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The map label for this gene is xapA [C]

Identifier: 51891953

GI number: 51891953

Start: 915063

End: 915860

Strand: Reverse

Name: xapA [C]

Synonym: STH815

Alternate gene names: 51891953

Gene position: 915860-915063 (Counterclockwise)

Preceding gene: 51891954

Following gene: 51891952

Centisome position: 25.68

GC content: 73.56

Gene sequence:

>798_bases
ATGGTCGATACGGTCATCATCGGGGGTACGGCGGCGTACCACCTGCAGTTCGACCCGGGCTGGACGGAGCGGACCGTGGA
GACCCCCTTCGGCCCGGCCGGACCGTTCCGGATCTTCGCGGTGGCAGGGCGGCCGGTCGCCTTCCTCAGCCGGCACGGCG
GCGAGGGGCGACTGGGGGTCACGCCGCCCTTCATTAACTACCGGGCCAACGTGTGGGCGGCCCGCGCGCTGGGCGCCCGG
CGGGTACTGAGCTGGAACAGCGCCGGCTCGATGGTGCGCGCGCTGCCGCCGGGGAGCCTGGCGGTGGTGTCGGACCTGAT
CGACTGGACCCGGCGACGGCCGGACAGCTTCGGGGCGGCGGCGCGTGATCCGGCGGTGCGCGATACGGTGGTGCGCCATC
CGGCACCGCCCGCCGGACATGCCACCGGGCCCGCATACGCCGGGCTGTTCGACCCGGACCTGCGCGCCCGGCTGGTGCAG
GCGGCCGCGGCCTGCGGTCACCGGGCCGCGCCAAGGGCCGTCTACGCCGCCACCGAGGGCGCCCGGCTGGAGACCCGGGC
GGAGATCGCCCTCCTGGCCCAGGCGGGGGCCGAGCTGGTGGGCATGACCCTCGCACCGGAGGTCTTCCTGGCCCGGGAGC
TGGGGATGGCCTACGGGTCGATCTGCTGGGTGTCCAATTACGCGACGGGCGTGCCCTTCGACGGCCCGGAGCAGCGGCTG
TTCGGGCCGGAGGTGGGACAGCTAATGTTCCGGATCATGCTGCGGCTGCTGGAGGAGGAGGCGAATGCATATGGGTGA

Upstream 100 bases:

>100_bases
ACGCCGCCGCAGTACGTGAGCGTGATCGCCACGGACCGGGGGCTGTTCTCCCCCTGGAACGTGCGGGACTACTTCAGGGC
CCCGGAGCCGGAGGAGTAGC

Downstream 100 bases:

>100_bases
GGTGCTGTTCATCCTGCCGGAGGCGATGGCCGCCGGGGTAGGTTCACCTGGCGCTGGGCACCCCGGGCTCCGGCACCCCG
GGACCGGGGCTCCCGAGACC

Product: methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MVDTVIIGGTAAYHLQFDPGWTERTVETPFGPAGPFRIFAVAGRPVAFLSRHGGEGRLGVTPPFINYRANVWAARALGAR
RVLSWNSAGSMVRALPPGSLAVVSDLIDWTRRRPDSFGAAARDPAVRDTVVRHPAPPAGHATGPAYAGLFDPDLRARLVQ
AAAACGHRAAPRAVYAATEGARLETRAEIALLAQAGAELVGMTLAPEVFLARELGMAYGSICWVSNYATGVPFDGPEQRL
FGPEVGQLMFRIMLRLLEEEANAYG

Sequences:

>Translated_265_residues
MVDTVIIGGTAAYHLQFDPGWTERTVETPFGPAGPFRIFAVAGRPVAFLSRHGGEGRLGVTPPFINYRANVWAARALGAR
RVLSWNSAGSMVRALPPGSLAVVSDLIDWTRRRPDSFGAAARDPAVRDTVVRHPAPPAGHATGPAYAGLFDPDLRARLVQ
AAAACGHRAAPRAVYAATEGARLETRAEIALLAQAGAELVGMTLAPEVFLARELGMAYGSICWVSNYATGVPFDGPEQRL
FGPEVGQLMFRIMLRLLEEEANAYG
>Mature_265_residues
MVDTVIIGGTAAYHLQFDPGWTERTVETPFGPAGPFRIFAVAGRPVAFLSRHGGEGRLGVTPPFINYRANVWAARALGAR
RVLSWNSAGSMVRALPPGSLAVVSDLIDWTRRRPDSFGAAARDPAVRDTVVRHPAPPAGHATGPAYAGLFDPDLRARLVQ
AAAACGHRAAPRAVYAATEGARLETRAEIALLAQAGAELVGMTLAPEVFLARELGMAYGSICWVSNYATGVPFDGPEQRL
FGPEVGQLMFRIMLRLLEEEANAYG

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=223, Percent_Identity=31.390134529148, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980569, Length=231, Percent_Identity=29.4372294372294, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130079, Length=224, Percent_Identity=33.0357142857143, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221459247, Length=205, Percent_Identity=35.609756097561, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 28291; Mature: 28291

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDTVIIGGTAAYHLQFDPGWTERTVETPFGPAGPFRIFAVAGRPVAFLSRHGGEGRLGV
CCCEEEECCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCEEEHHCCCCCCCCCC
TPPFINYRANVWAARALGARRVLSWNSAGSMVRALPPGSLAVVSDLIDWTRRRPDSFGAA
CCCCCCCCCCHHHHHHHCHHHEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
ARDPAVRDTVVRHPAPPAGHATGPAYAGLFDPDLRARLVQAAAACGHRAAPRAVYAATEG
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCC
ARLETRAEIALLAQAGAELVGMTLAPEVFLARELGMAYGSICWVSNYATGVPFDGPEQRL
CCCHHHHHHHHHHHHCHHHEEHHHCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCC
FGPEVGQLMFRIMLRLLEEEANAYG
CCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVDTVIIGGTAAYHLQFDPGWTERTVETPFGPAGPFRIFAVAGRPVAFLSRHGGEGRLGV
CCCEEEECCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCEEEHHCCCCCCCCCC
TPPFINYRANVWAARALGARRVLSWNSAGSMVRALPPGSLAVVSDLIDWTRRRPDSFGAA
CCCCCCCCCCHHHHHHHCHHHEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
ARDPAVRDTVVRHPAPPAGHATGPAYAGLFDPDLRARLVQAAAACGHRAAPRAVYAATEG
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCC
ARLETRAEIALLAQAGAELVGMTLAPEVFLARELGMAYGSICWVSNYATGVPFDGPEQRL
CCCHHHHHHHHHHHHCHHHEEHHHCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCC
FGPEVGQLMFRIMLRLLEEEANAYG
CCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]