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The map label for this gene is gcp [H]

Identifier: 51892986

GI number: 51892986

Start: 1993342

End: 1994304

Strand: Reverse

Name: gcp [H]

Synonym: STH1848

Alternate gene names: 51892986

Gene position: 1994304-1993342 (Counterclockwise)

Preceding gene: 51892987

Following gene: 51892985

Centisome position: 55.92

GC content: 73.52

Gene sequence:

>963_bases
GTGCAGACGAGGCTGTTTCTCGGGATTGATACCAGCTACTACACCTGTTCCGTGGCGCTGGTGGACGAGGACGGGCGGCT
GCTGGAGGATCAGCGCCGCCTGATCTCCGTGGCGGAAGGCGAACGGGGTGTGGCGCCCAACGAGGCCGTGTGGGCGCACC
TGAACGCCCTGCCCGACCTGGCGGAGCCGGTGCTGCGCAGACACGGCCGGTCGGTGGCGGCGGTGGCCGCCTCGGTGAAG
CCCCGGCCGGTGGAGGGATCATACCTCCCGCCCTTCCGGGTCGGGGAGGGGTTTGGCCGCGCGCTCGCGTCGGCCCTGGG
CGTGCCCTTCTACCCGACCACCCACCAGGAGATGCACATTCAGGCCGGCCTCTGGTCGGCGGACACGCCGCCCCGGGGTG
ACCGGTTCCTGGCGGTGCACCTGTCGGGAGGGACCACCGAGCTCATTCGGGTGACCCGGCGGCCCGGCGGCTTCGGCGAG
GAGCTGCTGGGCGGCACCCAGGACCTGCACGCCGGCCAGTTCGTCGACCGGGTCGGGGTGGCCCTGGGGCTGCCCTTCCC
GGCCGGACCGCATCTGGAGCGGCTAGCCGCGTCCGGCGAGCCGGGGCGCGTGCGGCTGCCCTCCGCGGTGCGGGGGTACA
CCGTATCGTTCTCGGGGCCGGAGAGCGCGGCACAGCGGCTGGTGGGACAGGCCGCGCCCGCCGACCTGGCCCTGGCCGTG
TTGCACACGGTGGCCCGGACGGTGGAGAAGTGGCTGCTGCACGCGATGGAGGAGACCGGGCTCCGGGAGGTCCTCATCGT
CGGCGGCGTGGCGGCCAATCAGATCGTACGGGCACGCCTGCGCCACCGGCTGGAGCACCCCGCCGTCGGGGCGCGCCTCG
CCTTTGCCCAGCCGCGGTTCAGCACGGACAACGCAGTCGGCACGGCCCTGCTCGCACGGGCGTGCCACGGCGTGTCGTCA
TAG

Upstream 100 bases:

>100_bases
GAGGCGGTGGAGCTCGCCAAGACCTTCTCCACCGCGGATTCGTCGCGCTTCGTCAACGGAATTCTCGGTTCGGTCATTCG
CGGAATGAAGGGTGCTGCCG

Downstream 100 bases:

>100_bases
AAGACGACGAGGAAACGGAGGCGATCGCGTGACTGCAGGAGTGATCGACGGCAAGCAGGTCGCGGCTCAGGTGCAGGAAG
AGGTGGCGCGGGAGGTGGCC

Product: O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MQTRLFLGIDTSYYTCSVALVDEDGRLLEDQRRLISVAEGERGVAPNEAVWAHLNALPDLAEPVLRRHGRSVAAVAASVK
PRPVEGSYLPPFRVGEGFGRALASALGVPFYPTTHQEMHIQAGLWSADTPPRGDRFLAVHLSGGTTELIRVTRRPGGFGE
ELLGGTQDLHAGQFVDRVGVALGLPFPAGPHLERLAASGEPGRVRLPSAVRGYTVSFSGPESAAQRLVGQAAPADLALAV
LHTVARTVEKWLLHAMEETGLREVLIVGGVAANQIVRARLRHRLEHPAVGARLAFAQPRFSTDNAVGTALLARACHGVSS

Sequences:

>Translated_320_residues
MQTRLFLGIDTSYYTCSVALVDEDGRLLEDQRRLISVAEGERGVAPNEAVWAHLNALPDLAEPVLRRHGRSVAAVAASVK
PRPVEGSYLPPFRVGEGFGRALASALGVPFYPTTHQEMHIQAGLWSADTPPRGDRFLAVHLSGGTTELIRVTRRPGGFGE
ELLGGTQDLHAGQFVDRVGVALGLPFPAGPHLERLAASGEPGRVRLPSAVRGYTVSFSGPESAAQRLVGQAAPADLALAV
LHTVARTVEKWLLHAMEETGLREVLIVGGVAANQIVRARLRHRLEHPAVGARLAFAQPRFSTDNAVGTALLARACHGVSS
>Mature_320_residues
MQTRLFLGIDTSYYTCSVALVDEDGRLLEDQRRLISVAEGERGVAPNEAVWAHLNALPDLAEPVLRRHGRSVAAVAASVK
PRPVEGSYLPPFRVGEGFGRALASALGVPFYPTTHQEMHIQAGLWSADTPPRGDRFLAVHLSGGTTELIRVTRRPGGFGE
ELLGGTQDLHAGQFVDRVGVALGLPFPAGPHLERLAASGEPGRVRLPSAVRGYTVSFSGPESAAQRLVGQAAPADLALAV
LHTVARTVEKWLLHAMEETGLREVLIVGGVAANQIVRARLRHRLEHPAVGARLAFAQPRFSTDNAVGTALLARACHGVSS

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family [H]

Homologues:

Organism=Homo sapiens, GI8923380, Length=320, Percent_Identity=30, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789445, Length=311, Percent_Identity=33.4405144694534, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71995670, Length=329, Percent_Identity=28.2674772036474, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357207, Length=329, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861 [H]

Pfam domain/function: PF00814 Peptidase_M22 [H]

EC number: =3.4.24.57 [H]

Molecular weight: Translated: 34127; Mature: 34127

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRLFLGIDTSYYTCSVALVDEDGRLLEDQRRLISVAEGERGVAPNEAVWAHLNALPDL
CCCEEEEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHH
AEPVLRRHGRSVAAVAASVKPRPVEGSYLPPFRVGEGFGRALASALGVPFYPTTHQEMHI
HHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEE
QAGLWSADTPPRGDRFLAVHLSGGTTELIRVTRRPGGFGEELLGGTQDLHAGQFVDRVGV
EECCCCCCCCCCCCEEEEEEECCCCEEEHEEECCCCCCCHHHHCCCCHHHHHHHHHHHHH
ALGLPFPAGPHLERLAASGEPGRVRLPSAVRGYTVSFSGPESAAQRLVGQAAPADLALAV
HEECCCCCCCCHHHHHCCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHH
LHTVARTVEKWLLHAMEETGLREVLIVGGVAANQIVRARLRHRLEHPAVGARLAFAQPRF
HHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
STDNAVGTALLARACHGVSS
CCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQTRLFLGIDTSYYTCSVALVDEDGRLLEDQRRLISVAEGERGVAPNEAVWAHLNALPDL
CCCEEEEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHH
AEPVLRRHGRSVAAVAASVKPRPVEGSYLPPFRVGEGFGRALASALGVPFYPTTHQEMHI
HHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEE
QAGLWSADTPPRGDRFLAVHLSGGTTELIRVTRRPGGFGEELLGGTQDLHAGQFVDRVGV
EECCCCCCCCCCCCEEEEEEECCCCEEEHEEECCCCCCCHHHHCCCCHHHHHHHHHHHHH
ALGLPFPAGPHLERLAASGEPGRVRLPSAVRGYTVSFSGPESAAQRLVGQAAPADLALAV
HEECCCCCCCCHHHHHCCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHH
LHTVARTVEKWLLHAMEETGLREVLIVGGVAANQIVRARLRHRLEHPAVGARLAFAQPRF
HHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
STDNAVGTALLARACHGVSS
CCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]