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The map label for this gene is folD

Identifier: 51892985

GI number: 51892985

Start: 1992453

End: 1993313

Strand: Reverse

Name: folD

Synonym: STH1847

Alternate gene names: 51892985

Gene position: 1993313-1992453 (Counterclockwise)

Preceding gene: 51892986

Following gene: 51892984

Centisome position: 55.9

GC content: 69.34

Gene sequence:

>861_bases
GTGACTGCAGGAGTGATCGACGGCAAGCAGGTCGCGGCTCAGGTGCAGGAAGAGGTGGCGCGGGAGGTGGCCGCCCTGAA
GGCGGAGGGCCTCACGCCGGGGCTGGCGGTGGTGCTGGTGGGCGACGACCCCGCCAGCAAGGTCTACACGGCCAACAAGG
AGCGGACGGCCAAAGAGCTGGGCATGCACTCGGTGCTCTACCACCTGCCCGCGACGACCACCCAGCAGGAGCTGGCGGAC
CTGGTCATGCAGCTCAACCGGGACCCCGCCATCCACGGCATCCTCGTGCAGTCGCCGCTGCCGGAAGGGCTGGACATGGA
CGCCGTCATCCGGCTCATCGACCCGCGGAAGGACGTGGACGGCTTCCATCCCGAGAATGTGGGCCGGCTGTGGATCGGTC
AGGACGGGCTGGTGCCCTGTACGCCGGCGGGCGTCATGCGGTTGCTGGACGCCTACGGCGTTGACCCGAAGGGCAAACAC
GCGGTGGTGGTCGGCCGGTCCAACATCGTCGGCAAACCCATGGCGGCCCTGCTGCTACAGCGGCACGCGACCGTGACCAT
CTGCCACTCCCGCACGCCGGACCTGGCGGAGACCTGCCGCCGGGCCGACATCCTGGTGGCCGCTGTGGGCCGGCTGCAGA
TGATCACCGCGGAGCACGTCAAGCCCGGCGCCGTGGTGATCGACGTGGGCATCAACCCGGTTCCCGGCTTCAAGAAGCGC
ATCCGGGGCGACGTCGACTTCGACAGCGTCCAGGAGGTCGCCGGCCTCATCACGCCGGTGCCGGGGGGCGTGGGGCCAAT
GACGATCGCCATGCTGATGGCGAACACGGTCAAGGCGGCCAGAATGCAGACCGGCCGGTAG

Upstream 100 bases:

>100_bases
CCGCGGTTCAGCACGGACAACGCAGTCGGCACGGCCCTGCTCGCACGGGCGTGCCACGGCGTGTCGTCATAGAAGACGAC
GAGGAAACGGAGGCGATCGC

Downstream 100 bases:

>100_bases
GCTGCGCCCCGCCGGACGGCCTCACGGGTGCGCGAGGCAGCCCCTTCCGGGCGCATGAGGAGGCGATGCTTTGGAGTCCT
TCGCTCTGGCGGAGAGCGGG

Product: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTAGVIDGKQVAAQVQEEVAREVAALKAEGLTPGLAVVLVGDDPASKVYTANKERTAKELGMHSVLYHLPATTTQQELAD
LVMQLNRDPAIHGILVQSPLPEGLDMDAVIRLIDPRKDVDGFHPENVGRLWIGQDGLVPCTPAGVMRLLDAYGVDPKGKH
AVVVGRSNIVGKPMAALLLQRHATVTICHSRTPDLAETCRRADILVAAVGRLQMITAEHVKPGAVVIDVGINPVPGFKKR
IRGDVDFDSVQEVAGLITPVPGGVGPMTIAMLMANTVKAARMQTGR

Sequences:

>Translated_286_residues
MTAGVIDGKQVAAQVQEEVAREVAALKAEGLTPGLAVVLVGDDPASKVYTANKERTAKELGMHSVLYHLPATTTQQELAD
LVMQLNRDPAIHGILVQSPLPEGLDMDAVIRLIDPRKDVDGFHPENVGRLWIGQDGLVPCTPAGVMRLLDAYGVDPKGKH
AVVVGRSNIVGKPMAALLLQRHATVTICHSRTPDLAETCRRADILVAAVGRLQMITAEHVKPGAVVIDVGINPVPGFKKR
IRGDVDFDSVQEVAGLITPVPGGVGPMTIAMLMANTVKAARMQTGR
>Mature_285_residues
TAGVIDGKQVAAQVQEEVAREVAALKAEGLTPGLAVVLVGDDPASKVYTANKERTAKELGMHSVLYHLPATTTQQELADL
VMQLNRDPAIHGILVQSPLPEGLDMDAVIRLIDPRKDVDGFHPENVGRLWIGQDGLVPCTPAGVMRLLDAYGVDPKGKHA
VVVGRSNIVGKPMAALLLQRHATVTICHSRTPDLAETCRRADILVAAVGRLQMITAEHVKPGAVVIDVGINPVPGFKKRI
RGDVDFDSVQEVAGLITPVPGGVGPMTIAMLMANTVKAARMQTGR

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=289, Percent_Identity=46.0207612456747, Blast_Score=247, Evalue=8e-66,
Organism=Homo sapiens, GI222418558, Length=292, Percent_Identity=46.2328767123288, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI94721354, Length=294, Percent_Identity=45.9183673469388, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI36796743, Length=225, Percent_Identity=29.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786741, Length=281, Percent_Identity=50.5338078291815, Blast_Score=255, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17568735, Length=292, Percent_Identity=46.9178082191781, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=44.5993031358885, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321643, Length=301, Percent_Identity=43.1893687707641, Blast_Score=225, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6322933, Length=318, Percent_Identity=24.8427672955975, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136816, Length=295, Percent_Identity=49.4915254237288, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI17136818, Length=295, Percent_Identity=49.4915254237288, Blast_Score=261, Evalue=3e-70,
Organism=Drosophila melanogaster, GI62472483, Length=287, Percent_Identity=46.6898954703833, Blast_Score=236, Evalue=9e-63,
Organism=Drosophila melanogaster, GI45551871, Length=287, Percent_Identity=46.6898954703833, Blast_Score=236, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24645718, Length=287, Percent_Identity=46.6898954703833, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17137370, Length=287, Percent_Identity=46.6898954703833, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_SYMTH (Q67NB1)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075676.1
- HSSP:   P11586
- ProteinModelPortal:   Q67NB1
- SMR:   Q67NB1
- GeneID:   2979342
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1847
- NMPDR:   fig|292459.1.peg.1782
- HOGENOM:   HBG328751
- OMA:   TYVRNKQ
- BioCyc:   STHE292459:STH1847-MONOMER
- BRENDA:   1.5.1.5
- BRENDA:   3.5.4.9
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30375; Mature: 30244

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGVIDGKQVAAQVQEEVAREVAALKAEGLTPGLAVVLVGDDPASKVYTANKERTAKEL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCHHHHHHHH
GMHSVLYHLPATTTQQELADLVMQLNRDPAIHGILVQSPLPEGLDMDAVIRLIDPRKDVD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCC
GFHPENVGRLWIGQDGLVPCTPAGVMRLLDAYGVDPKGKHAVVVGRSNIVGKPMAALLLQ
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHH
RHATVTICHSRTPDLAETCRRADILVAAVGRLQMITAEHVKPGAVVIDVGINPVPGFKKR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
IRGDVDFDSVQEVAGLITPVPGGVGPMTIAMLMANTVKAARMQTGR
HCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAGVIDGKQVAAQVQEEVAREVAALKAEGLTPGLAVVLVGDDPASKVYTANKERTAKEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCHHHHHHHH
GMHSVLYHLPATTTQQELADLVMQLNRDPAIHGILVQSPLPEGLDMDAVIRLIDPRKDVD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCC
GFHPENVGRLWIGQDGLVPCTPAGVMRLLDAYGVDPKGKHAVVVGRSNIVGKPMAALLLQ
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHH
RHATVTICHSRTPDLAETCRRADILVAAVGRLQMITAEHVKPGAVVIDVGINPVPGFKKR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
IRGDVDFDSVQEVAGLITPVPGGVGPMTIAMLMANTVKAARMQTGR
HCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA