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The map label for this gene is fabF [H]

Identifier: 51892098

GI number: 51892098

Start: 1077584

End: 1078825

Strand: Reverse

Name: fabF [H]

Synonym: STH960

Alternate gene names: 51892098

Gene position: 1078825-1077584 (Counterclockwise)

Preceding gene: 51892099

Following gene: 51892087

Centisome position: 30.25

GC content: 71.34

Gene sequence:

>1242_bases
ATGGAGCGACGGGTAGTGGTCACCGGCATGGGGCTGATCTCGCCCCTGGGCAACAGCGTCCGGGCCAACTGGGAGGCGGC
GGTGGCGGGCCGCTCAGGCATCGGCCCGATCACCCGCTTCGACGCCTCCCGCCTGCCGACCCGGTTCGCCGGCGAGGTGC
GCGACTTCGACCCCGCGACGGTGATGGACCCCAAGGAGGTCCGGCGGTACGATCCCTTCATCCACTACGCCCTGGCCGCG
GCCGCGGAGGCGGTGGAGGACGCGGGCCTCACCTTCGAGGGCGAGCTGGCCGAGCGCACCGGCGTCGTGTTCGGCAGCGG
CATGGGCGGTCTGGAGGGCATCGTGGAGAACGCCCTGATCCTGCAGGAGCGGGGCCCCCGGCGGATCTCGCCGTTCTTCG
TCCCGCGCTGCATCATCAACAGCGCCGCCGGCCTGATCTCGATGAAGTACGGCGTGCATGGGCCCAACTACGGGACGGTG
TCCGCCTGTGCCTCGGCGGGCCACGCCATCGCCGACGCGATGCACATCATCCGTCGCGGCGACGCCGACGTCATGATCAC
CGGCGGCAGCGAGGCGACCATCACGGAGCTGGCGTTTGCCGGCTTCAGCTCCGCCAAGGCGCTCTCCACCCGGAACGACG
ACCCCCAGGGCGCCTCCCGCCCGTTTGACGCGGACCGGGACGGCTTTGTCATGAGCGAGGGCGCGGGCTGCCTGGTGCTG
GAGGAGCTGGAGCACGCCAGGCGGCGGGGCGCCCGGATCTACGCCGAACTGGCCGGCGCCGGCATGTCGGGGGATGCGTA
CCACATCACCGCGCCGCACCCGGAGGGCCGGGGCGCGGTCCTGGCGATGAAGGGCGCCCTGCGCAGCGCCCGGCTGAACC
CGGAGGACGTGGGCTACATCAACGCGCACGCCACCTCCACCGACCTGGGCGACGTGCAGGAGAGCCTGGCGATCGAGCAG
GTCTTCGGCGATCACGCCCGGAAGCTGGCCGTCTCCGGCACCAAGTCGATGCACGGCCACCTCCTGGGGGCGGCGGGGGC
CATCGAGGCGATCCTGACCGTGCTCTCGCTGTACCACCAGGTGCTGCTGCCGACCATCAACCTGCACAGGCCCGACCCGG
AGTGCCGCTTGGACTACGTGCCCCACACGGCCCGGGAGGTCCGCGGTGTGGAGGCTGCCCTCTGTAACAACTTCGGCTTC
GGCGGCACCAACGTGTCGCTCGCGTTCCGCCGCTTTGTCTAG

Upstream 100 bases:

>100_bases
CCGGCGCGCCGGACCTGGAACTGAACGCCATGGGGCAGAGCCTGGTGGCGATGCTCCGTTCCTATCTGCTTCCTGAACCT
CTATTGAAGGAGTGAACCGT

Downstream 100 bases:

>100_bases
CGCCTCGGCGCCGGGCGCCGTCACGCCCGGCGCCGTTCAGCCTACCGCCCCTCCGCCGCCCGGATGCGCCGCATGATCGA
CGGGTGGGAGTAGCTGAGGA

Product: 3-oxoacyl-[acyl-carrier-protein] synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MERRVVVTGMGLISPLGNSVRANWEAAVAGRSGIGPITRFDASRLPTRFAGEVRDFDPATVMDPKEVRRYDPFIHYALAA
AAEAVEDAGLTFEGELAERTGVVFGSGMGGLEGIVENALILQERGPRRISPFFVPRCIINSAAGLISMKYGVHGPNYGTV
SACASAGHAIADAMHIIRRGDADVMITGGSEATITELAFAGFSSAKALSTRNDDPQGASRPFDADRDGFVMSEGAGCLVL
EELEHARRRGARIYAELAGAGMSGDAYHITAPHPEGRGAVLAMKGALRSARLNPEDVGYINAHATSTDLGDVQESLAIEQ
VFGDHARKLAVSGTKSMHGHLLGAAGAIEAILTVLSLYHQVLLPTINLHRPDPECRLDYVPHTAREVRGVEAALCNNFGF
GGTNVSLAFRRFV

Sequences:

>Translated_413_residues
MERRVVVTGMGLISPLGNSVRANWEAAVAGRSGIGPITRFDASRLPTRFAGEVRDFDPATVMDPKEVRRYDPFIHYALAA
AAEAVEDAGLTFEGELAERTGVVFGSGMGGLEGIVENALILQERGPRRISPFFVPRCIINSAAGLISMKYGVHGPNYGTV
SACASAGHAIADAMHIIRRGDADVMITGGSEATITELAFAGFSSAKALSTRNDDPQGASRPFDADRDGFVMSEGAGCLVL
EELEHARRRGARIYAELAGAGMSGDAYHITAPHPEGRGAVLAMKGALRSARLNPEDVGYINAHATSTDLGDVQESLAIEQ
VFGDHARKLAVSGTKSMHGHLLGAAGAIEAILTVLSLYHQVLLPTINLHRPDPECRLDYVPHTAREVRGVEAALCNNFGF
GGTNVSLAFRRFV
>Mature_413_residues
MERRVVVTGMGLISPLGNSVRANWEAAVAGRSGIGPITRFDASRLPTRFAGEVRDFDPATVMDPKEVRRYDPFIHYALAA
AAEAVEDAGLTFEGELAERTGVVFGSGMGGLEGIVENALILQERGPRRISPFFVPRCIINSAAGLISMKYGVHGPNYGTV
SACASAGHAIADAMHIIRRGDADVMITGGSEATITELAFAGFSSAKALSTRNDDPQGASRPFDADRDGFVMSEGAGCLVL
EELEHARRRGARIYAELAGAGMSGDAYHITAPHPEGRGAVLAMKGALRSARLNPEDVGYINAHATSTDLGDVQESLAIEQ
VFGDHARKLAVSGTKSMHGHLLGAAGAIEAILTVLSLYHQVLLPTINLHRPDPECRLDYVPHTAREVRGVEAALCNNFGF
GGTNVSLAFRRFV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=46.88995215311, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=55.4054054054054, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI41872631, Length=422, Percent_Identity=27.9620853080569, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=53.7712895377129, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=38.6473429951691, Blast_Score=248, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=41.6867469879518, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=44.5736434108527, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=360, Percent_Identity=27.2222222222222, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=261, Percent_Identity=25.6704980842912, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.9955156950673, Blast_Score=289, Evalue=7e-79,
Organism=Saccharomyces cerevisiae, GI6325025, Length=245, Percent_Identity=25.3061224489796, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=45.9715639810426, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI221330659, Length=382, Percent_Identity=26.1780104712042, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19920632, Length=400, Percent_Identity=26, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24581345, Length=402, Percent_Identity=23.3830845771144, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43833; Mature: 43833

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVVVTGMGLISPLGNSVRANWEAAVAGRSGIGPITRFDASRLPTRFAGEVRDFDPAT
CCCEEEEECCHHHHHCCCCCCCCCCEEECCCCCCCCHHHCCHHHCCHHHCCCCCCCCCCC
VMDPKEVRRYDPFIHYALAAAAEAVEDAGLTFEGELAERTGVVFGSGMGGLEGIVENALI
CCCHHHHHHHCHHHHHHHHHHHHHHHHCCCEEECCHHHHCCEEEECCCCHHHHHHHHHHE
LQERGPRRISPFFVPRCIINSAAGLISMKYGVHGPNYGTVSACASAGHAIADAMHIIRRG
EECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHCC
DADVMITGGSEATITELAFAGFSSAKALSTRNDDPQGASRPFDADRDGFVMSEGAGCLVL
CCCEEEECCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
EELEHARRRGARIYAELAGAGMSGDAYHITAPHPEGRGAVLAMKGALRSARLNPEDVGYI
HHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCEEEEEEHHHHHCCCCHHHCCEE
NAHATSTDLGDVQESLAIEQVFGDHARKLAVSGTKSMHGHLLGAAGAIEAILTVLSLYHQ
ECCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHEHHHHHHHHHHHHHHHHHH
VLLPTINLHRPDPECRLDYVPHTAREVRGVEAALCNNFGFGGTNVSLAFRRFV
HHCCCCCCCCCCCCCEEECCCCHHHHHCCHHHHHHCCCCCCCCCHHHHEEECC
>Mature Secondary Structure
MERRVVVTGMGLISPLGNSVRANWEAAVAGRSGIGPITRFDASRLPTRFAGEVRDFDPAT
CCCEEEEECCHHHHHCCCCCCCCCCEEECCCCCCCCHHHCCHHHCCHHHCCCCCCCCCCC
VMDPKEVRRYDPFIHYALAAAAEAVEDAGLTFEGELAERTGVVFGSGMGGLEGIVENALI
CCCHHHHHHHCHHHHHHHHHHHHHHHHCCCEEECCHHHHCCEEEECCCCHHHHHHHHHHE
LQERGPRRISPFFVPRCIINSAAGLISMKYGVHGPNYGTVSACASAGHAIADAMHIIRRG
EECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHCC
DADVMITGGSEATITELAFAGFSSAKALSTRNDDPQGASRPFDADRDGFVMSEGAGCLVL
CCCEEEECCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
EELEHARRRGARIYAELAGAGMSGDAYHITAPHPEGRGAVLAMKGALRSARLNPEDVGYI
HHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCEEEEEEHHHHHCCCCHHHCCEE
NAHATSTDLGDVQESLAIEQVFGDHARKLAVSGTKSMHGHLLGAAGAIEAILTVLSLYHQ
ECCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHEHHHHHHHHHHHHHHHHHH
VLLPTINLHRPDPECRLDYVPHTAREVRGVEAALCNNFGFGGTNVSLAFRRFV
HHCCCCCCCCCCCCCEEECCCCHHHHHCCHHHHHHCCCCCCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]