRELGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA